IL304888A - שתל קאראטופלסטי אנדותלילאלי ושיטות להכנתו - Google Patents
שתל קאראטופלסטי אנדותלילאלי ושיטות להכנתוInfo
- Publication number
- IL304888A IL304888A IL304888A IL30488823A IL304888A IL 304888 A IL304888 A IL 304888A IL 304888 A IL304888 A IL 304888A IL 30488823 A IL30488823 A IL 30488823A IL 304888 A IL304888 A IL 304888A
- Authority
- IL
- Israel
- Prior art keywords
- graft
- collagen
- support layer
- methacrylate
- crosslinked
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 49
- 230000003511 endothelial effect Effects 0.000 title description 23
- 238000002360 preparation method Methods 0.000 title description 9
- 239000000463 material Substances 0.000 claims description 36
- 102000008186 Collagen Human genes 0.000 claims description 33
- 108010035532 Collagen Proteins 0.000 claims description 33
- 229920001436 collagen Polymers 0.000 claims description 33
- 108010010803 Gelatin Proteins 0.000 claims description 19
- 239000008273 gelatin Substances 0.000 claims description 19
- 229920000159 gelatin Polymers 0.000 claims description 19
- 235000019322 gelatine Nutrition 0.000 claims description 19
- 235000011852 gelatine desserts Nutrition 0.000 claims description 19
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 18
- 239000000017 hydrogel Substances 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 14
- 238000004132 cross linking Methods 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 5
- JUYQFRXNMVWASF-UHFFFAOYSA-M lithium;phenyl-(2,4,6-trimethylbenzoyl)phosphinate Chemical compound [Li+].CC1=CC(C)=CC(C)=C1C(=O)P([O-])(=O)C1=CC=CC=C1 JUYQFRXNMVWASF-UHFFFAOYSA-M 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 description 46
- 210000004027 cell Anatomy 0.000 description 14
- 210000000399 corneal endothelial cell Anatomy 0.000 description 14
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 12
- 210000004087 cornea Anatomy 0.000 description 9
- 238000002513 implantation Methods 0.000 description 9
- 239000007943 implant Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 230000014509 gene expression Effects 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 5
- 239000004971 Cross linker Substances 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 210000002159 anterior chamber Anatomy 0.000 description 4
- 210000002555 descemet membrane Anatomy 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 238000010899 nucleation Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- GJKGAPPUXSSCFI-UHFFFAOYSA-N 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone Chemical compound CC(C)(O)C(=O)C1=CC=C(OCCO)C=C1 GJKGAPPUXSSCFI-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000155 isotopic effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000003892 spreading Methods 0.000 description 3
- 230000007480 spreading Effects 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 201000004569 Blindness Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000002045 capillary electrochromatography Methods 0.000 description 2
- 208000015636 celiac disease-epilepsy-cerebral calcification syndrome Diseases 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 210000003038 endothelium Anatomy 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical group [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 210000003683 corneal stroma Anatomy 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 210000000871 endothelium corneal Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229910052722 tritium Chemical group 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Landscapes
- Prostheses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL304888A IL304888A (he) | 2023-07-31 | 2023-07-31 | שתל קאראטופלסטי אנדותלילאלי ושיטות להכנתו |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL304888A IL304888A (he) | 2023-07-31 | 2023-07-31 | שתל קאראטופלסטי אנדותלילאלי ושיטות להכנתו |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL304888A true IL304888A (he) | 2024-04-01 |
Family
ID=90573413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL304888A IL304888A (he) | 2023-07-31 | 2023-07-31 | שתל קאראטופלסטי אנדותלילאלי ושיטות להכנתו |
Country Status (1)
| Country | Link |
|---|---|
| IL (1) | IL304888A (he) |
-
2023
- 2023-07-31 IL IL304888A patent/IL304888A/he unknown
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