IL294272A - Substituted bicyclic piperidine derivatives are useful as t-cell activators - Google Patents
Substituted bicyclic piperidine derivatives are useful as t-cell activatorsInfo
- Publication number
- IL294272A IL294272A IL294272A IL29427222A IL294272A IL 294272 A IL294272 A IL 294272A IL 294272 A IL294272 A IL 294272A IL 29427222 A IL29427222 A IL 29427222A IL 294272 A IL294272 A IL 294272A
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- oxo
- carbonitrile
- naphthyridine
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201911053552 | 2019-12-23 | ||
| PCT/US2020/066507 WO2021133750A1 (en) | 2019-12-23 | 2020-12-22 | Substituted bicyclic piperidine derivatives useful as t cell activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL294272A true IL294272A (en) | 2022-08-01 |
Family
ID=74191945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL294272A IL294272A (en) | 2019-12-23 | 2020-12-22 | Substituted bicyclic piperidine derivatives are useful as t-cell activators |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US11964973B2 (https=) |
| EP (1) | EP4081523B1 (https=) |
| JP (1) | JP7653440B2 (https=) |
| KR (1) | KR20220119455A (https=) |
| CN (1) | CN114901660B (https=) |
| AR (1) | AR120823A1 (https=) |
| AU (1) | AU2020412615A1 (https=) |
| BR (1) | BR112022012195A2 (https=) |
| CA (1) | CA3163013A1 (https=) |
| CL (1) | CL2022001710A1 (https=) |
| CO (1) | CO2022008675A2 (https=) |
| DK (1) | DK4081523T3 (https=) |
| ES (1) | ES3008848T3 (https=) |
| FI (1) | FI4081523T3 (https=) |
| HR (1) | HRP20250149T1 (https=) |
| HU (1) | HUE070934T2 (https=) |
| IL (1) | IL294272A (https=) |
| LT (1) | LT4081523T (https=) |
| MX (1) | MX2022007842A (https=) |
| PE (1) | PE20221487A1 (https=) |
| PL (1) | PL4081523T3 (https=) |
| PT (1) | PT4081523T (https=) |
| RS (1) | RS66482B1 (https=) |
| SI (1) | SI4081523T1 (https=) |
| SM (1) | SMT202500102T1 (https=) |
| TW (1) | TWI843922B (https=) |
| WO (1) | WO2021133750A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL294032A (en) | 2019-12-24 | 2022-08-01 | Carna Biosciences Inc | Compounds that regulate diacylglycerol kinase |
| MX2023014762A (es) | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| WO2023122778A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Pyridazinone derivatives useful as t cell activators |
| WO2023150186A1 (en) * | 2022-02-01 | 2023-08-10 | Arvinas Operations, Inc. | Dgk targeting compounds and uses thereof |
| EP4486741A4 (en) | 2022-03-01 | 2026-04-08 | Insilico Medicine Ip Ltd | Diacylglycerol Kinase (DGK) Alpha Inhibitors and Their Uses |
| WO2023165525A1 (en) * | 2022-03-01 | 2023-09-07 | Insilico Medicine Ip Limited | Diacylglycerol kinase (dgk) alpha inhibitors and uses thereof |
| US20250215014A1 (en) * | 2022-03-31 | 2025-07-03 | InventisBio Co., Ltd. | Kinase inhibitors, preparation methods and uses thereof |
| US12600723B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US12600722B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| WO2024137865A1 (en) * | 2022-12-22 | 2024-06-27 | Gossamer Bio Services, Inc. | Compounds useful as t cell activators |
| EP4658650A1 (en) * | 2023-02-02 | 2025-12-10 | Beone Medicines I GmbH | Heterocyclic compounds |
| EP4661869A1 (en) | 2023-02-06 | 2025-12-17 | Bayer Aktiengesellschaft | Combinations of dgk (diacylglycerol kinase) inhibitors and immune checkpoint inhibitors and modulators |
