IL259200B2 - Strength enhancers and method of achieving strength enhancement in an electronic vapor device - Google Patents
Strength enhancers and method of achieving strength enhancement in an electronic vapor deviceInfo
- Publication number
- IL259200B2 IL259200B2 IL259200A IL25920018A IL259200B2 IL 259200 B2 IL259200 B2 IL 259200B2 IL 259200 A IL259200 A IL 259200A IL 25920018 A IL25920018 A IL 25920018A IL 259200 B2 IL259200 B2 IL 259200B2
- Authority
- IL
- Israel
- Prior art keywords
- acid
- percent
- vaporization formulation
- concentration
- vapor
- Prior art date
Links
- 239000003623 enhancer Substances 0.000 title description 37
- 238000000034 method Methods 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims description 116
- 238000009472 formulation Methods 0.000 claims description 101
- 238000009834 vaporization Methods 0.000 claims description 98
- 230000008016 vaporization Effects 0.000 claims description 98
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 63
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 59
- 239000002253 acid Substances 0.000 claims description 45
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 41
- 229960002715 nicotine Drugs 0.000 claims description 36
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 36
- 239000000654 additive Substances 0.000 claims description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 claims description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 21
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 20
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 15
- 150000007513 acids Chemical class 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- 230000000996 additive effect Effects 0.000 claims description 13
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 12
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 12
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 claims description 11
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims description 11
- 229930007503 menthone Natural products 0.000 claims description 11
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 10
- 239000005770 Eugenol Substances 0.000 claims description 10
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 10
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 10
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 10
- 229960002217 eugenol Drugs 0.000 claims description 10
- OVBFMEVBMNZIBR-UHFFFAOYSA-N 2-methylvaleric acid Chemical compound CCCC(C)C(O)=O OVBFMEVBMNZIBR-UHFFFAOYSA-N 0.000 claims description 8
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims description 8
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
- GJWSUKYXUMVMGX-UHFFFAOYSA-N citronellic acid Chemical compound OC(=O)CC(C)CCC=C(C)C GJWSUKYXUMVMGX-UHFFFAOYSA-N 0.000 claims description 8
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 8
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 8
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 8
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims description 8
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 8
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims description 8
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 8
- 235000011054 acetic acid Nutrition 0.000 claims description 7
- 244000203593 Piper nigrum Species 0.000 claims description 6
- 235000008184 Piper nigrum Nutrition 0.000 claims description 6
- ZOJBYZNEUISWFT-UHFFFAOYSA-N allyl isothiocyanate Chemical compound C=CCN=C=S ZOJBYZNEUISWFT-UHFFFAOYSA-N 0.000 claims description 6
- 239000004310 lactic acid Substances 0.000 claims description 6
- 235000014655 lactic acid Nutrition 0.000 claims description 6
- 229960000448 lactic acid Drugs 0.000 claims description 6
- 229940107700 pyruvic acid Drugs 0.000 claims description 6
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 5
- 241000746375 Andrographis Species 0.000 claims description 5
- 239000005711 Benzoic acid Substances 0.000 claims description 5
- 244000080208 Canella winterana Species 0.000 claims description 5
- 235000008499 Canella winterana Nutrition 0.000 claims description 5
- 240000004160 Capsicum annuum Species 0.000 claims description 5
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 5
- 244000163122 Curcuma domestica Species 0.000 claims description 5
- 235000003392 Curcuma domestica Nutrition 0.000 claims description 5
- 240000002943 Elettaria cardamomum Species 0.000 claims description 5
- 239000001510 FEMA 4602 Substances 0.000 claims description 5
- 239000006000 Garlic extract Substances 0.000 claims description 5
- BLILOGGUTRWFNI-UHFFFAOYSA-N Monomenthyl succinate Chemical compound CC(C)C1CCC(C)CC1OC(=O)CCC(O)=O BLILOGGUTRWFNI-UHFFFAOYSA-N 0.000 claims description 5
- 244000250129 Trigonella foenum graecum Species 0.000 claims description 5
- 235000001484 Trigonella foenum graecum Nutrition 0.000 claims description 5
- 239000001068 allium cepa oil Substances 0.000 claims description 5
- 235000010233 benzoic acid Nutrition 0.000 claims description 5
- 229960004365 benzoic acid Drugs 0.000 claims description 5
- 235000013614 black pepper Nutrition 0.000 claims description 5
- 235000005300 cardamomo Nutrition 0.000 claims description 5
- 229930016911 cinnamic acid Natural products 0.000 claims description 5
- 235000013985 cinnamic acid Nutrition 0.000 claims description 5
- 229940017545 cinnamon bark Drugs 0.000 claims description 5
- 229960004106 citric acid Drugs 0.000 claims description 5
- 235000015165 citric acid Nutrition 0.000 claims description 5
- 235000003373 curcuma longa Nutrition 0.000 claims description 5
- 235000020706 garlic extract Nutrition 0.000 claims description 5
- 239000010651 grapefruit oil Substances 0.000 claims description 5
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 5
- CUNIMRNZTKYNGN-UHFFFAOYSA-N n-(2-hydroxyethyl)-2,3-dimethyl-2-propan-2-ylbutanamide Chemical compound CC(C)C(C)(C(C)C)C(=O)NCCO CUNIMRNZTKYNGN-UHFFFAOYSA-N 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- 235000019198 oils Nutrition 0.000 claims description 5
- 235000006408 oxalic acid Nutrition 0.000 claims description 5
- 235000020748 rosemary extract Nutrition 0.000 claims description 5
- 229940092258 rosemary extract Drugs 0.000 claims description 5
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 claims description 5
- 239000010678 thyme oil Substances 0.000 claims description 5
- 235000001019 trigonella foenum-graecum Nutrition 0.000 claims description 5
- 235000013976 turmeric Nutrition 0.000 claims description 5
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 4
- NIONDZDPPYHYKY-SNAWJCMRSA-N (2E)-hexenoic acid Chemical compound CCC\C=C\C(O)=O NIONDZDPPYHYKY-SNAWJCMRSA-N 0.000 claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000001602 (E)-hex-3-enoic acid Substances 0.000 claims description 4
- 239000001124 (E)-prop-1-ene-1,2,3-tricarboxylic acid Substances 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims description 4
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 claims description 4
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims description 4
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims description 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 4
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 claims description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 4
- AWQSAIIDOMEEOD-UHFFFAOYSA-N 5,5-Dimethyl-4-(3-oxobutyl)dihydro-2(3H)-furanone Chemical compound CC(=O)CCC1CC(=O)OC1(C)C AWQSAIIDOMEEOD-UHFFFAOYSA-N 0.000 claims description 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 4
- 235000002566 Capsicum Nutrition 0.000 claims description 4
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 claims description 4
- XXHDAWYDNSXJQM-UHFFFAOYSA-N Chloride-3-Hexenoic acid Natural products CCC=CCC(O)=O XXHDAWYDNSXJQM-UHFFFAOYSA-N 0.000 claims description 4
- 229930008398 Citronellate Natural products 0.000 claims description 4
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- 239000005639 Lauric acid Substances 0.000 claims description 4
- 239000005642 Oleic acid Substances 0.000 claims description 4
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 4
- 235000021314 Palmitic acid Nutrition 0.000 claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- NIONDZDPPYHYKY-UHFFFAOYSA-N Z-hexenoic acid Natural products CCCC=CC(O)=O NIONDZDPPYHYKY-UHFFFAOYSA-N 0.000 claims description 4
- 229940091181 aconitic acid Drugs 0.000 claims description 4
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 claims description 4
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims description 4
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 4
- 235000019253 formic acid Nutrition 0.000 claims description 4
- 239000010649 ginger oil Substances 0.000 claims description 4
- 239000004220 glutamic acid Substances 0.000 claims description 4
- 239000010655 horseradish oil Substances 0.000 claims description 4
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 229940099690 malic acid Drugs 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- 229940041616 menthol Drugs 0.000 claims description 4
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 4
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 4
- 229960002446 octanoic acid Drugs 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- 229960002969 oleic acid Drugs 0.000 claims description 4
- 235000021313 oleic acid Nutrition 0.000 claims description 4
- HVAMZGADVCBITI-UHFFFAOYSA-N pent-4-enoic acid Chemical compound OC(=O)CCC=C HVAMZGADVCBITI-UHFFFAOYSA-N 0.000 claims description 4
- 235000019260 propionic acid Nutrition 0.000 claims description 4
