EP2862454B1 - Liquid composition for an electronic cigarette - Google Patents

Liquid composition for an electronic cigarette Download PDF

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Publication number
EP2862454B1
EP2862454B1 EP14189319.8A EP14189319A EP2862454B1 EP 2862454 B1 EP2862454 B1 EP 2862454B1 EP 14189319 A EP14189319 A EP 14189319A EP 2862454 B1 EP2862454 B1 EP 2862454B1
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EP
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Prior art keywords
trp
liquid composition
composition according
glycerol
activator
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EP14189319.8A
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German (de)
French (fr)
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EP2862454A1 (en
EP2862454B8 (en
Inventor
Olaf Meinert
Ilonka Paul
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Valeo GmbH
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Valeo GmbH
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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes

Definitions

  • the present invention relates to a liquid composition (e-liquid) for use in electronic cigarettes and the use of a modulator and at least one TRP agonist / activator ("TRP" in English means “transient receptor potential” and can be described as “ temporary receptor potential "are translated) in a liquid, non-nicotine-containing composition that simulates the tobacco smoke or the inhalation sensation of a conventional tobacco cigarette.
  • TRP TRP agonist / activator
  • Smoking tobacco cigarettes is now prohibited in almost all public spaces. This includes workplaces, bars, restaurants and many other premises.
  • US 2013/152956 A1 describes a device for simulating the chemical sensation of smoking.
  • the device comprises an outer layer, a porous medium and a chemesthetic agent.
  • the porous medium is arranged within the outer layer.
  • the chemesthetic agent is located within the porous medium and activates a TRP channel.
  • the CN 102266125 A describes an electronic cigarette of traditional Chinese medicine for smoking cessation.
  • the electronic cigarette includes a battery stick, an atomizer and a smoke nozzle.
  • the atomizer points into the Smoke nozzle inserted front end and is connected to the battery.
  • the annular smoke nozzle has a hollow column and a ventilation hole.
  • the hollow column serves as a medication chamber, the one below the column is attached to an atomizer with a sleeve.
  • the medication chamber is filled with air and medication.
  • the atomizer has a conductive metal body which is provided with an electrode which is connected to an insulating silica gel tube via a sleeve.
  • the connecting electrode and the silica gel tube are provided with a heating element and a connecting body.
  • US 5,893,371 describes a non-nicotine method and device for reducing the need for tobacco smoke and for using one or more black pepper or red pepper ingredients that are introduced into the user's respiratory tract by inhalation from a vapor delivery system or an aerosol delivery system.
  • the one or more components of black and / or red pepper include essential oils of black and / or red pepper as well as pepper-irritating substances, including capsaicin, piperine and phellandrene.
  • CN 102960852 describes vapor solutions for electronic cigarettes with the following components in percent by weight: 30-45% propylene glycol, 20-35% glycerol, 5-15% deionized water, 5-15% alcohol, 15-45% TCM liquid, 2-5 percent tobacco taste , 2-6 percent tobacco extract and 0.1-2 percent shaping agent.
  • the TCM fluid consists of Bulbus Fritillariae Cirrhosae, mint leaves, loquat leaves, dendranthema indicum, violets, sweet-smelling osmanthus and green tea.
  • a tobacco smoker / e-cigarette vaporizer visibly feels uncomfortable during his stay in non-smoking areas.
  • the regular drop in the nicotine level in the body of a smoker / steamer favors this discomfort, but this is not the only or most important factor that controls the desire for a tobacco or e-cigarette. Rather, the use of tobacco or e-cigarettes to suppress the customary ritual, prohibited by use, to inhale the smoke / steam and to release it with relish is the main cause of this discomfort and the increasing desire for it Ritual satisfaction.
  • a special part of this is the "flash" or "kick" in the throat and lungs that is felt when inhaling. This sensation, which is caused by the irritation of certain receptors, is important for the smoker / steamer in order to satisfy his desire.
  • liquids containing nicotine are that, although the satisfaction of the addiction is achieved, toxins are still supplied to the body.
  • This disadvantage was countered by providing liquids which, mostly by adding additional flavoring substances, attempt to bring about a "real smoking experience" which corresponds to that of smoking conventional cigarettes or vaping with nicotine-containing liquid, but which is considerably less or contain no nicotine at all.
  • these liquids have the disadvantage that the chemosensorics addressed by the nicotine, i.e. the "flash" caused by the nicotine is completely absent.
  • a liquid composition for an electronic cigarette that is to say a liquid, which overcomes these disadvantages.
  • a liquid which does not contain any toxins such as nicotine, but which nevertheless generates the "flash" described above by the user, ie it addresses the chemosensory receptors in the way that nicotine, which is used by smokers, does.
  • the at least one TRP agonist / activator preferably activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8.
  • TRP agonists / activators are combined with one another in such a way that different TRP channels are activated.
  • extracts comprising black pepper, horseradish, garlic, bell pepper, cinnamon, mint and acetic and citric acid are preferably used as TRP agonist / activator.
  • the at least one TRP agonist / activator is preferably based on the constituents of TRP channel subtypes.
  • the liquid composition according to the invention can serve as a modulator.
  • the present invention further relates to the use of a liquid composition according to the invention for electronic cigarettes which does not contain nicotine in order to inhale cigarette smoke.
  • the liquid composition for an electronic cigarette comprises a TRP modulator and at least one TRP agonist / activator, wherein the interaction of the modulator and the at least one agonist / activator results in a chemosensory imitation of inhaled cigarette smoke, and the liquid composition does not contain any nicotine contains.
  • the chemical components are mixed together.
  • the basic components of the liquid (propylene glycol, glycerin, ethanol and flavoring agents) are obtained directly from the chemical manufacturer or from the flavoring supplier.
  • the grains of compassion thus acquired cannot be introduced into the liquid in the conventional form, but the corresponding active ingredient must first be extracted from this raw material. This is usually done by extracting the active ingredient from the raw material using ethanol using Soxhlet extraction. This binds the active ingredient directly into the ethanol, which is then introduced into the liquid.
  • the person skilled in the art knows how the active substances are treated in order to be able to be used in the liquid composition.
  • Nicotine has been proven to be a neurotoxin which, together with other active ingredients in conventional cigarettes, acts on sensory and autonomous afferent nerve endings and sends sensory information from the mouth, throat and respiratory tract to the brain via the vagus, trigeminal nerve and other cranial nerves.
  • the brain acts accordingly and induces vegetative reflexes and effects in the central nervous system, which rely on the subjective experience of smoking, including "scratching the throat” and behavioral rituals saved to relieve the desire.
  • Cigarette smoking causes EEG changes and activates the associated, subjective behavioral rituals via sensory reflexes before the nicotine in the smoke is absorbed and nerve reactions can report this active ingredient to the brain.
  • the sensory senses include taste, sense of smell and "chemical sensitivity” (also known as the "usual chemical sense", or trigeminal chemosensory).
  • chemical sensor technology relates to effects, e.g. B. sensations of pain or temperature mediating nerve endings.
  • specific substances such as hot peppers (capsaicin), black pepper (piperine), menthol, garlic (allicin), horseradish and wasabi (allyl isothiocyanates), camphor, wintergreen , Cinnamon (cinnamaldehyde), carbonic acid eg in beverages (carbon dioxide) and some air pollutants.
  • Such sensations in the mouth and in the nasal cavities are mediated through the trigeminal nerve and are elements of the somatosensory system.
  • chemical signals are transmitted to the brain via the vagus nerve, which can directly influence brain activity in the somatosensory cortex and other
  • the present invention takes advantage of the fact that the appetite switching is satisfied by chemosensory stimulation without supplying the actual active substance, such as nicotine, to the body.
  • chemosensory stimulation the brain assumes that with the usual inhalation the usual stimulating nicotine has been added.
  • the positive is additional and no less strong Influenced by imitating tactile, kinesthetic and organoleptic aspects of smoking, for example by optically visible evaporation of the liquid, suggesting that it is the same habitual ritual as smoking a cigarette, although it is only a much more harmless vaporization Ingredients without toxins.
  • TRP Transient Receptor Potential
  • TRP channels represent a class of receptors on sensory nerves that have the ability to activate them by triggering.
  • TRP channels transmit the sensations of sharp, hot or cold, as well as components in the inhaled air to the central nervous system.
  • the activation of the sensory nerve endings carried out by the TRP channels also induces local effects, for example coughing, sneezing, regulation of body temperature or other subjective sensations.
  • the activation of TRP channels also requires only very small constituents of the relevant TRP-relevant active ingredient, so that a concentration that is theoretically damaging even can be avoided in principle.
  • the TRP channel activators are supplied with minimal volatile components in the inhaled air in order to induce chemosensory stimulation similar to cigarette smoke without having to absorb a bioactive active substance concentration in the body.
  • An exemplary liquid composition is given below for a product unit of 10000 mg: 4500 mg propylene glycol, 4000 mg glycerol, 1000 mg food flavorings, 487 mg ethanol, furthermore with the following components that are responsible for a chemosensory reaction: 1.25 mg Piper nigrum, 3.75 mg Melegueta Aframomum, 1.25 mg benzoin, 0.5 mg allicin, 0.7 mg isothiocyanate, 0.425 mg Zingiberis rhizoma, 4.15 mg capsaicin, 0.625 mg Zanthoxylum piperitum, 0.35 mg curcumin.
  • composition is as follows: propylene glycol: 40% to 50%, glycerins: 36% to 44%, food flavors: 9% to 11%, ethanol: 4.3% to 5.3%, further with the following as a whole for one Ingredients responsible for chemosensory reactions: Piper nigrum: 0.12% to 0.13%, Melegueta Aframomum: 0.03% to 0.04%, benzoin: 0.012% to 0.014%, allicin: 0.0049% to 0.0051% , Isothiocyanate: 0.006% to 0.008%, Zingiberis rhizoma: 0.0038% to 0.0047%, capsaicin: 0.0037% to 0.0046%, Zanthoxylum piperitum: 0.0056% to 0.0069%, curcumin: 0 , 0031% to 0.0039%.
  • TRP V1 is a temperature-sensitive channel, the activation threshold of which can be lowered, for example, by using ethanol as a TRP modulator. This enables the sensory heat sensation to be achieved by TRP V1 agonists, such as extracts from chilli, Szechuan pepper or mustard, by using even lower concentrations.
  • TRP activators make it possible to imitate subjective and physiological chemosensory experiences, such as inhaling cigarette smoke.
  • Known TRP activators are, for example, extracts from black pepper, horseradish, garlic, paprika, cinnamon, mint and other known TRP channels activating substances, as well as acetic and citric acid. By using a complex mixture of these active ingredients, the activation ability can be both diversified and potentiated.
  • the use of low concentrations of these activators in the liquid supports the ability of the receptors for rapid desensitization, so that after only a short time (within the inhalation interval of an electric cigarette) the chemosensory stimulation can take place again and in full sensation size.
  • the active compounds according to the invention are: 6-paradol, 1'-acetoxychavicol acetate, isothiocyanates, camphor, grains of paradise and thymol.
  • these activators are used in the liquid mixtures.
  • the liquid composition according to the invention makes it possible to activate each individual TRP channel (TRP A1, TRP V1, TRP V3 and TRP M8).
  • the activation of each individual TRP channel with the respective activators is decisive in order to achieve a corresponding inhalation sensation similar to tobacco smoke.
  • the activation of a single channel is typically not sufficient.
  • the desired inclusion of the TRP M8 receptor in the functional basis is based on its ability to suppress the cough caused by inhalation through stimulation / activation.
  • a complex combination of different activators together with a suitable selection of modulators is often necessary to achieve the desired result.
  • 6-paradol is used in combination as an activator together with glycerol as a modulator, particularly good results are achieved in the activation of each individual TRP channel. This applies in particular and preferably if the glycerol makes up a quarter or more, and preferably two thirds or less, of the liquid composition (based on the weight, here expressed in “%”, ie in percent by weight).
  • Weight percentages of the glycerol are 30% or more, more preferably 33% or more, even more preferably 36% or more and particularly preferably 39% or more. Upper limits of the weight fraction of glycerol are 55% or less, more preferably 50% or less, even more preferably 45% or less and particularly preferably 41% or less. The best results are achieved with a preferred weight percentage of glycerol of 40%.
  • the weight fraction of the glycerol, expressed in percent by weight is accordingly 30% to 55%, more preferably 33% to 50%, even more preferably 36% to 45%, and particularly preferably 39% to 41%.
  • the composition has a very low allergenic potential.
  • the allicin obtained from some mustard seeds which is used here in a few exemplary embodiments in a weight fraction of 0.0049% - 0.0051%, is suspected of triggering allergenic reactions.
  • the other constituents used according to the invention in particular glycerol and 6-paradol, do not regularly trigger any allergenic reactions.
  • TRP activators are based on the components of the TRP channel subtypes. Through the use of active ingredient mixtures, it is possible to activate or deactivate various TRP channels in variable intensities by means of time slots of variable length. This control affects not only the intensity and time sheets, but also the local space by the chemosensory sensation takes place, such as: oral cavity, pharynx, lung. Tests in this regard have shown that activating a subchannel increases the actual chemosensory sensation without having to increase the concentration of the actual active ingredient.
  • TRP channels have the property of activating so-called TRP channels in the human body chemosensory, since in humans TRP channels play an important role in the perception of taste (sweet, sour, umami), pheromones, temperature (warm, hot, cold) , Pain u. a. play.
  • ethanol optionally also one or more volatile agonists of the TRPA1, TRPV1, TRPV3 and / or TRPM8 channels, as well as, if necessary, volatile, low-molecular carboxylic acid and flavoring substances can be used as a basic component with partially modulatory capabilities of the liquid mixtures.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract from the chilli pepper, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract of the black pepper, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract from Zingiberaceae (ginger family), which activates the TRP receptor TRP-1 and TRP-2 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract of isothiocyanates, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract from cloves, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract from camphor, which activates the TRP receptor TRPV1 + TRPV2 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract from Aframomum Melegueta (grains of paradise), which activates the TRP receptor TRPA1 + TRPV1 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract of thyme, which activates the TRP receptor TRPV3 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract from peppermint, which activates the TRP receptor TRPM8 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract from the vanilla, which activates the TRP receptor TRPV3 by inhalation and causes a chemosensory reaction.
  • One component of differently concentrated liquid mixtures for electrical evaporation is an extract from eucalyptus, which activates the TRP receptor TRPM8 by inhalation and causes a chemosensory reaction.
  • a component of differently concentrated liquid mixtures for electrical evaporation are flavor extracts that activate the TRP receptor TRPM8 by inhalation and cause a chemosensory reaction.
  • a component of differently concentrated liquid mixtures for electrical evaporation is caffeine, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.
  • a component of differently concentrated liquid mixtures for electrical evaporation are low molecular weight organic acids, which activate a TRP receptor by inhalation and cause a chemosensory reaction.
  • a component of differently concentrated liquid mixtures for electrical evaporation is ethanol, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.
  • liquid mixtures according to the invention convey a "real" feeling of smoking, i.e. the "flash” already described takes place without the use of toxins such as nicotine.
  • the smallest components of the extracts in the liquid are sufficient to achieve the desired effect.
  • compositions with different proportions by weight of glycerin were prepared by lowering or increasing the proportion accordingly, with the propylene glycol content being adjusted accordingly to produce compositions with equal total weights.
  • the ratings of the eleven compositions produced (compositions 1a to 11a) by the subjects were averaged and are summarized in Table 1 below:
  • Table 1 Composition No. Glycerol content (% by weight) Average rating 1a 0 4.1 2a 10th 3.8 3a 20th 3.5 4a 30th 2.5 5a 40 1.4 6a 50 2.4 7a 60 2.9 8a 70 3.7 9a 80 4.0 10a 90 4.3 11a 100 4.7
  • compositions 1b to 11b were asked to use compositions as in Table 1 above for smoke generation and to assess their inhalation sensation again according to the scale above.
  • the corresponding ratings by the test subjects were again averaged and are summarized in Table 2 below: Table 2 Composition No. Glycerol content (% by weight) Average rating 1b 0 5.3 2 B 10th 4.9 3b 20th 4.5 4b 30th 3.4 5b 40 2.6 6b 50 3.5 7b 60 4.9 8b 70 4.8 9b 80 5.1 10b 90 5.3 11b 100 5.7
  • TRP agonist / activator 6-paradol here Melegueta Aframomum
  • glycerol as TRP modulator in all comparable compositions led to a generally better assessment of the inhalation sensation than that similar to tobacco smoke. It can also be clearly seen that the glycerol contents preferred according to the invention led to a further increase in the positive inhalation sensation.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Description

