KR20180094868A - Strength enhancers and methods for achieving strength enhancement in electronic smoking devices - Google Patents

Abstract

For electronic smoking device (60) Wherein the vaporization-pre-formulation is provided with a vapor forming agent comprising at least one of propylene glycol and glycerol, and at least one of a carbamate, thymol, monomenthyl succinate, N- (2-hydroxyethyl) 3-dimethyl-2-isopropylbutanamide. ≪ / RTI > An electronic smoking device (20) including a catheter (70) including a reservoir (14) containing a vaporization agent, a mouse-end piece, and a heater (19) configured to heat the vaporization agent 60 are provided. The electronic smoking device 60 is connected to the catheter 70 and includes a puff sensor 16 configured to sense a puff occurring at the mouth-end piece, and a puff sensor 16 configured to power the heater 19 Further comprising a power supply portion including a power supply.

Description

Strength enhancers and methods for achieving strength enhancement in electronic smoking devices

BACKGROUND OF THE INVENTION Field of the Invention [0001] The present invention relates generally to a vapor-phase preparation for an electronic smoking device. Particularly, the present invention relates to a strength-enhancing agent in a vapor-phase preparation.

An electronic smoking device (or an e-smoking device) is used to vaporize a pre-vaporizer, such as, for example, a liquid material, by steam to an adult smoker to inhale the vapor. Electronic smoking devices are typically used to vaporize the vaporization- And a heater for generating steam. The electronic smoking device may comprise a plurality of electronic smoking elements, including a power source, a cartridge containing a heater or an electronic smoking tank, and a reservoir containing a vaporization agent.

Cigarette-based smoking articles produce vapors that are known to produce the sensory experience desired by adult smokers, including low to moderate harsh feelings in the throat and warm feelings and intensity in the chest of adult smokers.

For electronic smoking devices, the intensity of the steam, which is typically understood as the rough feeling of steam, and the sensation experienced in the chest of an adult smoker, as is typically understood as a feeling experienced in the throat of an adult smoker, May vary based on the content and concentration of the vaporization-prep agent used to form the vapor during the < Desc / Clms Page number 7 > Typically, for similar amounts of nicotine in vaporization-prime formulations, the electronic smoking apparatus has a rougher feel than the tobacco-based product, but has a lower strength than the tobacco-based product. In addition, as the amount of nicotine in the vapor phase of the vapor generated by the electronic smoking device increases, the rough feeling of the electronic smoking device increases.

According to a first aspect, the present invention is directed to an electronic smoking device configured to achieve a desired balance of strength and roughness, wherein the strength is increased without increasing the rough feel.

According to a second aspect, the present invention relates to an electronic smoking device configured to provide an adult smoker with a sensory experience similar to the sensory experience enjoyed while smoking a cigarette-based product.

According to a third aspect, the present invention relates to an electronic smoking device which is configured to provide a sensory experience that includes roughness in the throat and strength and warmth in the chest at a level similar to that experienced when smoking a cigarette- . To achieve the desired balance of strength and rough feel, the strength of the electronic smoking article can be increased without increasing its rough feel.

According to a fourth aspect of the present invention, the gas phase-preform for an electronic smoking device comprises a vapor-forming agent and a mixture of one or more strength-enhancing agents or additives.

The vaporization-pre-formulation may comprise water, one or more acids, or both water and one or more acids.

The vaporization-precursor formulation can be a liquid formulation.

The vaporization-prerequisite may include nicotine.

The one or more strength enhancing agents or additives may comprise at least one of carbacrol, thymol, monomenthyl succinate, N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropylbutanamide.

In at least one embodiment, the one or more strength enhancers or additives may comprise at least one of cinnamaldehyde, menton, eugenol, gingerol or vanillylacetone and a firestone roll.

The at least one strength enhancer or additive is selected from the group consisting of capsicum, allyl isothiocyanate, piperine, iso eugenol, carbacol, thymol, menthol, monomenthyl succinate and N- (2- hydroxyethyl) And 2-isopropylbutane amide.

In at least one embodiment, the compounds as well as others are selected from the group consisting of, for example, horseradish oil, garlic extract, onion oil, pepper, cayenne pepper, ginger oil, Oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil, and andrographis extract. The one or more strength enhancers or additives may comprise at least one of these extracts.

The one or more strength enhancers or additives may be selected from the group consisting of transient receptor potential cation channels, subfamily A, member 1 (transient receptor potential cation channel, subfamily A, member 1, TRPA1), transient receptor potential cation channel subfamily V member 1 (TPRV1) A receptor in the respiratory tract of an adult smoker, or one or more compounds that activate the nicotinic-acetylcholine receptors of an adult smoker, wherein the agents are part of the smoker and are carried in the respiratory tract of an adult smoker during smoking .

In at least one embodiment, the one or more strength enhancers or additives may include one or more of the above compounds in a composition range of from about 0.0001% to about 1%, or a concentration range of up to 2%, than others. Optionally, the concentration of the one or more strength enhancers or additives may be greater than about 2% when several strength enhancers are used in combination. For example, the total concentration of strength enhancer may be up to about 5%.

