IL28504A - N-arylsulphonyl n'-isoquinuclidyl ureas - Google Patents
N-arylsulphonyl n'-isoquinuclidyl ureasInfo
- Publication number
- IL28504A IL28504A IL28504A IL2850467A IL28504A IL 28504 A IL28504 A IL 28504A IL 28504 A IL28504 A IL 28504A IL 2850467 A IL2850467 A IL 2850467A IL 28504 A IL28504 A IL 28504A
- Authority
- IL
- Israel
- Prior art keywords
- ureas
- urea
- isoquinuclidyl
- arylsulphonyl
- hours
- Prior art date
Links
- 235000013877 carbamide Nutrition 0.000 title description 14
- 150000003672 ureas Chemical class 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 6
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 9
- 239000004202 carbamide Substances 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 230000000994 depressogenic effect Effects 0.000 description 6
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 6
- 229960002277 tolazamide Drugs 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 239000013543 active substance Substances 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920000846 Crystalate Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- -1 alkali metal salts Chemical class 0.000 description 2
- 150000001340 alkali metals Chemical group 0.000 description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KPUSZZFAYGWAHZ-UHFFFAOYSA-N 3-azabicyclo[2.2.2]octane Chemical compound C1CC2CCC1NC2 KPUSZZFAYGWAHZ-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 235000019759 Maize starch Nutrition 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000004421 aryl sulphonamide group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- CNWSQCLBDWYLAN-UHFFFAOYSA-N butylurea Chemical compound CCCCNC(N)=O CNWSQCLBDWYLAN-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 125000000565 sulfonamide group Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0050003 | 1966-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL28504A true IL28504A (en) | 1971-10-20 |
Family
ID=7103453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL28504A IL28504A (en) | 1966-08-22 | 1967-08-15 | N-arylsulphonyl n'-isoquinuclidyl ureas |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3764605A (OSRAM) |
| AT (1) | AT275542B (OSRAM) |
| BE (1) | BE702903A (OSRAM) |
| CH (1) | CH487860A (OSRAM) |
| DE (1) | DE1670736A1 (OSRAM) |
| DK (1) | DK119830B (OSRAM) |
| ES (2) | ES344342A1 (OSRAM) |
| FI (1) | FI45659C (OSRAM) |
| FR (1) | FR7050M (OSRAM) |
| GB (1) | GB1199758A (OSRAM) |
| IL (1) | IL28504A (OSRAM) |
| NL (1) | NL6711508A (OSRAM) |
| NO (1) | NO123429B (OSRAM) |
| SE (1) | SE330698B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443243A (en) * | 1981-07-16 | 1984-04-17 | Ciba-Geigy Corporation | N-Phenylsulfonyl-N-triazinylureas |
| JP2000169474A (ja) * | 1998-12-07 | 2000-06-20 | Kotobuki Seiyaku Kk | イソキヌクリジン誘導体及びその製造方法並びにこれを含有する高コレステロール血症治療剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2075359A (en) * | 1930-10-16 | 1937-03-30 | Du Pont | Insecticide |
| US1915334A (en) * | 1930-10-16 | 1933-06-27 | Du Pont | Fluosilicate of organic heterocyclic bases and process of making it |
| DE1191826B (de) * | 1963-09-03 | 1965-04-29 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung neuer Benzolsulfonylsemicarbazide und ihrer Salze |
-
1966
- 1966-08-22 DE DE19661670736 patent/DE1670736A1/de active Pending
-
1967