Die vorliegende Erfindung bezieht sich auf eine flüssige Zusammensetzung (e-Liquid) zur Verwendung in elektronischen Zigaretten sowie die Verwendung von einem Modulator und zumindest einem TRP-Agonisten/Aktivator ("TRP" bedeutet in englischer Sprache "Transient Receptor Potential" und kann als "vorübergehendes Rezeptor-Potential" übersetzt werden) in einer flüssigen, nicht nikotinhaltigen Zusammensetzung, die den Tabakrauch bzw. das Inhalationsempfinden einer herkömmlichen Tabakzigarette simuliert.The present invention relates to a liquid composition (e-liquid) for use in electronic cigarettes and the use of a modulator and at least one TRP agonist / activator ("TRP" in English means "transient receptor potential" and can be described as " temporary receptor potential "are translated) in a liquid, non-nicotine-containing composition that simulates the tobacco smoke or the inhalation sensation of a conventional tobacco cigarette.

Das Rauchen von Tabakzigaretten ist mittlerweile in nahezu allen öffentlichen Räumen verboten. Dies schließt sowohl Arbeitsplätze, Bars, Restaurants und viele weitere Räumlichkeiten ein. Außerdem ist es das Ziel vieler Tabak- und e-Zigarettennutzer, zwar die Nikotinkonzentration und damit den vermeintlichen Nikotin-Bedarf sukzessive zu senken, um den Körper nicht unnötig vielen Giftstoffen auszusetzen, nicht jedoch auf das Verhaltensritual und die Zuführung des Genussmittels Zigarette selbst zu verzichten. Deshalb greifen viele Raucher mittlerweile zu der elektronischen bzw. e-Zigarette.Smoking tobacco cigarettes is now prohibited in almost all public spaces. This includes workplaces, bars, restaurants and many other premises. In addition, it is the goal of many tobacco and e-cigarette users to successively reduce the nicotine concentration and thus the supposed nicotine requirement in order not to expose the body to unnecessarily many toxins, but not to do without the behavioral ritual and the consumption of the luxury cigarette itself . That is why many smokers are now using the electronic or e-cigarette.

Es sind unterschiedliche e-Zigaretten bereits bekannt. Deren Funktionsweise besteht darin, dass eine flüssige Zusammensetzung, auch als "Liquid" bezeichnet, welche meistens aromatisiert ist und auch Nikotin enthält, in dieser elektronischen Zigarette mittels einer Verdampfungseinheit verdampft wird und dadurch die Funktion einer herkömmlichen Zigarette simuliert wird.Different e-cigarettes are already known. Their mode of operation consists in that a liquid composition, also referred to as "liquid", which is mostly flavored and also contains nicotine, is vaporized in this electronic cigarette by means of an evaporation unit, thereby simulating the function of a conventional cigarette.

US 2013/152956 A1 beschreibt eine Vorrichtung zum Simulieren des chemischen Empfindens des Rauchens. Die Vorrichtung umfasst eine äußere Schicht, ein poröses Medium und ein chemästhetisches Mittel. Das poröse Medium ist innerhalb der äußeren Schicht angeordnet. Das chemästhetische Mittel befindet sich innerhalb des porösen Mediums und aktiviert einen TRP-Kanal. US 2013/152956 A1 describes a device for simulating the chemical sensation of smoking. The device comprises an outer layer, a porous medium and a chemesthetic agent. The porous medium is arranged within the outer layer. The chemesthetic agent is located within the porous medium and activates a TRP channel.

