AU2018249558A1 - Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof - Google Patents
Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof Download PDFInfo
- Publication number
- AU2018249558A1 AU2018249558A1 AU2018249558A AU2018249558A AU2018249558A1 AU 2018249558 A1 AU2018249558 A1 AU 2018249558A1 AU 2018249558 A AU2018249558 A AU 2018249558A AU 2018249558 A AU2018249558 A AU 2018249558A AU 2018249558 A1 AU2018249558 A1 AU 2018249558A1
- Authority
- AU
- Australia
- Prior art keywords
- substituted
- unsubstituted
- membered
- certain embodiments
- monocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CC(C)(CC1*)CC(Nc2c3[s]cn2)=C1[C@]3(C)c1ccccc1 Chemical compound CC(C)(CC1*)CC(Nc2c3[s]cn2)=C1[C@]3(C)c1ccccc1 0.000 description 8
- CFLYTMDVJBKTQU-XQRVVYSFSA-N C/C(/[N](C)(=C=S)#C)=C/S Chemical compound C/C(/[N](C)(=C=S)#C)=C/S CFLYTMDVJBKTQU-XQRVVYSFSA-N 0.000 description 1
- HQHZAZIWBYUWPH-XCVCLJGOSA-N CB(/C(/c1ccccc1)=C/C)[N+]([O-])=O Chemical compound CB(/C(/c1ccccc1)=C/C)[N+]([O-])=O HQHZAZIWBYUWPH-XCVCLJGOSA-N 0.000 description 1
- CLESVRTZYWZTST-UHFFFAOYSA-N CC(C)(C1)CC(Nc2c(C3(C)c4cc(F)ccc4)[s]cn2)=C3C1=O Chemical compound CC(C)(C1)CC(Nc2c(C3(C)c4cc(F)ccc4)[s]cn2)=C3C1=O CLESVRTZYWZTST-UHFFFAOYSA-N 0.000 description 1
- GIYKGABBTBHAKJ-FBMWCMRBSA-N CCC([C@@H](c1ccccc1)C(C(CC(C)(C)C1)=O)=C1N1)c2c1nc[s]2 Chemical compound CCC([C@@H](c1ccccc1)C(C(CC(C)(C)C1)=O)=C1N1)c2c1nc[s]2 GIYKGABBTBHAKJ-FBMWCMRBSA-N 0.000 description 1
- AOACOOLGPJYCEM-UHFFFAOYSA-N CCC1(c2cc(F)ccc2)C(C(CC(C)(C)C2)=O)=C2Nc2c1[s]cn2 Chemical compound CCC1(c2cc(F)ccc2)C(C(CC(C)(C)C2)=O)=C2Nc2c1[s]cn2 AOACOOLGPJYCEM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762481981P | 2017-04-05 | 2017-04-05 | |
| US62/481,981 | 2017-04-05 | ||
| PCT/US2018/026339 WO2018187630A1 (en) | 2017-04-05 | 2018-04-05 | Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2018249558A1 true AU2018249558A1 (en) | 2019-11-07 |
Family
ID=63712671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018249558A Abandoned AU2018249558A1 (en) | 2017-04-05 | 2018-04-05 | Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11203601B2 (enExample) |
| EP (1) | EP3606528B1 (enExample) |
| JP (1) | JP7157075B2 (enExample) |
| KR (1) | KR20190136063A (enExample) |
| CN (1) | CN110958882B (enExample) |
| AU (1) | AU2018249558A1 (enExample) |
| BR (1) | BR112019020810A2 (enExample) |
| CA (1) | CA3058198A1 (enExample) |
| CO (1) | CO2019012324A2 (enExample) |
| EA (1) | EA201992359A1 (enExample) |
| IL (1) | IL269701A (enExample) |
| MX (1) | MX2019011987A (enExample) |
| SG (1) | SG11201909115WA (enExample) |
| WO (1) | WO2018187630A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2909204T3 (en) | 2012-10-12 | 2019-04-01 | Broad Inst Inc | GSK3 INHIBITORS AND METHODS FOR USE THEREOF |
| KR20190136063A (ko) | 2017-04-05 | 2019-12-09 | 더 브로드 인스티튜트, 인코퍼레이티드 | 글리코겐 신타제 키나제 3 (gsk3) 억제제로서의 트리시클릭 화합물 및 그의 용도 |
| CN110041349B (zh) * | 2019-05-15 | 2021-06-01 | 湖南科技大学 | 一种含螺二氢嘧啶衍生物及其制备方法和应用 |
| WO2023246820A1 (zh) * | 2022-06-20 | 2023-12-28 | 上海优替济生生物医药有限公司 | 体外诱导干细胞样记忆细胞的化合物及其应用 |
| CN121666382A (zh) | 2023-05-10 | 2026-03-13 | 缆图药品公司 | GSK3α抑制剂和其使用方法 |
| WO2024259178A1 (en) | 2023-06-14 | 2024-12-19 | The Broad Institute, Inc. | Glycogen synthase kinase 3 inhibitors and uses thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2722416A1 (de) | 1977-05-18 | 1978-11-30 | Thomae Gmbh Dr K | Neue thiazolo-pyridine |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| JPH05157164A (ja) | 1991-12-03 | 1993-06-22 | Aisin Aw Co Ltd | 車両用自動変速機のサーボ油圧制御装置 |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| RU2152944C1 (ru) | 1993-04-08 | 2000-07-20 | Дзе Дюпон Мерк Фармасьютикал Компани | Полициклические соединения, их производные, фармацевтические препараты как усилители и метод лечения нарушения мыслительной деятельности |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5750528A (en) | 1995-02-01 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Blockade of neuronal m-channels as a therapeutic approach to the treatment of neurological disease |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| TW526202B (en) | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