- 229940095574 propionic acid Drugs 0.000 claims description 4
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 4
- 239000004334 sorbic acid Substances 0.000 claims description 4
- 235000010199 sorbic acid Nutrition 0.000 claims description 4
- 229940075582 sorbic acid Drugs 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 229960001367 tartaric acid Drugs 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims description 4
- UAXOELSVPTZZQG-UHFFFAOYSA-N tiglic acid Natural products CC(C)=C(C)C(O)=O UAXOELSVPTZZQG-UHFFFAOYSA-N 0.000 claims description 4
- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 claims description 4
- XXHDAWYDNSXJQM-ONEGZZNKSA-N trans-hex-3-enoic acid Chemical compound CC\C=C\CC(O)=O XXHDAWYDNSXJQM-ONEGZZNKSA-N 0.000 claims description 4
- 229940005605 valeric acid Drugs 0.000 claims description 4
- 239000012808 vapor phase Substances 0.000 claims description 4
- 235000002283 Capsicum annuum var aviculare Nutrition 0.000 claims description 3
- 235000013303 Capsicum annuum var. frutescens Nutrition 0.000 claims description 3
- 235000002284 Capsicum baccatum var baccatum Nutrition 0.000 claims description 3
- 240000008574 Capsicum frutescens Species 0.000 claims description 3
- 235000002568 Capsicum frutescens Nutrition 0.000 claims description 3
- BJIOGJUNALELMI-ONEGZZNKSA-N Isoeugenol Natural products COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 claims description 3
- 235000016720 allyl isothiocyanate Nutrition 0.000 claims description 3
- 239000001390 capsicum minimum Substances 0.000 claims description 3
- GTZCVFVGUGFEME-IWQZZHSRSA-N cis-aconitic acid Chemical compound OC(=O)C\C(C(O)=O)=C\C(O)=O GTZCVFVGUGFEME-IWQZZHSRSA-N 0.000 claims description 3
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 claims description 3
- 235000019100 piperine Nutrition 0.000 claims description 3
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 claims description 3
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 claims description 3
- 229940075559 piperine Drugs 0.000 claims description 3
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 description 20
- 239000012071 phase Substances 0.000 description 15
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 12
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 9
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 9
- 229940117916 cinnamic aldehyde Drugs 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 239000007789 gas Substances 0.000 description 9
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 9
- 235000002780 gingerol Nutrition 0.000 description 9
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 9
- -1 coumarin, lignans Chemical class 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 244000061176 Nicotiana tabacum Species 0.000 description 6
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 6
- 239000005844 Thymol Substances 0.000 description 6
- 229960000583 acetic acid Drugs 0.000 description 6
- 210000002345 respiratory system Anatomy 0.000 description 6
- 229960000790 thymol Drugs 0.000 description 6
- 230000004913 activation Effects 0.000 description 5
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 5
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 5
- 235000007746 carvacrol Nutrition 0.000 description 5
- 238000004891 communication Methods 0.000 description 5
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- 101000764872 Homo sapiens Transient receptor potential cation channel subfamily A member 1 Proteins 0.000 description 4
- 102100026186 Transient receptor potential cation channel subfamily A member 1 Human genes 0.000 description 4
- 239000012190 activator Substances 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 229940123416 TRP agonist Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000019504 cigarettes Nutrition 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000012669 liquid formulation Substances 0.000 description 3
- 239000011344 liquid material Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 235000013772 propylene glycol Nutrition 0.000 description 3
- 239000000779 smoke Substances 0.000 description 3
- 230000000391 smoking effect Effects 0.000 description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- QQRSPHJOOXUALR-UHFFFAOYSA-N Apiole Chemical compound COC1=CC(CC=C)=C(OC)C2=C1OCO2 QQRSPHJOOXUALR-UHFFFAOYSA-N 0.000 description 2
- 241000723346 Cinnamomum camphora Species 0.000 description 2
- LIKYNOPXHGPMIH-UHFFFAOYSA-N Dillapiole Chemical compound C=CCC1=C(OC)C(OC)=C2OCOC2=C1 LIKYNOPXHGPMIH-UHFFFAOYSA-N 0.000 description 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 description 2
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 description 2
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 102100029613 Transient receptor potential cation channel subfamily V member 1 Human genes 0.000 description 2
- 108050004388 Transient receptor potential cation channel subfamily V member 1 Proteins 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229930008380 camphor Natural products 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 229930016834 coumestan Natural products 0.000 description 2
- ZZIALNLLNHEQPJ-UHFFFAOYSA-N coumestrol Chemical compound C1=C(O)C=CC2=C1OC(=O)C1=C2OC2=CC(O)=CC=C12 ZZIALNLLNHEQPJ-UHFFFAOYSA-N 0.000 description 2
- WTWBUQJHJGUZCY-UHFFFAOYSA-N cuminaldehyde Chemical compound CC(C)C1=CC=C(C=O)C=C1 WTWBUQJHJGUZCY-UHFFFAOYSA-N 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 239000003075 phytoestrogen Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000001007 puffing effect Effects 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 150000003505 terpenes Chemical class 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 2
- 235000012141 vanillin Nutrition 0.000 description 2
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- WTOYNNBCKUYIKC-JMSVASOKSA-N (+)-nootkatone Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CC(=O)C=C21 WTOYNNBCKUYIKC-JMSVASOKSA-N 0.000 description 1
- MATGKVZWFZHCLI-LSDHHAIUSA-N (-)-matairesinol Chemical compound C1=C(O)C(OC)=CC(C[C@@H]2[C@H](C(=O)OC2)CC=2C=C(OC)C(O)=CC=2)=C1 MATGKVZWFZHCLI-LSDHHAIUSA-N 0.000 description 1
- PUETUDUXMCLALY-HOTGVXAUSA-N (-)-secoisolariciresinol Chemical compound C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 PUETUDUXMCLALY-HOTGVXAUSA-N 0.000 description 1
- SSBZLMMXFQMHDP-REDNKFHQSA-N (1r,2s,5e,9e,12s)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol Chemical compound O1[C@]2(C)CC[C@@]1(C(C)C)C/C=C(C)/CC/C=C(C)/CC[C@@H]2O SSBZLMMXFQMHDP-REDNKFHQSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- DCSCXTJOXBUFGB-JGVFFNPUSA-N (R)-(+)-Verbenone Natural products CC1=CC(=O)[C@@H]2C(C)(C)[C@H]1C2 DCSCXTJOXBUFGB-JGVFFNPUSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- DCSCXTJOXBUFGB-SFYZADRCSA-N (R)-(+)-verbenone Chemical compound CC1=CC(=O)[C@H]2C(C)(C)[C@@H]1C2 DCSCXTJOXBUFGB-SFYZADRCSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- NKRBAUXTIWONOV-UHFFFAOYSA-N 1'-Acetoxyeugenol acetate Natural products COC1=CC(C(OC(C)=O)C=C)=CC=C1OC(C)=O NKRBAUXTIWONOV-UHFFFAOYSA-N 0.000 description 1
- JAMQIUWGGBSIKZ-ZDUSSCGKSA-N 1'-acetoxychavicol acetate Chemical compound CC(=O)O[C@@H](C=C)C1=CC=C(OC(C)=O)C=C1 JAMQIUWGGBSIKZ-ZDUSSCGKSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- GWNBMLCISLLOAU-UHFFFAOYSA-N 4-oxo-2-phenylchromene-3-carbaldehyde Chemical class O1C2=CC=CC=C2C(=O)C(C=O)=C1C1=CC=CC=C1 GWNBMLCISLLOAU-UHFFFAOYSA-N 0.000 description 1
- 244000227206 Aframomum melegueta Species 0.000 description 1
- 235000015752 Aframomum melegueta Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 240000003291 Armoracia rusticana Species 0.000 description 1
- 235000011330 Armoracia rusticana Nutrition 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 235000002567 Capsicum annuum Nutrition 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- XUSYGBPHQBWGAD-PJSUUKDQSA-N Carnosol Chemical compound CC([C@@H]1C2)(C)CCC[C@@]11C(=O)O[C@@H]2C2=C1C(O)=C(O)C(C(C)C)=C2 XUSYGBPHQBWGAD-PJSUUKDQSA-N 0.000 description 1
- MMFRMKXYTWBMOM-UHFFFAOYSA-N Carnosol Natural products CCc1cc2C3CC4C(C)(C)CCCC4(C(=O)O3)c2c(O)c1O MMFRMKXYTWBMOM-UHFFFAOYSA-N 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229910000881 Cu alloy Inorganic materials 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
- 229920002079 Ellagic acid Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 102000003568 TRPV3 Human genes 0.000 description 1
- 101150043371 Trpv3 gene Proteins 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000001857 aframomum melegueta rosc. k. schum. Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000002484 apiole Nutrition 0.000 description 1
- 229940070436 apiole Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 235000017663 capsaicin Nutrition 0.000 description 1
- 229960002504 capsaicin Drugs 0.000 description 1
- 239000001511 capsicum annuum Substances 0.000 description 1
- 235000004654 carnosol Nutrition 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000000723 chemosensory effect Effects 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 239000000788 chromium alloy Substances 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 235000004211 dillapiole Nutrition 0.000 description 1
- WTOYNNBCKUYIKC-UHFFFAOYSA-N dl-nootkatone Natural products C1CC(C(C)=C)CC2(C)C(C)CC(=O)C=C21 WTOYNNBCKUYIKC-UHFFFAOYSA-N 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003571 electronic cigarette Substances 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 229930003949 flavanone Natural products 0.000 description 1
- 150000002208 flavanones Chemical class 0.000 description 1