CN 102266125 A beschreibt eine elektronische Zigarette der traditionellen chinesischen Medizin zur Raucherentwöhnung. Die elektronische Zigarette umfasst eine Batteriestange, einen Zerstäuber und eine Rauchdüse. Der Zerstäuber weist ein in die Rauchdüse eingeführtes Vorderende auf und ist mit der Batterie verbunden. Die ringförmige Rauchdüse weist eine hohle Säule und ein Belüftungsloch auf. Die hohle Säule dient als Medikamentenkammer, die unter Säule ist mit einer Hülse auf einem Zerstäuber angebracht. Die Medikamentenkammer ist mit Luft und Medikament befüllt. Der Zerstäuber weist einen leitfähigen Metallkörper auf, der mit einer Elektrode versehen ist, die über eine Hülse mit einem isolierenden Silicagel-Rohr verbunden ist. Die verbindende Elektrode und das Silicagel-Rohr sind mit einem Heizelement und einem Verbindungskörper versehen. CN 102266125 A describes an electronic cigarette of traditional Chinese medicine for smoking cessation. The electronic cigarette includes a battery stick, an atomizer and a smoke nozzle. The atomizer points into the Smoke nozzle inserted front end and is connected to the battery. The annular smoke nozzle has a hollow column and a ventilation hole. The hollow column serves as a medication chamber, the one below the column is attached to an atomizer with a sleeve. The medication chamber is filled with air and medication. The atomizer has a conductive metal body which is provided with an electrode which is connected to an insulating silica gel tube via a sleeve. The connecting electrode and the silica gel tube are provided with a heating element and a connecting body.

US 5,893,371 beschreibt ein Nicht-Nikotinverfahren und -gerät zur Verringerung des Bedarfs an Tabakrauch und zur Verwendung eines oder mehrerer Bestandteile aus schwarzem Pfeffer oder rotem Pfeffer, die durch Inhalation von einem Dampfzufuhrsystem oder einem Aerosolabgabesystem in den Atemtrakt des Benutzers eingebracht werden. Der eine oder die mehreren Bestandteile von schwarzem und / oder rotem Pfeffer umfassen ätherische Öle von schwarzem und / oder rotem Pfeffer sowie pfefferreizende Substanzen, einschließlich Capsaicin, Piperin und Phellandren. US 5,893,371 describes a non-nicotine method and device for reducing the need for tobacco smoke and for using one or more black pepper or red pepper ingredients that are introduced into the user's respiratory tract by inhalation from a vapor delivery system or an aerosol delivery system. The one or more components of black and / or red pepper include essential oils of black and / or red pepper as well as pepper-irritating substances, including capsaicin, piperine and phellandrene.

CN 102960852 beschreibt Dampflösungen für elektronische Zigaretten mit den folgenden Komponenten in Gewichtsprozent: 30-45% Propylenglykol, 20-35% Glycerin, 5-15% entionisiertes Wasser, 5-15% Alkohol, 15-45% TCM-Flüssigkeit, 2-5 Prozent Tabakgeschmack, 2-6 Prozent Tabakextrakt und 0,1-2 Prozent Formierungsmittel. Die TCM-Flüssigkeit besteht aus Bulbus Fritillariae Cirrhosae, Minzblättchen, Wollmispelblättchen, Dendranthema Indicum, Veilchen, süß duftendem Osmanthus und grünem Tee. CN 102960852 describes vapor solutions for electronic cigarettes with the following components in percent by weight: 30-45% propylene glycol, 20-35% glycerol, 5-15% deionized water, 5-15% alcohol, 15-45% TCM liquid, 2-5 percent tobacco taste , 2-6 percent tobacco extract and 0.1-2 percent shaping agent. The TCM fluid consists of Bulbus Fritillariae Cirrhosae, mint leaves, loquat leaves, dendranthema indicum, violets, sweet-smelling osmanthus and green tea.

Unter den oben genannten immer mehr verschärften Voraussetzungen bezüglich des Rauchens fühlt sich ein Tabakraucher/e-Zigaretten-Dampfer während seines Aufenthaltes in Rauchverbotsarealen sichtlich unwohl. Der turnusmäßige Abfall des Nikotinspiegels im Körper eines Rauchers/Dampfers begünstigt dieses Unwohlsein, jedoch ist dies nicht der einzige oder wichtigste Faktor, der das Verlangen nach einer Tabak- oder e-Zigarette steuert. Vielmehr ist das durch Nutzungsverbote erzwungene Unterdrücken des gewohnten Rituals an einer Tabak- oder e-Zigarette zu ziehen, den Rauch/Dampf zu inhalieren und genüsslich wieder auszustoßen die Hauptursache für dieses Unwohlsein und dem stärker werdenden Verlangen nach dieser Ritualbefriedigung. Ein besonderer Teil hierbei ist der beim Inhalieren empfundene "Flash" oder auch "Kick" im Mund-Rachen und Lungenbereich. Dieses Empfinden, das durch die Reizung bestimmter Rezeptoren hervorgerufen wird, ist für den Raucher/Dampfer wichtig, um sein Verlangen zu stillen.Under the above-mentioned increasingly strict requirements regarding smoking, a tobacco smoker / e-cigarette vaporizer visibly feels uncomfortable during his stay in non-smoking areas. The regular drop in the nicotine level in the body of a smoker / steamer favors this discomfort, but this is not the only or most important factor that controls the desire for a tobacco or e-cigarette. Rather, the use of tobacco or e-cigarettes to suppress the customary ritual, prohibited by use, to inhale the smoke / steam and to release it with relish is the main cause of this discomfort and the increasing desire for it Ritual satisfaction. A special part of this is the "flash" or "kick" in the throat and lungs that is felt when inhaling. This sensation, which is caused by the irritation of certain receptors, is important for the smoker / steamer in order to satisfy his desire.

Bisher besteht die Möglichkeit, anstelle von nikotinhaltigen Liquids für e-Zigaretten nikotinfreie Liquids für e-Zigaretten zu nutzen, um diesem Verlangen nach "gesundem Rauchen" entgegenzukommen und dem Verlangen der Ritualbefriedigung entgegenzuwirken, da e-Zigaretten die Ausübung des beschriebenen Rituals durch ihre Handhabung begünstigen. Nachteilig ist hier jedoch, dass die Chemosensorik (hier insbesondere das als "Flash" bezeichnete Inhalationsgefühl wie vorher beschrieben) im Speziellen durch das Fehlen des Nikotins vollkommen ausbleibt. Auch das Hinzufügen von Aromastoffen zu dem Liquid kann diesen Flash nicht hervorrufen. Als Beispiel für das Hinzufügen von Aromastoffen und/oder Nikotin wird auf das chinesische Patent mit der Nummer CN 101926506 B und die Europäische Patentanmeldung EP 2 563 265 A2 verwiesen.So far, it has been possible to use nicotine-free liquids for e-cigarettes instead of nicotine-containing liquids for e-cigarettes in order to meet this desire for "healthy smoking" and to counteract the demand for ritual satisfaction, since e-cigarettes practice the ritual described by their handling favor. The disadvantage here, however, is that the chemical sensor technology (in particular the inhalation sensation referred to as "flash" as described above) is completely absent, especially due to the lack of nicotine. The addition of flavorings to the liquid cannot cause this flash either. As an example of adding flavorings and / or nicotine is to the Chinese patent number CN 101926506 B and the European patent application EP 2 563 265 A2 referred.

Insofern besteht der Nachteil bei Liquids, denen Nikotin beigesetzt ist, darin, dass zwar die Befriedigung der Sucht erreicht wird, aber dennoch Giftstoffe dem Körper zugeführt werden. Diesem Nachteil wurde begegnet, indem Liquide zur Verfügung gestellt wurden, die - meist durch zusätzliches Hinzufügen von Aromastoffen - versuchen, ein "echtes Raucherlebnis" herbeizuführen, das dem des Rauchens von herkömmlichen Zigaretten oder des Dampfens mit nikotinhaltigem Liquid entspricht, die aber wesentlich weniger oder gar kein Nikotin enthalten. Allerdings haben diese Liquids den Nachteil, dass die durch das Nikotin angesprochene Chemosensorik, d.h. der durch das Nikotin hervorgerufene "Flash", völlig ausbleibt.In this respect, the disadvantage of liquids containing nicotine is that, although the satisfaction of the addiction is achieved, toxins are still supplied to the body. This disadvantage was countered by providing liquids which, mostly by adding additional flavoring substances, attempt to bring about a "real smoking experience" which corresponds to that of smoking conventional cigarettes or vaping with nicotine-containing liquid, but which is considerably less or contain no nicotine at all. However, these liquids have the disadvantage that the chemosensorics addressed by the nicotine, i.e. the "flash" caused by the nicotine is completely absent.

Deshalb ist es die Aufgabe der vorliegenden Erfindung, eine flüssige Zusammensetzung für eine elektronische Zigarette, also ein Liquid, bereitzustellen, das diese Nachteile überwindet. Es wird erfindungsgemäß ein Liquid bereitgestellt, das keinerlei Giftstoffe wie beispielsweise Nikotin enthält, das aber dennoch den oben beschriebenen "Flash" beim Nutzer erzeugt, d.h. die chemosensorischen Rezeptoren in der Art anspricht, wie es das vom Raucher gewohnte Nikotin tut.It is therefore the object of the present invention to provide a liquid composition for an electronic cigarette, that is to say a liquid, which overcomes these disadvantages. According to the invention, a liquid is provided which does not contain any toxins such as nicotine, but which nevertheless generates the "flash" described above by the user, ie it addresses the chemosensory receptors in the way that nicotine, which is used by smokers, does.

