EP2862454A1 - Liquid composition for an electronic cigarette - Google Patents

Liquid composition for an electronic cigarette Download PDF

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Publication number
EP2862454A1
EP2862454A1 EP20140189319 EP14189319A EP2862454A1 EP 2862454 A1 EP2862454 A1 EP 2862454A1 EP 20140189319 EP20140189319 EP 20140189319 EP 14189319 A EP14189319 A EP 14189319A EP 2862454 A1 EP2862454 A1 EP 2862454A1
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EP
European Patent Office
Prior art keywords
trp
liquid composition
activator
ethanol
agonist
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Granted
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EP20140189319
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German (de)
French (fr)
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EP2862454B1 (en
EP2862454B8 (en
Inventor
Olaf Meinert
Ilonka Paul
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Valeo GmbH
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Valeo Laboratories GmbH
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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes

Definitions

  • the present invention relates to a liquid composition (e-liquid) for use in electronic cigarettes and to the use of a modulator and at least one TRP agonist / activator ("TRP" in English means “transient receptor potential” and can be used as " transient receptor potential) in a liquid, non-nicotine-containing composition that simulates the tobacco smoke or sensation of inhalation of a conventional tobacco cigarette.
  • TRP TRP agonist / activator
  • a tobacco smoker / e-cigarette steamer feels visibly uncomfortable during his stay in smoking-prohibiting areas.
  • the regular drop in nicotine levels in the body of a smoker / steamer favors this malaise, but this is not the only or most important factor controlling the craving for a tobacco or e-cigarette. Rather, the forced by use prohibitions suppressing the usual ritual on a tobacco or e-cigarette to draw, the smoke / vapor to inhale and expunge relish with relish the main cause of this malaise and the growing desire for this Ritual satisfaction.
  • a special part of this is the perceived during inhalation "flash" or "kick" in the mouth and throat and lung. This sensation, which is caused by the irritation of certain receptors, is important to the smoker / steamer in order to satisfy his desire.
  • liquids that nicotine is buried in are that while the satisfaction of the addiction is achieved, but still toxins are supplied to the body.
  • This disadvantage has been addressed by providing liquids that - mostly by adding flavors - try to create a "real smoking experience” similar to that of smoking cigarettes or nicotine-containing liquid smoking, but much less do not contain any nicotine.
  • these liquids have the disadvantage that the chemosensorics addressed by nicotine, i. the nicotine-induced "flash" is completely absent.
  • a liquid composition for an electronic cigarette ie a liquid
  • a liquid that contains no toxins such as nicotine, but still generates the above-described "flash" at the user, ie the chemosensory receptors in the way responds, as it does the smoker's usual nicotine.
  • the at least one TRP agonist / activator preferably activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8.
  • TRP agonists / activators are combined to activate different TRP channels.
  • Extracts comprising black pepper, horseradish, garlic, paprika, cinnamon, mint and vinegar and citric acid as TRP agonist / activator are preferably used in the liquid composition according to the invention.
  • active ingredients with at least 6-paradol and analogues serve as TRP agonist / activator.
  • 6-paradol and analogs include at least 1'-acetoxychavicol acetate and analogs, isothiocyanates and analogs, camphor and analogs, grains of paradise, thymol and analogues, and ethanol.
  • the at least one TRP agonist / activator is preferably based on the components of TRP channel subtypes.
  • liquid composition according to the invention preferably serve ethanol, glycol or glycerol as a modulator.
  • the present invention relates to a use of a modulator and at least one TRP agonist / activator in a liquid composition for electronic cigarettes that does not contain nicotine to inhale cigarette smoke.
  • the liquid composition for an electronic cigarette comprises a TRP modulator and at least one TRP agonist / activator, wherein the interaction of modulator and the at least one agonist / activator chemosensory imitation of inhaled cigarette smoke, and the liquid composition no Contains nicotine.
  • a modulator and at least one TRP agonist / activator is used in a liquid composition for electronic cigarettes that does not contain nicotine to inhale cigarette smoke.
  • the at least one TRP agonist / activator activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8. Furthermore, it is advantageous that multiple TRP agonists / activators are combined to activate different TRP channels. As a further advantageous embodiment, extracts containing black pepper, horseradish, garlic, paprika, cinnamon, mint and acetic and citric acid are used as the TRP agonist / activator.
  • drugs having at least 6-paradole and analogs comprise at least 1'-acetoxy-chiacicol acetate and analogs, isothiocyanates and analogues, camphors and analogues, grains of paradise, thymol and analogues, and ethanol.
  • the at least one TRP agonist / activator is based on the components of TRP channel subtypes.
  • ethanol, glycol or glycerol serve as a modulator.
  • the chemical components are mixed together.
  • the basic components of the liquid (propylene glycol, glycerine, ethanol and flavorings) are obtained directly from the chemical manufacturer or from the flavor supplier.
  • the ingredients of the liquid composition (BioNic) to be patented, for the most part, can not be conventionally sourced, at least not in the form as used in the present invention.
  • the grains of compassion so acquired can not be incorporated in the conventional form in the liquid, but it must first be extracted from this raw material, the corresponding active ingredient. This is usually done by extracting the active substance by means of ethanol by Soxhlet extraction from the raw material.
  • the active ingredient is bound directly into the ethanol, which is then introduced into the liquid. It is known to the person skilled in the art how the active substances are treated in order to be used in the liquid composition.
  • Nicotine has been shown to be a neurotoxin that, along with other conventional cigarettes, acts on sensory and autonomic afferent nerve endings, sending sensory information from the mouth, throat, and airways to the brain via the vagus, trigeminal, and other cranial nerves.
  • the brain acts accordingly, inducing autonomic reflexes and central nervous system effects that rely on the subjective experience of smoking, including "throat scratching" and behavioral behaviors stored to relieve the craving.
  • Cigarette smoking causes EEG changes and activates related, subjective behavioral reflexes on sensory reflexes, even before nicotine in the smoke is absorbed and nerve reactions can report that drug to the brain.
  • herbal analogues In order to simulate a smoking sensation as in a conventional cigarette, but without using toxins such as nicotine, herbal analogues were sought which produce these or similar chemosensory effects and no longer require the use of nicotine as a neurotoxin.
  • the sensory senses include taste, sense of smell and "chemical sensitivity” (also known as the "common chemical sense", or trigeminal chemosensorics).
  • Chemosensorics refers to effects, e.g. B. on nerve endings mediating sensations of pain or temperature.
  • specific substances such as pepperoni (capsaicin), black pepper (piperine), menthol, garlic (allicin), horseradish and wasabi (allyl isothiocyanate), camphor, wintergreen , Cinnamon (cinnamaldehyde), carbonic acid, for example, in drinks (carbon dioxide) and some air pollutants is caused.
  • Such sensations in the oral cavity and in the nasal cavities become over mediate the trigeminal nerve and are elements of the somatosensory system.
  • chemical signals are transmitted to the brain via the vagus nerve, which can directly influence the brain
  • the appetitive circuit is satisfied by chemosensory stimulation, without supplying the body with the actual active substance such as nicotine. Due to the chemosensory stimulation, the brain assumes that with the usual inhalation and the usual stimulating nicotine was supplied. In addition, and not less strong is the positive influence of the imitation of tactile, kinaesthetic and organoleptic aspects of smoking, for example, by an optically visible evaporation of the liquid and thus suggests that it is the same habitual ritual as smoking a cigarette, although it is merely an evaporation of much more harmless ingredients without toxins.
  • TRP Transient Receptor Potential
  • TRP channels are a class of receptors on sensory nerves that have the ability to activate them by triggering. TRP channels transmit the sensations of spicy, hot or cold, as well as components in the inhaled air to the central nervous system. In addition to chemosensory stimulation, activation of the sensory nerve endings by the TRP channels also induces local effects, such as coughing, sneezing, regulation of body temperature or other subjective sensations. In addition, the activation of TRP channels requires only very low constituents of the corresponding TRP-relevant active substance, so that in principle even a theoretically harmful concentration can be avoided.
  • the TRP channel activators provide minimal volatile components in the inspired air to induce a cigarette smoke-like chemosensory stimulation without the need to absorb a bioactive drug concentration in the body.
  • the following is an exemplary liquid composition at a product unit of 10000 mg: 4500 mg propylene glycol, 4000 mg Glycerols, 1000 mg food flavorings, 487 mg ethanol, further containing the following components in their entirety for a chemosensory reaction: 1.25 mg Piper nigrum, 3.75 mg Melegueta Aframomum, 1.25 mg benzoin, 0.5 mg allicin, 0 , 7 mg isothiocyanate, 0.425 mg zingiberis rhizoma, 4.15 mg capsaicin, 0.625 mg Zanthoxylum piperitum, 0.35 mg curcumin.
  • composition is as follows: propylene glycol: 40% to 50%, glycerols: 36% to 44%, food flavors: 9% to 11%, ethanol: 4.3% to 5.3%, further comprising the following as a whole for one chemosensory response components: Piper nigrum: 0.12% to 0.13%, Melegueta Aframomum: 0.03% to 0.04%, Benzoin: 0.012% to 0.014%, Allicin: 0.0049% to 0.0051% , Isothiocyanate: 0.006% to 0.008%, Zingiberis rhizoma: 0.0038% to 0.0047%, Capsaicin: 0.0037% to 0.0046%, Zanthoxylum piperitum: 0.0056% to 0.0069%, Curcumin: 0 , 0031% to 0.0039%.
  • TRP V1 is a temperature-sensing channel whose activation threshold can still be lowered by using ethanol as a TRP modulator.
  • TRP V1 agonists such as extracts of chilli, Szechuan pepper or mustard by using even lower concentrations can be achieved.
  • TRP activators provide a unique basis for the chemosensory imitation of inhaled cigarette smoke without the necessity of using incinerated, often carcinogenic substances.
  • TRP activators enables the imitation of subjective and physiological chemosensory experiences, such as the inhalation of cigarette smoke.
  • Known TRP activators are, for example, extracts of black pepper, horseradish, garlic, paprika, cinnamon, mint and other known TRP channels activating substances, as well as acetic and citric acid. By utilizing a complex mixture of these agents, the activation ability can be both broad and potentiated.
  • the use of low concentrations of these activators in the liquid supports the ability of the receptors for a rapid desensitization, so that after only a short time (as part of an inhalation interval of an electric cigarette) the chemosensory stimulation can be done again and in full sensation size.
  • TRP activators offer in particular the active ingredients which contain 6-paradol and analogues. These include, for example: 1'-acetoxychavicol acetate and analogs, isothiocyanates and analogs, camphor and analogs, grains of paradise, thymol and analogs, and ethanol. Among others, these activators are used in the liquid mixtures.
  • the liquid composition according to the invention makes it possible to activate each individual TRP channel (TRP A1, TRP V1, TRP V3 and TRP M8). The activation of each individual TRP channel with the respective activators is decisive here in order to achieve a corresponding tobacco smoke-like inhalation sensation.
  • the desired inclusion of the TRP M8 receptor in the functional base is based on its ability to suppress by stimulation / activation the inhalation sensation caused by coughing.
  • a complex composition of different activators is necessary along with a suitable choice of modulators.
  • the glycerine is one-quarter or more, and preferably two-thirds or less, of the liquid composition (by weight, expressed in "%", that is, percent by weight).
  • Particularly preferred weight fractions of the glycerol are 30% or more, more preferably 33% or more, even more preferably 36% or more and especially preferably 39% or more.
  • Upper limits of the content by weight of the glycerin are preferably 55% or less, more preferably 50% or less, still more preferably 45% or less, and particularly preferably 41% or less.
  • the proportion by weight of glycerol expressed in percent by weight is accordingly preferably 30%. to 55%, more preferably 33% to 50%, even more preferably 36% to 45%, and most preferably 39% to 41%.
  • the composition has a very low allergenic potential.
  • the allicin used in some exemplary embodiments of 0.0049% -0.0051% by weight, derived from mustard seeds, is suspected of inducing allergenic reactions.
  • the other constituents used according to the invention in particular glycerol and 6-paradole or analogues thereof, regularly trigger no allergenic reactions.
  • TRP activators are based on the constituents of the TRP channel subtypes.
  • the use of drug mixtures creates the possibility of activating or deactivating various TRP channels in variable intensities by means of also variably long time arcs.
  • This control affects not only the intensity and time arcs, but also the local space by the chemosensory sensation takes place, such as: oral cavity, pharynx, lung space.
  • Related tests have shown that activation of a subchannel enhances the actual chemosensory sensation without having to raise the concentration of the drug itself.
  • TRP channels in the human body chemosensory, since in humans TRP channels play an important role in the perception of taste (sweet, sour, umami), pheromones, temperature (hot, hot, cold) , Pain u. a. play.
  • ethanol in addition to glycol and glycerol, ethanol, optionally additionally one or more volatile agonists of TRPA1, TRPV1, TRPV3 and / or TRPM8 channels, and, if necessary, volatile, low molecular weight carboxylic acid and flavoring agents can be used.
  • One component of different concentrated liquid mixtures for electrical evaporation is an extract from the chili pepper, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.
  • a component of differently concentrated liquid mixtures for electrical evaporation is an extract of black pepper, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.
  • One component of different concentrated liquid mixtures for electrical evaporation is an extract of zingiberaceae (ginger plants), which activates the TRP receptor TRP-1 and TRP-2 by inhalation and causes a chemosensory reaction.
  • An ingredient of different concentrated liquid mixtures for electrical evaporation is an extract of isothiocyanates, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract of cloves, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract of camphor, which activates the TRP receptor TRPV1 + TRPV2 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract of Aframomum melegueta (grains of paradise), which activates the TRP receptor TRPA1 + TRPV1 by inhalation and causes a chemosensory reaction.
  • a component of differently concentrated liquid mixtures for electrical evaporation is an extract of Zanthoxylum piperitum (Szechuan pepper), which by inhalation the TRP receptor TRPA1 + TRPV1 activated and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract of thyme, which activates the TRP receptor TRPV3 by inhalation and causes a chemosensory reaction.
  • One component of different concentrated liquid mixtures for electrical evaporation is an extract of peppermint, which activates the TRP receptor TRPM8 by inhalation and causes a chemosensory reaction.
  • One component of the differently concentrated liquid mixtures for electrical evaporation is an extract of vanilla, which activates the TRP receptor TRPV3 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract of eucalyptus, which activates the TRP receptor TRPM8 by inhalation and causes a chemosensory reaction.
  • An ingredient of liquid concentrated mixtures for electrical evaporation are flavor extracts that activate the TRPM8 TRPM8 by inhalation and induce a chemosensory reaction.
  • One component of different concentrated liquid mixtures for electrical evaporation is caffeine, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.
  • One component of different concentrated liquid mixtures for electrical evaporation are low molecular weight organic acids that activate a TRP receptor by inhalation and cause a chemosensory reaction.
  • One component of different concentrated liquid mixtures for electrical evaporation is ethanol, which activates the TRPV receptor TRPV1 by inhalation and causes a chemosensory reaction.
  • liquid mixtures according to the invention solves the object of the present invention.
  • a "real" smoke feeling is mediated, i. the already described “flash” takes place without toxins such as nicotine being used.
  • the smallest constituents of the extracts in the liquid are sufficient to achieve the desired effect.
  • compositions having different weight percentages of glycerol were prepared by appropriately decreasing or increasing the level, with the propylene glycol content adjusted accordingly to produce compositions having the same total weights.
  • the scores of the prepared eleven compositions (compositions 1a to 11a) by the subjects were averaged and summarized in the following Table 1: Table 1 Composition no. Glycerol content (% by weight) Average rating 1a 0 4.1 2a 10 3.8 3a 20 3.5 4a 30 2.5 5a 40 1.4 6a 50 2,4 7a 60 2.9 8a 70 3.7 9a 80 4.0 10a 90 4.3 11a 100 4.7
  • compositions 1 b to 11 b were asked to use compositions as in Table 1 above for the production of smoke and to assess the inhalation sensation in turn according to the above grading scale.
  • the corresponding grades by the subjects were again averaged and summarized in the following Table 2: Table 2 Composition no.
  • Glycerol content (% by weight) Average rating 1b 0 5.3 2 B 10 4.9 3b 20 4.5 4b 30 3.4 5b 40 2.6 6b 50 3.5 7b 60 4.9 8b 70 4.8 9b 80 5.1 10b 90 5.3 11b 100 5.7
  • TRP agonist / activator selected from 6-paradol and analogues (here Melegueta Aframomum) and glycerol as TRP modulator in all comparable compositions to a usually at least a grade better assessment of the inhalation sense than similar to tobacco smoke. Furthermore, it is clear that the inventively preferred Glyceringehalte led to a further increase in the positive inhalation sensation.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Die vorliegenden Erfindung bezieht sich auf eine flüssige Zusammensetzung für eine elektronische Zigarette, umfassend einen TRP-Modulator und zumindest einen TRP-Agonisten/Aktivator, wobei durch das Zusammenwirken von Modulator und dem zumindest einen Agonisten/Aktivator eine chemosensorischen Nachahmung von inhaliertem Zigarettenrauch erfolgt, und wobei die flüssige Zusammensetzung kein Nikotin enthält. Ferner bezieht sich die Erfindung auf eine Verwendung von einem Modulator und zumindest einem TRP-Agonisten/Aktivatoren in einer flüssigen Zusammensetzung für elektronische Zigaretten, das kein Nikotin enthält, um Zigarettenrauch zu inhalieren.The present invention relates to a liquid composition for an electronic cigarette, comprising a TRP modulator and at least one TRP agonist / activator, wherein the interaction of modulator and the at least one agonist / activator chemosensory imitation of inhaled cigarette smoke takes place, and wherein the liquid composition does not contain nicotine. Further, the invention relates to a use of a modulator and at least one TRP agonist / activator in a liquid composition for electronic cigarettes that does not contain nicotine to inhale cigarette smoke.

