IL266415B2 - Innovative pharmaceutical composition - Google Patents

Innovative pharmaceutical composition

Info

Publication number
IL266415B2
IL266415B2 IL266415A IL26641519A IL266415B2 IL 266415 B2 IL266415 B2 IL 266415B2 IL 266415 A IL266415 A IL 266415A IL 26641519 A IL26641519 A IL 26641519A IL 266415 B2 IL266415 B2 IL 266415B2
Authority
IL
Israel
Prior art keywords
suitably
compound
formulation
inhibitors
pct
Prior art date
Application number
IL266415A
Other languages
English (en)
Hebrew (he)
Other versions
IL266415A (en
IL266415B1 (en
Original Assignee
Glaxosmithkline Llc
Glaxo Group Ltd
Novartis Pharma Ag
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50828398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL266415(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc, Glaxo Group Ltd, Novartis Pharma Ag, Novartis Ag filed Critical Glaxosmithkline Llc
Publication of IL266415A publication Critical patent/IL266415A/en
Publication of IL266415B1 publication Critical patent/IL266415B1/en
Publication of IL266415B2 publication Critical patent/IL266415B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
IL266415A 2012-11-30 2013-11-26 Innovative pharmaceutical composition IL266415B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261731597P 2012-11-30 2012-11-30
PCT/US2013/071816 WO2014085371A1 (en) 2012-11-30 2013-11-26 Novel pharmaceutical composition

Publications (3)

Publication Number Publication Date
IL266415A IL266415A (en) 2019-06-30
IL266415B1 IL266415B1 (en) 2023-11-01
IL266415B2 true IL266415B2 (en) 2024-03-01

Family

ID=50828398

Family Applications (3)

Application Number Title Priority Date Filing Date
IL266415A IL266415B2 (en) 2012-11-30 2013-11-26 Innovative pharmaceutical composition
IL300664A IL300664A (en) 2012-11-30 2013-11-26 Innovative pharmaceutical composition
IL238971A IL238971B (en) 2012-11-30 2015-05-21 Innovative pharmaceutical composition

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL300664A IL300664A (en) 2012-11-30 2013-11-26 Innovative pharmaceutical composition
IL238971A IL238971B (en) 2012-11-30 2015-05-21 Innovative pharmaceutical composition

Country Status (28)

Country Link
US (2) US20150328320A1 (enExample)
EP (2) EP3400933A1 (enExample)
JP (1) JP6232443B2 (enExample)
KR (1) KR102206432B1 (enExample)
CN (2) CN107970214A (enExample)
AR (1) AR093648A1 (enExample)
AU (1) AU2013352369B2 (enExample)
BR (1) BR112015012111A8 (enExample)
CA (1) CA2891346A1 (enExample)
CL (1) CL2015001459A1 (enExample)
EA (2) EA028246B1 (enExample)
ES (1) ES2686730T3 (enExample)
IL (3) IL266415B2 (enExample)
IN (1) IN2015DN04094A (enExample)
MA (1) MA38121A1 (enExample)
MX (1) MX2015006867A (enExample)
MY (1) MY170427A (enExample)
NZ (1) NZ628395A (enExample)
PE (1) PE20151024A1 (enExample)
PH (1) PH12015501168A1 (enExample)
PL (1) PL2925299T3 (enExample)
PT (1) PT2925299T (enExample)
SG (1) SG11201503688SA (enExample)
TN (1) TN2015000198A1 (enExample)
TW (2) TW201434468A (enExample)
UY (1) UY35157A (enExample)
WO (1) WO2014085371A1 (enExample)
ZA (1) ZA201503346B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102293907B1 (ko) * 2015-06-30 2021-08-26 한미약품 주식회사 이리노테칸 함유 경구용 고형제제 및 그 제조방법
US20200178569A1 (en) * 2016-04-29 2020-06-11 Alvin Kershman Method of Coating an Edible Thermoplastic Pet Chew
TW201818936A (zh) 2016-11-25 2018-06-01 大陸商江蘇恆瑞醫藥股份有限公司 一種吡啶酮類衍生物醫藥組成物及其製備方法
KR102230721B1 (ko) * 2019-02-01 2021-03-22 주식회사 오스코텍 피리도피리미딘계 염산염을 포함하는 경구용 고형제제 및 이의 제조방법
EP4048271A4 (en) * 2019-10-22 2023-10-04 Chemistryrx Methods for treating congenital epidermal hyperplasia
MX2024007452A (es) * 2021-12-15 2024-07-09 Sillajen Inc Composiciones farmaceuticas que comprenden beta-ciclodextrinas modificadas.
KR20250008895A (ko) * 2022-05-12 2025-01-16 주식회사 지뉴브 안정한 액상 제약 제제
WO2025132408A2 (en) 2023-12-21 2025-06-26 Synthon B.V. Solvates of trametinib

Citations (3)

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Publication number Priority date Publication date Assignee Title
US6077871A (en) * 1997-11-26 2000-06-20 Pfizer Inc. Droloxifene pharmaceutical compositions
US20060014768A1 (en) * 2004-06-11 2006-01-19 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
US20120183613A1 (en) * 2010-12-20 2012-07-19 Demarini Douglas J Novel Pharmaceutical Composition

Family Cites Families (20)