Zur Lösung der vorstehenden Aufgabe stellt die vorliegende Erfindung eine flüssige Zusammensetzung für eine elektronische Zigarette bereit umfassend:

  • Glycerin als einen TRP-Modulator, wobei der Gewichtsanteil des Glycerins ausgedrückt in Gewichtsprozent 30% bis 55% beträgt, und
  • zumindest einen TRP-Agonisten/Aktivator ausgewählt aus 6-Paradol, 1'-Acetoxychavicolacetat, Isothiocyanaten, Kampfer, Paradieskörnern und Thymol, wobei
    durch das Zusammenwirken von Modulator und dem zumindest einen Agonisten/Aktivator eine chemosensorischen Nachahmung von inhaliertem Zigarettenrauch erfolgt, und
  • wobei die flüssige Zusammensetzung kein Nikotin enthält.
To achieve the above object, the present invention provides a liquid composition for an electronic cigarette comprising:
  • Glycerin as a TRP modulator, the weight fraction of the glycerin expressed in weight percent being 30% to 55%, and
  • at least one TRP agonist / activator selected from 6-paradol, 1'-acetoxychavicol acetate, isothiocyanates, camphor, grains of paradise and thymol, where
    the interaction of the modulator and the at least one agonist / activator results in a chemosensory imitation of inhaled cigarette smoke, and
  • the liquid composition containing no nicotine.

In der flüssigen Zusammensetzung aktiviert der zumindest eine TRP-Agonist/Aktivator vorzugsweise zumindest einen aus den TRP-Rezeptoren TRPA1, TRPV1, TRPV3 und TRPM8.In the liquid composition, the at least one TRP agonist / activator preferably activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8.

In der erfindungsgemäßen flüssigen Zusammensetzung sind mehrere TRP-Agonisten/Aktivatoren so miteinander kombiniert, dass unterschiedliche TRP-Kanäle aktiviert werden.In the liquid composition according to the invention, several TRP agonists / activators are combined with one another in such a way that different TRP channels are activated.

In der erfindungsgemäßen flüssigen Zusammensetzung dienen bevorzugt Extrakte umfassend schwarzen Pfeffer, Meerrettich, Knoblauch, Paprika, Zimt, Minze und Essig- und Zitronensäure als TRP- Agonist/Aktivator.In the liquid composition according to the invention, extracts comprising black pepper, horseradish, garlic, bell pepper, cinnamon, mint and acetic and citric acid are preferably used as TRP agonist / activator.

In der erfindungsgemäßen flüssigen Zusammensetzung basiert der zumindest eine TRP-Agonist/Aktivator vorzugsweise auf den Bestandteilen von TRP-Kanal Subtypen.In the liquid composition according to the invention, the at least one TRP agonist / activator is preferably based on the constituents of TRP channel subtypes.

In der erfindungsgemäßen flüssigen Zusammensetzung können, neben den 30% bis 55% Glycerin, Ethanol oder Glycol als Modulator dienen.In addition to the 30% to 55% glycerol, ethanol or glycol, the liquid composition according to the invention can serve as a modulator.

In einer bevorzugten Ausführungsform umfasst die erfindungsgemäße flüssige Zusammensetzung für eine elektronische Zigarette:

  • Propyleneglycol: 40% bis 50%
  • Glycerine: 36% bis 44%
  • Lebensmittelaromen: 9% bis 11%
  • Ethanol: 4,3% bis 5,3%,
  • Piper nigrum: 0,12% bis 0,13%
  • Melegueta Aframomum: 0,03% bis 0,04%
  • Benzoe: 0,012% bis 0,014%
  • Allicin: 0,0049% bis 0,0051%
  • Isothiocyanat: 0,006% bis 0,008%
  • Zingiberis rhizoma: 0,0038% bis 0,0047%
  • Capsaicin: 0,0037% bis 0,0046%
  • Zanthoxylum piperitum: 0,0056% bis 0,0069%
  • Kurkumin: 0,0031% bis 0,0039%.
In a preferred embodiment, the liquid composition according to the invention for an electronic cigarette comprises:
  • Propylene glycol: 40% to 50%
  • Glycerins: 36% to 44%
  • Food flavors: 9% to 11%
  • Ethanol: 4.3% to 5.3%,
  • Piper nigrum: 0.12% to 0.13%
  • Melegueta Aframomum: 0.03% to 0.04%
  • Benzoin: 0.012% to 0.014%
  • Allicin: 0.0049% to 0.0051%
  • Isothiocyanate: 0.006% to 0.008%
  • Zingiberis rhizoma: 0.0038% to 0.0047%
  • Capsaicin: 0.0037% to 0.0046%
  • Zanthoxylum piperitum: 0.0056% to 0.0069%
  • Curcumin: 0.0031% to 0.0039%.

In einer besonders bevorzugten Ausführungsform besteht die erfindungsgemäße flüssige Zusammensetzung für eine elektronische Zigarette aus:

  • Propyleneglycol: 45%
  • Glycerine: 40%
  • Lebensmittelaromen: 10%
  • Ethanol: 4,8%
  • Piper nigrum: 0,122%
  • Melegueta Aframomum: 0,035%
  • Benzoe: 0,013%
  • Allicin: 0,0050%
  • Isothiocyanat: 0,007%
  • Zingiberis rhizoma: 0,0042%
  • Capsaicin: 0,0041%
  • Zanthoxylum piperitum: 0,0062%
  • Kurkumin: 0,0035%.
In a particularly preferred embodiment, the liquid composition according to the invention for an electronic cigarette consists of:
  • Propylene glycol: 45%
  • Glycerine: 40%
  • Food flavors: 10%
  • Ethanol: 4.8%
  • Piper nigrum: 0.122%
  • Melegueta Aframomum: 0.035%
  • Benzoin: 0.013%
  • Allicin: 0.0050%
  • Isothiocyanate: 0.007%
  • Zingiberis rhizoma: 0.0042%
  • Capsaicin: 0.0041%
  • Zanthoxylum piperitum: 0.0062%
  • Curcumin: 0.0035%.

Ferner betrifft die vorliegende Erfindung eine Verwendung einer erfindungsgemäßen flüssigen Zusammensetzung für elektronische Zigaretten, die kein Nikotin enthält, um Zigarettenrauch zu inhalieren.The present invention further relates to the use of a liquid composition according to the invention for electronic cigarettes which does not contain nicotine in order to inhale cigarette smoke.

Die der vorliegenden Erfindung zugrunde liegende Aufgabe wird zudem durch die flüssige Zusammensetzung gemäß der angefügten Ansprüche gelöst.The object underlying the present invention is also achieved by the liquid composition according to the appended claims.

Allgemein umfasst die flüssige Zusammensetzung für eine elektronische Zigarette einen TRP-Modulator und zumindest einen TRP-Agonisten/Aktivator, wobei durch das Zusammenwirken von Modulator und dem zumindest einen Agonisten/Aktivator eine chemosensorische Nachahmung von inhaliertem Zigarettenrauch erfolgt, und wobei die flüssige Zusammensetzung kein Nikotin enthält.In general, the liquid composition for an electronic cigarette comprises a TRP modulator and at least one TRP agonist / activator, wherein the interaction of the modulator and the at least one agonist / activator results in a chemosensory imitation of inhaled cigarette smoke, and the liquid composition does not contain any nicotine contains.

Vorteilhafterweise aktiviert der zumindest eine TRP-Agonist/Aktivator zumindest einen aus den TRP-Rezeptoren TRPA1, TRPV1, TRPV3 und TRPM8. Des Weiteren ist es vorteilhaft, dass mehrere TRP-Agonisten/Aktivatoren so miteinander kombiniert werden, dass unterschiedliche TRP-Kanäle aktiviert werden. Als weitere vorteilhafte Ausgestaltung werden als TRP- Agonist/Aktivator Extrakte umfassend schwarzen Pfeffer, Meerrettich, Knoblauch, Paprika, Zimt, Minze und Essig- und Zitronensäure verwendet. Des Weiteren dienen als TRP-Agonist/Aktivator Wirkstoffe ausgewählt aus 6-Paradol, 1'-Acetoxychavicolacetat, Isothiocyanaten, Kampfer, Paradieskörnern und Thymol. Vorteilhafterweise basiert der zumindest eine TRP-Agonist/Aktivator auf den Bestandteilen von TRP-Kanal Subtypen.
In einer weiteren bevorzugten Ausführungsform umfasst die flüssige Zusammensetzung Propyleneglycol: 40% bis 50%, Glycerine: 36% bis 44%, Lebensmittelaromen: 9% bis 11%, Ethanol: 4,3% bis 5,3%, wobei die Zusammensetzung ferner umfasst:

  • Piper nigrum: 0,12% bis 0,13%
  • Melegueta Aframomum: 0,03% bis 0,04%
  • Benzoe: 0,012% bis 0,014%
  • Allicin: 0,0049% bis 0,0051%
  • Isothiocyanat: 0,006% bis 0,008%
  • Zingiberis rhizoma: 0,0038% bis 0,0047%
  • Capsaicin: 0,0037% bis 0,0046%
  • Zanthoxylum piperitum: 0,0056% bis 0,0069%
  • Kurkumin: 0,0031% bis 0,0039%.
The at least one TRP agonist / activator advantageously activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8. Furthermore, it is advantageous that several TRP agonists / activators are combined with one another in such a way that different TRP channels are activated. As a further advantageous embodiment, extracts comprising black pepper, horseradish, garlic, paprika, cinnamon, mint and acetic and citric acid are used as the TRP agonist / activator. Furthermore, actives selected from 6-paradol, 1'-acetoxychavicol acetate, isothiocyanates, camphor, grains of paradise and thymol serve as TRP agonist / activator. The at least one TRP agonist / activator is advantageously based on the constituents of TRP channel subtypes.
In a further preferred embodiment, the liquid composition comprises propylene glycol: 40% to 50%, glycerins: 36% to 44%, food flavors: 9% to 11%, ethanol: 4.3% to 5.3%, the composition further comprising :
  • Piper nigrum: 0.12% to 0.13%
  • Melegueta Aframomum: 0.03% to 0.04%
  • Benzoin: 0.012% to 0.014%
  • Allicin: 0.0049% to 0.0051%
  • Isothiocyanate: 0.006% to 0.008%
  • Zingiberis rhizoma: 0.0038% to 0.0047%
  • Capsaicin: 0.0037% to 0.0046%
  • Zanthoxylum piperitum: 0.0056% to 0.0069%
  • Curcumin: 0.0031% to 0.0039%.

