IL282191A - שיטות ותכשירים לעריכת רנ" א - Google Patents
שיטות ותכשירים לעריכת רנ" אInfo
- Publication number
- IL282191A IL282191A IL282191A IL28219121A IL282191A IL 282191 A IL282191 A IL 282191A IL 282191 A IL282191 A IL 282191A IL 28219121 A IL28219121 A IL 28219121A IL 282191 A IL282191 A IL 282191A
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- methods
- rnas
- editing
- editing rnas
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/34—Allele or polymorphism specific uses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018110105 | 2018-10-12 | ||
| CN2019082713 | 2019-04-15 | ||
| PCT/CN2019/110782 WO2020074001A1 (en) | 2018-10-12 | 2019-10-12 | Methods and Compositions for Editing RNAs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL282191A true IL282191A (he) | 2021-05-31 |
Family
ID=70163607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL282191A IL282191A (he) | 2018-10-12 | 2021-04-08 | שיטות ותכשירים לעריכת רנ" א |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20210355494A1 (he) |
| EP (2) | EP3864152B1 (he) |
| JP (2) | JP7252328B2 (he) |
| CN (4) | CN116218836A (he) |
| AU (2) | AU2019357450B2 (he) |
| BR (1) | BR112021006844A8 (he) |
| CA (1) | CA3115864A1 (he) |
| CL (1) | CL2021000880A1 (he) |
| CO (1) | CO2021005956A2 (he) |
| CR (1) | CR20210243A (he) |
| DK (1) | DK3864152T3 (he) |
| EC (1) | ECSP21033637A (he) |
| ES (1) | ES2962434T3 (he) |
| IL (1) | IL282191A (he) |
| MX (1) | MX2021004187A (he) |
| PE (1) | PE20211402A1 (he) |
| PH (1) | PH12021550805A1 (he) |
| SG (1) | SG11202103666PA (he) |
| TW (1) | TW202028466A (he) |
| WO (1) | WO2020074001A1 (he) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11932856B2 (en) | 2017-03-03 | 2024-03-19 | The Regents Of The University Of California | RNA targeting of mutations via suppressor tRNAs and deaminases |
| US20220307020A1 (en) | 2019-04-15 | 2022-09-29 | Edigene Inc. | Methods and compositions for editing rnas |
| CR20220063A (es) | 2019-07-12 | 2022-07-22 | Univ Beijing | Edición de ácido ribonucleico (arn) dirigido aprovechando la adenosina desaminasa que actúa sobre ácido ribonucleico endógeno (adar) utilizando ácidos ribonucleicos (arn) modificados genéticamente |
| CN115038789A (zh) | 2019-12-02 | 2022-09-09 | 塑造治疗公司 | 治疗性编辑 |
| WO2021136404A1 (zh) | 2019-12-30 | 2021-07-08 | 博雅辑因（北京）生物科技有限公司 | 一种治疗Usher综合征的方法和其组合物 |
| JP2023509179A (ja) | 2019-12-30 | 2023-03-07 | 北京▲輯▼因医▲療▼科技有限公司 | Ｌｅａｐｅｒ技術に基づくｍｐｓ ｉｈの治療方法及び組成物 |
| EP4137161A4 (en) * | 2020-04-15 | 2023-10-11 | EdiGene Therapeutics (Beijing) Inc. | METHOD AND MEDICATION FOR THE TREATMENT OF HURLER SYNDROME |
| AU2021279027A1 (en) * | 2020-05-28 | 2022-12-08 | Korro Bio, Inc. | Methods and compositions for the ADAR-mediated editing of SERPINA1 |
| CN113897359A (zh) * | 2020-07-06 | 2022-01-07 | 博雅辑因（北京）生物科技有限公司 | 一种改善的rna编辑方法 |
| EP4177345A1 (en) | 2020-07-06 | 2023-05-10 | EdiGene Therapeutics (Beijing) Inc. | Improved rna editing method |
| IL278401A (he) | 2020-10-29 | 2022-05-01 | Yeda Res & Dev | פולינוקלאוטידים לעריכה של רנ" א ושיטה לשימוש בהם |
| EP4240338A1 (en) * | 2021-01-04 | 2023-09-13 | The Regents of The University of California | <smallcaps/>? ? ?in vivo? ? ? ? ?programmable rna editingvia recruitment of endogenous adars |
| CN117015605A (zh) * | 2021-01-12 | 2023-11-07 | 北京大学 | 使用工程化rna通过利用内源性adar进行靶向rna编辑 |
| US20230123513A1 (en) * | 2021-06-15 | 2023-04-20 | Massachusetts Institute Of Technology | Deaminase-based rna sensors |
| WO2023278436A1 (en) * | 2021-06-29 | 2023-01-05 | Shape Therapeutics Inc. | Engineered guide rnas and polynucleotides |
| WO2023020574A1 (en) * | 2021-08-18 | 2023-02-23 | Peking University | Engineered adar-recruiting rnas and methods of use thereof |
| WO2023060186A1 (en) | 2021-10-07 | 2023-04-13 | Hepatx Corporation | Methods of tracking donor cells in a recipient |
| CA3236182A1 (en) * | 2021-10-29 | 2023-05-04 | Z. Josh Huang | Compositions and systems for rna-programable cell editing and methods of making and using same |
| WO2023143539A1 (en) * | 2022-01-28 | 2023-08-03 | Edigene Therapeutics (Beijing) Inc. | Engineered adar-recruiting rnas and methods of use thereof |
| WO2023185231A1 (en) * | 2022-04-02 | 2023-10-05 | Edigene Therapeutics (Beijing) Inc. | Engineered adar-recruiting rnas and methods of use for usher syndrome |
| WO2024086650A1 (en) * | 2022-10-18 | 2024-04-25 | Locanabio, Inc. | Compositions and methods comprising programmable snrnas for rna editing |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016094845A2 (en) | 2014-12-12 | 2016-06-16 | Woolf Tod M | Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides |
| WO2016097212A1 (en) * | 2014-12-17 | 2016-06-23 | Proqr Therapeutics Ii B.V. | Targeted rna editing |
| JP6624743B2 (ja) | 2015-07-14 | 2019-12-25 | 学校法人福岡大学 | 部位特異的ｒｎａ変異導入方法およびそれに使用する標的編集ガイドｒｎａならびに標的ｒｎａ−標的編集ガイドｒｎａ複合体 |
| DE102015012522B3 (de) * | 2015-09-26 | 2016-06-02 | Eberhard Karls Universität Tübingen | Verfahren und Substanzen zur gerichteten RNA-Editierung |
| WO2017220751A1 (en) * | 2016-06-22 | 2017-12-28 | Proqr Therapeutics Ii B.V. | Single-stranded rna-editing oligonucleotides |
| PL3507366T3 (pl) * | 2016-09-01 | 2021-05-04 | Proqr Therapeutics Ii B.V. | Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rna |
| WO2018134301A1 (en) | 2017-01-19 | 2018-07-26 | Proqr Therapeutics Ii B.V. | Oligonucleotide complexes for use in rna editing |
| US11932856B2 (en) | 2017-03-03 | 2024-03-19 | The Regents Of The University Of California | RNA targeting of mutations via suppressor tRNAs and deaminases |
| US11739308B2 (en) | 2017-03-15 | 2023-08-29 | The Broad Institute, Inc. | Cas13b orthologues CRISPR enzymes and systems |
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2019
- 2019-10-12 BR BR112021006844A patent/BR112021006844A8/pt unknown
- 2019-10-12 CN CN202210724157.3A patent/CN116218836A/zh active Pending
- 2019-10-12 CR CR20210243A patent/CR20210243A/es unknown
- 2019-10-12 CN CN202210717093.4A patent/CN115651927B/zh active Active
- 2019-10-12 EP EP19870299.5A patent/EP3864152B1/en active Active
- 2019-10-12 SG SG11202103666PA patent/SG11202103666PA/en unknown
- 2019-10-12 US US17/284,232 patent/US20210355494A1/en active Pending
- 2019-10-12 MX MX2021004187A patent/MX2021004187A/es unknown
- 2019-10-12 CA CA3115864A patent/CA3115864A1/en active Pending
- 2019-10-12 CN CN202210740517.9A patent/CN116042611A/zh active Pending
- 2019-10-12 PE PE2021000498A patent/PE20211402A1/es unknown
- 2019-10-12 WO PCT/CN2019/110782 patent/WO2020074001A1/en unknown
- 2019-10-12 AU AU2019357450A patent/AU2019357450B2/en active Active
- 2019-10-12 CN CN201980067380.1A patent/CN113631708B/zh active Active
- 2019-10-12 EP EP23184286.5A patent/EP4306116A3/en active Pending
- 2019-10-12 DK DK19870299.5T patent/DK3864152T3/da active
- 2019-10-12 ES ES19870299T patent/ES2962434T3/es active Active
- 2019-10-12 JP JP2021520227A patent/JP7252328B2/ja active Active
- 2019-10-14 TW TW108136892A patent/TW202028466A/zh unknown
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2021
- 2021-04-08 IL IL282191A patent/IL282191A/he unknown
- 2021-04-09 CL CL2021000880A patent/CL2021000880A1/es unknown
- 2021-04-09 US US17/226,961 patent/US20210310026A1/en active Pending
- 2021-04-12 PH PH12021550805A patent/PH12021550805A1/en unknown
- 2021-05-06 CO CONC2021/0005956A patent/CO2021005956A2/es unknown
- 2021-05-12 EC ECSENADI202133637A patent/ECSP21033637A/es unknown
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2023
- 2023-03-22 JP JP2023045897A patent/JP2023078373A/ja active Pending
- 2023-04-11 AU AU2023202184A patent/AU2023202184A1/en active Pending
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