Description

Die vorliegende Erfindung bezieht sich auf eine flüssige Zusammensetzung (e-Liquid) zur Verwendung in elektronischen Zigaretten sowie die Verwendung von einem Modulator und zumindest einem TRP-Agonisten/Aktivator ("TRP" bedeutet in englischer Sprache "Transient Receptor Potential" und kann als "vorübergehendes Rezeptor-Potential" übersetzt werden) in einer flüssigen, nicht nikotinhaltigen Zusammensetzung, die den Tabakrauch bzw das Inhalationsempfinden einer herkömmlichen Tabakzigarette simuliert.The present invention relates to a liquid composition (e-liquid) for use in electronic cigarettes and to the use of a modulator and at least one TRP agonist / activator ("TRP" in English means "transient receptor potential" and can be used as " transient receptor potential) in a liquid, non-nicotine-containing composition that simulates the tobacco smoke or sensation of inhalation of a conventional tobacco cigarette.

Das Rauchen von Tabakzigaretten ist mittlerweile in nahezu allen öffentlichen Räumen verboten. Dies schließt sowohl Arbeitsplätze, Bars, Restaurants und viele weitere Räumlichkeiten ein. Außerdem ist es das Ziel vieler Tabak- und e-Zigarettennutzer, zwar die Nikotinkonzentration und damit den vermeintlichen Nikotin-Bedarf sukzessive zu senken, um den Körper nicht unnötig vielen Giftstoffen auszusetzen, nicht jedoch auf das Verhaltensritual und die Zuführung des Genussmittels Zigarette selbst zu verzichten. Deshalb greifen viele Raucher mittlerweile zu der elektronischen bzw. e-Zigarette.The smoking of tobacco cigarettes is now banned in almost all public spaces. This includes jobs, bars, restaurants and many more. In addition, it is the goal of many tobacco and e-cigarette users, although the nicotine concentration and thus the supposed nicotine need to gradually reduce so as not to expose the body unnecessarily many toxins, but not to renounce the behavioral ritual and the supply of the stimulant cigarette itself , That is why many smokers are now using the electronic or e-cigarette.