- 235000011981 flavanones Nutrition 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002216 flavonol derivatives Chemical class 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- LRBQNJMCXXYXIU-QWKBTXIPSA-N gallotannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@H]2[C@@H]([C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-QWKBTXIPSA-N 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 229930005346 hydroxycinnamic acid Natural products 0.000 description 1
- DEDGUGJNLNLJSR-UHFFFAOYSA-N hydroxycinnamic acid group Chemical class OC(C(=O)O)=CC1=CC=CC=C1 DEDGUGJNLNLJSR-UHFFFAOYSA-N 0.000 description 1
- 235000010359 hydroxycinnamic acids Nutrition 0.000 description 1
- ZJTDDBZRNWYHKQ-UHFFFAOYSA-N incensole Natural products CC(C)C12CC=C(/C)CCC=C(/C)CCCC(O)C(C)(C1)O2 ZJTDDBZRNWYHKQ-UHFFFAOYSA-N 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 150000002540 isothiocyanates Chemical class 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 235000000055 matairesinol Nutrition 0.000 description 1
- RNXYRAQIZQGUIK-UHFFFAOYSA-N matairesinol Natural products COc1cc(CC2OCC(=O)C2Cc3ccc(O)c(OC)c3)ccc1O RNXYRAQIZQGUIK-UHFFFAOYSA-N 0.000 description 1
- OGFXBIXJCWAUCH-UHFFFAOYSA-N meso-secoisolariciresinol Natural products C1=2C=C(O)C(OC)=CC=2CC(CO)C(CO)C1C1=CC=C(O)C(OC)=C1 OGFXBIXJCWAUCH-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 229910001120 nichrome Inorganic materials 0.000 description 1
- 229910000623 nickel–chromium alloy Inorganic materials 0.000 description 1
- 229940116315 oxalic acid Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- JAMQIUWGGBSIKZ-UHFFFAOYSA-N rac-galangal acetate Natural products CC(=O)OC(C=C)C1=CC=C(OC(C)=O)C=C1 JAMQIUWGGBSIKZ-UHFFFAOYSA-N 0.000 description 1
- KKOXKGNSUHTUBV-UHFFFAOYSA-N racemic zingiberene Natural products CC(C)=CCCC(C)C1CC=C(C)C=C1 KKOXKGNSUHTUBV-UHFFFAOYSA-N 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000010272 rosemarinol Nutrition 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 235000004239 secoisolariciresinol Nutrition 0.000 description 1
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 description 1
- 235000017700 silymarin Nutrition 0.000 description 1
- 229960004245 silymarin Drugs 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 235000019529 tetraterpenoid Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 229940117960 vanillin Drugs 0.000 description 1
- DCSCXTJOXBUFGB-UHFFFAOYSA-N verbenone Natural products CC1=CC(=O)C2C(C)(C)C1C2 DCSCXTJOXBUFGB-UHFFFAOYSA-N 0.000 description 1
- 235000008210 xanthophylls Nutrition 0.000 description 1
- 150000003735 xanthophylls Chemical class 0.000 description 1
- KKOXKGNSUHTUBV-LSDHHAIUSA-N zingiberene Chemical compound CC(C)=CCC[C@H](C)[C@H]1CC=C(C)C=C1 KKOXKGNSUHTUBV-LSDHHAIUSA-N 0.000 description 1
- 229930001895 zingiberene Natural products 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
- A24B15/303—Plant extracts other than tobacco
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/34—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a carbocyclic ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/42—Treatment of tobacco products or tobacco substitutes by chemical substances by organic and inorganic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Manufacture Of Tobacco Products (AREA)
- Catching Or Destruction (AREA)
- Junction Field-Effect Transistors (AREA)
- Physical Vapour Deposition (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
259200/- 1 – 0255436276- STRENGTH ENHANCERS AND METHOD OF ACHIEVING STRENGTH ENHANCEMENT IN AN ELECTRONIC VAPOR DEVICE The present invention relates generally to a pre-vaporization formulation for e-vaping devices. More particularly, the present invention relates to strength enhancers in pre-vaporization formulations. Electronic vaping devices (or e-vaping devices) are used to vaporize a pre-vaporization formulation such as, for example, a liquid material, into a vapor in order for an adult vaper to inhale the vapor. E-vaping devices typically include a heater which vaporizes the pre-vaporization formulation to produce the vapor. An e-vaping device may include several e-vaping elements including a power source, a cartridge or e-vaping tank including the heater, and a reservoir holding the pre-vaporization formulation. A tobacco-based smoking article produces a vapor known to create a desired sensory experience for adult smokers, including a low to moderate harshness response in the throat and a perceived warmth or strength in the chest of an adult smoker. With respect to e-vaping devices, the harshness of the vapor, which is typically understood as the sensation experienced in the throat of an adult vaper, and the strength of the vapor, which is typically understood as the sensation experienced in the chest of the adult vaper, may vary based on the contents and concentrations of the pre-vaporization formulation used to form the vapor during vaping by an adult vaper. Typically, for a similar amount of nicotine in the pre-vaporization formulation, an e-vaping device is harsher than a tobacco-based product, but has a strength that is lower than the strength of the tobacco-based product. Also, as an amount of nicotine in the gas phase of the vapor generated by the e-vaping device increases, the harshness of the e-vaping device increases. WO 2009/001085 A2 discloses an inhalable composition comprising at least 22 volume % oxygen, and nicotine or a nicotine derivative or salt. The composition may comprise a solvent. Specific examples of suitable solvents include propylene glycol, polypropylene glycol, polyethylene glycol (PEG), glycerol, ethanol and propanol. The composition may also include an antioxidant. Suitable antioxidants include phenolic compounds, flavonols, flavanones, flavones, flavon-3-ols, anthocyanins (flavonals), isoflavones, coumestans, carotenes, xanthophylls, phytosterols and tocopherols. Suitable phenolic compounds include monophenols, apiole, carnosol, carvacrol, dillapiole, rosemarinol and flavonoids (polyphenols). Suitable coumestans (phytoestrogens) include coumestrol, ellagic acid, gallic acid, salicylic acid, tannic acid, vanillin, capsaicin, curcumin (oxidizes to vanillin), hydroxycinnamic acids, caffeic acid, chlorogenic acid, cinnamic acid, ferulic acid, coumarin, lignans (phytoestrogens), silymarin and matairesinol, secoisolariciresinol, terpenes (isoprenoids) and carotenoids (tetraterpenoids). The composition 259200/- 2 – 0255436276- may also include an essential oil. Suitable essential oils include geraniol, nerol, phenethyl alcohol, eugenol methyl ether, farrnesol, linalool, citronellol, rose, cuminaldehyde, zingiberene, Farnesol, verbenone, nootkatone, myrcene, menthol citral, citronellal, pinene, thymol and menthone. US 2015/038576 A1 discloses compositions for delivery to the respiratory tract of a subject, comprising: a liquid including an agent, the agent being an activator of a TRPV3 channel, and the agent including a terpenoid compound. The terpenoid compound may include one or more of camphor, carvacrol, thymol and incensole of either a plant or synthetic origin. US 2015/038576 A1 discloses exemplary compositions comprising propylene glycol. EP 2 862 454 A1 discloses a liquid composition for an electronic cigarette comprising glycerol as a TRP modulator and at least one TRP agonist / activator selected from 6-paradole and analogues, wherein interaction of the TRP modulator and at least one TRP agonist / activator results in chemosensory imitation of inhaled cigarette smoke, and wherein the liquid composition contains no nicotine. Preferably, 6-paradole and analogues comprise 1'-acetoxychavicol acetate and analogues, isothiocyanates and analogues, camphor and analogues, grains of paradise, thymol and analogues and ethanol. One or more extracts comprising black pepper, horseradish, garlic, paprika, cinnamon, mint and acetic acid and citric acid may be used as another TRP agonist / activator in the liquid composition. According to a first aspect the present invention relates to an e-vaping device configured to achieve a desirable balance of strength and harshness, where strength is increased without increasing harshness. According to a second aspect the present invention relates to an e-vaping device that is configured to provide a perceived sensory experience for adult vapers that is similar to the sensory experience enjoyed while smoking a tobacco-based cigarette. According to a third aspect the present invention relates to an e-vaping device that is configured to provide a sensory experience including levels of harshness in the throat and perceived strength or warmth in the chest that are similar to those experienced when smoking a tobacco-based product. In achieving a desirable balance of strength and harshness, the strength of the e-vaping product may be increased without increasing the harshness thereof. According to a fourth aspect of the present invention, a pre-vaporization formulation for an e-vaping device includes a mixture of a vapor former and one or more strength enhancers or additives. The pre-vaporization formulation may include water, one or more acids, or both water and one or more acids. The pre-vaporization formulation may be a liquid formulation. The pre-vaporization formulation may comprise nicotine. 