IL269701A - Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof - Google Patents

Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof

Info

Publication number
IL269701A
IL269701A IL26970119A IL26970119A IL269701A IL 269701 A IL269701 A IL 269701A IL 26970119 A IL26970119 A IL 26970119A IL 26970119 A IL26970119 A IL 26970119A IL 269701 A IL269701 A IL 269701A
Authority
IL
Israel
Prior art keywords
inhibitors
glycogen synthase
synthase kinase
tricyclic compounds
tricyclic
Prior art date
Application number
IL26970119A
Other languages
English (en)
Hebrew (he)
Original Assignee
Broad Inst Inc
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Broad Inst Inc, Biogen Ma Inc filed Critical Broad Inst Inc
Publication of IL269701A publication Critical patent/IL269701A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/20—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL26970119A 2017-04-05 2019-09-26 Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof IL269701A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762481981P 2017-04-05 2017-04-05
PCT/US2018/026339 WO2018187630A1 (en) 2017-04-05 2018-04-05 Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
IL269701A true IL269701A (en) 2019-11-28

Family

ID=63712671

Family Applications (1)

Application Number Title Priority Date Filing Date
IL26970119A IL269701A (en) 2017-04-05 2019-09-26 Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof

Country Status (14)

Country Link
US (2) US11203601B2 (enExample)
EP (1) EP3606528B1 (enExample)
JP (1) JP7157075B2 (enExample)
KR (1) KR20190136063A (enExample)
CN (1) CN110958882B (enExample)
AU (1) AU2018249558A1 (enExample)
BR (1) BR112019020810A2 (enExample)
CA (1) CA3058198A1 (enExample)
CO (1) CO2019012324A2 (enExample)
EA (1) EA201992359A1 (enExample)
IL (1) IL269701A (enExample)
MX (1) MX2019011987A (enExample)
SG (1) SG11201909115WA (enExample)
WO (1) WO2018187630A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096594B2 (en) 2012-10-12 2015-08-04 The Broad Institute, Inc. Kinase inhibitors and methods of use thereof
WO2018187630A1 (en) 2017-04-05 2018-10-11 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof
CN110041349B (zh) * 2019-05-15 2021-06-01 湖南科技大学 一种含螺二氢嘧啶衍生物及其制备方法和应用
CN119053690A (zh) * 2022-06-20 2024-11-29 上海优替济生生物医药有限公司 体外诱导干细胞样记忆细胞的化合物及其应用
AU2024269298A1 (en) 2023-05-10 2025-11-27 Blueprint Medicines Corporation Gsk3a inhibitors and methods of use thereof
WO2024259178A1 (en) 2023-06-14 2024-12-19 The Broad Institute, Inc. Glycogen synthase kinase 3 inhibitors and uses thereof

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Also Published As

Publication number Publication date
WO2018187630A1 (en) 2018-10-11
KR20190136063A (ko) 2019-12-09
EP3606528A1 (en) 2020-02-12
US12486289B2 (en) 2025-12-02
CN110958882B (zh) 2023-08-29
WO2018187630A8 (en) 2019-01-03
CA3058198A1 (en) 2018-10-11
CN110958882A (zh) 2020-04-03
US20220112216A1 (en) 2022-04-14
AU2018249558A1 (en) 2019-11-07
JP7157075B2 (ja) 2022-10-19
MX2019011987A (es) 2020-07-14
EA201992359A1 (ru) 2020-03-12
SG11201909115WA (en) 2019-10-30
BR112019020810A2 (pt) 2020-04-28
CO2019012324A2 (es) 2020-05-15
JP2020516616A (ja) 2020-06-11
EP3606528A4 (en) 2020-12-23
EP3606528B1 (en) 2023-10-18
US11203601B2 (en) 2021-12-21
US20200109154A1 (en) 2020-04-09

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