IL263469B - Compounds for delivering glutathione to a target and methods of making and using the same - Google Patents

Compounds for delivering glutathione to a target and methods of making and using the same

Info

Publication number
IL263469B
IL263469B IL263469A IL26346918A IL263469B IL 263469 B IL263469 B IL 263469B IL 263469 A IL263469 A IL 263469A IL 26346918 A IL26346918 A IL 26346918A IL 263469 B IL263469 B IL 263469B
Authority
IL
Israel
Prior art keywords
amino
compounds
aryl
bromide
triphenylphosphonium bromide
Prior art date
Application number
IL263469A
Other languages
English (en)
Hebrew (he)
Other versions
IL263469A (en
Inventor
M Hagen Tory
S Beckman Joseph
R Beilby Pamela
Original Assignee
Univ Oregon State
M Hagen Tory
S Beckman Joseph
R Beilby Pamela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oregon State, M Hagen Tory, S Beckman Joseph, R Beilby Pamela filed Critical Univ Oregon State
Publication of IL263469A publication Critical patent/IL263469A/en
Publication of IL263469B publication Critical patent/IL263469B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL263469A 2016-06-09 2017-06-07 Compounds for delivering glutathione to a target and methods of making and using the same IL263469B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662348030P 2016-06-09 2016-06-09
PCT/US2017/036393 WO2017214297A1 (en) 2016-06-09 2017-06-07 Compounds for delivering glutathione to a target and methods of making and using the same

Publications (2)

Publication Number Publication Date
IL263469A IL263469A (en) 2019-01-31
IL263469B true IL263469B (en) 2022-08-01

Family

ID=60578926

Family Applications (1)

Application Number Title Priority Date Filing Date
IL263469A IL263469B (en) 2016-06-09 2017-06-07 Compounds for delivering glutathione to a target and methods of making and using the same

Country Status (7)

Country Link
US (2) US20190106456A1 (enExample)
EP (1) EP3468563B1 (enExample)
JP (3) JP7482495B2 (enExample)
AU (1) AU2017277532B2 (enExample)
CA (1) CA3025665A1 (enExample)
IL (1) IL263469B (enExample)
WO (1) WO2017214297A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113456825B (zh) * 2021-06-17 2023-07-11 温州医科大学 一种线粒体靶向的谷胱甘肽衍生物纳米制剂及应用
CN113480595B (zh) * 2021-06-17 2023-07-11 温州医科大学 一种线粒体靶向谷胱甘肽衍生物、制备方法及应用
WO2024172390A1 (ko) * 2023-02-13 2024-08-22 가톨릭대학교 산학협력단 신규한 미토콘드리아 표적화 화합물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160129070A1 (en) * 2014-11-10 2016-05-12 South Dakota Board Of Regents Glutathione Disulfide Compositions and Related Methods for the Treatment of Cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069208A1 (en) 1997-11-25 2003-04-10 University Of Otago Mitochondrially targeted antioxidants
US20070142267A1 (en) 1998-11-23 2007-06-21 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
US6747009B2 (en) * 2002-09-19 2004-06-08 Universiteit Leiden Peptidomimetic glutathione analogs
US7585846B2 (en) 2003-11-25 2009-09-08 University Of Rochester Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
ES2919563T3 (es) * 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
WO2013177293A1 (en) 2012-05-22 2013-11-28 Biogen Idec Ma Inc. Trapping reagents for reactive metabolites screening