259200/- 3 – 0255436276- The one or more strength enhancers or additives may include at least one of carvacrol, thymol, monomenthyl succinate, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropyl butanamide. In at least one embodiment, the one or more strength enhancers or additives may include at least one of cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol. The one or more strength enhancers or additives may include at least one of capsicum, allyl isothiocyanate, piperine, isoeugenol, carvacrol, thymol, menthol, monomenthyl succinate and N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropyl butanamide. In at least one embodiment, the above compounds as well as others can be found in extracts such as, for example, horseradish oil, garlic extract, onion oil, black pepper, cayenne pepper, ginger oil, thyme oil, cinnamon bark oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil and andrographis extract. The one or more strength enhancers or additives may include at least one of these extracts. The one or more strength enhancers or additives may include one or more compounds that activate receptors in the respiratory system of an adult vaper such as the transient receptor potential cation channel, subfamily A, member 1 (TRPA1), the transient receptor potential cation channel subfamily V member 1 (TPRV1), or the nicotinic-acetylcholine receptors in an adult vaper, the agonists becoming part of the vapor and are carried in the respiratory tract of the adult vaper during vaping. In at least one embodiment, the one or more strength enhancers or additives may include one or more of the above-listed compounds, among others, in a composition range of between about 0.0001 percent and about 1 percent, or in concentrations of up to about 2 percent. Optionally, the concentration of the one or more strength enhancers or additives may be greater than about 2 percent when several strength enhancers are used in combination. For example, the total concentration of strength enhancers may be up to about 5 percent. In at least one embodiment, harshness reduction compounds such as acids can be included in the pre-vaporization formulation in order to achieve a desired balance of increased strength and decreased harshness in an e-vaping device. In at least one embodiment, the one or more strength enhancers or additives may be used in a pre-vaporization formulation that does not include nicotine, the one or more strength enhancers or additives providing a level of strength that is similar to the strength experienced by an adult vaper when vaping a nicotine-containing vaping device or a tobacco-based article. For example, such strength enhancers or additives may be included in smoke cessation inhalation devices. In at least one embodiment, the one or more strength enhancers or additives increase the strength of the e-vaping device without increasing the delivery of nicotine and without increasing the harshness of the e-vaping article. 259200/- 4 – 0255436276- The pre-vaporization formulation may comprise nicotine in an amount of between about 0.5 percent and about 2 percent by weight or greater, or between about 0.5 percent and about percent or greater. In at least one embodiment, the vapor formed by the vapor former includes a gas phase and a particulate phase, and the concentration of nicotine in the vapor phase is less than or equal to about 1 percent. According to a fifth aspect of the present invention, a pre-vaporization formulation of an e-vaping device includes a mixture of a vapor former, nicotine in an amount of between about 0.percent and about 2 percent by weight or greater, or between about 0.5 percent and about percent or greater, and one or more strength enhancers or additives. In at least one embodiment, the vapor formed by the vapor former includes a gas phase and a particulate phase, and the concentration of nicotine in the vapor phase is less than or equal to about 1 percent. The pre-vaporization formulation may include water, one or more acids, or both water and one or more acids. The pre-vaporization formulation may be a liquid formulation. The one or more strength enhancers or additives may comprise one or more of the optional or preferred strength enhancers or additives according to the fourth aspect of the present invention. The pre-vaporization formulation according to the fourth or fifth aspect of the present invention may include one or more acids. The pre-vaporization formulation may include one or more acids in a concentration of between about 0.1 percent and about 5 percent. The one or more acids may have a boiling point of at least about 100 degrees Celsius and configured to volatilize when heated by a heater in the e-vaping device. The pre-vaporization formulation may be configured to form a vapor having a particulate phase and a gas phase when heated by the heater in the e-vaping device, the particulate phase containing protonated nicotine and the gas phase containing unprotonated nicotine. In embodiments, the vapor has a majority amount of the protonated nicotine and a minority amount of the unprotonated nicotine. In at least one embodiment, the pre-vaporization formulation is configured to form a vapor having a nicotine gas phase component upon operation of the e-vaping device. The acid may be included in an amount sufficient to reduce the nicotine gas phase component by about 70 percent or greater. In other embodiments, the addition of one or more acids may reduce the gas phase nicotine content by an amount in the range of between about 40 percent and about 70 percent by weight, or in the range of between about 40 percent and about 90 percent by weight. In at least one embodiment, the acid may be selected to have a liquid to vapor transfer efficiency of about 50 percent or greater. The acid may be present in an amount sufficient to reduce the nicotine gas phase component. In at least one embodiment, the acid includes at least one of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, malic acid, tartaric acid, succinic acid, citric acid, benzoic acid, oleic acid, 259200/- 5 – 0255436276- aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, 1-glutamic acid, heptanoic acid, hexanoic acid, 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid and sulfuric acid. In at least one embodiment, the acid includes pyruvic acid, lactic acid, benzoic acid and acetic acid. The vapor former may include propylene glycol and glycerol or glycerin. The vapor former may include substantially equal concentrations of propylene glycol and glycerol or glycerin. The pre-vaporization formulation may include water in a concentration of between about percent and about 20 percent. According to a sixth aspect of the present invention an e-vaping device includes a first section and a second section. The first section includes a pre-vaporization formulation reservoir including a pre-vaporization formulation such as, for example, a liquid material, a heater, a wick in communication with the pre-vaporization formulation reservoir and in communication with the heater, a mouth-end piece, and a connector at a distal end of the first section. The second section includes a power supply, and a connector at a proximal end of the second section configured to matingly connect with the connector of the first section. According to a seventh aspect of the present invention an e-vaping device includes a first section and a second section. The first section may be a cartomizer. The first section includes a pre-vaporization formulation reservoir including a pre-vaporization formulation, a heater, and a mouth end piece. The heater is configured to heat the pre-vaporization formulation. The second section may be a power supply section. The second section includes a power source configured to supply power to the heater. The pre-vaporization formulation may be a pre-vaporization formulation according to the fourth or fifth aspect of the present invention, in accordance with any of the embodiments described herein. The first section may comprise a wick in communication with the pre-vaporization formulation reservoir and in communication with the heater. The first section may comprise a connector at a distal end of the first section. The second section may include a puff sensor configured to sense a puff taking place at the mouth-end piece. The second section may comprise a connector at a proximal end of the second section configured to matingly connect with the connector of the first section. The above and other features and advantages of example embodiments will become more apparent by describing in detail, example embodiments with reference to the attached drawings. The accompanying drawings are intended to depict example embodiments and should not be interpreted to limit the intended scope of the claims. The accompanying drawings are not to be 259200/- 6 – 0255436276- considered as drawn to scale unless explicitly noted. Fig. 1 is a side view of an e-vaping device, according to an example embodiment; Fig. 2 is a cross-sectional view of an e-vaping device, according to an example embodiment; and Fig. 3 is a cross-sectional view of another example embodiment of an e-vaping device. Some detailed example embodiments are disclosed herein. However, specific structural and functional details disclosed herein are merely representative for purposes of describing example embodiments. Example embodiments may, however, be embodied in many alternate forms and should not be construed as limited to only the embodiments set forth herein. Accordingly, while example embodiments are capable of various modifications and alternative forms, embodiments thereof are shown by way of example in the drawings and will herein be described in detail. It should be understood, however, that there is no intent to limit example embodiments to the particular forms disclosed, but to the contrary, example embodiments are to cover all modifications, equivalents, and alternatives falling within the scope of example embodiments. Like numbers