In einer weiteren bevorzugten spezifischen Ausführungsform enthält die flüssige Zusammensetzung:

  • Propyleneglycol: 45%
  • Glycerine: 40%
  • Lebensmittelaromen: 10%
  • Ethanol: 4,8%
  • wobei die Zusammensetzung ferner enthält:
    • Piper nigrum: 0,122%
    • Melegueta Aframomum: 0,035%
    • Benzoe: 0,013%
    • Allicin: 0,0050%
    • Isothiocyanat: 0,007%
    • Zingiberis rhizoma: 0,0042%
    • Capsaicin: 0,0041%
    • Zanthoxylum piperitum: 0,0062%
    • Kurkumin: 0,0035%.
In a further preferred specific embodiment, the liquid composition contains:
  • Propylene glycol: 45%
  • Glycerine: 40%
  • Food flavors: 10%
  • Ethanol: 4.8%
  • the composition further comprising:
    • Piper nigrum: 0.122%
    • Melegueta Aframomum: 0.035%
    • Benzoin: 0.013%
    • Allicin: 0.0050%
    • Isothiocyanate: 0.007%
    • Zingiberis rhizoma: 0.0042%
    • Capsaicin: 0.0041%
    • Zanthoxylum piperitum: 0.0062%
    • Curcumin: 0.0035%.

Herstellung der Zusammensetzung:Preparation of the composition:

Die chemischen Komponenten sind miteinander vermischt. Die Grundbestandteile des Liquids (Propylenglycol, Glycerin, Ethanol und Aromastoffe) werden direkt vom Chemikalienhersteller, bzw. vom Aromen-Lieferanten bezogen. Die Bestandteile der hier beschriebenen flüssigen Zusammensetzung (BioNic) hingegen können größtenteils nicht herkömmlich bezogen werden, zumindest nicht in der Form, wie sie in der vorliegenden Erfindung verwendet werden. Zum Beispiel kann man Paradieskörner (Aframomum melegueta) im Gewürzhandel erwerben. Allerdings können die so erworbenen Paradieskörner nicht in der herkömmlichen Form in das Liquid eingebracht werden, sondern es muss zunächst aus diesem Rohstoff der entsprechende Wirkstoff extrahiert werden. Dies geschieht zumeist, indem man den Wirkstoff mittels Ethanol per Soxhlet-Extraktion aus dem Rohstoff extrahiert. Damit wird der Wirkstoff direkt in das Ethanol gebunden, welches dann in das Liquid eingebracht wird. Dem Fachmann ist bekannt, wie die Wirkstoffe behandelt werden, um in der flüssigen Zusammensetzung verwendet werden zu können.The chemical components are mixed together. The basic components of the liquid (propylene glycol, glycerin, ethanol and flavoring agents) are obtained directly from the chemical manufacturer or from the flavoring supplier. The components of the liquid composition (BioNic) described here, on the other hand, for the most part cannot be obtained conventionally, at least not in the form used in the present invention. For example, you can buy grains of paradise (Aframomum melegueta) in the spice trade. However, the grains of paradise thus acquired cannot be introduced into the liquid in the conventional form, but the corresponding active ingredient must first be extracted from this raw material. This is usually done by extracting the active ingredient from the raw material using ethanol using Soxhlet extraction. This binds the active ingredient directly into the ethanol, which is then introduced into the liquid. The person skilled in the art knows how the active substances are treated in order to be able to be used in the liquid composition.

Nikotin ist nachgewiesenermaßen ein Nervengift, das zusammen mit anderen Wirkstoffen der herkömmlichen Zigarette auf sensorische und autonome afferente Nervenenden wirkt und sensorische Informationen aus dem Mund, Rachen und Atemwegen über den Vagus, Trigeminus und andere Hirnnerven an das Gehirn sendet. Das Gehirn handelt entsprechend und induziert vegetative Reflexe und Effekte in das zentrale Nervensystem, die auf die subjektive Erfahrung des Rauchens, darunter "Hals kratzen" und zur Entlastung des Verlangens gespeicherte Verhaltensrituale, zurückgreifen. Das Zigarettenrauchen verursacht EEG-Veränderungen und aktiviert damit verbundene, subjektive Verhaltensrituale über sensorische Reflexe, noch bevor das im Rauch befindliche Nikotin absorbiert wird und Nervenreaktionen diesen Wirkstoff an das Gehirn melden können.Nicotine has been proven to be a neurotoxin which, together with other active ingredients in conventional cigarettes, acts on sensory and autonomous afferent nerve endings and sends sensory information from the mouth, throat and respiratory tract to the brain via the vagus, trigeminal nerve and other cranial nerves. The brain acts accordingly and induces vegetative reflexes and effects in the central nervous system, which rely on the subjective experience of smoking, including "scratching the throat" and behavioral rituals saved to relieve the desire. Cigarette smoking causes EEG changes and activates the associated, subjective behavioral rituals via sensory reflexes before the nicotine in the smoke is absorbed and nerve reactions can report this active ingredient to the brain.

Um ein Rauchgefühl wie bei einer herkömmlichen Zigarette zu simulieren, allerdings ohne Giftstoffe wie Nikotin zu verwenden, wurden pflanzliche Analogstoffe gesucht, die diese oder ähnliche chemosensorischen Wirkungen hervorrufen und den Einsatz von Nikotin als Nervengift nicht länger notwendig machen. Die sensorischen Sinne umfassen Geschmack, Geruchssinn und "chemikalische Sensibilität" (auch bekannt als den "üblichen chemischen Sinn", oder Trigeminus Chemosensorik). Die Chemosensorik bezieht sich auf Wirkungen, z. B. auf Nervenenden vermittelnde Empfindungen von Schmerz oder Temperatur. Inkludiert sind hier beispielsweise die Empfindung "scharf, heiß oder kühl", die durch die Einnahme spezifischer Substanzen, wie Peperoni (Capsaicin), schwarzer Pfeffer (Piperin), Menthol, Knoblauch (Allicin), Meerrettich und Wasabi (Allylisothiocyanate), Kampfer, Wintergrün, Zimt (Zimtaldehyd), Kohlensäure z.B. bei Getränken (Kohlendioxid) und einige Luftschadstoffe verursacht wird. Solche Empfindungen im Mundraum und in den Nasen-Hohlräumen werden über den Trigeminus-Nerv vermittelt und sind Elemente des somatosensorischen Systems. In den Hals- und Atemwegen, sowie der Lunge werden über den Vagus-Nerv chemische Signale an das Gehirn übertragen, die direkt die Hirnaktivität im somatosensorischen Kortex und anderen Regionen beeinflussen können. Dies sind u.a. auch appetitive Schaltungen in Form von Heißhunger auf bestimmte Nahrungsmittel, aber auch Verlangen nach Tabakrauch, ohne dabei die Absorption der Wirkstoffe in der Blutbahn oder das Gehirn zu berücksichtigen.In order to simulate a smoking sensation like that of a conventional cigarette, but without using toxins such as nicotine, plant analogues were sought that produce these or similar chemosensory effects and no longer require the use of nicotine as a neurotoxin. The sensory senses include taste, sense of smell and "chemical sensitivity" (also known as the "usual chemical sense", or trigeminal chemosensory). The chemical sensor technology relates to effects, e.g. B. sensations of pain or temperature mediating nerve endings. This includes, for example, the sensation "hot, hot or cool", caused by the consumption of specific substances such as hot peppers (capsaicin), black pepper (piperine), menthol, garlic (allicin), horseradish and wasabi (allyl isothiocyanates), camphor, wintergreen , Cinnamon (cinnamaldehyde), carbonic acid eg in beverages (carbon dioxide) and some air pollutants. Such sensations in the mouth and in the nasal cavities are mediated through the trigeminal nerve and are elements of the somatosensory system. In the throat, airways and lungs, chemical signals are transmitted to the brain via the vagus nerve, which can directly influence brain activity in the somatosensory cortex and other regions. These include also appetizing circuits in the form of cravings for certain foods, but also cravings for tobacco smoke, without taking into account the absorption of the active substances in the bloodstream or the brain.

Bei der vorliegenden Erfindung wird der Umstand ausgenützt, dass die appetitive Schaltung durch chemosensorische Stimulation befriedigt wird, ohne dem Körper den eigentlichen Wirkstoff wie Nikotin zuzuführen. Durch die chemosensorische Stimulation geht das Gehirn davon aus, dass mit der gewohnten Inhalation auch das gewohnt stimulierende Nikotin zugeführt wurde. Zusätzlich und nicht minder stark ist die positive Beeinflussung durch die Nachahmung taktiler, kinästhetischer und organoleptischer Aspekte des Rauchens, indem beispielsweise eine optisch sichtbare Verdampfung des Liquids erfolgt und somit suggeriert wird, dass es sich um dasselbe gewohnte Ritual wie beim Rauchen einer Zigarette handelt, obwohl es sich lediglich um eine Verdampfung weitaus harmloserer Bestandteile ohne Giftstoffe handelt.The present invention takes advantage of the fact that the appetite switching is satisfied by chemosensory stimulation without supplying the actual active substance, such as nicotine, to the body. Through the chemosensory stimulation, the brain assumes that with the usual inhalation the usual stimulating nicotine has been added. The positive is additional and no less strong Influenced by imitating tactile, kinesthetic and organoleptic aspects of smoking, for example by optically visible evaporation of the liquid, suggesting that it is the same habitual ritual as smoking a cigarette, although it is only a much more harmless vaporization Ingredients without toxins.

Die TRP (Transient Receptor Potential)-lonenkanäle stellen eine Klasse von Rezeptoren auf sensorischen Nerven dar, die die Fähigkeit besitzen, diese durch Auslösung zu aktivieren. TRP Kanäle übermitteln die Empfindungen von scharf, heiß oder kalt, sowie Bestandteile in der eingeatmeten Luft an das zentrale Nervensystem. Die durch die TRP-Kanäle vorgenommene Aktivierung der sensorischen Nervenenden induzieren neben der chemosensorischen Stimulation auch lokale Effekte, zum Beispiel Husten, Niesen, Regulierung der Körpertemperatur oder sonstige subjektive Empfindungen. Für die Aktivierung von TRP-Kanälen bedarf es zudem nur sehr geringer Bestandteile des entsprechenden TRP relevanten Wirkstoffs, so dass grundsätzlich eine selbst theoretisch schädigende Konzentration vermieden werden kann. Den TRP Kanal Aktivatoren reichen minimalste volatile Bestandteile in der eingeatmeten Luft, um eine Zigarettenrauch ähnelnde chemosensorische Stimulation hervorzurufen ohne eine bioaktive Wirkstoffkonzentration in den Körper aufnehmen zu müssen. Im Folgenden ist eine beispielhafte Liquidzusammensetzung bei einer Produkteinheit von 10000 mg angegeben: 4500 mg Propyleneglycol, 4000 mg Glycerine, 1000 mg Lebensmittelaromen, 487 mg Ethanol, ferner mit folgenden in der Gesamtheit für eine chemosensorische Reaktion zuständigen Bestandteilen: 1,25 mg Piper nigrum, 3,75 mg Melegueta Aframomum, 1,25 mg Benzoe, 0,5 mg Allicin, 0,7 mg Isothiocyanat, 0,425 mg Zingiberis rhizoma, 4,15 mg Capsaicin, 0,625 mg Zanthoxylum piperitum, 0,35 mg Kurkumin. Allgemeiner ist die Zusammensetzung folgende: Propyleneglycol: 40% bis 50%, Glycerine: 36% bis 44% , Lebensmittelaromen: 9% bis 11%, Ethanol: 4,3% bis 5,3%, ferner mit folgenden in der Gesamtheit für eine chemosensorische Reaktion zuständigen Bestandteilen: Piper nigrum: 0,12% bis 0,13%, Melegueta Aframomum: 0,03% bis 0,04%, Benzoe: 0,012% bis 0,014%, Allicin: 0,0049% bis 0,0051%, Isothiocyanat: 0,006% bis 0,008%, Zingiberis rhizoma: 0,0038% bis 0,0047%, Capsaicin: 0,0037% bis 0,0046%, Zanthoxylum piperitum: 0,0056% bis 0,0069%, Kurkumin: 0,0031% bis 0,0039%.The TRP (Transient Receptor Potential) ion channels represent a class of receptors on sensory nerves that have the ability to activate them by triggering. TRP channels transmit the sensations of sharp, hot or cold, as well as components in the inhaled air to the central nervous system. In addition to chemosensory stimulation, the activation of the sensory nerve endings carried out by the TRP channels also induces local effects, for example coughing, sneezing, regulation of body temperature or other subjective sensations. The activation of TRP channels also requires only very small constituents of the relevant TRP-relevant active ingredient, so that a concentration that is theoretically damaging even can be avoided in principle. The TRP channel activators are supplied with minimal volatile components in the inhaled air in order to induce chemosensory stimulation similar to cigarette smoke without having to absorb a bioactive active substance concentration in the body. An exemplary liquid composition is given below for a product unit of 10000 mg: 4500 mg propylene glycol, 4000 mg glycerol, 1000 mg food flavorings, 487 mg ethanol, furthermore with the following components that are responsible for a chemosensory reaction: 1.25 mg Piper nigrum, 3.75 mg Melegueta Aframomum, 1.25 mg benzoin, 0.5 mg allicin, 0.7 mg isothiocyanate, 0.425 mg Zingiberis rhizoma, 4.15 mg capsaicin, 0.625 mg Zanthoxylum piperitum, 0.35 mg curcumin. More generally, the composition is as follows: propylene glycol: 40% to 50%, glycerins: 36% to 44%, food flavors: 9% to 11%, ethanol: 4.3% to 5.3%, further with the following as a whole for one Ingredients responsible for chemosensory reactions: Piper nigrum: 0.12% to 0.13%, Melegueta Aframomum: 0.03% to 0.04%, benzoin: 0.012% to 0.014%, allicin: 0.0049% to 0.0051% , Isothiocyanate: 0.006% to 0.008%, Zingiberis rhizoma: 0.0038% to 0.0047%, capsaicin: 0.0037% to 0.0046%, Zanthoxylum piperitum: 0.0056% to 0.0069%, curcumin: 0 , 0031% to 0.0039%.

In einem für die elektrische Zigarette entwickelten Liquid können mehrere dieser TRP Kanalaktivatoren zum Einsatz kommen, die unter bestimmten Voraussetzungen in Kombination die sensorischen Eigenschaften noch verstärken können. Der TRP V1 beispielsweise ist ein temperatursensorischer Kanal, dessen Aktivierungschwelle beispielsweise durch den Einsatz von Ethanol als TRP-Modulator noch gesenkt werden kann. Dadurch lässt sich das sensorische Wärmeempfinden durch TRP V1-Agonisten, wie zum Beispiel Extrakte aus Chilli, Szechuan Pfeffer oder Senf durch den Einsatz noch geringerer Konzentrationen erreichen.In a liquid developed for the electronic cigarette, several of these TRP channel activators can be used, which, under certain conditions, can further enhance the sensory properties when combined. The TRP V1, for example, is a temperature-sensitive channel, the activation threshold of which can be lowered, for example, by using ethanol as a TRP modulator. This enables the sensory heat sensation to be achieved by TRP V1 agonists, such as extracts from chilli, Szechuan pepper or mustard, by using even lower concentrations.

Durch das synergetische Zusammenwirken von TRP-Agonisten und Modulatoren bietet sich eine einzigartige Basis für die chemosensorische Nachahmung von inhaliertem Zigarettenrauch, ohne dass der Einsatz von durch Verbrennung entstandenen, oftmals kanzerogenen Stoffen notwendig ist. Durch den Einsatz von TRP Aktivatoren wird die Nachahmung von subjektiven und physiologischen chemosensorischen Erfahrungen, wie beispielsweise das Inhalieren von Zigarettenrauch, ermöglicht. Bekannte TRP-Aktivatoren sind beispielsweise Extrakte aus schwarzem Pfeffer, Meerrettich, Knoblauch, Paprika, Zimt, Minze und weiteren bekannten TRP-Kanäle aktivierenden Stoffen, sowie Essig- und Zitronensäure. Durch Nutzung eines komplexen Gemisches dieser Wirkstoffe kann die Aktivierungsfähigkeit sowohl breit gefächert als auch potenziert werden. Zudem unterstützt der Einsatz geringer Konzentrationen dieser Aktivatoren im Liquid die Fähigkeit der Rezeptoren für eine schnelle Desensibilisierung, so dass nach nur kurzer Zeit (im Rahmen eines Inhalationsintervalls einer elektrischen Zigarette) die chemosensorische Stimulation erneut und in voller Empfindungsgröße erfolgen kann.The synergetic interaction of TRP agonists and modulators offers a unique basis for the chemosensory imitation of inhaled cigarette smoke without the use of often carcinogenic substances resulting from combustion. The use of TRP activators makes it possible to imitate subjective and physiological chemosensory experiences, such as inhaling cigarette smoke. Known TRP activators are, for example, extracts from black pepper, horseradish, garlic, paprika, cinnamon, mint and other known TRP channels activating substances, as well as acetic and citric acid. By using a complex mixture of these active ingredients, the activation ability can be both diversified and potentiated. In addition, the use of low concentrations of these activators in the liquid supports the ability of the receptors for rapid desensitization, so that after only a short time (within the inhalation interval of an electric cigarette) the chemosensory stimulation can take place again and in full sensation size.