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Publication number Priority date Publication date Assignee Title
US5559235A (en) 1991-10-29 1996-09-24 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
US5342947A (en) 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5491237A (en) 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
RS50569B (sr) * 2004-06-11 2010-05-07 Japan Tobacco Inc. Derivati 5-amino-2,4,7-triokso-3,4,7,8-tetrahidro-2h-pirido (2,3-d)pirimidina i slična jedinjenja za lečenje raka
ES2408216T3 (es) * 2004-12-07 2013-06-19 Onyx Therapeutics, Inc. Composición para la inhibición del proteasoma
CN1872055A (zh) * 2005-06-01 2006-12-06 李�杰 适合儿童应用的阿莫西林与盐酸氨溴索的复方制剂及其处方和制备方法
PL2952197T3 (pl) * 2005-10-26 2017-09-29 Cydex Pharmaceuticals, Inc. Kompozycje eteru sulfoalkilowego cyklodekstryny i sposoby ich wytwarzania
HRP20120960T1 (hr) * 2007-01-16 2012-12-31 Bipar Sciences, Inc. Formulacije za lijeäśenje raka
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
CN101352419B (zh) * 2007-07-26 2010-08-11 天津药物研究院 一种醋溴茶碱无糖型颗粒剂及其制备方法
KR101478779B1 (ko) * 2007-11-22 2015-01-05 에스케이케미칼주식회사 재수화시간이 향상된 택산 유도체 함유 동결건조 조성물 및이의 제조방법
PL3560498T3 (pl) * 2009-10-16 2022-12-12 Novartis Ag Kombinacja zawierająca inhibitor mek i inhibitor b-raf
CA2817287A1 (en) * 2010-11-11 2012-05-18 Bayer Intellectual Property Gmbh Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-c]quinolines
US20130023531A1 (en) * 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
CA2820709C (en) * 2011-02-28 2016-02-16 Sunshine Lake Pharma Co., Ltd. Substituted quinoline compounds and methods of use
WO2012136776A1 (en) * 2011-04-07 2012-10-11 Bayer Intellectual Property Gmbh Imidazopyridazines as akt kinase inhibitors
CN102600132B (zh) * 2012-03-13 2014-05-14 齐鲁制药有限公司 一种含氨磺必利的口服制剂
CN102626394A (zh) * 2012-03-15 2012-08-08 合肥科大生物技术有限公司 一种精氨酸布洛芬颗粒剂及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077871A (en) * 1997-11-26 2000-06-20 Pfizer Inc. Droloxifene pharmaceutical compositions
US20060014768A1 (en) * 2004-06-11 2006-01-19 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
US20120183613A1 (en) * 2010-12-20 2012-07-19 Demarini Douglas J Novel Pharmaceutical Composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LEIJEN S, SOETEKOUW PMB ET AL.,, A PHASE I, OPEN-LABEL, RANDOMIZED CROSSOVER STUDY TO ASSESS THE EFFECT OF DOSING OF THE MEK 1/2 INHIBITOR SELUMETINIB (AZD6244; ARRY- 142866) IN THE PRESENCE AND ABSENCE OF FOOD IN PATIENTS WITH ADVANCED SOLID TUMORS, 31 December 2011 (2011-12-31) *
MIRANDA JC ET AL.,, CYCLODEXTRINS AND TERNARY COMPLEXES: TECHNOLOGY TO IMPROVE SOLUBILITY OF POORLY SOLUBLE DRUGS, 31 December 2011 (2011-12-31) *
STELLA V.J. ET. AL.,, STELLA VJ, HE Q. CYCLODEXTRINS. TOXICOL PATHOL. 2008 JAN;36(1):30-42. DOI: 10.1177/0192623307310945. PMID: 18337219., 31 January 2008 (2008-01-31) *

Also Published As

Publication number Publication date
NZ628395A (en) 2016-10-28
IN2015DN04094A (enExample) 2015-10-09
ZA201503346B (en) 2016-01-27
EA201791411A1 (ru) 2018-03-30
EP2925299A4 (en) 2016-06-29
UY35157A (es) 2014-06-30
PL2925299T3 (pl) 2018-11-30
PT2925299T (pt) 2018-10-16
BR112015012111A8 (pt) 2018-01-23
JP6232443B2 (ja) 2017-11-15
IL238971A0 (en) 2015-07-30
PE20151024A1 (es) 2015-07-27
CN104902876B (zh) 2018-01-19
IL266415A (en) 2019-06-30
KR20150091352A (ko) 2015-08-10
IL238971B (en) 2019-05-30
EP2925299B1 (en) 2018-06-06
IL300664A (en) 2023-04-01
TW201434468A (zh) 2014-09-16
BR112015012111A2 (pt) 2017-07-11
IL266415B1 (en) 2023-11-01
TW201831187A (zh) 2018-09-01
US20150328320A1 (en) 2015-11-19
SG11201503688SA (en) 2015-06-29
KR102206432B1 (ko) 2021-01-22
CN104902876A (zh) 2015-09-09
ES2686730T3 (es) 2018-10-19
JP2016501874A (ja) 2016-01-21
CN107970214A (zh) 2018-05-01
CL2015001459A1 (es) 2015-12-18
CA2891346A1 (en) 2014-06-05
EA201591047A1 (ru) 2015-11-30
HK1209047A1 (en) 2016-03-24
AR093648A1 (es) 2015-06-17
EP3400933A1 (en) 2018-11-14
EA028246B1 (ru) 2017-10-31
MX2015006867A (es) 2015-10-05
PH12015501168A1 (en) 2015-08-10
MY170427A (en) 2019-07-31
US20170189408A1 (en) 2017-07-06
AU2013352369B2 (en) 2016-07-28
EP2925299A1 (en) 2015-10-07
AU2013352369A1 (en) 2015-05-28
MA38121A1 (fr) 2016-10-31
WO2014085371A1 (en) 2014-06-05
TN2015000198A1 (en) 2016-10-03

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