IL27321A - 3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation - Google Patents

3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation

Info

Publication number
IL27321A
IL27321A IL27321A IL2732167A IL27321A IL 27321 A IL27321 A IL 27321A IL 27321 A IL27321 A IL 27321A IL 2732167 A IL2732167 A IL 2732167A IL 27321 A IL27321 A IL 27321A
Authority
IL
Israel
Prior art keywords
formula
acid
physiologically acceptable
alkoxy
quaternary ammonium
Prior art date
Application number
IL27321A
Other languages
English (en)
Hebrew (he)
Original Assignee
Merck Ag E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Ag E filed Critical Merck Ag E
Publication of IL27321A publication Critical patent/IL27321A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL27321A 1966-02-16 1967-01-25 3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation IL27321A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM0068414 1966-02-16

Publications (1)

Publication Number Publication Date
IL27321A true IL27321A (en) 1970-09-17

Family

ID=7312594

Family Applications (1)

Application Number Title Priority Date Filing Date
IL27321A IL27321A (en) 1966-02-16 1967-01-25 3, 4 - Zis - 4 - Aril - Isoflavanes and their preparation

Country Status (11)

Country Link
US (1) US3535344A (instruction)
BE (1) BE694025A (instruction)
CH (1) CH494222A (instruction)
DE (1) DE1543749A1 (instruction)
DK (1) DK118611B (instruction)
ES (1) ES336869A1 (instruction)
FR (1) FR6192M (instruction)
GB (1) GB1103094A (instruction)
IL (1) IL27321A (instruction)
NL (1) NL6702140A (instruction)
SE (1) SE328301B (instruction)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053626A (en) * 1973-03-13 1977-10-11 Merck Patent Gesellschaft Mit Beschrankter Haftung Cholesterol level-lowering phenoxyacetic acids
ATE275959T1 (de) 1992-05-19 2004-10-15 Graham Edmund Kelly Verwendung von isoflavon phyto-östrogen extrakten von soja oder klee
US5446061A (en) * 1993-11-05 1995-08-29 Eli Lilly And Company Methods for lowering serum cholesterol
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
US5446071A (en) * 1994-11-18 1995-08-29 Eli Lilly And Company Methods for lowering serum cholesterol
CA2208859A1 (en) * 1995-01-13 1996-07-18 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis or for anticoagulative treatment
BE1010487A6 (nl) 1996-06-11 1998-10-06 Unilin Beheer Bv Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen.
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
ZA979646B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
ZA979647B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
US5994390A (en) * 1996-10-28 1999-11-30 Novo Nordisk Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA979644B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
JP2001502709A (ja) * 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連疾患または症候群の予防または治療に有用な新規なシス―３，４―クロマン誘導体
US5958967A (en) * 1996-10-28 1999-09-28 Novo Nordisk A/S Cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US6043269A (en) * 1996-10-28 2000-03-28 Novo Nordisk A/S cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
WO1998018773A1 (en) * 1996-10-28 1998-05-07 Novo Nordisk A/S Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
CA2269936A1 (en) * 1996-10-28 1998-05-07 Lise Brown Christiansen Novel trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
EP0937062B1 (en) * 1996-10-28 2002-12-11 Novo Nordisk A/S Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5919817A (en) * 1996-10-28 1999-07-06 Novo Nordisk A/S Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US6316494B1 (en) 1996-10-28 2001-11-13 Novo Nordisk A/S cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
EP0937057B1 (en) * 1996-10-28 2003-01-15 Novo Nordisk A/S Novel (-)-enantiomers of cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
EP0934299A1 (en) * 1996-10-28 1999-08-11 Novo Nordisk A/S NOVEL $i(CIS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES
US5985306A (en) * 1996-10-28 1999-11-16 Novo Nordisk A/S (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes
US6146668A (en) 1997-04-28 2000-11-14 Novogen, Inc. Preparation of isoflavones from legumes
NZ527735A (en) * 1997-05-01 2005-10-28 Novogen Inc Treatment or prevention of menopausal symptoms and osteoporosis
AUPP112497A0 (en) * 1997-12-24 1998-01-22 Novogen Research Pty Ltd Compositions and method for protecting skin from UV induced immunosupression and skin damage
AUPP260798A0 (en) 1998-03-26 1998-04-23 Novogen Research Pty Ltd Treatment of medical related conditions with isoflavone containing extracts of clover
KR20000001793A (ko) * 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체
AUPP868599A0 (en) * 1999-02-15 1999-03-11 Novogen Research Pty Ltd Production of isoflavone derivatives
US20090233999A1 (en) * 1999-09-06 2009-09-17 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
AUPQ266199A0 (en) * 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
AUPQ520300A0 (en) * 2000-01-21 2000-02-17 Novogen Research Pty Ltd Food product and process
EP1282615B1 (en) * 2000-03-01 2011-10-19 N.V. Organon Chroman derivatives as estrogenic compounds
AUPR363301A0 (en) * 2001-03-08 2001-04-05 Novogen Research Pty Ltd Dimeric isoflavones
US20050119301A1 (en) * 2001-03-16 2005-06-02 Alan Husband Treatment of restenosis
AU2004290613B2 (en) * 2003-11-18 2010-03-25 Novogen Research Pty Ltd Isoflavonoid prodrugs, compositions thereof and therapeutic methods involving same
EP1685140A4 (en) * 2003-11-18 2009-02-25 Novogen Res Pty Ltd PRODRUGS BASED ON ISOFLAVONOIDS, COMPOSITIONS THEREOF AND THERAPEUTIC PROCESSES INVOLVING THEM
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
CN101056868B (zh) 2004-09-21 2012-05-02 马休爱德华兹股份有限公司 取代的苯并二氢吡喃衍生物、药物及其在治疗中的应用
CA2816319C (en) 2010-11-01 2020-06-30 Marshall Edwards, Inc. Isoflavonoid compounds and methods for the treatment of cancer
HUE054998T2 (hu) 2015-02-02 2021-10-28 Mei Pharma Inc Kombinációs terápiák emlõrák kezelésében való alkalmazásra

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340276A (en) * 1964-04-01 1967-09-05 Ciba Geigy Corp 3, 4-diphenyl-chromans
CH471113A (de) * 1965-01-29 1969-04-15 Merck Ag E Verfahren zur Herstellung von wasserlöslichen Flavanoidderivaten
US3436393A (en) * 1965-12-27 1969-04-01 Parke Davis & Co 4'-methoxy-2,2,4-trialkyl-delta**3-isoflavan compounds

Also Published As

Publication number Publication date
SE328301B (instruction) 1970-09-14
NL6702140A (instruction) 1967-08-17
BE694025A (instruction) 1967-08-14
US3535344A (en) 1970-10-20
GB1103094A (en) 1968-02-14
DE1543749A1 (de) 1969-12-11
DK118611B (da) 1970-09-14
CH494222A (de) 1970-07-31
FR6192M (instruction) 1968-07-22
ES336869A1 (es) 1968-05-01

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