IL263123B - Compounds for use in targeting cancer stem cells in the adjuvant or neoadjuvant treatment of cancer - Google Patents
Compounds for use in targeting cancer stem cells in the adjuvant or neoadjuvant treatment of cancerInfo
- Publication number
- IL263123B IL263123B IL263123A IL26312318A IL263123B IL 263123 B IL263123 B IL 263123B IL 263123 A IL263123 A IL 263123A IL 26312318 A IL26312318 A IL 26312318A IL 263123 B IL263123 B IL 263123B
- Authority
- IL
- Israel
- Prior art keywords
- cancer
- protide
- treatment
- stem cells
- cpf
- Prior art date
Links
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Classifications
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K31/66—Phosphorus compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Molecular Biology (AREA)
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- Hematology (AREA)
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- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| PCT/GB2017/051560 WO2017207993A1 (en) | 2016-06-01 | 2017-05-31 | Cancer treatments |
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| IL (1) | IL263123B (enExample) |
| MA (1) | MA45129A (enExample) |
| MX (1) | MX2018014840A (enExample) |
| MY (1) | MY199129A (enExample) |
| PH (1) | PH12018502491A1 (enExample) |
| SG (1) | SG11201810196RA (enExample) |
| WO (1) | WO2017207993A1 (enExample) |
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| HRP20160346T1 (hr) | 2011-03-01 | 2016-05-06 | Nucana Biomed Limited | Fosforoamidatni derivati 5-fluoro-2'-deoksiuridina za upotrebu u tretmanu raka |
| KR102548806B1 (ko) | 2014-11-28 | 2023-06-27 | 뉴카나 피엘씨 | 항암제로서 새로운 2' 및/또는 5' 아미노산 에스테르 포스포르아미데이트 3'-디옥시아데노신 유도체 |
| GB201522764D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
| GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
| GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| GB201715011D0 (en) | 2017-09-18 | 2017-11-01 | Nucana Biomed Ltd | Floxuridine synthesis |
| WO2020081690A1 (en) * | 2018-10-17 | 2020-04-23 | Xibin Liao | 6-mercaptopurine nucleoside analogues |
| JP2020164521A (ja) * | 2019-03-29 | 2020-10-08 | 国立大学法人 長崎大学 | 抗ウィルス薬 |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AR121356A1 (es) | 2020-02-18 | 2022-05-11 | Gilead Sciences Inc | Compuestos antivirales |
| EP4323362B1 (en) | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| CA3228162A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
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| WO2006100439A1 (en) * | 2005-03-21 | 2006-09-28 | University College Cardiff Consultants Limited | Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer |
| WO2012117246A1 (en) * | 2011-03-01 | 2012-09-07 | Nucana Biomed Limited | Phosphoramidate derivatives of 5 - fluoro - 2 ' - deoxyuridine for use in the treatment of cancer |
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| GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| US7888330B2 (en) | 2005-11-09 | 2011-02-15 | Wayne State University | Phosphoramidate derivatives of FAU |
| CA2736564A1 (en) | 2007-09-10 | 2009-03-19 | Boston Biomedical, Inc. | Novel compositions and methods for cancer treatment |
| US20110191868A1 (en) | 2008-04-10 | 2011-08-04 | Massachusetts Institute Of Technology | Methods for identification and use of agents targeting cancer stem cells |
| US20120070411A1 (en) | 2010-09-22 | 2012-03-22 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| CA2947939A1 (en) | 2014-05-28 | 2015-12-03 | Idenix Pharmaceuticals Llc | Nucleoside derivatives for the treatment of cancer |
| DK3119794T3 (en) * | 2014-06-25 | 2018-01-22 | NuCana plc | FORMULA CONTAINING A GEMCITABIN PRODRUG |
| WO2015198058A1 (en) * | 2014-06-25 | 2015-12-30 | Nucana Biomed Limited | Gemcitabine prodrugs |
| KR102548806B1 (ko) | 2014-11-28 | 2023-06-27 | 뉴카나 피엘씨 | 항암제로서 새로운 2' 및/또는 5' 아미노산 에스테르 포스포르아미데이트 3'-디옥시아데노신 유도체 |
| MX390506B (es) * | 2015-05-14 | 2025-03-20 | NuCana plc | Nuc-1031 (gemcitabina-[fenil-benzoxi-l-alaninil])-fosfato) para usarse en el tratamiento neoadyuvante y adyuvante en pacientes con cáncer. |
| GB201522764D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
| GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| GB201713916D0 (en) | 2017-08-30 | 2017-10-11 | Nucana Biomed Ltd | Treatment regimens |
| GB201715011D0 (en) | 2017-09-18 | 2017-11-01 | Nucana Biomed Ltd | Floxuridine synthesis |
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2018
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006100439A1 (en) * | 2005-03-21 | 2006-09-28 | University College Cardiff Consultants Limited | Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer |
| WO2012117246A1 (en) * | 2011-03-01 | 2012-09-07 | Nucana Biomed Limited | Phosphoramidate derivatives of 5 - fluoro - 2 ' - deoxyuridine for use in the treatment of cancer |
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| SHE M ET AL., RESISTANCE OF LEUKEMIC STEM-LIKE CELLS IN AML CELL LINE KG1A TO NATURAL KILLERCELL-MEDIATED CYTOTOXICITY, 21 December 2011 (2011-12-21) * |
Also Published As
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| KR20220142538A (ko) | 2022-10-21 |
| CA3025442C (en) | 2024-02-20 |
| PH12018502491A1 (en) | 2019-09-09 |
| EA201892803A1 (ru) | 2019-06-28 |
| US20190374564A1 (en) | 2019-12-12 |
| MA45129A (fr) | 2021-05-05 |
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| JP7367910B2 (ja) | 2023-10-24 |
| GB201609600D0 (en) | 2016-07-13 |
| EA038030B1 (ru) | 2021-06-25 |
| SG11201810196RA (en) | 2018-12-28 |
| US20230218655A1 (en) | 2023-07-13 |
| KR20190011770A (ko) | 2019-02-07 |
| AU2017273124A1 (en) | 2018-12-13 |
| US11400107B2 (en) | 2022-08-02 |
| AU2017273124B2 (en) | 2022-09-29 |
| BR112018074981A2 (pt) | 2019-03-12 |
| CL2021002669A1 (es) | 2022-05-27 |
| CL2018003443A1 (es) | 2019-08-09 |
| MX2018014840A (es) | 2019-03-14 |
| WO2017207993A1 (en) | 2017-12-07 |
| ZA201807811B (en) | 2024-05-30 |
| JP2022051965A (ja) | 2022-04-01 |
| JP2019521971A (ja) | 2019-08-08 |
| MY199129A (en) | 2023-10-17 |
| IL263123A (en) | 2018-12-31 |
| CN109562119A (zh) | 2019-04-02 |
| CA3025442A1 (en) | 2017-12-07 |
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| HK1237283B (en) | Cancer treatments | |
| HK1237283A1 (en) | Cancer treatments | |
| EA040796B1 (ru) | Лечение рака |