refer to like elements throughout the description of the figures. It should be understood that when an element or layer is referred to as being "on," "connected to," "coupled to," or "covering" another element or layer, it may be directly on, connected to, coupled to, or covering the other element or layer or intervening elements or layers may be present. In contrast, when an element is referred to as being "directly on," "directly connected to," or "directly coupled to" another element or layer, there are no intervening elements or layers present. Like numbers refer to like elements throughout the specification. It should be understood that, although the terms first, second, third, and so forth may be used herein to describe various elements, components, regions, layers or sections, these elements, components, regions, layers, or sections should not be limited by these terms. These terms are only used to distinguish one element, component, region, layer, or section from another element, component, region, layer, or section. Therefore, a first element, component, region, layer, or section discussed below could be termed a second element, component, region, layer, or section without departing from the teachings of example embodiments. Spatially relative terms (for example, "beneath," "below," "lower," "above," "upper," and the like) may be used herein for ease of description to describe one element or feature's relationship to another element or feature as illustrated in the figures. It should be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Therefore, the term 259200/- 7 – 0255436276- "below" may encompass both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly. The terminology used herein is for the purpose of describing various embodiments only and is not intended to be limiting of example embodiments. As used herein, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "includes," "including," "comprises," and "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, or groups thereof. Example embodiments are described herein with reference to cross-sectional illustrations that are schematic illustrations of idealized embodiments (and intermediate structures) of example embodiments. As such, variations from the shapes of the illustrations as a result, for example, of manufacturing techniques or tolerances, are to be expected. Therefore, example embodiments should not be construed as limited to the shapes of regions illustrated herein but are to include deviations in shapes that result, for example, from manufacturing. Therefore, the regions illustrated in the figures are schematic in nature and their shapes are not intended to illustrate the actual shape of a region of a device and are not intended to limit the scope of example embodiments. Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which example embodiments belong. It will be further understood that terms, including those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein. When the terms "about" or "substantially" are used in this specification in connection with a numerical value, it is intended that the associated numerical value include a tolerance of ±percent around the stated numerical value. Moreover, when reference is made to percentages in this specification, it is intended that those percentages are based on weight, that is, weight percentages. The expression "up to" includes amounts of zero to the expressed upper limit and all values therebetween. When ranges are specified, the range includes all values therebetween such as increments of 0.1 percent. As used herein, the term "vapor former" describes any suitable known compound or mixture of compounds that, in use, facilitates formation of a vapor and that is substantially resistant to thermal degradation at the operating temperature of the e-vaping device. Suitable 259200/- 8 – 0255436276- vapor-formers consist of various compounds such as, for example, polyhydric alcohols including at least one of propylene glycol, and glycerol or glycerin. In at least one embodiment, the vapor former is propylene glycol. Fig. 1 is a side view of an e-vaping device 60, according to an example embodiment. In Fig. 1, the e-vaping device 60 includes a first section or cartomizer 70 and a second section 72, which are coupled together at a threaded joint 74 or by other connecting structure such as one or more of a snug-fit, snap-fit, detent, clamp or clasp or the like. In one embodiment, the first section or cartomizer 70 may be a replaceable cartridge and the second section 72 may be a reusable section. Alternatively, the first section or cartomizer 70 and the second section 72 may be integrally formed in one piece. Fig. 2 is a cross-sectional view of an example embodiment of an e-vaping device. As shown in Fig. 2, the first section or cartomizer 70 can house a mouth-end insert 20, a capillary vapor generator including a capillary tube 18, a heater 19 to heat at least a portion of the capillary tube 18, and a reservoir 14. The second section 72 can house a power supply 12, a control circuitry 11 configured to control the power supply 12, and a puff sensor 16. The puff sensor is configured to sense when an adult vaper is puffing on the e-vaping device 60, which triggers operation of the power supply via the control circuitry 11 to activate the heater 19 to heat the pre-vaporization formulation housed in the reservoir 14 and form a vapor. A threaded portion 74 of the second section 72 can be connected to a battery charger, when not connected to the first section or cartomizer 70, to charge the battery or power supply 12. As shown in Fig. 3, in other example embodiments, a valve 40 can be a two-way valve, and the reservoir 14 can be pressurized. For example, the reservoir 14 can be pressurized using a pressurization arrangement 405 configured to apply constant pressure to the reservoir 14. As such, emission of vapor formed via heating of the pre-vaporization formulation housed in the reservoir 14 is facilitated. In example embodiments, the capillary tube 18 is formed of or includes a conductive material, and therefore acts as its own heater 19 by passing current through the tube. The capillary tube 18 may be any electrically conductive material capable of being resistively heated, while retaining the necessary structural integrity at the operating temperatures experienced by the capillary tube 18, and which is non-reactive with the pre-vaporization formulation. Suitable materials for forming the capillary tube 18 are one or more of stainless steel, copper, copper alloys, porous ceramic materials coated with film resistive material, nickel-chromium alloys, and combinations thereof. For example, the capillary tube 18 is a stainless steel capillary tube 18 and serves as a heater 19 via electrical leads 26 attached thereto for passage of direct or alternating current along a length of the capillary tube 18. Therefore, the stainless steel capillary tube 18 is 259200/- 9 – 0255436276- heated by resistance heating. Alternatively, the capillary tube 18 may be a non-metallic tube such as, for example, a glass tube. In such an embodiment, the heater 19 is formed of or includes a conductive material capable of being resistively heated, such as, for example, stainless steel, nichrome or platinum wire, arranged along the glass tube. When the heater arranged along the glass tube is heated, pre-vaporization formulation in the capillary tube 18 is heated to a temperature sufficient to at least partially volatilize pre-vaporization formulation in the capillary tube 18. In at least one embodiment, at least two electrical leads 26 are bonded to the metallic capillary tube 18. In at least one embodiment, one electrical lead 26 is coupled to a first, upstream portion 101 of the capillary tube 18 and a second electrical lead 26 is coupled to a downstream, end portion 102 of the capillary tube 18. In operation, when an adult vaper puffs on the e-vaping device, the puff sensor 16 detects a pressure gradient caused by the puffing of the adult vaper, and the control circuitry 11 activates the heater 19 to heat the pre-vaporization formulation located in the reservoir 14. Once the capillary tube 18 is heated, the pre-vaporization formulation contained within a heated portion of the capillary tube 18 is volatilized and expressed out of the outlet 63, where the pre-vaporization formulation expands and mixes with air and forms a vapor in mixing chamber 240. The power supply 12 of example embodiments can include a battery arranged in the second section 72 of the e-vaping device 60. The power supply 12 is configured to apply voltage across the heater 19, and the heater 19 volatilizes the pre-vaporization formulation housed in the reservoir 14. In at least one embodiment, the electrical contacts or connection between the heater and the electrical leads 26 are substantially conductive and temperature resistant while the heater is substantially resistive so that heat generation occurs primarily along the heater 19 and not at the contacts. The power supply or battery 12 may be rechargeable and include circuitry allowing the battery to be chargeable by an external charging device. In this case, the circuitry, when charged, provides power for a pre-determined number of puffs, after which the circuitry may have to be re-connected to an external charging device. In at least one embodiment, the e-vaping device 60 may include control circuitry which can be on a printed circuit board 11. The control circuitry 11 may also include a heater activation light 27 that is configured to glow when the heater 19 is activated. In at least one embodiment, the heater activation light 27 comprises at least one LED and is at a distal end 28 of the e-vaping device 60 so that the heater activation light 27 illuminates a cap which takes on the appearance of a burning coal during a puff. Moreover, the heater activation light 27 can be configured to be visible to the adult vaper. The light 27 may also be configured such that the adult vaper can 259200/- 10 – 0255436276- activate, deactivate, or activate and deactivate the light 27 when desired, such that the light would not activate during vaping if desired. In at least one embodiment, the e-vaping device 60 further includes a mouth-end insert having at least two off-axis, diverging outlets 21. In at least one embodiment, the mouth-end insert 20 includes at least two diverging outlets 21 (for example, 3 to 8 outlets or more). In at least one embodiment, the outlets 21 of the mouth-end insert 20 are located at ends of off-axis passages 23 and are angled outwardly in relation to the longitudinal direction of the e-vaping device 60 (that is, divergently). As used herein, the term "off-axis" denotes an angle to the longitudinal direction of the e-vaping device. Also, the mouth-end insert (or flow guide) 20 may include outlets uniformly distributed around the mouth-end insert 20 so as to substantially uniformly distribute vapor in an adult vaper's mouth during use. In at least one embodiment, the e-vaping device 60 is about the same size as a conventional cigarette. In some embodiments, the e-vaping device 60 may be about millimeters to about 110 millimeters long, for example about 80 millimeters to about 1millimeters long and about 7 millimeters to about 10 millimeters in diameter. The outer cylindrical housing 22 of the e-vaping device 60 may be formed of or include any suitable material or combination of materials. In at least one embodiment, the outer cylindrical housing 22 is formed at least partially of metal and is part of the electrical circuit connecting the control circuitry 11, the power supply 12, the puff sensor 16 and the heater 19. Fig. 3 is a cross-sectional view of an e-vaping device according to an example embodiment. As shown in Fig. 3, the e-vaping device 60 can also include a middle section (third section) 73, which can house the liquid pre-vaporization formulation reservoir 14 and the heater 19. The middle section 73 can be configured to be fitted with a threaded joint 74' at an upstream end of the first section or cartomizer 70 and a threaded joint 74 at a downstream end of the second section 72. In this example embodiment, the first section or cartomizer 70 houses the mouth-end insert 20, while the second section 72 houses the power supply 12 and the control circuitry that is configured to control the power supply 12. In at least one embodiment, the first section or cartomizer 70, the second section 72 and the third section 73 include a common outer cylindrical housing 22 extending in a longitudinal direction along the length of the e-vaping device 60. Moreover, in at least one embodiment, the middle section 73 is disposable and one or both of the first section or cartomizer 70 and the second section 72 are reusable. The sections 70, 72, 73 can be attached by threaded connections or connectors 74 and 74’ whereby the middle section 73 can be replaced when the reservoir 14 is used up. In another embodiment, the first section or cartomizer 70 is replaceable so as to avoid the need for cleaning one or both of the capillary tube 18 and the heater 19. In at least one embodiment, the first section or cartomizer 70, the second section 72 and the middle 259200/- 11 – 0255436276- section 73 may be integrally formed without threaded connections to form a disposable e-vaping device. In the example embodiment illustrated in Fig. 3, the reservoir 14 is a tubular, elongated body formed of or including an elastomeric material so as to be one or both of flexible and compressible when squeezed. In at least one embodiment, the elastomeric material can be one of silicone, plastic, rubber, latex, and combinations thereof. In at least one embodiment, the reservoir 14 is in fluid communication with a capillary tube so that when squeezed, the reservoir 14 can deliver a volume of a pre-vaporization formulation such as a liquid material to the capillary tube 18. Contemporaneously to delivering pre-vaporization formulation to the capillary, the power supply 12 is activated upon the application of the manual pressure on the reservoir 14, and the capillary tube 18 is heated to form a heated section wherein the pre-vaporization formulation is volatilized. Upon discharge from the heated capillary tube 18, the volatilized material expands, mixes with air and forms a vapor. As shown in Fig. 3, the reservoir 14 includes a valve 40 configured to maintain the liquid pre-vaporization formulation within the reservoir 14 and to open when the reservoir 14 is squeezed and pressure is applied to the reservoir 14. In at least one embodiment, the valve opens when a critical, minimum pressure is reached so as to avoid inadvertent dispensing pre-vaporization formulation from the reservoir 14 or activating the heater 19. In at least one embodiment, the pressure required to press the pressure switch 44 is high enough such that accidental heating is avoided. Such arrangement avoids activation of the heater 19 in the absence of pre-vaporization formulation being pumped through the capillary. Once pressure upon the reservoir 14 is relieved, the valve 40 closes and the heated capillary tube 18 discharges any pre-vaporization formulation remaining downstream of the valve 40. In at least one embodiment, the strength enhancers or additives may include cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol. The strength enhancers may also include capsicum, allyl isothiocyanate, piperine, isoeugenol, carvacrol, thymol, menthol, monomenthyl succinate and N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropyl butanamide. The strength enhancers include one or more compounds that activate receptors in the respiratory system of an adult vaper such as the transient receptor potential cation channel, subfamily A, member 1 (TRPA1), the transient receptor potential cation channel subfamily V member 1 (TPRV1), or the nicotinic-acetylcholine receptor agonists in an adult vaper, the receptors becoming part of the particulate phase and are carried in the respiratory tract of the adult vaper with the particulate phase during vaping. In at least one embodiment, the above compounds as well as others can be found in extracts such as, for example, horseradish oil, garlic extract, onion oil, black pepper, cayenne 259200/- 12 – 0255436276- pepper, ginger oil, thyme oil, cinnamon bark oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil and andrographis extract. In at least one embodiment, the pre-vaporization formulation may include one or more strength enhancers in a composition range of between about 0.0001 percent and about 1 percent, in concentrations of up to about 2 percent, or in concentrations of more than about 2 percent and less than about 5 percent when the strength enhancer is a combination of a plurality of strength enhancers. These strength enhancers may activate receptors in the respiratory system of an adult vaper. In at least one embodiment, a pre-vaporization formulation such as, for example, a liquid formulation, of an e-vaping device includes a mixture of one or more of a vapor former, one or more strength enhancers, nicotine, one or more acids, and water. The pre-vaporization formulation optionally includes water. Water may be included in an amount ranging from about 5 percent by weight based on the weight of the pre-vaporization formulation to about 40 percent by weight based on the weight of the pre-vaporization formulation. For example, water may be included at about 20 percent by weight based on the weight of the pre-vaporization formulation. The following examples describe various combinations and corresponding concentrations of the strength enhancers. The amount of nicotine in the various formulations may be between about 0.5 percent and about 1.5 percent or between about 0.5 percent and about 2 percent. The various strength enhancers are discussed above. The acid discussed below includes at least one of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, malic acid, tartaric acid, succinic acid, citric acid, benzoic acid, oleic acid, aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, 1-glutamic acid, heptanoic acid, hexanoic acid, 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid and sulfuric acid. The following examples of pre-vaporization formulations are discussed: EXAMPLE 1: A pre-vaporization formulation solution includes about a few ppm or about 0.001 percent to about 0.1 percent of a strength enhancer or additive, about 60 percent to about percent of a vapor former (for example, propylene glycol and glycerol in substantially equal concentrations), about 10 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and up to about 5 percent of an acid. EXAMPLE 2: A pre-vaporization formulation solution includes about 1 percent of a strength enhancer or additive, about 60 percent to about 80 percent vapor former (for example, 259200/- 13 – 0255436276- propylene glycol and glycerol), about 15 percent to about 20 percent water, and about 1 percent to about 2 percent nicotine by weight (NBW), and up to about 3 percent of an acid. EXAMPLE 3: A pre-vaporization formulation solution includes about 1.5 percent of a strength enhancer or additive, about 60 percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 1.5 percent nicotine by weight (NBW), and up to about 1 percent of an acid. EXAMPLE 4: A pre-vaporization formulation solution includes about 2 percent of a strength enhancer or additive, about 60 percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and substantially no acid or about 0.1 percent of the acid. EXAMPLE 5: A pre-vaporization formulation solution includes about 2 percent to about percent of a combination of a plurality of strength enhancers or additives, about 60 percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and substantially no acid or about 0.1 percent of the acid. EXAMPLE 6: A pre-vaporization formulation solution includes about 0.1 percent of one of cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol, about percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and up to about 5 percent of an acid. EXAMPLE 7: A pre-vaporization formulation solution includes about 1 percent of one or more of cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol, about percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and up to about 3 percent of an acid. EXAMPLE 8: A pre-vaporization formulation solution includes about 1.5 percent of one or more of cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol, about percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and up to about 1 percent of an acid. Alternatively, the pre-vaporization formulation includes about 1.5 percent of a combination of two or more of cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol. EXAMPLE 9: A pre-vaporization formulation solution includes about 2 percent of a combination of cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol, about 60 percent to about 80 percent vapor former (for example, propylene glycol and glycerol), 259200/- 14 – 0255436276- about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and substantially no acid. EXAMPLE 10: A pre-vaporization formulation solution includes more than about 2 percent of more than one of cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol, about 60 percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and substantially no acid. Alternatively, the pre-vaporization formulation includes more than about 2 percent of a combination of two or more of cinnamaldehyde, menthone, eugenol, zingerone or vanillyacetone, and gingerol. EXAMPLE 11: A pre-vaporization formulation solution includes about 0.1 percent to about 2.5 percent of a combination of horseradish oil, garlic extract, onion oil, black pepper, cayenne pepper, ginger oil, thyme oil, cinnamon bark oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil and andrographis extract, about 60 percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and an optional amount of acid of up to about 5 percent. EXAMPLE 12: A pre-vaporization formulation solution for a smoke cessation device includes about 0.1 percent to about 2 percent of a strength enhancer or additive, about 60 percent to about 80 percent vapor former (for example, propylene glycol and glycerol), about 10 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and between about 0.1 percent to about 5 percent of an acid. In at least one embodiment, the acid is operative upon the vapor generated from the pre-vaporization formulation upon operation of the e-vaping device so as to reduce the amount of perceived throat harshness, while the strength enhancer is operative upon the vapor to increase the perceived strength of the vapor. According to at least one example embodiment, the acid has the capacity to transfer into a vaporized formulation. Liquid to vapor transfer efficiency of an acid is the ratio of the mass fraction of the acid in the vaporized formulation to the mass fraction of the acid in the pre-vaporization formulation. In at least one embodiment, the acid has a pre-vaporization formulation such as a liquid to vapor transfer efficiency of about 50 percent or greater, for example about percent or greater. For example, pyruvic acid, lactic acid, oxalic acid, acetic acid and glycolic acid have a liquid to vapor transfer efficiency of about 50 percent or greater. In at least one embodiment, the pre-vaporization formulation includes an acid having a liquid to vapor transfer efficiency of about 50 percent or greater. In another embodiment, the pre-vaporization formulation excludes any acid having a liquid to vapor transfer efficiency of about 25 percent or less. 259200/- 15 – 0255436276- According to at least one example embodiment, the acid has a boiling point of at least about 100 degrees Celsius, and may be included in the pre-vaporization formulation in an amount sufficient to adjust the pH of the pre-vaporization formulation in the range of about 3 to about 8. According to at least one example embodiment, the pre-vaporization formulation includes one or more of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, malic acid, tartaric acid, succinic acid, citric acid, benzoic acid, oleic acid, aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, 1-glutamic acid, heptanoic acid, hexanoic acid, 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid, sulfuric acid, and combinations thereof. The acid also may be incorporated in the form of a salt. The pre-vaporization formulation also includes a vapor former, optionally water, nicotine, and flavorants. Example embodiments having therefore been described, it will be obvious that the same may be varied in many ways. Such variations are not to be regarded as a departure from the intended scope of example embodiments, and all such modifications as would be obvious to one skilled in the art are intended to be included within the scope of the following claims.
Claims (16)
1./ 02554362125- CLAIMS: 1. A pre-vaporization formulation for an e-vaping device, the pre-vaporization formulation comprising: a vapor former comprising substantially equal concentrations of propylene glycol and glycerol; nicotine; one or more acids in a concentration of between 0.1 percent and 5 percent; and an additive including at least one of monomenthyl succinate, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropyl butanamide.
2. The pre-vaporization formulation of claim 1, wherein the additive further comprises at least one of piperine, allyl isothiocyanate, capsicum, isoeugenol and menthol.
3. The pre-vaporization formulation of claim 1 or 2, wherein the additive is an extract from at least one of zingerone, garlic extract, onion oil, thyme oil, cinnamon bark oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil and and rographis extract.
4. The pre-vaporization formulation of any one of the preceding claims, wherein the additive further comprises an extract from at least one of cinnalmaldehyde, menthone, eugenol, horseradish oil, black pepper, cayenne pepper, and ginger oil.
5. The pre-vaporization formulation of any one of the preceding claims, wherein a concentration of the additive is in a range of 0.0001 percent to 1 percent.
6. The pre-vaporization formulation of any one of the preceding claims, wherein a concentration of a combination of a plurality of additives in the pre-vaporization formulation is greater than 2 percent.
7. The pre-vaporization formulation of claim 6, wherein the concentration of the combination of the plurality of additives in the pre-vaporization formulation is between percent and 5 percent.
8. The pre-vaporization formulation of claim 1, wherein a concentration of nicotine in a vapor phase of the vapor former is less than or equal to 1 percent. 259200/ 02554362125-
9. The pre-vaporization formulation of claim 1 or 8, wherein a concentration of nicotine is in a range of 0.5 percent to 2 percent by weight.
10. The pre-vaporization formulation of any one of the preceding claims, further comprising water in a concentration of 10 percent to 20 percent.
11. The pre-vaporization formulation of claim 1, wherein the one or more acids comprise at least one of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, malic acid, tartaric acid, succinic acid, citric acid, benzoic acid, oleic acid, aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, 1-glutamic acid, heptanoic acid, hexanoic acid, 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid and sulfuric acid.
12. The pre-vaporization formulation of claim 1 or 11, wherein the one or more acids have a liquid to vapor transfer efficiency that is greater than 50 percent.
13. An e-vaping device, comprising: a cartomizer including a reservoir holding a pre-vaporization formulation, a mouth-end piece, and a heater configured to heat the pre-vaporization formulation; and a power supply section connected to the cartomizer and including a puff sensor configured to sense a puff taking place at the mouth-end piece, and a power source configured to supply power to the heater; wherein the pre-vaporization formulation includes: a vapor former comprising substantially equal concentrations of propylene glycol and glycerol; nicotine; one or more acids in a concentration of between 0.1 percent and 5 percent; and an additive including at least one of monomenthyl succinate, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropyl butanamide. 259200/ 02554362125-
14. The e-vaping device of claim 13, wherein the additive is an extract from at least one of zingerone, garlic extract, onion oil, thyme oil, cinnamon bark oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil and rographis extract.
15. The e-vaping device of claim 13 or 14, wherein at least one of: a concentration of the additive is in a range of 0.0001 percent to 1 percent; and a concentration of a combination of a plurality of additives in the pre-vaporization formulation is greater than 2 percent.
