IL295626A - קומבינצית תרופות משולשת הכוללת dabrafenib, מעכב erk ומעכב raf - Google Patents

קומבינצית תרופות משולשת הכוללת dabrafenib, מעכב erk ומעכב raf

Info

Publication number
IL295626A
IL295626A IL295626A IL29562622A IL295626A IL 295626 A IL295626 A IL 295626A IL 295626 A IL295626 A IL 295626A IL 29562622 A IL29562622 A IL 29562622A IL 295626 A IL295626 A IL 295626A
Authority
IL
Israel
Prior art keywords
braf
dabrafenib
compound
seq
pharmaceutic
Prior art date
Application number
IL295626A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL295626A publication Critical patent/IL295626A/he

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL295626A 2020-02-28 2021-02-26 קומבינצית תרופות משולשת הכוללת dabrafenib, מעכב erk ומעכב raf IL295626A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062983020P 2020-02-28 2020-02-28
PCT/IB2021/051641 WO2021171260A2 (en) 2020-02-28 2021-02-26 A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor or a pd-1 inhibitor

Publications (1)

Publication Number Publication Date
IL295626A true IL295626A (he) 2022-10-01

Family

ID=76845267

Family Applications (1)

Application Number Title Priority Date Filing Date
IL295626A IL295626A (he) 2020-02-28 2021-02-26 קומבינצית תרופות משולשת הכוללת dabrafenib, מעכב erk ומעכב raf

Country Status (9)

Country Link
EP (1) EP4110341A2 (he)
JP (1) JP2023516155A (he)
KR (1) KR20220148846A (he)
CN (1) CN115279374A (he)
AU (1) AU2021225491A1 (he)
CA (1) CA3173356A1 (he)
IL (1) IL295626A (he)
TW (1) TW202146024A (he)
WO (1) WO2021171260A2 (he)

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL129299A0 (en) 1999-03-31 2000-02-17 Mor Research Applic Ltd Monoclonal antibodies antigens and diagnosis of malignant diseases
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
ATE514713T1 (de) 2002-12-23 2011-07-15 Wyeth Llc Antikörper gegen pd-1 und ihre verwendung
NZ563193A (en) 2005-05-09 2010-05-28 Ono Pharmaceutical Co Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
EP2170959B1 (en) 2007-06-18 2013-10-02 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor pd-1
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
CN102203125A (zh) 2008-08-25 2011-09-28 安普利穆尼股份有限公司 Pd-1拮抗剂及其使用方法
EP2342229A1 (en) 2008-09-12 2011-07-13 ISIS Innovation Limited Pd-1 specific antibodies and uses thereof
CA2998281C (en) 2008-09-26 2022-08-16 Dana-Farber Cancer Institute, Inc. Human anti-pd-1 antobodies and uses therefor
US20130017199A1 (en) 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
EP2545078A1 (en) 2010-03-11 2013-01-16 UCB Pharma, S.A. Pd-1 antibody
CN103608040B (zh) 2011-04-20 2017-03-01 米迪缪尼有限公司 结合b7‑h1和pd‑1的抗体和其他分子
CA2840018C (en) 2011-07-24 2019-07-16 Curetech Ltd. Variants of humanized immunomodulatory monoclonal antibodies
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
SG11201508528TA (en) 2013-05-02 2015-11-27 Anaptysbio Inc Antibodies directed against programmed death-1 (pd-1)
CA3175360C (en) 2013-05-31 2024-05-28 Sorrento Therapeutics, Inc. Antigen binding proteins that bind pd-1
US20160145355A1 (en) 2013-06-24 2016-05-26 Biomed Valley Discoveries, Inc. Bispecific antibodies
CN112457403B (zh) 2013-09-13 2022-11-29 广州百济神州生物制药有限公司 抗pd1抗体及其作为治疗剂与诊断剂的用途
SI3063143T1 (sl) 2013-11-01 2018-09-28 Novartis Ag, Aminoheteroaril benzamidi kot inhibitorji kinaze
HUE046249T2 (hu) 2013-12-12 2020-02-28 Shanghai hengrui pharmaceutical co ltd PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗pd-1抗體類和使用彼等之方法
AU2017329090B9 (en) * 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
US20210121460A1 (en) * 2018-03-30 2021-04-29 Novartis Ag A triple pharmaceutical combination comprising dabrafenib, trametinib and an erk inhibitor

Also Published As

Publication number Publication date
KR20220148846A (ko) 2022-11-07
WO2021171260A3 (en) 2021-10-07
CN115279374A (zh) 2022-11-01
TW202146024A (zh) 2021-12-16
EP4110341A2 (en) 2023-01-04
CA3173356A1 (en) 2021-09-02
AU2021225491A1 (en) 2022-10-20
JP2023516155A (ja) 2023-04-18
WO2021171260A2 (en) 2021-09-02

Similar Documents

Publication Publication Date Title
CN111065411B (zh) Pd-1抗体和vegfr抑制剂联合治疗小细胞肺癌的用途
IL295678A (he) שילוב רוקחי משולש המכיל דברפניב, מעכב erk ומעכב shp2
AU2012321110B2 (en) Combination treatment
IL290727B1 (he) פורמולציה לעיכוב יצירת אגוניסטים של 5–ht 2b ושיטות לשימוש בה
JP6208235B2 (ja) 多発性硬化症治療のためのビオチンの使用
IL301910A (he) קנאבידיאול סינתטי דרך העור לטיפול באפילפסיה מוקדית במבוגרים
WO2018223923A1 (zh) Pd-1抗体与vegf配体或vegf受体抑制剂联合在制备治疗肿瘤的药物中的用途
US20200113883A1 (en) Durable treatment with 4-aminopyridine in patients with demyelination
US20230146896A1 (en) Composition and method for treating alzheimer's disease
EA028060B1 (ru) Комбинированная терапия бокового амиотрофического склероза
JP7357646B2 (ja) 乾癬の治療のための組成物及び方法
TW202106716A (zh) 包含抗cd123免疫結合物之治療組合
AU2022202508A1 (en) Treatment of alopecia areata
IL297043A (he) שילוב תרופות הכולל tno155 ונזרטיניב
IL295626A (he) קומבינצית תרופות משולשת הכוללת dabrafenib, מעכב erk ומעכב raf
Kandjani et al. S1PR1 modulators in multiple sclerosis: Efficacy, safety, comparison, and chemical structure insights
JP2024516003A (ja) 糖尿病網膜症および関連する状態を治療するための方法および組成物
IL302383A (he) שיטה למתן בטוח של נוגדנים אנטי-טאו
WO2024158972A1 (en) Methods and compositions for preventing the progression of diabetic retinopathy and related conditions
IL305490A (he) שיטות טיפול בלימפומה B-Cell באמצעות טיפול קומבינציה
IL301596A (he) הרכב רוקחות
MM et al. EXPERIENCE WITH BORTEZOMIB IN ABO INCOMPATIBLE RENAL TRANSPLANTATION-A CASE SERIES
TW202330614A (zh) 抗trem2抗體及其用途
KR20240116529A (ko) 알츠하이머병 치료에 사용하기 위한 alz-801
WO2023215384A2 (en) Use of myostatin inhibitor for treating spinal muscular atrophy