IL295626A - A triple drug combination that includes dabrafenib, an erk inhibitor and a raf inhibitor - Google Patents

A triple drug combination that includes dabrafenib, an erk inhibitor and a raf inhibitor

Info

Publication number
IL295626A
IL295626A IL295626A IL29562622A IL295626A IL 295626 A IL295626 A IL 295626A IL 295626 A IL295626 A IL 295626A IL 29562622 A IL29562622 A IL 29562622A IL 295626 A IL295626 A IL 295626A
Authority
IL
Israel
Prior art keywords
braf
dabrafenib
compound
seq
pharmaceutic
Prior art date
Application number
IL295626A
Other languages
English (en)
Hebrew (he)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL295626A publication Critical patent/IL295626A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL295626A 2020-02-28 2021-02-26 A triple drug combination that includes dabrafenib, an erk inhibitor and a raf inhibitor IL295626A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062983020P 2020-02-28 2020-02-28
PCT/IB2021/051641 WO2021171260A2 (en) 2020-02-28 2021-02-26 A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor or a pd-1 inhibitor

Publications (1)

Publication Number Publication Date
IL295626A true IL295626A (en) 2022-10-01

Family

ID=76845267

Family Applications (1)

Application Number Title Priority Date Filing Date
IL295626A IL295626A (en) 2020-02-28 2021-02-26 A triple drug combination that includes dabrafenib, an erk inhibitor and a raf inhibitor

Country Status (9)

Country Link
EP (1) EP4110341A2 (ja)
JP (1) JP2023516155A (ja)
KR (1) KR20220148846A (ja)
CN (1) CN115279374A (ja)
AU (1) AU2021225491A1 (ja)
CA (1) CA3173356A1 (ja)
IL (1) IL295626A (ja)
TW (1) TW202146024A (ja)
WO (1) WO2021171260A2 (ja)

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL129299A0 (en) 1999-03-31 2000-02-17 Mor Research Applic Ltd Monoclonal antibodies antigens and diagnosis of malignant diseases
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
CA2508660C (en) 2002-12-23 2013-08-20 Wyeth Antibodies against pd-1 and uses therefor
SI2439273T1 (sl) 2005-05-09 2019-05-31 Ono Pharmaceutical Co., Ltd. Človeška monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka z uporabo protiteles proti PD-1 samostojno ali v kombinaciji z ostalimi imunoterapevtiki
KR101586617B1 (ko) 2007-06-18 2016-01-20 머크 샤프 앤 도메 비.브이. 사람 프로그램된 사멸 수용체 pd-1에 대한 항체
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
JP2012510429A (ja) 2008-08-25 2012-05-10 アンプリミューン、インコーポレーテッド Pd−1アンタゴニストおよびその使用方法
WO2010029435A1 (en) 2008-09-12 2010-03-18 Isis Innovation Limited Pd-1 specific antibodies and uses thereof
SI2342226T1 (sl) 2008-09-26 2016-11-30 Dana-Farber Cancer Institute Inc. Humana protitelesa proti PD-1, PD-L1 in PD-L2 in njihove uporabe
US20130017199A1 (en) 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
US8993731B2 (en) 2010-03-11 2015-03-31 Ucb Biopharma Sprl PD-1 antibody
DK2699264T3 (en) 2011-04-20 2018-06-25 Medimmune Llc ANTIBODIES AND OTHER MOLECULES BINDING B7-H1 AND PD-1
RU2604814C2 (ru) 2011-07-24 2016-12-10 Кьюртек Лтд. Варианты гуманизированных иммуномодулирующих моноклональных антител
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
SG11201508528TA (en) 2013-05-02 2015-11-27 Anaptysbio Inc Antibodies directed against programmed death-1 (pd-1)
US9676853B2 (en) 2013-05-31 2017-06-13 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-1
US20160145355A1 (en) 2013-06-24 2016-05-26 Biomed Valley Discoveries, Inc. Bispecific antibodies
PL3702373T3 (pl) 2013-09-13 2022-12-05 Beigene Switzerland Gmbh Przeciwciała anty-PD1 i ich zastosowanie jako środki terapeutyczne i diagnostyczne
HUE039306T2 (hu) 2013-11-01 2018-12-28 Novartis Ag Kináz inhibitor aminoheteroaril-benzamidok
SG10201804945WA (en) 2013-12-12 2018-07-30 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗pd-1抗體類和使用彼等之方法
WO2018051306A1 (en) * 2016-09-19 2018-03-22 Novartis Ag Therapeutic combinations comprising a raf inhibitor and a erk inhibitor
KR20200138303A (ko) * 2018-03-30 2020-12-09 노파르티스 아게 다브라페닙, 트라메티닙 및 erk 저해제를 포함하는 삼중 약제학적 조합물

Also Published As

Publication number Publication date
JP2023516155A (ja) 2023-04-18
WO2021171260A2 (en) 2021-09-02
EP4110341A2 (en) 2023-01-04
CA3173356A1 (en) 2021-09-02
TW202146024A (zh) 2021-12-16
WO2021171260A3 (en) 2021-10-07
KR20220148846A (ko) 2022-11-07
AU2021225491A1 (en) 2022-10-20
CN115279374A (zh) 2022-11-01

Similar Documents

Publication Publication Date Title
CN111065411B (zh) Pd-1抗体和vegfr抑制剂联合治疗小细胞肺癌的用途
AU2012321110B2 (en) Combination treatment
IL290727B1 (en) A formulation for inhibiting the formation of 5-ht 2b agonists and methods of using the same
JP6208235B2 (ja) 多発性硬化症治療のためのビオチンの使用
WO2018223923A1 (zh) Pd-1抗体与vegf配体或vegf受体抑制剂联合在制备治疗肿瘤的药物中的用途
IL295678A (en) A triple pharmaceutical combination containing davarfenib, an erk inhibitor and a shp2 inhibitor
US20200113883A1 (en) Durable treatment with 4-aminopyridine in patients with demyelination
IL301910A (en) Transcutaneous synthetic cannabidiol for the treatment of focal epilepsy in adults
US20230146896A1 (en) Composition and method for treating alzheimer's disease
EA028060B1 (ru) Комбинированная терапия бокового амиотрофического склероза
AU2022202508A1 (en) Treatment of alopecia areata
IL305332A (en) A combination of ABT-199 and achmetalstat for the treatment of AML
IL297043A (en) Drug combination including tno155 and nazaretinib
IL295626A (en) A triple drug combination that includes dabrafenib, an erk inhibitor and a raf inhibitor
JP7357646B2 (ja) 乾癬の治療のための組成物及び方法
TW202106716A (zh) 包含抗cd123免疫結合物之治療組合
IL297640A (en) Methods and combinations for cancer treatment using immune checkpoint inhibitor antibodies
IL302383A (en) A method for the safe administration of anti-tau antibodies
JP2024516003A (ja) 糖尿病網膜症および関連する状態を治療するための方法および組成物
IL301596A (en) Pharmacy composition
MM et al. EXPERIENCE WITH BORTEZOMIB IN ABO INCOMPATIBLE RENAL TRANSPLANTATION-A CASE SERIES
TW202330614A (zh) 抗trem2抗體及其用途
WO2023215384A2 (en) Use of myostatin inhibitor for treating spinal muscular atrophy
IL305624A (en) Methods for treating non-Hodgkin's lymphoma using 2-(2,6-deoxypyridin-3YL)-4-(2-FLUORO-4-((3-morpholinoazetidine-1-YL)methyl)benzyl)amino)isoindoline-1, - DIONEN
NZ750691B2 (en) Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same