In at least one embodiment, the rough feel reducing compounds, such as acids, may be included in the vaporization-prone formulations to achieve the desired balance of increased strength and reduced rough feel in electronic smoking devices.

In at least one embodiment, the one or more strength enhancers or additives may be used in a pre-vaporizer formulation that does not contain nicotine, and wherein the one or more strength enhancers or additives are selected from the group consisting of nicotine- Provides a level of strength similar to the strength experienced. For example, such strength enhancers or additives may be included in a smoking hose.

In at least one embodiment, the one or more strength enhancers or additives increase the strength of the electronic smoking device without increasing the transmission of nicotine and without increasing the rough feel of the smoking article.

The gas phase-agent may comprise nicotine in an amount of from about 0.5 wt.% To about 2 wt.% Or more, or from about 0.5 wt.% To about 5 wt.% Or more. In at least one embodiment, the vapor formed by the vapor former comprises gaseous and particulate phases, and the concentration of nicotine in the vapor phase is less than about 1%.

According to a fifth aspect of the present invention, the vaporization-pre-formulation of the electronic smoking device comprises a vapor forming agent, from about 0.5% to about 2% or more of nicotine in an amount from about 0.5% to about 5% One or more strength enhancers or a mixture of additives. In at least one embodiment, the vapor formed by the vapor former comprises gaseous and particulate phases, and the concentration of nicotine in the vapor phase is less than about 1%. The vaporization-pre-formulation may comprise water, one or more acids, or both water and one or more acids. The vaporization-precursor formulation can be a liquid formulation. The one or more strength enhancers or additives may comprise one or more of the optional or preferred strength enhancers or additives according to the fourth aspect of the present invention.

The pre-vaporization agent according to the fourth or fifth aspect of the present invention may comprise one or more acids. The gas phase-agent may comprise one or more acids at a concentration of about 0.1% to about 5%.

The at least one acid may have a boiling point of at least about 100 캜 and may be configured to be volatile when heated by a heater in an electronic smoking device. The vaporization-prerequisite may be configured to form a vapor having a particulate phase and a vapor phase when heated by a heater in an electronic smoking apparatus, the particulate phase containing quantized nicotine and the vapor phase containing non-quantized nicotine. In embodiments, the vapor has a large amount of quantized nicotine and a small amount of unquantized nicotine.

In at least one embodiment, the vaporization-prime agent is configured to form a vapor having a nicotine vapor phase component during operation of the electronic smoking device. The acid may be included in an amount sufficient to reduce the nicotine vapor component by about 70% or more. In other embodiments, the addition of one or more acids may reduce the gaseous nicotine content in an amount in the range of about 40 wt% to 70 wt%, or in the range of about 40 wt% to 90 wt%.

In at least one embodiment, the acid may be selected to have a conversion efficiency from vapor to liquid of at least about 50%. The acid may be present in an amount sufficient to reduce the nicotine vapor phase component.

In at least one embodiment the acid is selected from the group consisting of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, malic acid, tartaric acid, succinic acid, citric acid, benzoic acid, oleic acid, Butanedioic acid, lauric acid, lauric acid, isobutyric acid, lauric acid, isobutyric acid, lauric acid, At least one of 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid and sulfuric acid.

In at least one embodiment, the acid comprises pyruvic acid, lactic acid, benzoic acid, and acetic acid.

The vapor forming agent may comprise propylene glycol and glycerol or glycerin. The vapor forming agent may comprise substantially the same concentration of propylene glycol and glycerol or glycerin.

The vaporization-pre-formulation may comprise water at a concentration of from about 10% to about 20%.

According to a sixth aspect of the present invention, an electronic smoking device includes a first portion and a second portion. The first part may be, for example, a vapor-former preparation reservoir, a heater, a wick in communication with the heater, a mouth-end piece communicating with the vaporization-precursor reservoir, and a vapor- And a connector at the distal end of the first portion. The second portion includes a power supply and a connector at the proximal end of the second portion configured to mate with the connector of the first portion.

According to a seventh aspect of the present invention, an electronic smoking device includes a first portion and a second portion. The first part may be a catomizer. The first part contains a vaporization-prep agent reservoir, a heater and a mouse end piece including a vaporization-prep agent. The heater is configured to heat the vaporization precursor formulation. The second portion may be a power supply portion. The second portion includes a power source configured to power the heater. The vaporization precursor may be a vaporization precursor according to the fourth or fifth aspect of the present invention, according to any one of the embodiments described herein.

The first portion may include a wick in communication with the vaporization-pre-agent reservoir and in communication with the heater. The first portion may include a connector at the distal end of the first portion.

The second portion may include a puff sensor configured to sense a puff occurring at the mouth-end piece. The second portion may include a connector at the proximal end of the second portion configured to mate with the connector of the first portion.