| WO2025030002A2 (en) * | 2023-08-02 | 2025-02-06 | Arvinas Operations, Inc. | Dgk targeting compounds and uses thereof |
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| WO2004087880A2 (en) | 2003-03-26 | 2004-10-14 | Bayer Pharmaceuticals Corporation | Compounds and their use to treat diabetes and related disorders |
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| US7381401B2 (en) * | 2004-01-08 | 2008-06-03 | The University Of Chicago | T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase |
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2020
- 2020-12-18 AR ARP200103557A patent/AR120823A1/es not_active Application Discontinuation
- 2020-12-22 DK DK20842859.9T patent/DK4081523T3/da active
- 2020-12-22 HR HRP20250149TT patent/HRP20250149T1/hr unknown
- 2020-12-22 PE PE2022001172A patent/PE20221487A1/es unknown
- 2020-12-22 KR KR1020227025285A patent/KR20220119455A/ko active Pending
- 2020-12-22 CN CN202080089196.XA patent/CN114901660B/zh active Active
- 2020-12-22 EP EP20842859.9A patent/EP4081523B1/en active Active
- 2020-12-22 US US17/130,022 patent/US11964973B2/en active Active
- 2020-12-22 LT LTEPPCT/US2020/066507T patent/LT4081523T/lt unknown
- 2020-12-22 SM SM20250102T patent/SMT202500102T1/it unknown
- 2020-12-22 SI SI202030567T patent/SI4081523T1/sl unknown
- 2020-12-22 FI FIEP20842859.9T patent/FI4081523T3/fi active
- 2020-12-22 JP JP2022538810A patent/JP7653440B2/ja active Active
- 2020-12-22 PT PT208428599T patent/PT4081523T/pt unknown
- 2020-12-22 IL IL294272A patent/IL294272A/en unknown
- 2020-12-22 HU HUE20842859A patent/HUE070934T2/hu unknown
- 2020-12-22 TW TW109145532A patent/TWI843922B/zh not_active IP Right Cessation
- 2020-12-22 ES ES20842859T patent/ES3008848T3/es active Active
- 2020-12-22 RS RS20250119A patent/RS66482B1/sr unknown
- 2020-12-22 CA CA3163013A patent/CA3163013A1/en active Pending
- 2020-12-22 PL PL20842859.9T patent/PL4081523T3/pl unknown
- 2020-12-22 WO PCT/US2020/066507 patent/WO2021133750A1/en not_active Ceased
- 2020-12-22 BR BR112022012195A patent/BR112022012195A2/pt unknown
- 2020-12-22 MX MX2022007842A patent/MX2022007842A/es unknown
- 2020-12-22 AU AU2020412615A patent/AU2020412615A1/en active Pending
-
2022
- 2022-06-20 CL CL2022001710A patent/CL2022001710A1/es unknown
- 2022-06-22 CO CONC2022/0008675A patent/CO2022008675A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL4081523T3 (pl) | 2025-03-10 |
| AU2020412615A1 (en) | 2022-08-18 |
| AR120823A1 (es) | 2022-03-23 |
| CN114901660B (zh) | 2024-10-15 |
| EP4081523A1 (en) | 2022-11-02 |
| FI4081523T3 (fi) | 2025-03-06 |
| BR112022012195A2 (pt) | 2022-09-06 |
| US20210188845A1 (en) | 2021-06-24 |
| CA3163013A1 (en) | 2021-07-01 |
| EP4081523B1 (en) | 2024-12-25 |
| TW202136254A (zh) | 2021-10-01 |
| JP2023508052A (ja) | 2023-02-28 |
| LT4081523T (lt) | 2025-05-12 |
| TWI843922B (zh) | 2024-06-01 |
| SI4081523T1 (sl) | 2025-04-30 |
| CN114901660A (zh) | 2022-08-12 |
| HUE070934T2 (hu) | 2025-07-28 |
| CL2022001710A1 (es) | 2023-01-13 |
| KR20220119455A (ko) | 2022-08-29 |
| WO2021133750A1 (en) | 2021-07-01 |
| SMT202500102T1 (it) | 2025-05-12 |
| CO2022008675A2 (es) | 2022-07-19 |
| PE20221487A1 (es) | 2022-09-26 |
| MX2022007842A (es) | 2022-07-19 |
| JP7653440B2 (ja) | 2025-03-28 |
| HRP20250149T1 (hr) | 2025-04-11 |
| DK4081523T3 (da) | 2025-03-10 |
| RS66482B1 (sr) | 2025-03-31 |
| US11964973B2 (en) | 2024-04-23 |
| ES3008848T3 (en) | 2025-03-25 |
| PT4081523T (pt) | 2025-02-04 |
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