Es sind unterschiedliche e-Zigaretten bereits bekannt. Deren Funktionsweise besteht darin, dass eine flüssige Zusammensetzung, auch als "Liquid" bezeichnet, welche meistens aromatisiert ist und auch Nikotin enthält, in dieser elektronischen Zigarette mittels einer Verdampfungseinheit verdampft wird und dadurch die Funktion einer herkömmlichen Zigarette simuliert wird.Different e-cigarettes are already known. Their operation consists in that a liquid composition, also called "liquid", which is mostly flavored and also contains nicotine, is vaporized in this electronic cigarette by means of an evaporation unit and thereby the function of a conventional cigarette is simulated.

Unter den oben genannten immer mehr verschärften Voraussetzungen bezüglich des Rauchens fühlt sich ein Tabakraucher/e-Zigaretten-Dampfer während seines Aufenthaltes in Rauchverbotsarealen sichtlich unwohl. Der turnusmäßige Abfall des Nikotinspiegels im Körper eines Rauchers/Dampfers begünstigt dieses Unwohlsein, jedoch ist dies nicht der einzige oder wichtigste Faktor, der das Verlangen nach einer Tabak- oder e-Zigarette steuert. Vielmehr ist das durch Nutzungsverbote erzwungene Unterdrücken des gewohnten Rituals an einer Tabak- oder e-Zigarette zu ziehen, den Rauch/Dampf zu inhalieren und genüsslich wieder auszustoßen die Hauptursache für dieses Unwohlsein und dem stärker werdenden Verlangen nach dieser Ritualbefriedigung. Ein besonderer Teil hierbei ist der beim Inhalieren empfundene "Flash" oder auch "Kick" im Mund-Rachen und Lungenbereich. Dieses Empfinden, das durch die Reizung bestimmter Rezeptoren hervorgerufen wird, ist für den Raucher/Dampfer wichtig, um sein Verlangen zu stillen.Under the above-mentioned ever more stringent requirements regarding smoking, a tobacco smoker / e-cigarette steamer feels visibly uncomfortable during his stay in smoking-prohibiting areas. The regular drop in nicotine levels in the body of a smoker / steamer favors this malaise, but this is not the only or most important factor controlling the craving for a tobacco or e-cigarette. Rather, the forced by use prohibitions suppressing the usual ritual on a tobacco or e-cigarette to draw, the smoke / vapor to inhale and expunge relish with relish the main cause of this malaise and the growing desire for this Ritual satisfaction. A special part of this is the perceived during inhalation "flash" or "kick" in the mouth and throat and lung. This sensation, which is caused by the irritation of certain receptors, is important to the smoker / steamer in order to satisfy his desire.

Bisher besteht die Möglichkeit, anstelle von nikotinhaltigen Liquids für e-Zigaretten nikotinfreie Liquids für e-Zigaretten zu nutzen, um diesem Verlangen nach "gesundem Rauchen" entgegenzukommen und dem Verlangen der Ritualbefriedigung entgegenzuwirken, da e-Zigaretten die Ausübung des beschriebenen Rituals durch ihre Handhabung begünstigen. Nachteilig ist hier jedoch, dass die Chemosensorik (hier insbesondere das als "Flash" bezeichnete Inhalationsgefühl wie vorher beschrieben) im Speziellen durch das Fehlen des Nikotins vollkommen ausbleibt. Auch das Hinzufügen von Aromastoffen zu dem Liquid kann diesen Flash nicht hervorrufen. Als Beispiel für das Hinzufügen von Aromastoffen und/oder Nikotin wird auf das chinesische Patent mit der Nummer CN 101926506 B und die Europäische Patentanmeldung EP 2 563 265 A2 verwiesen.So far, instead of nicotine-containing liquids for e-cigarettes, it has been possible to use nicotine-free e-cigarette liquids in order to meet this desire for "healthy smoking" and to counteract the craving for ritual gratification, since e-cigarettes exercise the described ritual through their handling favor. However, it is disadvantageous here that the chemosensorics (here in particular the inhalation sensation referred to as "flash" as described above) in particular fails completely due to the absence of nicotine. Also, adding flavorings to the liquid can not cause this flash. As an example of the addition of flavorings and / or nicotine is referred to the Chinese patent number CN 101926506 B and the European patent application EP 2 563 265 A2 directed.

Insofern besteht der Nachteil bei Liquids, denen Nikotin beigesetzt ist, darin, dass zwar die Befriedigung der Sucht erreicht wird, aber dennoch Giftstoffe dem Körper zugeführt werden. Diesem Nachteil wurde begegnet, indem Liquide zur Verfügung gestellt wurden, die - meist durch zusätzliches Hinzufügen von Aromastoffen - versuchen, ein "echtes Raucherlebnis" herbeizuführen, das dem des Rauchens von herkömmlichen Zigaretten oder des Dampfens mit nikotinhaltigem Liquid entspricht, die aber wesentlich weniger oder gar kein Nikotin enthalten. Allerdings haben diese Liquids den Nachteil, dass die durch das Nikotin angesprochene Chemosensorik, d.h. der durch das Nikotin hervorgerufene "Flash", völlig ausbleibt.In this respect, the disadvantage of liquids that nicotine is buried in is that while the satisfaction of the addiction is achieved, but still toxins are supplied to the body. This disadvantage has been addressed by providing liquids that - mostly by adding flavors - try to create a "real smoking experience" similar to that of smoking cigarettes or nicotine-containing liquid smoking, but much less do not contain any nicotine. However, these liquids have the disadvantage that the chemosensorics addressed by nicotine, i. the nicotine-induced "flash" is completely absent.

Deshalb ist es die Aufgabe der vorliegenden Erfindung, eine flüssige Zusammensetzung für eine elektronische Zigarette, also ein Liquid, bereitzustellen, das diese Nachteile überwindet. Es wird erfindungsgemäß ein Liquid bereitgestellt, das keinerlei Giftstoffe wie beispielsweise Nikotin enthält, das aber dennoch den oben beschriebenen "Flash" beim Nutzer erzeugt, d.h. die chemosensorischen Rezeptoren in der Art anspricht, wie es das vom Raucher gewohnte Nikotin tut.Therefore, it is the object of the present invention to provide a liquid composition for an electronic cigarette, ie a liquid, which overcomes these disadvantages. It is inventively provided a liquid that contains no toxins such as nicotine, but still generates the above-described "flash" at the user, ie the chemosensory receptors in the way responds, as it does the smoker's usual nicotine.

Zur Lösung der vorstehenden Aufgabe stellt die vorliegende Erfindung eine flüssige Zusammensetzung für eine elektronische Zigarette bereit umfassend:

  • einen TRP-Modulator und
  • zumindest einen TRP-Agonisten/Aktivator, wobei
    durch das Zusammenwirken von Modulator und dem zumindest einen Agonisten/Aktivator eine chemosensorischen Nachahmung von inhaliertem Zigarettenrauch erfolgt, und
  • wobei die flüssige Zusammensetzung kein Nikotin enthält.
To achieve the above object, the present invention provides a liquid composition for an electronic cigarette comprising:
  • a TRP modulator and
  • at least one TRP agonist / activator, wherein
    chemosensory imitation of inhaled cigarette smoke occurs through the interaction of the modulator and the at least one agonist / activator, and
  • wherein the liquid composition does not contain nicotine.

In der flüssigen Zusammensetzung aktiviert der zumindest eine TRP-Agonist/Aktivator vorzugsweise zumindest einen aus den TRP-Rezeptoren TRPA1, TRPV1, TRPV3 und TRPM8.In the liquid composition, the at least one TRP agonist / activator preferably activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8.

In der erfindungsgemäßen flüssigen Zusammensetzung sind mehrere TRP-Agonisten/Aktivatoren so miteinander kombiniert, dass unterschiedliche TRP-Kanäle aktiviert werden.In the liquid composition of the invention, several TRP agonists / activators are combined to activate different TRP channels.

In der erfindungsgemäßen flüssigen Zusammensetzung dienen bevorzugt Extrakte umfassend schwarzen Pfeffer, Meerrettich, Knoblauch, Paprika, Zimt, Minze und Essigund Zitronensäure als TRP- Agonist/Aktivator.Extracts comprising black pepper, horseradish, garlic, paprika, cinnamon, mint and vinegar and citric acid as TRP agonist / activator are preferably used in the liquid composition according to the invention.

Es ist ferner bevorzugt, dass in der erfindungsgemäßen flüssigen Zusammensetzung Wirkstoffe mit zumindest 6-Paradol und Analoge als TRP-Agonist/Aktivator dienen. Vorzugsweise umfassen dabei 6-Paradol und Analoge zumindest 1'-Acetoxychavicolacetat und Analoge, Isothiocyanate und Analoge, Kampfer und Analoge, Paradieskörner, Thymol und Analoge und Ethanol.It is further preferred that in the liquid composition according to the invention, active ingredients with at least 6-paradol and analogues serve as TRP agonist / activator. Preferably, 6-paradol and analogs include at least 1'-acetoxychavicol acetate and analogs, isothiocyanates and analogs, camphor and analogs, grains of paradise, thymol and analogues, and ethanol.

In der erfindungsgemäßen flüssigen Zusammensetzung basiert der zumindest eine TRP-Agonist/Aktivator vorzugsweise auf den Bestandteilen von TRP-Kanal Subtypen.In the liquid composition of the invention, the at least one TRP agonist / activator is preferably based on the components of TRP channel subtypes.

In der erfindungsgemäßen flüssigen Zusammensetzung dienen vorzugsweise Ethanol, Glycol oder Glycerin als Modulator.In the liquid composition according to the invention preferably serve ethanol, glycol or glycerol as a modulator.

