IL27183A - Parenteral composition comprising freeze dried mannitol - Google Patents
Parenteral composition comprising freeze dried mannitolInfo
- Publication number
- IL27183A IL27183A IL2718366A IL2718366A IL27183A IL 27183 A IL27183 A IL 27183A IL 2718366 A IL2718366 A IL 2718366A IL 2718366 A IL2718366 A IL 2718366A IL 27183 A IL27183 A IL 27183A
- Authority
- IL
- Israel
- Prior art keywords
- mannitol
- freeze
- vehicle
- solution
- parenteral
- Prior art date
Links
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 title claims description 20
- 229930195725 Mannitol Natural products 0.000 title claims description 20
- 239000000594 mannitol Substances 0.000 title claims description 20
- 235000010355 mannitol Nutrition 0.000 title claims description 20
- 239000000203 mixture Substances 0.000 title claims description 11
- 229960001855 mannitol Drugs 0.000 claims description 19
- 238000001035 drying Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 4
- 230000008014 freezing Effects 0.000 claims description 4
- 241000219289 Silene Species 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000002510 pyrogen Substances 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 235000012970 cakes Nutrition 0.000 description 11
- 239000000463 material Substances 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000008215 water for injection Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- KNAHARQHSZJURB-UHFFFAOYSA-N Propylthiouracile Chemical compound CCCC1=CC(=O)NC(=S)N1 KNAHARQHSZJURB-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229960002662 propylthiouracil Drugs 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 235000011008 sodium phosphates Nutrition 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- SBKRTALNRRAOJP-BWSIXKJUSA-N N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide sulfuric acid Polymers OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O SBKRTALNRRAOJP-BWSIXKJUSA-N 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 108010093965 Polymyxin B Proteins 0.000 description 1
- 108010040201 Polymyxins Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 229940124575 antispasmodic agent Drugs 0.000 description 1
- -1 antispasmodics Substances 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 235000021463 dry cake Nutrition 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 239000003688 hormone derivative Substances 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 229940053050 neomycin sulfate Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229960003548 polymyxin b sulfate Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52387466A | 1966-02-01 | 1966-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL27183A true IL27183A (en) | 1970-07-19 |
Family
ID=24086788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL2718366A IL27183A (en) | 1966-02-01 | 1966-12-29 | Parenteral composition comprising freeze dried mannitol |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE693479A (en)van) |
| FR (1) | FR1552798A (en)van) |
| GB (1) | GB1153092A (en)van) |
| IL (1) | IL27183A (en)van) |
| NL (1) | NL6701162A (en)van) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0192321A3 (en) * | 1985-01-19 | 1987-09-02 | Beecham Group Plc | Enteric coated allergen pharmaceutical composition |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| BRPI0805837A2 (pt) | 2007-01-29 | 2011-08-30 | Eisai R&D Man Co Ltd | forma sólida de um composto, método para preparação dos cristais, composição farmacêutica, método de tratamento de cáncer, e uso do composto sólido |
-
1966
- 1966-12-29 IL IL2718366A patent/IL27183A/en unknown
-
1967
- 1967-01-02 GB GB12767A patent/GB1153092A/en not_active Expired
- 1967-01-25 NL NL6701162A patent/NL6701162A/xx unknown
- 1967-01-31 FR FR1552798D patent/FR1552798A/fr not_active Expired
- 1967-02-01 BE BE693479D patent/BE693479A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1153092A (en) | 1969-05-21 |
| BE693479A (en)van) | 1967-08-01 |
| NL6701162A (en)van) | 1967-08-02 |
| FR1552798A (en)van) | 1969-01-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU593839B2 (en) | Stable freeze-dried preparations of an anticancer platinum complex | |
| US5036060A (en) | Cyclophosphamide | |
| US4496537A (en) | Biologically stable alpha-interferon formulations | |
| US4537883A (en) | Lyophilized cyclophosphamide | |
| JPS61165322A (ja) | スパガリン類の注射用凍結乾燥製剤 | |
| FI89456B (fi) | Foerfarande foer framstaellning av ifosfamid-mesna-lyofilisat | |
| US3624209A (en) | Composition for treatment of gastro-intestinal disorders | |
| KR970007907B1 (ko) | 항생제 용액 및 이의 동결건조 방법 | |
| US5296237A (en) | Water-soluble pharmaceutical metallocene-complex composition | |
| US4477452A (en) | Composition of matter comprising a lyophilized preparation of a penicillin derivative | |
| DE69904727T2 (de) | Injizierbares arzneimittel auf basis eines pharmazeutisch verträglichen salzes von clopidogrel bzw. von ticlopidin | |
| JPS6248629A (ja) | アントラサイクリングリコシド溶液 | |
| US5204335A (en) | Ifosfamide lyophilisate and process for its preparation | |
| RU2033164C1 (ru) | Антимикробный лечебный препарат | |
| US5750131A (en) | Ifosfamide lyophilizate preparations | |
| IL27183A (en) | Parenteral composition comprising freeze dried mannitol | |
| CA1314231C (en) | Ifosphamide lyophilisate and process for its preparation | |
| FI70793C (fi) | Foerfarande foer framstaellning av en stabil 4'-(9-akridinylamino)metansulfon -m-anisidin(m-amsa)-komposition | |
| US5227374A (en) | Lyophilized cyclophosphamide | |
| KR100807650B1 (ko) | Ｎ-[ｏ-(ｐ-피발로일옥시벤젠술포닐아미노)벤조일]글리신·모노나트륨염·4수화물의 동결 건조 제제 및 그 제조 방법 | |
| JPH05508640A (ja) | 線維芽細胞成長因子を含む安定な医薬組成物 | |
| EP0318906B1 (en) | Lyophilized preparation of platinum compound | |
| JPH07157431A (ja) | 安定なプロスタグランジンｅ製剤 | |
| JPS61171421A (ja) | 安定なプロスタグランジンｅ類製剤の製造方法 | |
| EP0331934A1 (en) | New pharmaceutical compositions containing thymosin alpha 1 |