Als zur Nachahmung der chemosensorischen Auswirkungen von Tabakrauch zu nutzende TRP-Aktivatoren bieten sich erfindungsgemäß die Wirkstoffe an: 6-Paradol, 1'-Acetoxychavicolacetat, Isothiocyanate, Kampfer, Paradieskörner und Thymol. Unter weiteren werden diese Aktivatoren in den Liquid-Mixturen verwendet. Die erfindungsgemäße flüssige Zusammensetzung ermöglicht es, jeden einzelnen TRP-Kanal (TRP A1, TRP V1, TRP V3 und TRP M8) zu aktivieren. Die Aktivierung eines jeden einzelnen TRP-Kanals mit den jeweiligen Aktivatoren ist hierbei maßgeblich, um ein entsprechendes tabakrauchähnliches Inhalationsempfinden zu erzielen. Die Aktivierung nur eines einzelnen Kanals ist somit typischer Weise nicht ausreichend. So beruht beispielsweise die gewünschte Einbeziehung auch des TRP M8 Rezeptors in die Funktionsbasis auf dessen Fähigkeit durch Stimulanz/Aktivierung den durch das Inhalationsempfinden hervorgerufenen Hustenreiz zu unterdrücken. Somit ist zur Erreichung des gewünschten Ergebnisses oft eine komplexe Zusammensetzung unterschiedlicher Aktivatoren zusammen mit einer geeigneten Auswahl an Modulatoren notwendig. Erfindungsgemäß wurde überraschend gefunden, dass bei kombiniertem Einsatz von 6-Paradol als Aktivator zusammen mit Glycerin als Modulator besonders gute Erfolge bei der Aktivierung eines jeden einzelnen TRP-Kanals erzielt werden. Dies gilt insbesondere und bevorzugt, wenn das Glycerin ein Viertel oder mehr, und vorzugsweise zwei Drittel oder weniger der flüssigen Zusammensetzung ausmacht (bezogen auf das Gewicht, hier ausgedrückt in "%", also in Gewichtsprozent). Gewichtsanteile des Glycerins sind dabei 30% oder mehr, weiter bevorzugt 33% oder mehr, noch weiter bevorzugt 36% oder mehr und insbesondere bevorzugt 39% oder mehr. Obergrenzen des Gewichtsanteils des Glycerins liegen bei 55% oder weniger, mehr bevorzugt 50% oder weniger, noch mehr bevorzugt 45% oder weniger und insbesondere bevorzugt 41% oder weniger. Die besten Ergebnisse werden mit einem bevorzugten Gewichtsanteil des Glycerins von 40% erzielt. In der erfindungsgemäßen flüssigen Zusammensetzung beträgt der Gewichtsanteil des Glycerins ausgedrückt in Gewichtsprozent demnach 30% bis 55%, mehr bevorzugt 33% bis 50%, noch mehr bevorzugt 36% bis 45%, und insbesondere bevorzugt 39% bis 41%.As TRP activators to be used to imitate the chemosensory effects of tobacco smoke, the active compounds according to the invention are: 6-paradol, 1'-acetoxychavicol acetate, isothiocyanates, camphor, grains of paradise and thymol. Among other things, these activators are used in the liquid mixtures. The liquid composition according to the invention makes it possible to activate each individual TRP channel (TRP A1, TRP V1, TRP V3 and TRP M8). The activation of each individual TRP channel with the respective activators is decisive in order to achieve a corresponding inhalation sensation similar to tobacco smoke. The activation of a single channel is typically not sufficient. So For example, the desired inclusion of the TRP M8 receptor in the functional basis is based on its ability to suppress the cough caused by inhalation through stimulation / activation. A complex combination of different activators together with a suitable selection of modulators is often necessary to achieve the desired result. According to the invention, it was surprisingly found that when 6-paradol is used in combination as an activator together with glycerol as a modulator, particularly good results are achieved in the activation of each individual TRP channel. This applies in particular and preferably if the glycerol makes up a quarter or more, and preferably two thirds or less, of the liquid composition (based on the weight, here expressed in “%”, ie in percent by weight). Weight percentages of the glycerol are 30% or more, more preferably 33% or more, even more preferably 36% or more and particularly preferably 39% or more. Upper limits of the weight fraction of glycerol are 55% or less, more preferably 50% or less, even more preferably 45% or less and particularly preferably 41% or less. The best results are achieved with a preferred weight percentage of glycerol of 40%. In the liquid composition according to the invention, the weight fraction of the glycerol, expressed in percent by weight, is accordingly 30% to 55%, more preferably 33% to 50%, even more preferably 36% to 45%, and particularly preferably 39% to 41%.

Besonderer Wert wurde erfindungsgemäß gleichzeitig darauf gelegt, dass die Zusammensetzung ein sehr geringes allergenes Potential besitzt. Allenfalls das hier in einigen beispielhaften Ausführungsformen zu einem Gewichtsanteil von 0,0049% - 0,0051% verwendete, aus Senfkörnern gewonnene, Allicin steht im Verdacht allergene Reaktionen auszulösen. Die weiteren erfindungsgemäß eingesetzten Bestandteile, insbesondere Glycerin und 6-Paradol lösen demgegenüber regelmäßig keine allergene Reaktionen aus.According to the invention, particular importance was attached to the fact that the composition has a very low allergenic potential. At most, the allicin obtained from some mustard seeds, which is used here in a few exemplary embodiments in a weight fraction of 0.0049% - 0.0051%, is suspected of triggering allergenic reactions. In contrast, the other constituents used according to the invention, in particular glycerol and 6-paradol, do not regularly trigger any allergenic reactions.

Grundsätzlich basieren TRP Aktivatoren auf den Bestandteilen der TRP-Kanal Subtypen. Durch die Verwendung von Wirkstoffmixturen entsteht die Möglichkeit, diverse TRP-Kanäle in variablen Intensitäten durch ebenfalls variabel lange Zeitbögen zu aktivieren oder deaktivieren. Diese Steuerung betrifft nicht nur die Intensität und Zeitbögen, sondern auch den lokalen Raum, indem das chemosensorische Empfinden stattfindet, wie zum Beispiel: Mundhöhle, Rachen, Lungenraum. Diesbezügliche Tests haben aufgezeigt, dass durch die Aktivierung eines Subkanals das eigentliche chemosensorische Empfinden verstärkt wird ohne den eigentlichen Wirkstoff dafür in der Konzentration anheben zu müssen.Basically, TRP activators are based on the components of the TRP channel subtypes. Through the use of active ingredient mixtures, it is possible to activate or deactivate various TRP channels in variable intensities by means of time slots of variable length. This control affects not only the intensity and time sheets, but also the local space by the chemosensory sensation takes place, such as: oral cavity, pharynx, lung. Tests in this regard have shown that activating a subchannel increases the actual chemosensory sensation without having to increase the concentration of the actual active ingredient.

Die nachfolgend dargestellten Wirkstoffe haben die Eigenschaft, sogenannte TRP Kanäle im menschlichen Körper chemosensorisch zu aktivieren, da beim Menschen TRP-Kanäle eine wichtige Rolle bei der Wahrnehmung von Geschmack (süß, sauer, umami), Pheromonen, Temperatur (warm, heiß, kalt), Schmerz u. a. spielen.The active substances shown below have the property of activating so-called TRP channels in the human body chemosensory, since in humans TRP channels play an important role in the perception of taste (sweet, sour, umami), pheromones, temperature (warm, hot, cold) , Pain u. a. play.

Als Basisbestandteil mit teilweise modulatorischen Fähigkeiten der Liquid-Mixturen kann neben Glycol und Glycerin auch Ethanol, gegebenenfalls zusätzlich einen oder auch mehrere flüchtige Agonisten der TRPA1, TRPV1, TRPV3 und/oder TRPM8 Kanäle, sowie erforderlichenfalls flüchtige, niedermolekulare Carbonsäure und Aromastoffe herangezogen werden.In addition to glycol and glycerin, ethanol, optionally also one or more volatile agonists of the TRPA1, TRPV1, TRPV3 and / or TRPM8 channels, as well as, if necessary, volatile, low-molecular carboxylic acid and flavoring substances can be used as a basic component with partially modulatory capabilities of the liquid mixtures.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus der Chilischote, welches durch inhalative Aufnahme den TRP Rezeptor TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from the chilli pepper, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt des schwarzen Pfeffers, welches durch inhalative Aufnahme den TRP Rezeptor TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract of the black pepper, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Zingiberaceae (Ingwergewächsen), welches durch inhalative Aufnahme den TRP Rezeptor TRP-1 und TRP-2 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from Zingiberaceae (ginger family), which activates the TRP receptor TRP-1 and TRP-2 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Isothiocyanaten, welches durch inhalative Aufnahme den TRP Rezeptor TRPA1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract of isothiocyanates, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Nelken, welches durch inhalative Aufnahme den TRP Rezeptor TRPA1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from cloves, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Kampfer, welches durch inhalative Aufnahme den TRP Rezeptor TRPV1 + TRPV2 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from camphor, which activates the TRP receptor TRPV1 + TRPV2 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Aframomum Melegueta (Paradieskörner), welches durch inhalative Aufnahme den TRP Rezeptor TRPA1 + TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from Aframomum Melegueta (grains of paradise), which activates the TRP receptor TRPA1 + TRPV1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Zanthoxylum piperitum (Szechuanpfeffer), welches durch inhalative Aufnahme den TRP Rezeptor TRPA1 + TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from Zanthoxylum piperitum (Szechuan pepper), which activates the TRP receptor TRPA1 + TRPV1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Thymian, welches durch inhalative Aufnahme den TRP Rezeptor TRPV3 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract of thyme, which activates the TRP receptor TRPV3 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus der Pfefferminze, welches durch inhalative Aufnahme den TRP Rezeptor TRPM8 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from peppermint, which activates the TRP receptor TRPM8 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus der Vanille, welches durch inhalative Aufnahme den TRP Rezeptor TRPV3 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from the vanilla, which activates the TRP receptor TRPV3 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist ein Extrakt aus Eukalypten, welches durch inhalative Aufnahme den TRP Rezeptor TRPM8 aktiviert und eine chemosensorische Reaktion hervorruft.One component of differently concentrated liquid mixtures for electrical evaporation is an extract from eucalyptus, which activates the TRP receptor TRPM8 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung sind Aromenauszüge, die durch inhalative Aufnahme den TRP Rezeptor TRPM8 aktivieren und eine chemosensorische Reaktion hervorruft.A component of differently concentrated liquid mixtures for electrical evaporation are flavor extracts that activate the TRP receptor TRPM8 by inhalation and cause a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist Coffein, das durch inhalative Aufnahme den TRP Rezeptor TRPA1 aktiviert und eine chemosensorische Reaktion hervorruft.A component of differently concentrated liquid mixtures for electrical evaporation is caffeine, which activates the TRP receptor TRPA1 by inhalation and causes a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung sind niedermolekularische organische Säuren, die durch inhalative Aufnahme einen TRP Rezeptor aktivieren und eine chemosensorische Reaktion hervorruft.A component of differently concentrated liquid mixtures for electrical evaporation are low molecular weight organic acids, which activate a TRP receptor by inhalation and cause a chemosensory reaction.

Ein Bestandteil unterschiedlich konzentrierter Liquid-Mixturen zur elektrischen Verdampfung ist Ethanol, das durch inhalative Aufnahme den TRP Rezeptor TRPV1 aktiviert und eine chemosensorische Reaktion hervorruft.A component of differently concentrated liquid mixtures for electrical evaporation is ethanol, which activates the TRP receptor TRPV1 by inhalation and causes a chemosensory reaction.

Diese unterschiedlich konzentrierten Bestandteile diverser Liquid-Mixturen können nahezu beliebig miteinander kombiniert werden, um in einer einzelnen Mixtur unterschiedliche TRP-Kanäle zu aktivieren und chemosensorisch zu stimulieren.These differently concentrated components of various liquid mixtures can be combined with one another in almost any way, in order to activate different TRP channels in a single mixture and to stimulate them chemosensively.