In einer bevorzugten Ausführungsform umfasst die erfindungsgemäße flüssige Zusammensetzung für eine elektronische Zigarette:

  • Propyleneglycol: 40% bis 50%
  • Glycerine: 36% bis 44%
  • Lebensmittelaromen: 9% bis 11%
  • Ethanol: 4,3% bis 5,3%,
  • Piper nigrum: 0,12% bis 0,13%
  • Melegueta Aframomum: 0,03% bis 0,04%
  • Benzoe: 0,012% bis 0,014%
  • Allicin: 0,0049% bis 0,0051%
  • Isothiocyanat: 0,006% bis 0,008%
  • Zingiberis rhizoma: 0,0038% bis 0,0047%
  • Capsaicin: 0,0037% bis 0,0046%
  • Zanthoxylum piperitum: 0,0056% bis 0,0069%
  • Kurkumin: 0,0031% bis 0,0039%.
In a preferred embodiment, the liquid composition for an electronic cigarette according to the invention comprises:
  • Propylene glycol: 40% to 50%
  • Glycerine: 36% to 44%
  • Food Flavors: 9% to 11%
  • Ethanol: 4.3% to 5.3%,
  • Piper nigrum: 0.12% to 0.13%
  • Melegueta Aframomum: 0.03% to 0.04%
  • Benzoin: 0.012% to 0.014%
  • Allicin: 0.0049% to 0.0051%
  • Isothiocyanate: 0.006% to 0.008%
  • Zingiberis rhizoma: 0.0038% to 0.0047%
  • Capsaicin: 0.0037% to 0.0046%
  • Zanthoxylum piperitum: 0.0056% to 0.0069%
  • Curcumin: 0.0031% to 0.0039%.

In einer besonders bevorzugten Ausführungsform besteht die erfindungsgemäße flüssige Zusammensetzung für eine elektronische Zigarette aus:

  • Propyleneglycol: 45%
  • Glycerine: 40%
  • Lebensmittelaromen: 10%
  • Ethanol: 4,8%
  • Piper nigrum: 0,122%
  • Melegueta Aframomum: 0,035%
  • Benzoe: 0,013%
  • Allicin: 0,0050%
  • Isothiocyanat: 0,007%
  • Zingiberis rhizoma: 0,0042%
  • Capsaicin: 0,0041%
  • Zanthoxylum piperitum: 0,0062%
  • Kurkumin: 0,0035%.
In a particularly preferred embodiment, the liquid composition according to the invention for an electronic cigarette consists of:
  • Propylene glycol: 45%
  • Glycerine: 40%
  • Food flavors: 10%
  • Ethanol: 4.8%
  • Piper nigrum: 0.122%
  • Melegueta Aframomum: 0.035%
  • Benzoin: 0.013%
  • Allicin: 0.0050%
  • Isothiocyanate: 0.007%
  • Zingiberis rhizome: 0.0042%
  • Capsaicin: 0.0041%
  • Zanthoxylum piperitum: 0.0062%
  • Curcumin: 0.0035%.

Ferner betrifft die vorliegende Erfindung eine Verwendung von einem Modulator und zumindest einem TRP-Agonisten/Aktivatoren in einer flüssigen Zusammensetzung für elektronische Zigaretten, die kein Nikotin enthält, um Zigarettenrauch zu inhalieren.Further, the present invention relates to a use of a modulator and at least one TRP agonist / activator in a liquid composition for electronic cigarettes that does not contain nicotine to inhale cigarette smoke.

Die der vorliegenden Erfindung zugrunde liegende Aufgabe wird zudem durch die flüssige Zusammensetzung gemäß der angefügten Ansprüche gelöst.The object underlying the present invention is also achieved by the liquid composition according to the appended claims.

Allgemein umfasst die flüssige Zusammensetzung für eine elektronische Zigarette umfasst einen TRP-Modulator und zumindest einen TRP-Agonisten/Aktivator, wobei durch das Zusammenwirken von Modulator und dem zumindest einen Agonisten/Aktivator eine chemosensorische Nachahmung von inhaliertem Zigarettenrauch erfolgt, und wobei das flüssige Zusammensetzung kein Nikotin enthält. Ferner wird ein Modulator und zumindest ein TRP-Agonist/Aktivator in einer flüssigen Zusammensetzung für elektronische Zigaretten verwendet, die kein Nikotin enthält, um Zigarettenrauch zu inhalieren.In general, the liquid composition for an electronic cigarette comprises a TRP modulator and at least one TRP agonist / activator, wherein the interaction of modulator and the at least one agonist / activator chemosensory imitation of inhaled cigarette smoke, and the liquid composition no Contains nicotine. Further, a modulator and at least one TRP agonist / activator is used in a liquid composition for electronic cigarettes that does not contain nicotine to inhale cigarette smoke.

Vorteilhafterweise aktiviert der zumindest eine TRP-Agonist/Aktivator zumindest einen aus den TRP-Rezeptoren TRPA1, TRPV1, TRPV3 und TRPM8. Des Weiteren ist es vorteilhaft, dass mehrere TRP-Agonisten/Aktivatoren so miteinander kombiniert werden, dass unterschiedliche TRP-Kanäle aktiviert werden. Als weitere vorteilhafte Ausgestaltung werden als TRP- Agonist/Aktivator Extrakte umfassend schwarzen Pfeffer, Meerrettich, Knoblauch, Paprika, Zimt, Minze und Essig- und Zitronensäure dienen verwendet. Des Weiteren dienen als TRP-Agonist/Aktivator Wirkstoffe mit zumindest 6-Paradol und Analoge, wobei bevorzugt 6-Paradol und Analoge zumindest 1'-Acetoxychavicolacetat und Analoge, Isothiocyanate und Analoge, Kampfer und Analoge, Paradieskörner, Thymol und Analoge und Ethanol umfassen. Vorteilhafterweise basiert der zumindest eine TRP-Agonist/Aktivator auf den Bestandteilen von TRP-Kanal Subtypen. Bevorzugt dienen Ethanol, Glycol oder Glycerin als Modulator.Advantageously, the at least one TRP agonist / activator activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8. Furthermore, it is advantageous that multiple TRP agonists / activators are combined to activate different TRP channels. As a further advantageous embodiment, extracts containing black pepper, horseradish, garlic, paprika, cinnamon, mint and acetic and citric acid are used as the TRP agonist / activator. Further, as the TRP agonist / activator, drugs having at least 6-paradole and analogs, preferably 6-paradole and analogs, comprise at least 1'-acetoxy-chiacicol acetate and analogs, isothiocyanates and analogues, camphors and analogues, grains of paradise, thymol and analogues, and ethanol. Advantageously, the at least one TRP agonist / activator is based on the components of TRP channel subtypes. Preferably, ethanol, glycol or glycerol serve as a modulator.

In einer weiteren bevorzugten Ausführungsform umfasst die flüssige Zusammensetzung Propyleneglycol: 40% bis 50%, Glycerine: 36% bis 44%, Lebensmittelaromen: 9% bis 11%, Ethanol: 4,3% bis 5,3%, wobei die Zusammensetzung ferner umfasst:

  • Piper nigrum: 0,12% bis 0,13%
  • Melegueta Aframomum: 0,03% bis 0,04%
  • Benzoe: 0,012% bis 0,014%
  • Allicin: 0,0049% bis 0,0051%
  • Isothiocyanat: 0,006% bis 0,008%
  • Zingiberis rhizoma: 0,0038% bis 0,0047%
  • Capsaicin: 0,0037% bis 0,0046%
  • Zanthoxylum piperitum: 0,0056% bis 0,0069%
  • Kurkumin: 0,0031% bis 0,0039%.
In a further preferred embodiment, the liquid composition comprises propylene glycol: 40% to 50%, glycerols: 36% to 44%, food flavors: 9% to 11%, ethanol: 4.3% to 5.3%, the composition further comprising :
  • Piper nigrum: 0.12% to 0.13%
  • Melegueta Aframomum: 0.03% to 0.04%
  • Benzoin: 0.012% to 0.014%
  • Allicin: 0.0049% to 0.0051%
  • Isothiocyanate: 0.006% to 0.008%
  • Zingiberis rhizoma: 0.0038% to 0.0047%
  • Capsaicin: 0.0037% to 0.0046%
  • Zanthoxylum piperitum: 0.0056% to 0.0069%
  • Curcumin: 0.0031% to 0.0039%.

In einer weiteren bevorzugten spezifischen Ausführungsform enthält die flüssige Zusammensetzung:

  • Propyleneglycol: 45%
  • Glycerine: 40%
  • Lebensmittelaromen: 10%
  • Ethanol: 4,8%
wobei die Zusammensetzung ferner enthält:
  • Piper nigrum: 0,122%
  • Melegueta Aframomum: 0,035%
  • Benzoe: 0,013%
  • Allicin: 0,0050%
  • Isothiocyanat: 0,007%
  • Zingiberis rhizoma: 0,0042%
  • Capsaicin: 0,0041%
  • Zanthoxylum piperitum: 0,0062%
  • Kurkumin: 0,0035%.
In a further preferred specific embodiment, the liquid composition contains:
  • Propylene glycol: 45%
  • Glycerine: 40%
  • Food flavors: 10%
  • Ethanol: 4.8%
the composition further comprising:
  • Piper nigrum: 0.122%
  • Melegueta Aframomum: 0.035%
  • Benzoin: 0.013%
  • Allicin: 0.0050%
  • Isothiocyanate: 0.007%
  • Zingiberis rhizome: 0.0042%
  • Capsaicin: 0.0041%
  • Zanthoxylum piperitum: 0.0062%
  • Curcumin: 0.0035%.

Herstellung der Zusammensetzung:Preparation of the composition:

Die chemischen Komponenten sind miteinander vermischt. Die Grundbestandteile des Liquids (Propylenglycol, Glycerin, Ethanol und Aromastoffe) werden direkt vom Chemikalienhersteller, bzw. vom Aromen-Lieferanten bezogen. Die Bestandteile der zu patentierenden flüssigen Zusammensetzung (BioNic) hingegen können größtenteils nicht herkömmlich bezogen werden, zumindest nicht in der Form, wie wie sie in der vorliegenden Erfindung verwendet werden. Zum Beispiel kann man Paradieskörner (Aframomum melegueta) im Gewürzhandel erwerben. Allerdings können die so erworbenen Paradieskörner nicht in der herkömmlichen Form in das Liquid eingebracht werden, sondern es muss zunächst aus diesem Rohstoff der entsprechende Wirkstoff extrahiert werden. Dies geschieht zumeist, indem man den Wirkstoff mittels Ethanol per Soxhlet-Extraktion aus dem Rohstoff extrahiert. Damit wird der Wirkstoff direkt in das Ethanol gebunden, welches dann in das Liquid eingebracht wird. Dem Fachmann ist bekannt, wie die Wirkstoffe behandelt werden, um in der flüssigen Zusammensetzung verwendet werden zu können..The chemical components are mixed together. The basic components of the liquid (propylene glycol, glycerine, ethanol and flavorings) are obtained directly from the chemical manufacturer or from the flavor supplier. On the other hand, the ingredients of the liquid composition (BioNic) to be patented, for the most part, can not be conventionally sourced, at least not in the form as used in the present invention. For example, you can get grains of paradise (Aframomum melegueta) in the spice trade. However, the grains of paradise so acquired can not be incorporated in the conventional form in the liquid, but it must first be extracted from this raw material, the corresponding active ingredient. This is usually done by extracting the active substance by means of ethanol by Soxhlet extraction from the raw material. Thus, the active ingredient is bound directly into the ethanol, which is then introduced into the liquid. It is known to the person skilled in the art how the active substances are treated in order to be used in the liquid composition.

Nikotin ist nachgewiesenermaßen ein Nervengift, das zusammen mit anderen Wirkstoffen der herkömmlichen Zigarette auf sensorische und autonome afferente Nervenenden wirkt und sensorische Informationen aus dem Mund, Rachen und Atemwegen über den Vagus, Trigeminus und andere Hirnnerven an das Gehirn sendet. Das Gehirn handelt entsprechend und induziert vegetative Reflexe und Effekte in das zentrale Nervensystem, die auf die subjektive Erfahrung des Rauchens, darunter "Hals kratzen" und zur Entlastung des Verlangens gespeicherte Verhaltensrituale, zurückgreifen. Das Zigarettenrauchen verursacht EEG-Veränderungen und aktiviert damit verbundene, subjektive Verhaltensrituale über sensorische Reflexe, noch bevor das im Rauch befindliche Nikotin absorbiert wird und Nervenreaktionen diesen Wirkstoff an das Gehirn melden können.Nicotine has been shown to be a neurotoxin that, along with other conventional cigarettes, acts on sensory and autonomic afferent nerve endings, sending sensory information from the mouth, throat, and airways to the brain via the vagus, trigeminal, and other cranial nerves. The brain acts accordingly, inducing autonomic reflexes and central nervous system effects that rely on the subjective experience of smoking, including "throat scratching" and behavioral behaviors stored to relieve the craving. Cigarette smoking causes EEG changes and activates related, subjective behavioral reflexes on sensory reflexes, even before nicotine in the smoke is absorbed and nerve reactions can report that drug to the brain.

Um ein Rauchgefühl wie bei einer herkömmlichen Zigarette zu simulieren, allerdings ohne Giftstoffe wie Nikotin zu verwenden, wurden pflanzliche Analogstoffe gesucht, die diese oder ähnliche chemosensorischen Wirkungen hervorrufen und den Einsatz von Nikotin als Nervengift nicht länger notwendig machen. Die sensorischen Sinne umfassen Geschmack, Geruchssinn und "chemikalische Sensibilität" (auch bekannt als den "üblichen chemischen Sinn", oder Trigeminus Chemosensorik). Die Chemosensorik bezieht sich auf Wirkungen, z. B. auf Nervenenden vermittelnde Empfindungen von Schmerz oder Temperatur. Inkludiert sind hier beispielsweise die Empfindung "scharf, heiß oder kühl", die durch die Einnahme spezifischer Substanzen, wie Peperoni (Capsaicin), schwarzer Pfeffer (Piperin), Menthol, Knoblauch (Allicin), Meerrettich und Wasabi (Allylisothiocyanate), Kampfer, Wintergrün, Zimt (Zimtaldehyd), Kohlensäure z.B. bei Getränken (Kohlendioxid) und einige Luftschadstoffe verursacht wird. Solche Empfindungen im Mundraum und in den Nasen-Hohlräumen werden über den Trigeminus-Nerv vermittelt und sind Elemente des somatosensorischen Systems. In den Hals- und Atemwegen, sowie der Lunge werden über den Vagus-Nerv chemische Signale an das Gehirn übertragen, die direkt die Hirnaktivität im somatosensorischen Kortex und anderen Regionen beeinflussen können. Dies sind u.a. auch appetitive Schaltungen in Form von Heißhunger auf bestimmte Nahrungsmittel, aber auch Verlangen nach Tabakrauch, ohne dabei die Absorption der Wirkstoffe in der Blutbahn oder das Gehirn zu berücksichtigen.In order to simulate a smoking sensation as in a conventional cigarette, but without using toxins such as nicotine, herbal analogues were sought which produce these or similar chemosensory effects and no longer require the use of nicotine as a neurotoxin. The sensory senses include taste, sense of smell and "chemical sensitivity" (also known as the "common chemical sense", or trigeminal chemosensorics). Chemosensorics refers to effects, e.g. B. on nerve endings mediating sensations of pain or temperature. This includes, for example, the sensation of "hot, hot or cool" caused by ingesting specific substances such as pepperoni (capsaicin), black pepper (piperine), menthol, garlic (allicin), horseradish and wasabi (allyl isothiocyanate), camphor, wintergreen , Cinnamon (cinnamaldehyde), carbonic acid, for example, in drinks (carbon dioxide) and some air pollutants is caused. Such sensations in the oral cavity and in the nasal cavities become over mediate the trigeminal nerve and are elements of the somatosensory system. In the cervical and respiratory tract, as well as the lungs, chemical signals are transmitted to the brain via the vagus nerve, which can directly influence the brain activity in the somatosensory cortex and other regions. These include appetizing circuits in the form of cravings for certain foods, but also craving for tobacco smoke, without taking into account the absorption of the active ingredients in the bloodstream or the brain.

Bei der vorliegenden Erfindung wird der Umstand ausgenützt, dass die appetitive Schaltung durch chemosensorische Stimulation befriedigt wird, ohne dem Körper den eigentlichen Wirkstoff wie Nikotin zuzuführen. Durch die chemosensorische Stimulation geht das Gehirn davon aus, dass mit der gewohnten Inhalation auch das gewohnt stimulierende Nikotin zugeführt wurde. Zusätzlich und nicht minder stark ist die positive Beeinflussung durch die Nachahmung taktiler, kinästhetischer und organoleptischer Aspekte des Rauchens, indem beispielsweise eine optisch sichtbare Verdampfung des Liquids erfolgt und somit suggeriert wird, dass es sich um dasselbe gewohnte Ritual wie beim Rauchen einer Zigarette handelt, obwohl es sich lediglich um eine Verdampfung weitaus harmloserer Bestandteile ohne Giftstoffe handelt.In the present invention, the fact is utilized that the appetitive circuit is satisfied by chemosensory stimulation, without supplying the body with the actual active substance such as nicotine. Due to the chemosensory stimulation, the brain assumes that with the usual inhalation and the usual stimulating nicotine was supplied. In addition, and not less strong is the positive influence of the imitation of tactile, kinaesthetic and organoleptic aspects of smoking, for example, by an optically visible evaporation of the liquid and thus suggests that it is the same habitual ritual as smoking a cigarette, although it is merely an evaporation of much more harmless ingredients without toxins.

Die TRP (Transient Receptor Potential)-Ionenkanäle stellen eine Klasse von Rezeptoren auf sensorischen Nerven dar, die die Fähigkeit besitzen, diese durch Auslösung zu aktivieren. TRP Kanäle übermitteln die Empfindungen von scharf, heiß oder kalt, sowie Bestandteile in der eingeatmeten Luft an das zentrale Nervensystem. Die durch die TRP-Kanäle vorgenommene Aktivierung der sensorischen Nervenenden induzieren neben der chemosensorischen Stimulation auch lokale Effekte, zum Beispiel Husten, Niesen, Regulierung der Körpertemperatur oder sonstige subjektive Empfindungen. Für die Aktivierung von TRP-Kanälen bedarf es zudem nur sehr geringer Bestandteile des entsprechenden TRP relevanten Wirkstoffs, so dass grundsätzlich eine selbst theoretisch schädigende Konzentration vermieden werden kann. Den TRP Kanal Aktivatoren reichen minimalste volatile Bestandteile in der eingeatmeten Luft, um eine Zigarettenrauch ähnelnde chemosensorische Stimulation hervorzurufen ohne eine bioaktive Wirkstoffkonzentration in den Körper aufnehmen zu müssen. Im Folgenden ist eine beispielhafte Liquidzusammensetzung bei einer Produkteinheit von 10000 mg angegeben: 4500 mg Propyleneglycol, 4000 mg Glycerine, 1000 mg Lebensmittelaromen, 487 mg Ethanol, ferner mit folgenden in der Gesamtheit für eine chemosensorische Reaktion zuständigen Bestandteilen: 1,25 mg Piper nigrum, 3,75 mg Melegueta Aframomum, 1,25 mg Benzoe, 0,5 mg Allicin, 0,7 mg Isothiocyanat, 0,425 mg Zingiberis rhizoma, 4,15 mg Capsaicin, 0,625 mg Zanthoxylum piperitum, 0,35 mg Kurkumin. Allgemeiner ist die Zusammensetzung folgende: Propyleneglycol: 40% bis 50%, Glycerine: 36% bis 44% , Lebensmittelaromen: 9% bis 11%, Ethanol: 4,3% bis 5,3%, ferner mit folgenden in der Gesamtheit für eine chemosensorische Reaktion zuständigen Bestandteilen: Piper nigrum: 0,12% bis 0,13%, Melegueta Aframomum: 0,03% bis 0,04%, Benzoe: 0,012% bis 0,014%, Allicin: 0,0049 % bis 0,0051%, Isothiocyanat: 0,006% bis 0,008%, Zingiberis rhizoma: 0,0038% bis 0,0047%, Capsaicin: 0,0037% bis 0,0046%, Zanthoxylum piperitum: 0,0056% bis 0,0069%, Kurkumin: 0,0031% bis 0,0039%.The TRP (Transient Receptor Potential) ion channels are a class of receptors on sensory nerves that have the ability to activate them by triggering. TRP channels transmit the sensations of spicy, hot or cold, as well as components in the inhaled air to the central nervous system. In addition to chemosensory stimulation, activation of the sensory nerve endings by the TRP channels also induces local effects, such as coughing, sneezing, regulation of body temperature or other subjective sensations. In addition, the activation of TRP channels requires only very low constituents of the corresponding TRP-relevant active substance, so that in principle even a theoretically harmful concentration can be avoided. The TRP channel activators provide minimal volatile components in the inspired air to induce a cigarette smoke-like chemosensory stimulation without the need to absorb a bioactive drug concentration in the body. The following is an exemplary liquid composition at a product unit of 10000 mg: 4500 mg propylene glycol, 4000 mg Glycerols, 1000 mg food flavorings, 487 mg ethanol, further containing the following components in their entirety for a chemosensory reaction: 1.25 mg Piper nigrum, 3.75 mg Melegueta Aframomum, 1.25 mg benzoin, 0.5 mg allicin, 0 , 7 mg isothiocyanate, 0.425 mg zingiberis rhizoma, 4.15 mg capsaicin, 0.625 mg Zanthoxylum piperitum, 0.35 mg curcumin. More generally, the composition is as follows: propylene glycol: 40% to 50%, glycerols: 36% to 44%, food flavors: 9% to 11%, ethanol: 4.3% to 5.3%, further comprising the following as a whole for one chemosensory response components: Piper nigrum: 0.12% to 0.13%, Melegueta Aframomum: 0.03% to 0.04%, Benzoin: 0.012% to 0.014%, Allicin: 0.0049% to 0.0051% , Isothiocyanate: 0.006% to 0.008%, Zingiberis rhizoma: 0.0038% to 0.0047%, Capsaicin: 0.0037% to 0.0046%, Zanthoxylum piperitum: 0.0056% to 0.0069%, Curcumin: 0 , 0031% to 0.0039%.

In einem für die elektrische Zigarette entwickelten Liquid können mehrere dieser TRP Kanalaktivatoren zum Einsatz kommen, die unter bestimmten Voraussetzungen in Kombination die sensorischen Eigenschaften noch verstärken können. Der TRP V1 beispielsweise ist ein temperatursensorischer Kanal, dessen Aktivierungschwelle beispielsweise durch den Einsatz von Ethanol als TRP-Modulator noch gesenkt werden kann. Dadurch lässt sich das sensorische Wärmeempfinden durch TRP V1-Agonisten, wie zum Beispiel Extrakte aus Chilli, Szechuan Pfeffer oder Senf durch den Einsatz noch geringerer Konzentrationen erreichen.In a liquid developed for the electric cigarette several of these TRP channel activators can be used, which under certain conditions in combination can enhance the sensory properties even more. The TRP V1, for example, is a temperature-sensing channel whose activation threshold can still be lowered by using ethanol as a TRP modulator. Thus, the sensory heat sensation by TRP V1 agonists, such as extracts of chilli, Szechuan pepper or mustard by using even lower concentrations can be achieved.

Durch das synergetische Zusammenwirken von TRP-Agonisten und Modulatoren bietet sich eine einzigartige Basis für die chemosensorische Nachahmung von inhaliertem Zigarettenrauch, ohne dass der Einsatz von durch Verbrennung entstandenen, oftmals kanzerogenen Stoffen notwendig ist. Durch den Einsatz von TRP Aktivatoren wird die Nachahmung von subjektiven und physiologischen chemosensorischen Erfahrungen, wie beispielsweise das Inhalieren von Zigarettenrauch, ermöglicht. Bekannte TRP-Aktivatoren sind beispielsweise Extrakte aus schwarzem Pfeffer, Meerrettich, Knoblauch, Paprika, Zimt, Minze und weiteren bekannten TRP-Kanäle aktivierenden Stoffen, sowie Essig- und Zitronensäure. Durch Nutzung eines komplexen Gemisches dieser Wirkstoffe kann die Aktivierungsfähigkeit sowohl breit gefächert als auch potenziert werden. Zudem unterstützt der Einsatz geringer Konzentrationen dieser Aktivatoren im Liquid die Fähigkeit der Rezeptoren für eine schnelle Desensibilisierung, so dass nach nur kurzer Zeit (im Rahmen eines Inhalationsintervalls einer elektrischen Zigarette) die chemosensorische Stimulation erneut und in voller Empfindungsgröße erfolgen kann.The synergistic interaction of TRP agonists and modulators provides a unique basis for the chemosensory imitation of inhaled cigarette smoke without the necessity of using incinerated, often carcinogenic substances. The use of TRP activators enables the imitation of subjective and physiological chemosensory experiences, such as the inhalation of cigarette smoke. Known TRP activators are, for example, extracts of black pepper, horseradish, garlic, paprika, cinnamon, mint and other known TRP channels activating substances, as well as acetic and citric acid. By utilizing a complex mixture of these agents, the activation ability can be both broad and potentiated. In addition, the use of low concentrations of these activators in the liquid supports the ability of the receptors for a rapid desensitization, so that after only a short time (as part of an inhalation interval of an electric cigarette) the chemosensory stimulation can be done again and in full sensation size.

Als zur Nachahmung der chemosensorischen Auswirkungen von Tabakrauch zu nutzende TRP-Aktivatoren bieten sich erfindungsgemäß insbesondere die Wirkstoffe an, die 6-Paradol und Analoge enthalten. Dazu zählen beispielsweise: 1'-Acetoxychavicolacetat und Analoge, Isothiocyanate und Analoge, Kampfer und Analoge, Paradieskörner, Thymol und Analoge, sowie Ethanol. Unter weiteren werden diese Aktivatoren in den Liquid-Mixturen verwendet. Die erfindungsgemäße flüssige Zusammensetzung ermöglicht es, jeden einzelnen TRP-Kanal (TRP A1, TRP V1, TRP V3 und TRP M8) zu aktivieren. Die Aktivierung eines jeden einzelnen TRP-Kanals mit den jeweiligen Aktivatoren ist hierbei maßgeblich, um ein entsprechendes tabakrauchähnliches Inhalationsempfinden zu erzielen. Die Aktivierung nur eines einzelnen Kanals ist somit typischer Weise nicht ausreichend. So beruht beispielsweise die gewünschte Einbeziehung auch des TRP M8 Rezeptors in die Funktionsbasis auf dessen Fähigkeit durch Stimulanz/Aktivierung den durch das Inhalationsempfinden hervorgerufenen Hustenreiz zu unterdrücken. Somit ist zur Erreichung des gewünschten Ergebnisses oft eine komplexe Zusammensetzung unterschiedlicher Aktivatoren zusammen mit einer geeigneten Auswahl an Modulatoren notwendig. Erfindungsgemäß wurde überraschend gefunden, dass bei kombiniertem Einsatz von 6-Paradol bzw. Analogen davon als Aktivator zusammen mit Glycerin als Modulator besonders gute Erfolge bei der Aktivierung eines jeden einzelnen TRP-Kanals erzielt werden. Dies gilt insbesondere und bevorzugt, wenn das Glycerin ein Viertel oder mehr, und vorzugsweise zwei Drittel oder weniger der flüssigen Zusammensetzung ausmacht (bezogen auf das Gewicht, hier ausgedrückt in "%", also in Gewichtsprozent). Besonders bevorzugte Gewichtsanteile des Glycerins sind dabei 30% oder mehr, weiter bevorzugt 33% oder mehr, noch weiter bevorzugt 36% oder mehr und insbesondere bevorzugt 39% oder mehr. Obergrenzen des Gewichtsanteils des Glycerins liegen bei bevorzugt 55% oder weniger, mehr bevorzugt 50% oder weniger, noch mehr bevorzugt 45% oder weniger und insbesondere bevorzugt 41% oder weniger. Die besten Ergebnisse werden mit einem bevorzugten Gewichtsanteil des Glycerins von 40% erzielt. In der erfindungsgemäßen flüssigen Zusammensetzung beträgt der Gewichtsanteil des Glycerins ausgedrückt in Gewichtsprozent demnach bevorzugt 30% bis 55%, mehr bevorzugt 33% bis 50%, noch mehr bevorzugt 36% bis 45%, und insbesondere bevorzugt 39% bis 41%.As counteracting the chemosensory effects of tobacco smoke to be used TRP activators according to the invention offer in particular the active ingredients which contain 6-paradol and analogues. These include, for example: 1'-acetoxychavicol acetate and analogs, isothiocyanates and analogs, camphor and analogs, grains of paradise, thymol and analogs, and ethanol. Among others, these activators are used in the liquid mixtures. The liquid composition according to the invention makes it possible to activate each individual TRP channel (TRP A1, TRP V1, TRP V3 and TRP M8). The activation of each individual TRP channel with the respective activators is decisive here in order to achieve a corresponding tobacco smoke-like inhalation sensation. Activation of only a single channel is thus typically insufficient. Thus, for example, the desired inclusion of the TRP M8 receptor in the functional base is based on its ability to suppress by stimulation / activation the inhalation sensation caused by coughing. Thus, to achieve the desired result, often a complex composition of different activators is necessary along with a suitable choice of modulators. According to the invention, it has surprisingly been found that with combined use of 6-paradol or analogues thereof as activator together with glycerol as modulator, particularly good results are achieved in the activation of each individual TRP channel. This is especially and preferred when the glycerine is one-quarter or more, and preferably two-thirds or less, of the liquid composition (by weight, expressed in "%", that is, percent by weight). Particularly preferred weight fractions of the glycerol are 30% or more, more preferably 33% or more, even more preferably 36% or more and especially preferably 39% or more. Upper limits of the content by weight of the glycerin are preferably 55% or less, more preferably 50% or less, still more preferably 45% or less, and particularly preferably 41% or less. The best results are achieved with a preferred weight percentage of glycerol of 40%. In the liquid composition according to the invention, the proportion by weight of glycerol expressed in percent by weight is accordingly preferably 30%. to 55%, more preferably 33% to 50%, even more preferably 36% to 45%, and most preferably 39% to 41%.

Besonderer Wert wurde erfindungsgemäß gleichzeitig darauf gelegt, dass die Zusammensetzung ein sehr geringes allergenes Potential besitzt. Allenfalls das hier in einigen beispielhaften Ausführungsformen zu einem Gewichtsanteil von 0,0049%-0,0051% verwendete, aus Senfkörnern gewonnene, Allicin steht im Verdacht allergene Reaktionen auszulösen. Die weiteren erfindungsgemäß eingesetzten Bestandteile, insbesondere Glycerin und 6-Paradol bzw. Analoge davon lösen demgegenüber regelmäßig keine allergene Reaktionen aus.Particular importance has been attached to the invention at the same time that the composition has a very low allergenic potential. At best, the allicin used in some exemplary embodiments of 0.0049% -0.0051% by weight, derived from mustard seeds, is suspected of inducing allergenic reactions. In contrast, the other constituents used according to the invention, in particular glycerol and 6-paradole or analogues thereof, regularly trigger no allergenic reactions.

Grundsätzlich basieren TRP Aktivatoren auf den Bestandteilen der TRP-Kanal Subtypen. Durch die Verwendung von Wirkstoffmixturen entsteht die Möglichkeit, diverse TRP-Kanäle in variablen Intensitäten durch ebenfalls variabel lange Zeitbögen zu aktivieren oder deaktivieren. Diese Steuerung betrifft nicht nur die Intensität und Zeitbögen, sondern auch den lokalen Raum, indem das chemosensorische Empfinden stattfindet, wie zum Beispiel: Mundhöhle, Rachen, Lungenraum. Diesbezügliche Tests haben aufgezeigt, dass durch die Aktivierung eines Subkanals das eigentliche chemosensorische Empfinden verstärkt wird ohne den eigentlichen Wirkstoff dafür in der Konzentration anheben zu müssen.Basically, TRP activators are based on the constituents of the TRP channel subtypes. The use of drug mixtures creates the possibility of activating or deactivating various TRP channels in variable intensities by means of also variably long time arcs. This control affects not only the intensity and time arcs, but also the local space by the chemosensory sensation takes place, such as: oral cavity, pharynx, lung space. Related tests have shown that activation of a subchannel enhances the actual chemosensory sensation without having to raise the concentration of the drug itself.

Die nachfolgend dargestellten Wirkstoffe haben die Eigenschaft, sogenannte TRP Kanäle im menschlichen Körper chemosensorisch zu aktivieren, da beim Menschen TRP-Kanäle eine wichtige Rolle bei der Wahrnehmung von Geschmack (süß, sauer, umami), Pheromonen, Temperatur (warm, heiß, kalt), Schmerz u. a. spielen.The following active substances have the property of activating so-called TRP channels in the human body chemosensory, since in humans TRP channels play an important role in the perception of taste (sweet, sour, umami), pheromones, temperature (hot, hot, cold) , Pain u. a. play.

Als Basisbestandteil mit teilweise modulatorischen Fähigkeiten der Liquid-Mixturen kann neben Glycol und Glycerin auch Ethanol, gegebenenfalls zusätzlich einen oder auch mehrere flüchtige Agonisten der TRPA1, TRPV1, TRPV3 und/oder TRPM8 Kanäle, sowie erforderlichenfalls flüchtige, niedermolekulare Carbonsäure und Aromastoffe herangezogen werden.As a basic component with partially modulatory capabilities of the liquid mixtures, in addition to glycol and glycerol, ethanol, optionally additionally one or more volatile agonists of TRPA1, TRPV1, TRPV3 and / or TRPM8 channels, and, if necessary, volatile, low molecular weight carboxylic acid and flavoring agents can be used.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus der Chilischote, welches durch inhalative Aufnahme den TRP Rezeptor TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of different concentrated liquid mixtures for electrical evaporation is an extract from the chili pepper, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt des schwarzen Pfeffers, welches durch inhalative Aufnahme den TRP Rezeptor TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.A component of differently concentrated liquid mixtures for electrical evaporation is an extract of black pepper, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Zingiberaceae (Ingwergewächsen), welches durch inhalative Aufnahme den TRP Rezeptor TRP-1 und TRP-2 aktiviert und eine chemosensorische Reaktion hervorruft.One component of different concentrated liquid mixtures for electrical evaporation is an extract of zingiberaceae (ginger plants), which activates the TRP receptor TRP-1 and TRP-2 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Isothiocyanaten, welches durch inhalative Aufnahme den TRP Rezeptor TRPA1 aktiviert und eine chemosensorische Reaktion hervorruft.An ingredient of different concentrated liquid mixtures for electrical evaporation is an extract of isothiocyanates, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Nelken, welches durch inhalative Aufnahme den TRP Rezeptor TRPA1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract of cloves, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Kampfer, welches durch inhalative Aufnahme den TRP Rezeptor TRPV1 + TRPV2 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract of camphor, which activates the TRP receptor TRPV1 + TRPV2 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Aframomum Melegueta (Paradieskörner), welches durch inhalative Aufnahme den TRP Rezeptor TRPA1 + TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract of Aframomum melegueta (grains of paradise), which activates the TRP receptor TRPA1 + TRPV1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Zanthoxylum piperitum (Szechuanpfeffer), welches durch inhalative Aufnahme den TRP Rezeptor TRPA1 + TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.A component of differently concentrated liquid mixtures for electrical evaporation is an extract of Zanthoxylum piperitum (Szechuan pepper), which by inhalation the TRP receptor TRPA1 + TRPV1 activated and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Thymian, welches durch inhalative Aufnahme den TRP Rezeptor TRPV3 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract of thyme, which activates the TRP receptor TRPV3 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus der Pfefferminze, welches durch inhalative Aufnahme den TRP Rezeptor TRPM8 aktiviert und eine chemosensorische Reaktion hervorruft.One component of different concentrated liquid mixtures for electrical evaporation is an extract of peppermint, which activates the TRP receptor TRPM8 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus der Vanille, welches durch inhalative Aufnahme den TRP Rezeptor TRPV3 aktiviert und eine chemosensorische Reaktion hervorruft.One component of the differently concentrated liquid mixtures for electrical evaporation is an extract of vanilla, which activates the TRP receptor TRPV3 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Eukalypten, welches durch inhalative Aufnahme den TRP Rezeptor TRPM8 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract of eucalyptus, which activates the TRP receptor TRPM8 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung sind Aromenauszüge, die durch inhalative Aufnahme den TRP Rezeptor TRPM8 aktivieren und eine chemosensorische Reaktion hervorruft.An ingredient of liquid concentrated mixtures for electrical evaporation are flavor extracts that activate the TRPM8 TRPM8 by inhalation and induce a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist Coffein, das durch inhalative Aufnahme den TRP Rezeptor TRPA1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of different concentrated liquid mixtures for electrical evaporation is caffeine, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung sind niedermolekularische organische Säuren, die durch inhalative Aufnahme einen TRP Rezeptor aktivieren und eine chemosensorische Reaktion hervorruft.One component of different concentrated liquid mixtures for electrical evaporation are low molecular weight organic acids that activate a TRP receptor by inhalation and cause a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist Ethanol, das durch inhalative Aufnahme den TRP Rezeptor TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of different concentrated liquid mixtures for electrical evaporation is ethanol, which activates the TRPV receptor TRPV1 by inhalation and causes a chemosensory reaction.

Diese unterschiedlich konzentrierten Bestandteile diverser Liquid-Mixturen können nahezu beliebig miteinander kombiniert werden, um in einer einzelnen Mixtur unterschiedliche TRP-Kanäle zu aktivieren und chemosensorisch zu stimulieren.These differently concentrated components of various liquid mixtures can be combined with one another in almost any way, in order to activate and chemosensitise different TRP channels in a single mixture.

Die oben genannten unterschiedlichen Bestandteile für Liquid-Mixturen sowie die entsprechende Kombination daraus, welche so ausgewählt wird, dass der gewünschte TRP-Kanal bzw. eine mehrere verschiedene TRP-Kanäle aktiviert werden, löst die Aufgabe der vorliegenden Erfindung. Durch die erfindungsgemäßen Liquid-Mixturen wird ein "echtes" Rauchgefühl vermittelt, d.h. der bereits beschriebene "Flash" erfolgt, ohne dass dabei Giftstoffe wie Nikotin zum Einsatz kommen. Wie bereits erwähnt, reichen geringste Bestandteile der Extrakte in dem Liquid aus, um den erwünschten Effekt zu erzielen.The above different components for liquid mixtures and the corresponding combination thereof, which is selected so that the desired TRP channel or a plurality of different TRP channels are activated, solves the object of the present invention. By the liquid mixtures according to the invention a "real" smoke feeling is mediated, i. the already described "flash" takes place without toxins such as nicotine being used. As already mentioned, the smallest constituents of the extracts in the liquid are sufficient to achieve the desired effect.

In einem Versuch wurden hundertfünfzig freiwillige Probanden gebeten, verschiedene flüssige Zusammensetzungen für eine elektronische Zigarette zur Raucherzeugung einzusetzen und das dabei erlebte Inhalationsempfinden auf einer Skala von 1 bis 6 zu bewerten. Dabei wurde mit "1" ein besonders gutes tabakrauchähnliches Empfinden benotet, und mit "6" ein besonders schlechtes tabakrauchähnliches Empfinden. Die Zusammensetzungen wurden ausgehend von folgender Zusammensetzung hergestellt:

  • Propylenglycol: 45%
  • Glycerin: 40%
  • Lebensmittelaromen: 10%
  • Ethanol: 4,8%
wobei die Zusammensetzung ferner enthält:
  • Piper nigrum: 0,122%
  • Melegueta Aframomum: 0,035%
  • Benzoe: 0,013%
  • Allicin: 0,0050%
  • Isothiocyanat: 0,007%
  • Zingiberis rhizoma: 0,0042%
  • Capsaicin: 0,0041%
  • Zanthoxylum piperitum: 0,0062%
  • Kurkumin: 0,0035%.
In one experiment, one hundred and fifty volunteers were asked to use different liquid compositions for an electronic cigarette for smoking and to rate the experience of inhalation on a scale of 1 to 6. A very good tobacco-smoking-like sensation was rated "1", and with "6" a particularly bad tobacco-like sensation. The compositions were prepared starting from the following composition:
  • Propylene glycol: 45%
  • Glycerine: 40%
  • Food flavors: 10%
  • Ethanol: 4.8%
the composition further comprising:
  • Piper nigrum: 0.122%
  • Melegueta Aframomum: 0.035%
  • Benzoin: 0.013%
  • Allicin: 0.0050%
  • Isothiocyanate: 0.007%
  • Zingiberis rhizome: 0.0042%
  • Capsaicin: 0.0041%
  • Zanthoxylum piperitum: 0.0062%
  • Curcumin: 0.0035%.