| KR20030076650A (ko) | 2001-02-02 | 2003-09-26 | 미쯔비시 웰 파마 가부시키가이샤 | 디하이드로피라졸로피리딘 화합물 및 그의 약학적 용도 |
| US6977262B2 (en) | 2001-02-02 | 2005-12-20 | Mitsubishi Pharma Corporation | Dihydropyrazolopyridine compounds and pharmaceutical use thereof |
| DE10121217A1 (de) * | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| EP1395257A1 (en) * | 2001-06-12 | 2004-03-10 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| PT1746097E (pt) | 2005-07-20 | 2010-04-15 | Aventis Pharma Sa | Heterociclos fundidos de 1,4-di-hidropiridina, processo para a sua preparação, utilização e composições que os contêm |
| US8492378B2 (en) | 2006-08-03 | 2013-07-23 | Takeda Pharmaceutical Company Limited | GSK-3β inhibitor |
| US8778986B1 (en) | 2007-01-25 | 2014-07-15 | University Of South Florida | Treatment of glycogen synthase kinase-based disease |
| US20090181986A1 (en) | 2007-07-05 | 2009-07-16 | Matthew Abelman | Substituted heterocyclic compounds |
| WO2010098888A1 (en) | 2009-02-27 | 2010-09-02 | Massachusetts Institute Of Technology | Uses of chemicals to modulate gsk-3 signaling for treatment of bipolar disorder and other brain disorders |
| FR2945535B1 (fr) | 2009-05-18 | 2011-06-10 | Sanofi Aventis | Compose anticancereux et composition pharmaceutique le contenant |
| DE102011106990B3 (de) | 2011-07-08 | 2013-01-03 | Technische Universität Darmstadt | Verbindungen als Glykogen Synthase Kinase 3 (GSK-3) Inhibitoren für die Behandlung von GSK-3-vermittelten Erkrankungen |
| TW201406758A (zh) * | 2012-06-28 | 2014-02-16 | Daiichi Sankyo Co Ltd | 三環性化合物 |
| US20160375006A1 (en) | 2012-10-12 | 2016-12-29 | The Broad Institute, Inc. | Uses of paralog-selective inhibitors of gsk3 kinases |
| DK2909204T3 (en) * | 2012-10-12 | 2019-04-01 | Broad Inst Inc | GSK3 INHIBITORS AND METHODS FOR USE THEREOF |
| WO2015087996A1 (ja) | 2013-12-13 | 2015-06-18 | 第一三共株式会社 | イミダゾピリジン誘導体 |
| KR101602559B1 (ko) | 2014-04-29 | 2016-03-10 | 경북대학교 산학협력단 | 2,5,6,7-사중치환 티아졸로[4,5-b]피리딘 유도체 및 이의 용도 |
| AU2015311826B2 (en) | 2014-09-05 | 2019-05-23 | Merck Patent Gmbh | Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (IDO) antagonists for the treatment of cancer |
| KR20190136063A (ko) | 2017-04-05 | 2019-12-09 | 더 브로드 인스티튜트, 인코퍼레이티드 | 글리코겐 신타제 키나제 3 (gsk3) 억제제로서의 트리시클릭 화합물 및 그의 용도 |
-
2018
- 2018-04-05 KR KR1020197032599A patent/KR20190136063A/ko not_active Withdrawn
- 2018-04-05 AU AU2018249558A patent/AU2018249558A1/en not_active Abandoned
- 2018-04-05 CA CA3058198A patent/CA3058198A1/en active Pending
- 2018-04-05 EA EA201992359A patent/EA201992359A1/ru unknown
- 2018-04-05 EP EP18781394.4A patent/EP3606528B1/en active Active
- 2018-04-05 CN CN201880036981.1A patent/CN110958882B/zh active Active
- 2018-04-05 WO PCT/US2018/026339 patent/WO2018187630A1/en not_active Ceased
- 2018-04-05 SG SG11201909115W patent/SG11201909115WA/en unknown
- 2018-04-05 MX MX2019011987A patent/MX2019011987A/es unknown
- 2018-04-05 US US16/603,112 patent/US11203601B2/en active Active
- 2018-04-05 JP JP2019554982A patent/JP7157075B2/ja not_active Expired - Fee Related
- 2018-04-05 BR BR112019020810-0A patent/BR112019020810A2/pt not_active Application Discontinuation
-
2019
- 2019-09-26 IL IL26970119A patent/IL269701A/en unknown
- 2019-10-31 CO CONC2019/0012324A patent/CO2019012324A2/es unknown
-
2021
- 2021-10-22 US US17/507,922 patent/US12486289B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20220112216A1 (en) | 2022-04-14 |
| US12486289B2 (en) | 2025-12-02 |
| BR112019020810A2 (pt) | 2020-04-28 |
| CA3058198A1 (en) | 2018-10-11 |
| JP2020516616A (ja) | 2020-06-11 |
| CN110958882A (zh) | 2020-04-03 |
| IL269701A (en) | 2019-11-28 |
| CO2019012324A2 (es) | 2020-05-15 |
| JP7157075B2 (ja) | 2022-10-19 |
| WO2018187630A1 (en) | 2018-10-11 |
| EP3606528A1 (en) | 2020-02-12 |
| WO2018187630A8 (en) | 2019-01-03 |
| KR20190136063A (ko) | 2019-12-09 |
| EP3606528B1 (en) | 2023-10-18 |
| EA201992359A1 (ru) | 2020-03-12 |
| EP3606528A4 (en) | 2020-12-23 |
| US20200109154A1 (en) | 2020-04-09 |
| US11203601B2 (en) | 2021-12-21 |
| MX2019011987A (es) | 2020-07-14 |
| SG11201909115WA (en) | 2019-10-30 |
| CN110958882B (zh) | 2023-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |