IL278366A - - Google Patents

Info

Publication number
IL278366A
IL278366A IL27836620A IL27836620A IL278366A IL 278366 A IL278366 A IL 278366A IL 27836620 A IL27836620 A IL 27836620A IL 27836620 A IL27836620 A IL 27836620A IL 278366 A IL278366 A IL 278366A
Authority
IL
Israel
Application number
IL27836620A
Other languages
English (en)
Other versions
IL278366B2 (en
IL278366B1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of IL278366A publication Critical patent/IL278366A/en
Publication of IL278366B1 publication Critical patent/IL278366B1/en
Publication of IL278366B2 publication Critical patent/IL278366B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
IL278366A 2018-04-29 2019-04-29 BCL-2 inhibitors IL278366B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018085217 2018-04-29
CN2018107134 2018-09-21
PCT/CN2019/085001 WO2019210828A1 (en) 2018-04-29 2019-04-29 Bcl-2 INHIBITORS

Publications (3)

Publication Number Publication Date
IL278366A true IL278366A (enExample) 2020-12-31
IL278366B1 IL278366B1 (en) 2025-05-01
IL278366B2 IL278366B2 (en) 2025-09-01

Family

ID=68386968

Family Applications (1)

Application Number Title Priority Date Filing Date
IL278366A IL278366B2 (en) 2018-04-29 2019-04-29 BCL-2 inhibitors

Country Status (22)

Country Link
US (3) US11420968B2 (enExample)
EP (2) EP4545515A1 (enExample)
JP (4) JP2021521138A (enExample)
KR (1) KR102738032B1 (enExample)
CN (3) CN112437772B (enExample)
AU (1) AU2019264475C1 (enExample)
BR (1) BR112020022092A2 (enExample)
CA (1) CA3098348A1 (enExample)
DK (1) DK3788042T3 (enExample)
ES (1) ES3018793T3 (enExample)
FI (1) FI3788042T3 (enExample)
HR (1) HRP20250392T1 (enExample)
HU (1) HUE071493T2 (enExample)
IL (1) IL278366B2 (enExample)
LT (1) LT3788042T (enExample)
MX (2) MX2020011495A (enExample)
PL (1) PL3788042T3 (enExample)
PT (1) PT3788042T (enExample)
SG (1) SG11202009933WA (enExample)
SI (1) SI3788042T1 (enExample)
TW (1) TWI855062B (enExample)
WO (1) WO2019210828A1 (enExample)

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CN110177788B (zh) 2017-01-07 2023-03-24 重庆复创医药研究有限公司 作为bcl-2选择性凋亡诱导剂的化合物
SI3612531T1 (sl) 2017-04-18 2022-11-30 Shanghai Fochon Pharmaceutical Co., Ltd. Sredstva, ki sprožajo apoptozo
IL316472A (en) 2018-01-10 2024-12-01 Recurium Ip Holdings Llc Benzamide compounds
CN112437772B (zh) * 2018-04-29 2023-11-21 百济神州有限公司 Bcl-2抑制剂
WO2020140005A2 (en) 2018-12-29 2020-07-02 Newave Pharmaceutical Inc. Bcl-2 inhibitors
WO2021083135A1 (en) * 2019-10-28 2021-05-06 Beigene, Ltd. Bcl-2 INHIBITORS
WO2021110102A1 (en) * 2019-12-02 2021-06-10 Beigene, Ltd. Methods of cancer treatment using bcl-2 inhibitor
KR20220100992A (ko) 2019-12-06 2022-07-18 록쏘 온콜로지, 인코포레이티드 브루톤 티로신 키나제 억제제의 투여
BR112022012283A2 (pt) 2019-12-20 2022-08-30 Recurium Ip Holdings Llc Combinações
WO2021133817A1 (en) 2019-12-27 2021-07-01 Guangzhou Lupeng Pharmaceutical Company Ltd. 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
CN116969937B (zh) 2020-04-15 2026-03-24 百济神州(苏州)生物科技有限公司 Bcl-2抑制剂
MX2022014007A (es) * 2020-05-08 2023-02-09 Fochon Pharmaceuticals Ltd Compuestos como inhibidores de bcl-2.
WO2022089463A1 (zh) * 2020-10-28 2022-05-05 杭州和正医药有限公司 Bcl-2蛋白凋亡诱导剂及应用
BR112023017371A2 (pt) * 2021-03-19 2023-10-03 Eil Therapeutics Inc Compostos que têm ((3-nitrofenil)sulfonil)acetamida como inibidores de bcl-2
US20240239792A1 (en) * 2021-04-13 2024-07-18 Appicine Therapeutics (Hk) Limited Modulators of bcl-2 or bcl-2/bcl-xl and uses thereof
MX2023014275A (es) * 2021-06-02 2024-03-06 Beigene Switzerland Gmbh Métodos de tratamiento de la malignidad de células b utilizando un inhibidor de bcl-2.
CN115490708B (zh) * 2021-06-18 2025-01-24 苏州亚盛药业有限公司 磺酰胺类大环衍生物及其制备方法和用途
MX2024002465A (es) * 2021-08-31 2024-04-29 Beigene Ltd Formas solidas de inhibidores de bcl-2, metodo de preparacion y sus usos.
WO2023078398A1 (en) * 2021-11-05 2023-05-11 Fochon Pharmaceuticals, Ltd. Compounds as bcl-2 inhibitors
JP2024540590A (ja) * 2021-11-20 2024-10-31 フォチョン・バイオサイエンシーズ・リミテッド Bcl-2阻害剤としての化合物
JP7765790B2 (ja) * 2021-12-06 2025-11-07 杭州和正医薬有限公司 抗アポトーシスタンパク質bcl-2阻害剤、医薬組成物及びその使用
TW202400163A (zh) 2022-05-12 2024-01-01 英屬開曼群島商百濟神州有限公司 使用bcl-2抑制劑治療髓性惡性腫瘤之方法
WO2023231777A1 (en) * 2022-06-01 2023-12-07 Fochon Pharmaceuticals, Ltd. Compounds as bcl-2 inhibitors
KR20250079128A (ko) * 2022-07-21 2025-06-04 베이진 스위찰랜드 게엠베하 Bcl-2 저해제를 사용한 다발성 골수종의 치료 방법
WO2024140678A1 (en) * 2022-12-27 2024-07-04 Beigene (Suzhou) Co., Ltd. A ketal protected intermediate for sonrotoclax and preparation method thereof
WO2024140692A1 (en) * 2022-12-27 2024-07-04 Beigene (Suzhou) Co., Ltd. Salts and solid forms of sonrotoclax intermediate
WO2024140690A1 (en) * 2022-12-27 2024-07-04 Beigene (Suzhou) Co., Ltd. Intermediates of sonrotoclax and the method of preparing the same
TW202604488A (zh) 2024-06-26 2026-02-01 瑞士商百濟神州I有限責任公司 包含索托克拉固體分散體之醫藥調配物及其製備方法
WO2026019442A1 (en) * 2024-07-14 2026-01-22 Eil Therapeutics, Inc. Compounds having (3-nitrophenyl)acetamide as bcl-2 inhibitors

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CN109641897B (zh) 2016-09-01 2021-12-07 北京赛林泰医药技术有限公司 Bcl-2选择性抑制剂及其制备和用途
CN106565706B (zh) 2016-10-27 2018-05-01 广东东阳光药业有限公司 一种磺酰胺衍生物及其在药学中的应用
CN106749233B (zh) 2016-11-24 2020-04-21 中山大学 一类磺酰胺衍生物及其应用
CN110177788B (zh) 2017-01-07 2023-03-24 重庆复创医药研究有限公司 作为bcl-2选择性凋亡诱导剂的化合物
SI3612531T1 (sl) 2017-04-18 2022-11-30 Shanghai Fochon Pharmaceutical Co., Ltd. Sredstva, ki sprožajo apoptozo
MX2020002032A (es) 2017-08-23 2020-09-17 Guangzhou Lupeng Pharmaceutical Company Ltd Inhibidores de bcl-2.
CN112437772B (zh) 2018-04-29 2023-11-21 百济神州有限公司 Bcl-2抑制剂
WO2020140005A2 (en) 2018-12-29 2020-07-02 Newave Pharmaceutical Inc. Bcl-2 inhibitors
WO2021083135A1 (en) 2019-10-28 2021-05-06 Beigene, Ltd. Bcl-2 INHIBITORS
WO2021110102A1 (en) 2019-12-02 2021-06-10 Beigene, Ltd. Methods of cancer treatment using bcl-2 inhibitor

Also Published As

Publication number Publication date
IL278366B2 (en) 2025-09-01
HUE071493T2 (hu) 2025-09-28
IL278366B1 (en) 2025-05-01
AU2019264475B2 (en) 2024-09-26
SI3788042T1 (sl) 2025-06-30
AU2019264475A1 (en) 2020-11-12
JP2025119001A (ja) 2025-08-13
CN112437772A (zh) 2021-03-02
MX2020011495A (es) 2021-01-15
JP7688210B2 (ja) 2025-06-03
HRP20250392T1 (hr) 2025-05-23
ES3018793T3 (en) 2025-05-19
EP3788042A1 (en) 2021-03-10
EP3788042A4 (en) 2022-01-26
DK3788042T3 (en) 2025-04-07
EP3788042B1 (en) 2025-02-12
US12077536B2 (en) 2024-09-03
CN117683029A (zh) 2024-03-12
JP2024161475A (ja) 2024-11-19
PL3788042T3 (pl) 2025-06-02
US11420968B2 (en) 2022-08-23
EP4545515A1 (en) 2025-04-30
MX2023001689A (es) 2023-02-22
FI3788042T3 (fi) 2025-04-07
TWI855062B (zh) 2024-09-11
PT3788042T (pt) 2025-04-15
KR102738032B1 (ko) 2024-12-05
KR20210005677A (ko) 2021-01-14
JP2021521138A (ja) 2021-08-26
TW202043217A (zh) 2020-12-01
CA3098348A1 (en) 2019-11-07
CN112437772B (zh) 2023-11-21
US20210269433A1 (en) 2021-09-02
JP7540113B1 (ja) 2024-08-26
WO2019210828A1 (en) 2019-11-07
US20240376104A1 (en) 2024-11-14
BR112020022092A2 (pt) 2021-02-02
JP2024119916A (ja) 2024-09-03
US20220402915A1 (en) 2022-12-22
SG11202009933WA (en) 2020-11-27
AU2019264475C1 (en) 2025-01-30
CN117430601A (zh) 2024-01-23
LT3788042T (lt) 2025-03-25

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