Zusammensetzungen mit anderen Gewichtsanteilen an Glycerin wurden durch entsprechendes Erniedrigen oder Erhöhen des Anteils hergestellt, wobei der Propylenglycolgehalt entsprechend angepasst wurde, um Zusammensetzungen mit gleichen Gesamtgewichten herzustellen. Die Benotungen der hergestellten elf Zusammensatzungen (Zusammensetzungen 1a bis 11a) durch die Probanden wurden gemittelt und sind in nach folgender Tabelle 1 zusammengefasst: Tabelle 1 Zusammensetzung Nr. Glyceringehalt (Gew.%) Durchschnittliche Benotung 1a 0 4,1 2a 10 3,8 3a 20 3,5 4a 30 2,5 5a 40 1,4 6a 50 2,4 7a 60 2,9 8a 70 3,7 9a 80 4,0 10a 90 4,3 11a 100 4,7 Compositions having different weight percentages of glycerol were prepared by appropriately decreasing or increasing the level, with the propylene glycol content adjusted accordingly to produce compositions having the same total weights. The scores of the prepared eleven compositions (compositions 1a to 11a) by the subjects were averaged and summarized in the following Table 1: Table 1 Composition no. Glycerol content (% by weight) Average rating 1a 0 4.1 2a 10 3.8 3a 20 3.5 4a 30 2.5 5a 40 1.4 6a 50 2,4 7a 60 2.9 8a 70 3.7 9a 80 4.0 10a 90 4.3 11a 100 4.7

In einem weiteren Versuch wurden die Probanden gebeten, Zusammensetzungen wie in obiger Tabelle 1 zur Raucherzeugung einzusetzen und das Inhalationsempfinden wiederum gemäß obiger Notenskala zu beurteilen. Der Unterschied bestand jedoch darin, dass statt Melegueta Aframomum die gleiche Menge Borneol als TRP-Agonist/Aktivator in den Zusammensetzungen (Zusammensetzungen 1 b bis 11 b) enthalten war. Die entsprechenden Benotungen durch die Probanden wurden wiederum gemittelt und sind in nach folgender Tabelle 2 zusammengefasst: Tabelle 2 Zusammensetzung Nr. Glyceringehalt (Gew.%) Durchschnittliche Benotung 1b 0 5,3 2b 10 4,9 3b 20 4,5 4b 30 3,4 5b 40 2,6 6b 50 3,5 7b 60 4,9 8b 70 4,8 9b 80 5,1 10b 90 5,3 11b 100 5,7 In a further experiment, the subjects were asked to use compositions as in Table 1 above for the production of smoke and to assess the inhalation sensation in turn according to the above grading scale. The difference, however, was that instead of Melegueta Aframomum, the same amount of borneol as TRP agonist / activator in the compositions (Compositions 1 b to 11 b) was included. The corresponding grades by the subjects were again averaged and summarized in the following Table 2: Table 2 Composition no. Glycerol content (% by weight) Average rating 1b 0 5.3 2 B 10 4.9 3b 20 4.5 4b 30 3.4 5b 40 2.6 6b 50 3.5 7b 60 4.9 8b 70 4.8 9b 80 5.1 10b 90 5.3 11b 100 5.7

Es zeigt sich, dass die erfindungsgemäße Kombination von TRP-Agonisten/Aktivator ausgewählt aus 6-Paradol und Analogen (hier Melegueta Aframomum) und Glycerin als TRP-Modulator bei allen vergleichbaren Zusammensetzungen zu einer um in der Regel mindestens eine Note besseren Beurteilung des Inhalationsempfindens als tabakrauchähnlich führte. Ferner zeigt sich deutlich, dass die erfindungsgemäß bevorzugten Glyceringehalte zu einer weiteren Steigerung des positiven Inhalationsempfindens führten.It can be seen that the inventive combination of TRP agonist / activator selected from 6-paradol and analogues (here Melegueta Aframomum) and glycerol as TRP modulator in all comparable compositions to a usually at least a grade better assessment of the inhalation sense than similar to tobacco smoke. Furthermore, it is clear that the inventively preferred Glyceringehalte led to a further increase in the positive inhalation sensation.

Claims (10)

Flüssige Zusammensetzung für eine elektronische Zigarette, umfassend: - Glycerin als einen TRP-Modulator und - zumindest einen TRP-Agonisten/Aktivator ausgewählt aus 6-Paradol und Analogen, wobei
durch das Zusammenwirken von Modulator und dem zumindest einen Agonisten/Aktivator eine chemosensorischen Nachahmung von inhaliertem Zigarettenrauch erfolgt, und - wobei die flüssige Zusammensetzung kein Nikotin enthält. A liquid composition for an electronic cigarette, comprising: Glycerol as a TRP modulator and at least one TRP agonist / activator selected from 6-paradole and analogues, wherein
chemosensory imitation of inhaled cigarette smoke occurs through the interaction of the modulator and the at least one agonist / activator, and - wherein the liquid composition does not contain nicotine. Flüssige Zusammensetzung nach Anspruch 1, wobei der zumindest eine TRP-Agonist/Aktivator zumindest einen aus den TRP-Rezeptoren TRPA1, TRPV1, TRPV3 und TRPM8 aktiviert.The liquid composition of claim 1, wherein the at least one TRP agonist / activator activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8. Flüssige Zusammensetzung nach Anspruch 1 oder 2, wobei ein oder mehrere weitere TRP-Agonisten/Aktivatoren enthalten sind, die so miteinander kombiniert sind, dass unterschiedliche TRP-Kanäle aktiviert werden.A liquid composition according to claim 1 or 2, wherein one or more other TRP agonists / activators are combined so as to activate different TRP channels. Flüssige Zusammensetzung nach einem der Ansprüche 1 bis 3, wobei als weiterer TRP-Agonist/Aktivator ein oder mehrere Extrakte umfassend schwarzen Pfeffer, Meerrettich, Knoblauch, Paprika, Zimt, Minze und Essig- und Zitronensäure dienen.A liquid composition according to any one of claims 1 to 3, wherein as another TRP agonist / activator one or more extracts comprising black pepper, horseradish, garlic, paprika, cinnamon, mint and acetic and citric acid are used. Flüssige Zusammensetzung nach Anspruch 1, wobei 6-Paradol und Analoge zumindest 1'-Acetoxychavicolacetat und Analoge, Isothiocyanate und Analoge, Kampfer und Analoge, Paradieskörner, Thymol und Analoge und Ethanol umfassen.The liquid composition of claim 1, wherein 6-paradole and analogs comprise at least 1'-acetoxy-chiacicol acetate and analogs, isothiocyanates and analogues, camphors and analogues, grains of paradise, thymol and analogues and ethanol. Flüssige Zusammensetzung nach einem der vorhergehenden Ansprüche, wobei Ethanol oder Glycol als weiterer Modulator dienen.A liquid composition according to any one of the preceding claims, wherein ethanol or glycol serve as a further modulator. Flüssige Zusammensetzung nach einem der vorhergehenden Ansprüche, wobei der Gewichtsanteil des Glycerins ausgedrückt in Gewichtsprozent 30% bis 55%, bevorzugt 33% bis 50%, mehr bevorzugt 36% bis 45%, und insbesondere bevorzugt 39% bis 41% beträgt.A liquid composition according to any one of the preceding claims wherein the weight fraction of glycerol expressed in weight percent is from 30% to 55%, preferably from 33% to 50%, more preferably from 36% to 45%, and most preferably from 39% to 41%. Flüssige Zusammensetzung für eine elektronische Zigarette nach einem der vorhergehenden Ansprüche, umfassend: Propyleneglycol: 40% bis 50% Glycerine: 36% bis 44% Lebensmittelaromen: 9% bis 11% Ethanol: 4,3% bis 5,3%, Piper nigrum: 0,12% bis 0,13% Melegueta Aframomum: 0,03% bis 0,04% Benzoe: 0,012% bis 0,014% Allicin: 0,0049% bis 0,0051% Isothiocyanat: 0,006% bis 0,008% Zingiberis rhizoma: 0,0038% bis 0,0047% Capsaicin: 0,0037% bis 0,0046% Zanthoxylum piperitum: 0,0056% bis 0,0069% Kurkumin: 0,0031% bis 0,0039%. A liquid composition for an electronic cigarette according to any one of the preceding claims, comprising: Propylene glycol: 40% to 50% Glycerine: 36% to 44% Food Flavors: 9% to 11% Ethanol: 4.3% to 5.3%, Piper nigrum: 0.12% to 0.13% Melegueta Aframomum: 0.03% to 0.04% Benzoin: 0.012% to 0.014% Allicin: 0.0049% to 0.0051% Isothiocyanate: 0.006% to 0.008% Zingiberis rhizoma: 0.0038% to 0.0047% Capsaicin: 0.0037% to 0.0046% Zanthoxylum piperitum: 0.0056% to 0.0069% Curcumin: 0.0031% to 0.0039%. Flüssige Zusammensetzung für eine elektronische Zigarette nach Anspruch 8, bestehend aus: Propyleneglycol: 45% Glycerine: 40% Lebensmittelaromen: 10% Ethanol: 4,8% Piper nigrum: 0,122% Melegueta Aframomum: 0,035% Benzoe: 0,013% Allicin: 0,0050% Isothiocyanat: 0,007% Zingiberis rhizoma: 0,0042% Capsaicin: 0,0041% Zanthoxylum piperitum: 0,0062% Kurkumin: 0,0035%. A liquid composition for an electronic cigarette according to claim 8, consisting of: Propylene glycol: 45% Glycerine: 40% Food flavors: 10% Ethanol: 4.8% Piper nigrum: 0.122% Melegueta Aframomum: 0.035% Benzoin: 0.013% Allicin: 0.0050% Isothiocyanate: 0.007% Zingiberis rhizome: 0.0042% Capsaicin: 0.0041% Zanthoxylum piperitum: 0.0062% Curcumin: 0.0035%. Verwendung einer flüssigen Zusammensetzung nach einem der vorhergehenden Ansprüche, um Zigarettenrauch zu inhalieren.Use of a liquid composition according to any one of the preceding claims for inhaling cigarette smoke.
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