IL298605A - Compositions and methods for epigenome editing - Google Patents
Compositions and methods for epigenome editingInfo
- Publication number
- IL298605A IL298605A IL298605A IL29860522A IL298605A IL 298605 A IL298605 A IL 298605A IL 298605 A IL298605 A IL 298605A IL 29860522 A IL29860522 A IL 29860522A IL 298605 A IL298605 A IL 298605A
- Authority
- IL
- Israel
- Prior art keywords
- seq
- fusion protein
- aspects
- amino acid
- sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/85—Fusion polypeptide containing an RNA binding domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063035431P | 2020-06-05 | 2020-06-05 | |
| US202063118832P | 2020-11-27 | 2020-11-27 | |
| PCT/US2021/035937 WO2021248023A2 (en) | 2020-06-05 | 2021-06-04 | Compositions and methods for epigenome editing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL298605A true IL298605A (en) | 2023-01-01 |
Family
ID=78831718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL298605A IL298605A (en) | 2020-06-05 | 2021-06-04 | Compositions and methods for epigenome editing |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230212323A1 (https=) |
| EP (1) | EP4162054A4 (https=) |
| JP (1) | JP2023529844A (https=) |
| KR (1) | KR20230021081A (https=) |
| CN (1) | CN116057180A (https=) |
| AU (1) | AU2021282659A1 (https=) |
| BR (1) | BR112022024747A2 (https=) |
| CA (1) | CA3184882A1 (https=) |
| GB (1) | GB2612466B (https=) |
| IL (1) | IL298605A (https=) |
| MX (1) | MX2022015284A (https=) |
| WO (1) | WO2021248023A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113846019B (zh) * | 2021-03-05 | 2023-08-01 | 海南师范大学 | 一种海洋微拟球藻靶向表观基因组遗传调控方法 |
| KR20250010025A (ko) * | 2022-05-13 | 2025-01-20 | 인테그라 테라퓨틱스 | 도입유전자 발현 및 핵 국소화를 개선하기 위한 트랜스포사제의 용도 |
| KR20250165443A (ko) | 2023-02-17 | 2025-11-25 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | 후성유전학적 변형 제조를 위한 조성물 및 방법 |
| WO2024238682A2 (en) * | 2023-05-15 | 2024-11-21 | The Regents Of The University Of California | Cask gene editing system |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9115386B2 (en) * | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| ES2610356T3 (es) * | 2009-02-03 | 2017-04-27 | Amunix Operating Inc. | Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos |
| CN112301024A (zh) * | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| US10077453B2 (en) * | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| US20190100732A1 (en) * | 2016-06-02 | 2019-04-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Assay for the removal of methyl-cytosine residues from dna |
| WO2018053035A1 (en) * | 2016-09-13 | 2018-03-22 | The Jackson Laboratory | Targeted dna demethylation and methylation |
| AU2018213044B2 (en) * | 2017-01-26 | 2024-08-01 | The Regents Of The University Of California | Targeted gene demethylation in plants |
| KR102922694B1 (ko) * | 2018-04-19 | 2026-02-03 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 유전자 편집을 위한 조성물 및 방법 |
-
2021
- 2021-06-04 MX MX2022015284A patent/MX2022015284A/es unknown
- 2021-06-04 EP EP21818667.4A patent/EP4162054A4/en active Pending
- 2021-06-04 JP JP2022574471A patent/JP2023529844A/ja active Pending
- 2021-06-04 IL IL298605A patent/IL298605A/en unknown
- 2021-06-04 KR KR1020237000254A patent/KR20230021081A/ko active Pending
- 2021-06-04 BR BR112022024747A patent/BR112022024747A2/pt unknown
- 2021-06-04 GB GB2219608.3A patent/GB2612466B/en active Active
- 2021-06-04 CN CN202180047868.5A patent/CN116057180A/zh active Pending
- 2021-06-04 AU AU2021282659A patent/AU2021282659A1/en active Pending
- 2021-06-04 US US17/999,762 patent/US20230212323A1/en active Pending
- 2021-06-04 WO PCT/US2021/035937 patent/WO2021248023A2/en not_active Ceased
- 2021-06-04 CA CA3184882A patent/CA3184882A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3184882A1 (en) | 2021-12-09 |
| AU2021282659A1 (en) | 2023-01-05 |
| GB202219608D0 (en) | 2023-02-08 |
| MX2022015284A (es) | 2023-01-19 |
| BR112022024747A2 (pt) | 2023-03-07 |
| EP4162054A2 (en) | 2023-04-12 |
| WO2021248023A2 (en) | 2021-12-09 |
| EP4162054A4 (en) | 2025-01-22 |
| CN116057180A (zh) | 2023-05-02 |
| GB2612466A (en) | 2023-05-03 |
| WO2021248023A3 (en) | 2022-01-27 |
| JP2023529844A (ja) | 2023-07-12 |
| KR20230021081A (ko) | 2023-02-13 |
| GB2612466B (en) | 2026-04-01 |
| US20230212323A1 (en) | 2023-07-06 |
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