Die oben genannten unterschiedlichen Bestandteile für Liquid-Mixturen sowie die entsprechende Kombination daraus, welche so ausgewählt wird, dass der gewünschte TRP-Kanal bzw. eine mehrere verschiedene TRP-Kanäle aktiviert werden, löst die Aufgabe der vorliegenden Erfindung. Durch die erfindungsgemäßen Liquid-Mixturen wird ein "echtes" Rauchgefühl vermittelt, d.h. der bereits beschriebene "Flash" erfolgt, ohne dass dabei Giftstoffe wie Nikotin zum Einsatz kommen. Wie bereits erwähnt, reichen geringste Bestandteile der Extrakte in dem Liquid aus, um den erwünschten Effekt zu erzielen.The above-mentioned different constituents for liquid mixtures and the corresponding combination thereof, which is selected in such a way that the desired TRP channel or one of several different TRP channels are activated, achieve the object of the present invention. The liquid mixtures according to the invention convey a "real" feeling of smoking, i.e. the "flash" already described takes place without the use of toxins such as nicotine. As already mentioned, the smallest components of the extracts in the liquid are sufficient to achieve the desired effect.

In einem Versuch wurden hundertfünfzig freiwillige Probanden gebeten, verschiedene flüssige Zusammensetzungen für eine elektronische Zigarette zur Raucherzeugung einzusetzen und das dabei erlebte Inhalationsempfinden auf einer Skala von 1 bis 6 zu bewerten. Dabei wurde mit "1" ein besonders gutes tabakrauchähnliches Empfinden benotet, und mit "6" ein besonders schlechtes tabakrauchähnliches Empfinden. Die Zusammensetzungen wurden ausgehend von folgender Zusammensetzung hergestellt:

  • Propylenglycol: 45%
  • Glycerin: 40%
  • Lebensmittelaromen: 10%
  • Ethanol: 4,8%
  • wobei die Zusammensetzung ferner enthält:
    • Piper nigrum: 0,122%
    • Melegueta Aframomum: 0,035%
    • Benzoe: 0,013%
    • Allicin: 0,0050%
  • Isothiocyanat: 0,007%
  • Zingiberis rhizoma: 0,0042%
  • Capsaicin: 0,0041%
  • Zanthoxylum piperitum: 0,0062%
  • Kurkumin: 0,0035%.
In an experiment, a hundred and fifty volunteers were asked to use various liquid compositions for an electronic cigarette to generate smoke and to rate the inhalation sensation experienced on a scale of 1 to 6. "1" was a particularly good one Rating similar to tobacco smoke, and with "6" a particularly bad feeling similar to tobacco smoke. The compositions were prepared from the following composition:
  • Propylene glycol: 45%
  • Glycerin: 40%
  • Food flavors: 10%
  • Ethanol: 4.8%
  • the composition further comprising:
    • Piper nigrum: 0.122%
    • Melegueta Aframomum: 0.035%
    • Benzoin: 0.013%
    • Allicin: 0.0050%
  • Isothiocyanate: 0.007%
  • Zingiberis rhizoma: 0.0042%
  • Capsaicin: 0.0041%
  • Zanthoxylum piperitum: 0.0062%
  • Curcumin: 0.0035%.

Zusammensetzungen mit anderen Gewichtsanteilen an Glycerin wurden durch entsprechendes Erniedrigen oder Erhöhen des Anteils hergestellt, wobei der Propylenglycolgehalt entsprechend angepasst wurde, um Zusammensetzungen mit gleichen Gesamtgewichten herzustellen. Die Benotungen der hergestellten elf Zusammensetzungen (Zusammensetzungen 1a bis 11a) durch die Probanden wurden gemittelt und sind in nachfolgender Tabelle 1 zusammengefasst: Tabelle 1 Zusammensetzung Nr. Glyceringehalt (Gew.%) Durchschnittliche Benotung 1a 0 4,1 2a 10 3,8 3a 20 3,5 4a 30 2,5 5a 40 1,4 6a 50 2,4 7a 60 2,9 8a 70 3,7 9a 80 4,0 10a 90 4,3 11a 100 4,7 Compositions with different proportions by weight of glycerin were prepared by lowering or increasing the proportion accordingly, with the propylene glycol content being adjusted accordingly to produce compositions with equal total weights. The ratings of the eleven compositions produced (compositions 1a to 11a) by the subjects were averaged and are summarized in Table 1 below: Table 1 Composition No. Glycerol content (% by weight) Average rating 1a 0 4.1 2a 10th 3.8 3a 20th 3.5 4a 30th 2.5 5a 40 1.4 6a 50 2.4 7a 60 2.9 8a 70 3.7 9a 80 4.0 10a 90 4.3 11a 100 4.7

In einem weiteren Versuch wurden die Probanden gebeten, Zusammensetzungen wie in obiger Tabelle 1 zur Raucherzeugung einzusetzen und das Inhalationsempfinden wiederum gemäß obiger Notenskala zu beurteilen. Der Unterschied bestand jedoch darin, dass statt Melegueta Aframomum die gleiche Menge Borneol als TRP-Agonist/Aktivator in den Zusammensetzungen (Zusammensetzungen 1b bis 11b) enthalten war. Die entsprechenden Benotungen durch die Probanden wurden wiederum gemittelt und sind in nachfolgender Tabelle 2 zusammengefasst: Tabelle 2 Zusammensetzung Nr. Glyceringehalt (Gew.%) Durchschnittliche Benotung 1b 0 5,3 2b 10 4,9 3b 20 4,5 4b 30 3,4 5b 40 2,6 6b 50 3,5 7b 60 4,9 8b 70 4,8 9b 80 5,1 10b 90 5,3 11b 100 5,7 In a further experiment, the subjects were asked to use compositions as in Table 1 above for smoke generation and to assess their inhalation sensation again according to the scale above. The difference, however, was that instead of Melegueta Aframomum the same amount of borneol as TRP agonist / activator was contained in the compositions (compositions 1b to 11b). The corresponding ratings by the test subjects were again averaged and are summarized in Table 2 below: Table 2 Composition No. Glycerol content (% by weight) Average rating 1b 0 5.3 2 B 10th 4.9 3b 20th 4.5 4b 30th 3.4 5b 40 2.6 6b 50 3.5 7b 60 4.9 8b 70 4.8 9b 80 5.1 10b 90 5.3 11b 100 5.7

Es zeigt sich, dass die erfindungsgemäße Kombination von TRP-Agonisten/Aktivator 6-Paradol (hier Melegueta Aframomum) und Glycerin als TRP-Modulator bei allen vergleichbaren Zusammensetzungen zu einer um in der Regel mindestens eine Note besseren Beurteilung des Inhalationsempfindens als tabakrauchähnlich führte. Ferner zeigt sich deutlich, dass die erfindungsgemäß bevorzugten Glyceringehalte zu einer weiteren Steigerung des positiven Inhalationsempfindens führten.It can be seen that the combination according to the invention of TRP agonist / activator 6-paradol (here Melegueta Aframomum) and glycerol as TRP modulator in all comparable compositions led to a generally better assessment of the inhalation sensation than that similar to tobacco smoke. It can also be clearly seen that the glycerol contents preferred according to the invention led to a further increase in the positive inhalation sensation.

Claims (9)

  1. A liquid composition for an electronic cigarette, comprising:
    - glycerol as a TRP modulator, wherein the weight fraction of the glycerol, expressed in weight percent, is 30% to 55%, and
    - at least one TRP agonist / activator selected from 6-paradol, 1'-acetoxychavicol acetate, isothiocyanates, camphor, grains of paradise, and thymol, wherein
    the interaction of the modulator and the at least one agonist / activator results in a chemosensory imitation of inhaled cigarette smoke, and
    - wherein the liquid composition contains no nicotine.
  2. The liquid composition according to claim 1, wherein the at least one TRP agonist / activator activates at least one of the TRP receptors TRPA1, TRPV1, TRPV3 and TRPM8.
  3. The liquid composition according to claim 1 or 2, wherein one or more further TRP agonists / activators are contained, which are combined with one another in such a way that different TRP channels are activated.
  4. The liquid composition according to any one of claims 1 to 3, wherein one or more extracts comprising black pepper, horseradish, garlic, paprika, cinnamon, mint and acetic acid and citric acid serve as further TRP agonist / activator.
  5. The liquid composition according to one of the preceding claims, wherein ethanol or glycol serve as a further modulator.
  6. The liquid composition according to one of the preceding claims, wherein the weight fraction of the glycerol, expressed in weight percent, is 33% to 50%, more preferably 36% to 45%, and particularly preferably 39% to 41%.
  7. The liquid composition for an electronic cigarette according to one of the preceding claims, comprising:
    propylene glycol: 40% to 50%
    glycerols: 36% to 44%
    food flavours: 9% to 11%
    ethanol: 4.3% to 5.3%,
    Piper nigrum: 0.12% to 0.13%
    Melegueta Aframomum: 0.03% to 0.04%
    benzoin: 0.012% to 0.014%
    allicin: 0.0049% to 0.0051%
    isothiocyanate: 0.006% to 0.008%
    Zingiberis rhizoma: 0.0038% to 0.0047%
    capsaicin: 0.0037% to 0.0046%
    Zanthoxylum piperitum: 0.0056% to 0.0069%
    curcumin: 0.0031% to 0.0039%.
  8. The liquid composition for an electronic cigarette according to claim 7, consisting of:
    propylene glycol: 45%
    glycerol: 40%
    food flavours: 10%
    ethanol: 4.8%
    Piper nigrum: 0.122%
    Melegueta Aframomum: 0.035%
    benzoin: 0.013%
    allicin: 0.0050 %
    isothiocyanate: 0.007%
    Zingiberis rhizoma: 0.0042%
    capsaicin: 0.0041%
    Zanthoxylum piperitum: 0.0062%
    curcumin: 0.0035%.
  9. Use of a liquid composition according to one of the preceding claims to inhale cigarette smoke.
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