IL300611A - Anti-C5 antibodies and methods for their use - Google Patents

Anti-C5 antibodies and methods for their use

Info

Publication number
IL300611A
IL300611A IL300611A IL30061123A IL300611A IL 300611 A IL300611 A IL 300611A IL 300611 A IL300611 A IL 300611A IL 30061123 A IL30061123 A IL 30061123A IL 300611 A IL300611 A IL 300611A
Authority
IL
Israel
Prior art keywords
antibody
seq
amino acid
acid sequence
hvr
Prior art date
Application number
IL300611A
Other languages
English (en)
Hebrew (he)
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of IL300611A publication Critical patent/IL300611A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
IL300611A 2016-06-17 2017-06-16 Anti-C5 antibodies and methods for their use IL300611A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016120325 2016-06-17
PCT/JP2017/022253 WO2017217524A1 (en) 2016-06-17 2017-06-16 Anti-c5 antibodies and methods of use

Publications (1)

Publication Number Publication Date
IL300611A true IL300611A (en) 2023-04-01

Family

ID=59969459

Family Applications (2)

Application Number Title Priority Date Filing Date
IL300611A IL300611A (en) 2016-06-17 2017-06-16 Anti-C5 antibodies and methods for their use
IL263657A IL263657A (en) 2016-06-17 2018-12-12 Anti-c5 antibodies and methods of their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL263657A IL263657A (en) 2016-06-17 2018-12-12 Anti-c5 antibodies and methods of their use

Country Status (19)

Country Link
EP (1) EP3472316A4 (zh)
JP (3) JP6202774B1 (zh)
KR (2) KR101852739B1 (zh)
CN (3) CN115960223A (zh)
AU (1) AU2017285763B2 (zh)
BR (1) BR112018075688A2 (zh)
CA (1) CA3021956A1 (zh)
CL (1) CL2018003573A1 (zh)
CR (1) CR20190013A (zh)
EA (1) EA201990018A1 (zh)
IL (2) IL300611A (zh)
MX (2) MX2018015030A (zh)
MY (1) MY187848A (zh)
PE (1) PE20190394A1 (zh)
PH (1) PH12018502354A1 (zh)
SG (2) SG10201800265UA (zh)
TW (4) TW202337903A (zh)
UA (1) UA126561C2 (zh)
WO (1) WO2017217524A1 (zh)

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EP3056568B1 (en) 2006-03-31 2021-09-15 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
CN106519025B (zh) 2007-09-26 2021-04-23 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
CA2721052C (en) 2008-04-11 2023-02-21 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
TWI654203B (zh) 2010-11-30 2019-03-21 中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
AU2015365167B2 (en) 2014-12-19 2021-07-29 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies and methods of use
KR102534895B1 (ko) 2016-06-14 2023-05-24 리제너론 파아마슈티컬스, 인크. 항-c5 항체 및 이의 용도
KR101852739B1 (ko) * 2016-06-17 2018-04-30 추가이 세이야쿠 가부시키가이샤 항-c5 항체 및 사용 방법
KR20230079499A (ko) 2016-08-05 2023-06-07 추가이 세이야쿠 가부시키가이샤 Il-8 관련 질환의 치료용 또는 예방용 조성물
CN111278857A (zh) * 2017-10-04 2020-06-12 亚力兄制药公司 抗c5抗体治疗患有膜增生性肾小球肾炎的患者的剂量和施用
US11365265B2 (en) 2017-12-13 2022-06-21 Regeneron Pharmaceuticals, Inc. Anti-C5 antibody combinations and uses thereof
WO2020051418A1 (en) * 2018-09-06 2020-03-12 The Trustees Of The University Of Pennsylvania Humanized anti-c5 antibodies and uses thereof
BR112021021176A2 (pt) * 2019-04-24 2021-12-28 Kira Pharmaceuticals Us Llc Proteína de fusão, métodos para tratar uma doença ou distúrbio mediado pela via do complemento em um indivíduo e para reduzir a atividade de um sistema de complemento de um indivíduo, célula, e, animal não humano geneticamente modificado
CN113563467A (zh) * 2020-04-28 2021-10-29 上海普铭生物科技有限公司 针对人补体蛋白c5的抗体及其应用