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160129070A1 (en) * 2014-11-10 2016-05-12 South Dakota Board Of Regents Glutathione Disulfide Compositions and Related Methods for the Treatment of Cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ELLEN M. SHULMAN-ROSKES ET AL,, THE PARTITIONING OF PHOSPHORAMIDE MUSTARD AND ITS AZIRIDINIUM IONS AMONG ALKYLATION AND P-N BOND HYDROLYSIS REACTIONS, 1 February 1998 (1998-02-01) *
ERIKA BECHTOLD ET AL,, WATER-SOLUBLE TRIARYLPHOSPHINES AS BIOMARKERS FOR PROTEIN S -NITROSATION, 16 April 2010 (2010-04-16) *
MICHAEL P. GAMCSIK ET AL,, NMR STUDIES OF THE CONJUGATION OF MECHLORETHAMINE WITH GLUTATHIONE, 1 March 1990 (1990-03-01) *
SHEU S S ET AL,, TARGETING ANTIOXIDANTS TO MITOCHONDRIA: A NEW THERAPEUTIC DIRECTION, 1 February 2006 (2006-02-01) *
UTHPALA SENEVIRATNE ET AL,, MECHANISM-BASED TRIARYLPHOSPHINE-ESTER PROBES FOR CAPTURE OF ENDOGENOUS RSNOS, 22 May 2013 (2013-05-22) *

Also Published As

Publication number Publication date
JP2024150504A (ja) 2024-10-23
EP3468563A1 (en) 2019-04-17
JP2019518029A (ja) 2019-06-27
AU2017277532A1 (en) 2018-12-20
US20250282817A1 (en) 2025-09-11
EP3468563A4 (en) 2020-07-29
JP7482495B2 (ja) 2024-05-14
JP2022137094A (ja) 2022-09-21
WO2017214297A1 (en) 2017-12-14
EP3468563B1 (en) 2023-09-13
AU2017277532B2 (en) 2022-09-15
CA3025665A1 (en) 2017-12-14
IL263469A (en) 2019-01-31
US20190106456A1 (en) 2019-04-11

Similar Documents

Publication Publication Date Title
US20250282817A1 (en) Compounds for delivering glutathione to a target and methods of making and using the same
AU668107B2 (en) Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US20110065762A1 (en) Methods of use of antiviral compounds
EP0171414B1 (en) Orally effective ion chelators related to deferoxamine
CN112105601B (zh) 作为细胞死亡抑制剂的苯磺酰胺衍生物和相关的ferrostatin-1类似物
WO2022173805A1 (en) Amide and ether substituted n-(1h-indol-7-yl)benzenesulfonamides and uses thereof
CN111518038B (zh) 一种取代的嘧啶三酮化合物及包含该化合物的组合物及其用途
EP2852569B1 (en) Compositions and methods for the treatment of multiple sclerosis
CN111417620A (zh) 肌酸前药、其组合物以及使用方法
US20090318454A1 (en) Novel antioxidants and methods of treatment
US20140155440A1 (en) Cysteine and cystine bioisosteres to treat schizophrenia and reduce drug cravings
PT1043332E (pt) Dipeptídeos contendo ciclopentano-beta-aminoácidos
WO2020081917A1 (en) Βeta-catenin and b-cell lymphoma 9 (bcl9) inhibitors
US20060160748A1 (en) Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
US12162856B2 (en) β-catenin and B-cell lymphoma 9 (BCL9) inhibitors
US20070185072A1 (en) Nitrogeneous polycyclic derivatives useful as chelators of metal ions and their applications
US20160318892A1 (en) Prodrug compounds
WO2014068459A2 (en) Compositions and methods for the treatment of pain and neurological diseases
US20240254098A1 (en) Thioester prodrugs for the treatment of renal anomalies
US4874776A (en) Compound having mucus regulating and elastase-inhibitory activities, for the therapy of pulmonal emphysema and pulmonal fibrosis
US12269899B2 (en) Peptidomimetic inhibitors of β-catenin/Tcf protein-protein interaction
US20220289668A1 (en) N-formylhydroxylamines as neprilysin (nep) inhibitors, in particular as mixed aminopeptidase n (apn) and neprilysin (nep) inhibitors
WO2017085733A2 (en) Improved process for the synthesis of 2, 6-xylidine and its derivatives
WO2021163631A1 (en) Calpain-2 inhibitor compounds and methods of treatment
CN116283664A (zh) 一种硝基儿茶酚衍生物、包含其的药物组合物及其应用