- 1967-08-07 CH CH1108567A patent/CH487860A/de not_active IP Right Cessation
- 1967-08-15 IL IL28504A patent/IL28504A/en unknown
- 1967-08-16 NO NO169387A patent/NO123429B/no unknown
- 1967-08-16 DK DK416467AA patent/DK119830B/da unknown
- 1967-08-17 US US00661198A patent/US3764605A/en not_active Expired - Lifetime
- 1967-08-18 FI FI672219A patent/FI45659C/fi active
- 1967-08-21 NL NL6711508A patent/NL6711508A/xx unknown
- 1967-08-21 GB GB38460/67A patent/GB1199758A/en not_active Expired
- 1967-08-21 BE BE702903D patent/BE702903A/xx unknown
- 1967-08-22 ES ES344342A patent/ES344342A1/es not_active Expired
- 1967-08-22 SE SE11749/67A patent/SE330698B/xx unknown
- 1967-08-22 AT AT772767A patent/AT275542B/de active
- 1967-09-29 ES ES345565A patent/ES345565A1/es not_active Expired
- 1967-11-21 FR FR129107A patent/FR7050M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES344342A1 (es) | 1969-04-16 |
| GB1199758A (en) | 1970-07-22 |
| SE330698B (OSRAM) | 1970-11-30 |
| DE1670736A1 (de) | 1970-12-23 |
| AT275542B (de) | 1969-10-27 |
| BE702903A (OSRAM) | 1968-02-21 |
| ES345565A1 (es) | 1969-04-16 |
| NL6711508A (OSRAM) | 1968-02-23 |
| US3764605A (en) | 1973-10-09 |
| FR7050M (OSRAM) | 1969-06-16 |
| CH487860A (de) | 1970-03-31 |
| FI45659B (OSRAM) | 1972-05-02 |
| NO123429B (OSRAM) | 1971-11-15 |
| DK119830B (da) | 1971-03-01 |
| FI45659C (fi) | 1972-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3113949A (en) | Substituted pyrazole sulfonamides | |
| US3639477A (en) | Novel propoxyguanidine compounds and means of producing the same | |
| US4574124A (en) | Lipid absorption-inhibiting agents and their use | |
| JPS5946219B2 (ja) | 複素環式化合物の製法 | |
| HU180430B (en) | Process for preparing substituted 2-phenyl-imino-imidazolidines and acid addition salts thereof infulencing the cardiovascular system | |
| US3255201A (en) | 2-nitroimidazoles | |
| US4213995A (en) | 2-Phenylimino-imidazolidines and salts thereof | |
| US2907692A (en) | Composition for treating diabetes and a process of administering same | |
| US3290326A (en) | Esters of 4-lower alkyl-5-oxazole-car-bamic acid and intermediates therefor | |
| JPS6026112B2 (ja) | ２−フエニルアミノ−イミダゾリン−（２）化合物 | |
| IL28504A (en) | N-arylsulphonyl n'-isoquinuclidyl ureas | |
| US3896149A (en) | Novel pyrrolidone derivatives and manufacturing the same | |
| EP0009608B1 (en) | N-phenethylacetamide compounds, processes for their preparation and therapeutic compositions containing them | |
| US3932503A (en) | Benzenesulfonyl ureas | |
| US4310532A (en) | Methods and piperidinyl-alkyl-benzamide composition for inhibiting H2 histamine receptors | |
| US4198431A (en) | Alkyl N-(3-trifluoromethylphenyl)-anthranilate | |
| US4029666A (en) | Benzenesulfonyl-ureas and process for preparing them | |
| IE52289B1 (en) | 2-amino-3(halobenzoyl)-methylphenylacetic acids,esters and salts thereof | |
| US3813398A (en) | Benzenesulfonyl-semicarbazides and process for their manufacture | |
| US3564010A (en) | Guanidino ureido and thioureido-delta**1-pyrrolines | |
| DE2241269A1 (de) | Heterocyclische verbindungen und verfahren zu ihrer herstellung | |
| US2905590A (en) | Thioxanthene derivative | |
| US3483248A (en) | Preparation of 2-(4-biphenylyl) butyric acid | |
| US3294640A (en) | Controlling blood sugar with sulfonyl pyrazoles | |
| US3597479A (en) | Substituted anilino benzyl alcohols |