IL286538A - Cells, tissues, and organs for customized transplantation, which are humanized and specifically free from pathogens, from a non-human donor, as well as methods and products related to them - Google Patents

Cells, tissues, and organs for customized transplantation, which are humanized and specifically free from pathogens, from a non-human donor, as well as methods and products related to them

Info

Publication number
IL286538A
IL286538A IL286538A IL28653821A IL286538A IL 286538 A IL286538 A IL 286538A IL 286538 A IL286538 A IL 286538A IL 28653821 A IL28653821 A IL 28653821A IL 286538 A IL286538 A IL 286538A
Authority
IL
Israel
Prior art keywords
bespoke
humanized
transplantation
donor
organs
Prior art date
Application number
IL286538A
Other languages
English (en)
Hebrew (he)
Original Assignee
Xenotherapeutics Inc
Xenotherapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/054833 external-priority patent/WO2020072982A1/en
Application filed by Xenotherapeutics Inc, Xenotherapeutics Corp filed Critical Xenotherapeutics Inc
Publication of IL286538A publication Critical patent/IL286538A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL286538A 2019-03-25 2021-09-19 Cells, tissues, and organs for customized transplantation, which are humanized and specifically free from pathogens, from a non-human donor, as well as methods and products related to them IL286538A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962823455P 2019-03-25 2019-03-25
US201962848272P 2019-05-15 2019-05-15
PCT/US2019/054833 WO2020072982A1 (en) 2018-10-05 2019-10-04 Xenotransplantation products and methods
US202062964397P 2020-01-22 2020-01-22
US202062975611P 2020-02-12 2020-02-12
PCT/US2020/024780 WO2020198397A1 (en) 2019-03-25 2020-03-25 Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non- human) donor and methods and products relating to same

Publications (1)

Publication Number Publication Date
IL286538A true IL286538A (en) 2021-12-01

Family

ID=72609069

Family Applications (1)

Application Number Title Priority Date Filing Date
IL286538A IL286538A (en) 2019-03-25 2021-09-19 Cells, tissues, and organs for customized transplantation, which are humanized and specifically free from pathogens, from a non-human donor, as well as methods and products related to them

Country Status (10)

Country Link
EP (1) EP3945799A1 (ja)
JP (1) JP2022527061A (ja)
KR (1) KR20220004029A (ja)
CN (1) CN113784615A (ja)
AU (1) AU2020244827A1 (ja)
BR (1) BR112021018788A2 (ja)
CA (1) CA3133638A1 (ja)
IL (1) IL286538A (ja)
MX (1) MX2021011709A (ja)
WO (1) WO2020198397A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023538663A (ja) * 2020-08-24 2023-09-08 ゼノセラピューティクス インコーポレイテッド 付帯ゲノム破壊を最小限に抑えたサイレンシング、ヒト化、及び個別化のための、移植のための免疫学的に適合性のある細胞、組織、臓器、及び方法
WO2022133155A1 (en) * 2020-12-16 2022-06-23 Xenotherapeutics, Inc. Humanization of beta2-microglobulin in porcine genome resulting in functional expression of human βeta2-microglobulin within donor cells, tissues, or organs
WO2022256294A1 (en) * 2021-06-01 2022-12-08 University Of Massachusetts Cas9 nickase-mediated gene editing
WO2022256401A1 (en) * 2021-06-01 2022-12-08 Xenotherapeutics, Inc. Xenogeneic nerve transplants and methods
CN114574557B (zh) * 2022-05-09 2022-09-09 上海美迪西生物医药股份有限公司 Nk细胞治疗产品通用型临床前生物分布检测试剂盒
CN115236078A (zh) * 2022-07-12 2022-10-25 黑龙江省农业科学院食品加工研究所 一种加工稻米留皮度的测定方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL120909A0 (en) 1997-05-26 1997-09-30 Lrr & D Ltd Compositions and means for the treatment of burns and other cutaneous traumas
US6469229B1 (en) 1998-08-20 2002-10-22 The General Hospital Corporation Inbred miniature swine and uses thereof
IL137689A0 (en) 2000-08-03 2001-10-31 L R Res & Dev Ltd System for enhanced chemical debridement
EP1465481A4 (en) 2001-12-21 2007-09-12 Univ Missouri KNOCK-OUT PORK AND METHODS OF MAKING THE SAME
EP1539225B1 (en) 2002-04-23 2012-08-22 Mediwound, Ltd. Apparatus and methods for use in enzymatic escharotomy in burn induced compartment syndrome
CA2507486A1 (en) 2002-08-14 2004-02-26 Immerge Biotherapeutics, Inc. .alpha.(1,3)-galactosyltransferase null cells, methods of selecting and .alpha.(1,3)-galactosyltransferase null swine produced therefrom
WO2004028243A2 (en) 2002-08-21 2004-04-08 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
JP2007529278A (ja) 2004-03-17 2007-10-25 レビビコア， インコーポレイテッド 機能的α１，３ガラクトシルトランスフェラーゼを欠く動物に由来する組織生成物
AU2005261276A1 (en) 2004-07-13 2006-01-19 Mediwound Ltd. Compositions and methods for dermatological wound healing
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
JP5788323B2 (ja) 2008-10-02 2015-09-30 エル．アール． アールアンドディー リミテッド 界面層の創傷包帯
WO2013169929A1 (en) 2012-05-08 2013-11-14 The General Hospital Corporation Reducing immunogenicity of xenogeneic transplant tissues
LT3066201T (lt) 2013-11-07 2018-08-10 Editas Medicine, Inc. Su crispr susiję būdai ir kompozicijos su valdančiomis grnr
KR102659529B1 (ko) 2014-10-22 2024-04-23 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 이종이식에 적합한 삼중 트랜스제닉 돼지
US11284607B2 (en) 2015-03-24 2022-03-29 The Trustees Of Columbia University In The City Of New York Genetic modification of pigs for xenotransplantation
US20180184630A1 (en) 2015-06-26 2018-07-05 Indiana University Research & Technology Corporation Transgenic pigs with genetic modifications of sla
AU2016319131B2 (en) * 2015-09-09 2022-10-13 Revivicor, Inc. Multi-transgenic pig for xenotransplantation
WO2019006330A1 (en) * 2017-06-30 2019-01-03 Indiana University Research And Technology Corporation COMPOSITIONS AND METHODS FOR DETECTING REACTIVITY TO ALS

Also Published As

Publication number Publication date
BR112021018788A2 (pt) 2021-11-23
KR20220004029A (ko) 2022-01-11
AU2020244827A1 (en) 2021-09-30
MX2021011709A (es) 2022-01-06
EP3945799A1 (en) 2022-02-09
JP2022527061A (ja) 2022-05-30
CN113784615A (zh) 2021-12-10
CA3133638A1 (en) 2020-10-01
WO2020198397A1 (en) 2020-10-01

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