16. The e-vaping device of any one of claims 13 to 15, wherein at least one of: a concentration of nicotine in a vapor phase of the vapor former is less than or equal to 2 percent; the pre-vaporization formulation further includes water in a concentration of 10 percent to 20 percent; and the one or more acids have a liquid to vapor transfer efficiency that is greater than percent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/974,211 US20170172204A1 (en) | 2015-12-18 | 2015-12-18 | Strength enhancers and method of achieving strength enhancement in an electronic vapor device |
PCT/EP2016/081469 WO2017103136A1 (en) | 2015-12-18 | 2016-12-16 | Strength enhancers and method of achieving strength enhancement in an electronic vapor device |
Publications (3)
Publication Number | Publication Date |
---|---|
IL259200A IL259200A (en) | 2018-07-31 |
IL259200B1 IL259200B1 (en) | 2023-05-01 |
IL259200B2 true IL259200B2 (en) | 2023-09-01 |
Family
ID=57749910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL259200A IL259200B2 (en) | 2015-12-18 | 2016-12-16 | Strength enhancers and method of achieving strength enhancement in an electronic vapor device |
Country Status (12)
Country | Link |
---|---|
US (1) | US20170172204A1 (en) |
EP (1) | EP3389420B1 (en) |
JP (2) | JP2019503660A (en) |
KR (1) | KR20180094868A (en) |
CN (1) | CN108289496A (en) |
CA (1) | CA3001780A1 (en) |
ES (1) | ES2749951T3 (en) |
IL (1) | IL259200B2 (en) |
MX (1) | MX2018006898A (en) |
PL (1) | PL3389420T3 (en) |
RU (1) | RU2730706C2 (en) |
WO (1) | WO2017103136A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
US10279934B2 (en) | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
AU2014369867A1 (en) | 2013-12-23 | 2016-06-16 | Juul Labs, Inc. | Vaporization device systems and methods |
US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
EP3821735A1 (en) | 2014-12-05 | 2021-05-19 | Juul Labs, Inc. | Calibrated dose control |
BR112018016402B1 (en) | 2016-02-11 | 2023-12-19 | Juul Labs, Inc | SECURELY FIXED CARTRIDGES FOR VAPORIZER DEVICES |
MX2018009702A (en) | 2016-02-11 | 2019-07-08 | Juul Labs Inc | Fillable vaporizer cartridge and method of filling. |
US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
BR112019011291A2 (en) | 2016-12-02 | 2019-10-08 | Vmr Products Llc | combination vaporizer |
JP7066720B2 (en) * | 2016-12-29 | 2022-05-13 | ジェイティー インターナショナル エス.エイ. | Tobacco mousse |
CN107343668A (en) * | 2017-08-31 | 2017-11-14 | 云南巴菰生物科技有限公司 | A kind of purposes of the electronics tobacco tar for lifting fragrance texture and preparation method thereof with it |
USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
GB201807305D0 (en) * | 2018-05-03 | 2018-06-20 | Nicoventures Trading Ltd | Vaporisable formulation |
GB201817859D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
CN109619655A (en) * | 2019-01-18 | 2019-04-16 | 深圳市同信兴投资有限公司 | A kind of compound nicotine salt and its solution, preparation method and application |
FR3093405B1 (en) * | 2019-03-05 | 2022-07-29 | V F P France | VAPING COMPOSITIONS |
JP2022539964A (en) * | 2019-06-25 | 2022-09-14 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Cartridge containing nicotine and water immiscible solvent |
FR3110347B1 (en) | 2020-05-20 | 2022-06-03 | V F P France | VAPING COMPOSITIONS |
CN114468345B (en) * | 2021-12-28 | 2022-11-15 | 四川三联新材料有限公司 | Electronic cigarette liquid with pepper flavor and preparation method thereof |
CN115119957A (en) * | 2022-06-28 | 2022-09-30 | 深圳市艾普生物科技有限公司 | Antioxidant electronic cigarette oil and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009001085A2 (en) * | 2007-06-25 | 2008-12-31 | Kind Consumer Limited | An inhalable composition comprising nicotine |
US20150020823A1 (en) * | 2013-07-19 | 2015-01-22 | Altria Client Services Inc. | Liquid aerosol formulation of an electronic smoking article |
US20150038576A1 (en) * | 2013-08-02 | 2015-02-05 | Sentiens, Llc | Compositions and their use for smoking cessation and other treatments |
EP2862454A1 (en) * | 2013-10-18 | 2015-04-22 | Valeo Laboratories GmbH | Liquid composition for an electronic cigarette |
WO2015084544A1 (en) * | 2013-12-05 | 2015-06-11 | Ploom, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62175896U (en) * | 1986-04-25 | 1987-11-09 | ||
RU2174388C2 (en) * | 1995-08-29 | 2001-10-10 | В. Ман Филс С.А. | Aromatizing and refreshing composition |
WO2000015057A1 (en) * | 1998-09-17 | 2000-03-23 | Hou Wei Hsin | Cigarette filter made from surface activated particulate particles |
JP4608499B2 (en) * | 2003-11-04 | 2011-01-12 | フイルメニツヒ ソシエテ アノニム | Aroma ingredients for refreshing preparations |
US20080038386A1 (en) * | 2006-08-02 | 2008-02-14 | Ashok K Moza | Use of a liquid cooling sensate to provide a pungent, warming or tingling sensate composition |
US8646461B2 (en) * | 2011-12-14 | 2014-02-11 | Sentiens, Llc | Device and method for simulating chemosensation of smoking |
BR112014027156B1 (en) * | 2012-04-30 | 2021-03-16 | Philip Morris Products S.A. | smoking article, use of a cyclodextrin cooling agent inclusion method and method to provide a stable cooling sensation in the mouthpiece of a smoking article |
US20140261486A1 (en) * | 2013-03-12 | 2014-09-18 | R.J. Reynolds Tobacco Company | Electronic smoking article having a vapor-enhancing apparatus and associated method |
CA3208137A1 (en) | 2013-05-06 | 2014-11-13 | Juul Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
US9877511B2 (en) * | 2013-07-24 | 2018-01-30 | Altria Client Services Llc | Electronic smoking article |
MX2016010410A (en) * | 2014-02-10 | 2016-11-30 | Philip Morris Products Sa | Cartridge with a heater assembly for an aerosol-generating system. |
-
2015
- 2015-12-18 US US14/974,211 patent/US20170172204A1/en not_active Abandoned
-
2016
- 2016-12-16 EP EP16822652.0A patent/EP3389420B1/en active Active
- 2016-12-16 KR KR1020187015306A patent/KR20180094868A/en not_active Application Discontinuation
- 2016-12-16 CA CA3001780A patent/CA3001780A1/en active Pending
- 2016-12-16 RU RU2018125249A patent/RU2730706C2/en active
- 2016-12-16 ES ES16822652T patent/ES2749951T3/en active Active
- 2016-12-16 CN CN201680068322.7A patent/CN108289496A/en active Pending
- 2016-12-16 WO PCT/EP2016/081469 patent/WO2017103136A1/en active Application Filing
- 2016-12-16 JP JP2018526861A patent/JP2019503660A/en active Pending
- 2016-12-16 IL IL259200A patent/IL259200B2/en unknown
- 2016-12-16 MX MX2018006898A patent/MX2018006898A/en unknown
- 2016-12-16 PL PL16822652T patent/PL3389420T3/en unknown
-
2022
- 2022-05-18 JP JP2022081415A patent/JP2022103338A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009001085A2 (en) * | 2007-06-25 | 2008-12-31 | Kind Consumer Limited | An inhalable composition comprising nicotine |
US20150020823A1 (en) * | 2013-07-19 | 2015-01-22 | Altria Client Services Inc. | Liquid aerosol formulation of an electronic smoking article |
US20150038576A1 (en) * | 2013-08-02 | 2015-02-05 | Sentiens, Llc | Compositions and their use for smoking cessation and other treatments |
EP2862454A1 (en) * | 2013-10-18 | 2015-04-22 | Valeo Laboratories GmbH | Liquid composition for an electronic cigarette |
WO2015084544A1 (en) * | 2013-12-05 | 2015-06-11 | Ploom, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
Also Published As
Publication number | Publication date |
---|---|
ES2749951T3 (en) | 2020-03-24 |
CN108289496A (en) | 2018-07-17 |
MX2018006898A (en) | 2018-09-06 |
US20170172204A1 (en) | 2017-06-22 |
RU2018125249A (en) | 2020-01-20 |
IL259200A (en) | 2018-07-31 |
EP3389420A1 (en) | 2018-10-24 |
RU2018125249A3 (en) | 2020-04-14 |
CA3001780A1 (en) | 2017-06-22 |
WO2017103136A1 (en) | 2017-06-22 |
JP2019503660A (en) | 2019-02-14 |
EP3389420B1 (en) | 2019-09-11 |
KR20180094868A (en) | 2018-08-24 |
IL259200B1 (en) | 2023-05-01 |
JP2022103338A (en) | 2022-07-07 |
PL3389420T3 (en) | 2020-06-15 |
RU2730706C2 (en) | 2020-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3389420B1 (en) | Strength enhancers and method of achieving strength enhancement in an electronic vapor device | |
KR102667573B1 (en) | Pre-vapor preparations for controlling acidity in electronic smoking devices | |
RU2706839C2 (en) | Liquid composition for electronic device for hovering | |
US11337453B2 (en) | Liquid aerosol formulation of an electronic smoking article | |
US20150313275A1 (en) | Liquid aerosol formulation of an electronic smoking article | |
US20150027468A1 (en) | Electronic smoking article | |
WO2015009863A1 (en) | Electronic smoking article | |
US20180368472A1 (en) | Encapsulated ingredients for e-vaping devices and method of manufacturing thereof | |
JP7258761B2 (en) | Prevapor formulation for forming organic acids during operation of an e-vaping device |