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US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
EP1410671B1 (en) 2001-06-12 2011-01-12 TELEFONAKTIEBOLAGET LM ERICSSON (publ) Synchronisation in a umts terrestrial radio access network (utran)
ES2283594T5 (es) 2001-08-17 2016-03-15 Genentech, Inc. Inhibidores de la ruta del complemento que se unen a C5 y C5a sin impedir la formación de C5b
JP4333939B2 (ja) 2001-08-27 2009-09-16 ロード・コーポレーション トロリ線の吊架装置
DE10253331A1 (de) 2002-11-14 2004-06-03 Symrise Gmbh & Co. Kg Verwendung von trans-Pellitori als Aromastoff
US7267849B2 (en) 2004-03-02 2007-09-11 Nitto Denko Corporation Compensator for liquid crystal display
KR20080069889A (ko) 2007-03-20 2008-07-29 (주)화도 폴리에틸렌 관
CA2680760A1 (en) * 2007-03-22 2008-09-25 Novartis Ag C5 antigens and uses thereof
EP2138531B1 (en) 2007-04-11 2014-10-29 Sekisui Chemical Co., Ltd. Method for production of crosslinked polyvinyl acetal resin, and crosslinked polyvinyl acetal resin
CA2721052C (en) * 2008-04-11 2023-02-21 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
HUE026179T2 (en) * 2008-08-05 2016-05-30 Novartis Ag Preparations and methods for antibodies against complement C5 protein
KR20100054403A (ko) 2008-11-14 2010-05-25 삼성전자주식회사 온라인 공동 작문 장치 및 방법
CA2792740A1 (en) * 2010-03-11 2011-09-15 Rinat Neuroscience Corporation Antibodies with ph dependent antigen binding
TW201206466A (en) * 2010-03-11 2012-02-16 Rinat Neuroscience Corp Antibodies with pH dependent antigen binding
KR20110111007A (ko) 2010-04-02 2011-10-10 이화여자대학교 산학협력단 L/d 광학변환 및 광학분할을 위한 옥타하이드로-바이나프톨 유도체
KR20110122011A (ko) 2010-05-03 2011-11-09 황보철종 매장 포인트 통합 관리 시스템 및 그 방법
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US10280215B2 (en) * 2013-01-31 2019-05-07 Seoul National University R&Db Foundation Anti-C5 antibodies and methods of treating complement-related diseases
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NZ631007A (en) * 2014-03-07 2015-10-30 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
AU2015365167B2 (en) * 2014-12-19 2021-07-29 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies and methods of use
PE20240365A1 (es) * 2015-12-18 2024-03-04 Chugai Pharmaceutical Co Ltd Anticuerpos anti-c5 y metodos de uso
KR101852739B1 (ko) * 2016-06-17 2018-04-30 추가이 세이야쿠 가부시키가이샤 항-c5 항체 및 사용 방법

Also Published As

Publication number Publication date
JP7032077B2 (ja) 2022-03-08
TW201809000A (zh) 2018-03-16
EA201990018A1 (ru) 2019-08-30
JP6202774B1 (ja) 2017-09-27
MX2018015030A (es) 2019-04-22
CN115960223A (zh) 2023-04-14
KR102226975B1 (ko) 2021-03-11
JP2017226655A (ja) 2017-12-28
TWI789369B (zh) 2023-01-11
JP2018009021A (ja) 2018-01-18
KR20190009273A (ko) 2019-01-28
SG10201800265UA (en) 2018-02-27
CA3021956A1 (en) 2017-12-21
AU2017285763A1 (en) 2018-11-08
TW201808996A (zh) 2018-03-16
MX2023001360A (es) 2023-02-27
AU2017285763B2 (en) 2024-02-01
JP2022091748A (ja) 2022-06-21
CL2018003573A1 (es) 2019-02-01
KR101852739B1 (ko) 2018-04-30
EP3472316A1 (en) 2019-04-24
TW202337903A (zh) 2023-10-01
UA126561C2 (uk) 2022-11-02
RU2019100222A3 (zh) 2020-11-05
BR112018075688A2 (pt) 2019-04-02
TW202239766A (zh) 2022-10-16
TWI807666B (zh) 2023-07-01
PE20190394A1 (es) 2019-03-13
CN109312326A (zh) 2019-02-05
CN115925922A (zh) 2023-04-07
WO2017217524A1 (en) 2017-12-21
CN109312326B (zh) 2022-09-09
RU2019100222A (ru) 2020-07-17
CR20190013A (es) 2019-03-05
MY187848A (en) 2021-10-26
SG11201705584VA (en) 2018-05-30
TWI610941B (zh) 2018-01-11
EP3472316A4 (en) 2020-01-08
PH12018502354A1 (en) 2019-09-23
IL263657A (en) 2019-01-31

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