BRIEF DESCRIPTION OF THE DRAWINGS The foregoing and other features and advantages of an illustrative embodiment will become more apparent by describing in detail exemplary embodiments thereof with reference to the accompanying drawings. The accompanying drawings are intended to depict exemplary implementations and should not be construed as limiting the scope of the claims. The accompanying drawings are not to be construed as limitations, unless expressly stated to the contrary.
1 is a side view of an electronic smoking device according to an exemplary embodiment;
2 is a cross-sectional view of an electronic smoking device according to an exemplary embodiment;
3 is a cross-sectional view of another exemplary embodiment of an electronic smoking device.

Some detailed exemplary implementations are disclosed herein. However, the specific structural and functional details disclosed herein are merely representative examples for illustrating exemplary implementations. However, the exemplary implementations are implemented in many alternative forms and should not be construed as limited to the implementations described herein.

Thus, while the illustrative embodiments are susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and will be described in detail herein. It should be understood, however, that it is not intended that the exemplary implementations be limited to the particular forms disclosed, but on the contrary, the illustrative embodiments include all modifications, equivalents, and alternatives falling within the scope of example implementations. The same reference numerals denote the same elements throughout the description of the drawings.

When an element or layer is referred to as being "on", "connected to", "coupled to" or "covering" another element or layer, it may be bonded, It is to be understood that elements or layers may also be present. In contrast, when an element is referred to as being "directly on", "directly connected", or "directly bonded" to another element or layer, there are no intervening elements or layers present. Like numbers refer to like elements throughout.

Although the terms first, second, third, etc. may be used herein to describe various elements, components, regions, layers or portions, these elements, components, regions, layers, It should not be. These terms are only used to distinguish one element, element, region, layer or section from another element, element, region, layer or section. Thus, the first element, component, region, layer or portion discussed below may be referred to as a second element, component, region, layer or section without departing from the teachings of the exemplary embodiments.

The terms spatially relative (e.g., "under", "below", "under", "above", "above", "above", etc.) are used herein to refer to an element or feature Can be used to facilitate the description in describing the relationship. It is to be understood that spatially relative terms are intended to encompass different orientations of the device in use or operation as well as the orientations shown in the drawings. For example, if an apparatus in the figures is inverted, elements described as "below" or "below" another element or feature will be "on" another element or feature. Thus, the term "below" may include both top and bottom orientation. The device may be oriented in other ways (which may be rotated 90 degrees or in other orientations), and the spatially relative descriptors used herein may be interpreted accordingly.

The terminology used herein is for the purpose of describing various embodiments only and is not intended to limit the exemplary embodiments. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms, unless the context clearly indicates otherwise. The word "comprises," "comprises," and "comprising," when used in this specification, specify the presence of stated features, integers, steps, acts, elements, However, it will be understood that they do not preclude the presence or addition of one or more other features, numbers, steps, operations, elements, components or groups thereof.

Exemplary implementations are described herein with reference to cross-sectional views that are schematic illustrations of an ideal implementation (and intermediate features) of an exemplary implementation. As such, changes from the shape of the drawing are expected as a result of manufacturing techniques or tolerances. Thus, the exemplary implementations should not be construed as limited to the shapes of the regions illustrated herein, but should include variations in shape resulting from, for example, manufacture. Thus, the regions shown in the Figures are schematic in nature, and their shapes are not intended to illustrate the actual shape of the region of the device and are not intended to limit the scope of the exemplary embodiments.

Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the illustrative embodiment pertains. Terms, including those defined in commonly used dictionaries, shall be interpreted as having a meaning consistent with the meaning in the context of the relevant field and, unless explicitly defined herein, are to be construed as either ideal or overly formal Can not be done.

When the terms "about" or "substantially" are used in this specification in connection with numerical values, the associated numerical values are intended to include a tolerance of approximately 10% of the stated value. Moreover, when referring to percentages herein, these percentages are intended to be by weight, i.e., percent by weight. The expression "up to" includes the upper limit value represented by 0 and the amount of all the values therebetween. When a range is specified, the range includes all values in between, such as an increment of 0.1%.

As used herein, the term "vapor former" refers to any suitable known compound or compound that, in use, facilitates formation of vapor and is substantially resistant to thermal degradation at the operating temperature of the electronic smoking apparatus Lt; / RTI > Suitable steam-forming agents are, for example, various compounds such as polyhydric alcohols comprising at least one of propylene glycol and glycerol, or glycerin. In at least one embodiment, the vapor is propylene glycol.

1 is a side view of an electronic smoking device 60 according to an exemplary embodiment. 1, electronic smoking device 60 includes a first portion or catheter 70, a threaded joint 74 or other connection structure, or any other connection structure, such as snug fit, snap fit, detent, clamp, And a second portion 72 joined together by the second portion 72. In one embodiment, the first portion or catheter 70 may be a replaceable cartridge, and the second portion 72 may be a reusable portion. Alternatively, the first portion or catheter 70 and the second portion 72 may be integrally formed.

2 is a cross-sectional view of another exemplary embodiment of an electronic smoking device. 2, the first portion or catheter 70 includes a mouse end insert 20, a capillary vapor generator including a capillary 18, a heater 19 for heating at least a portion of the capillary 18 , And a reservoir 14, as shown in FIG.

The second portion 72 may receive the power supply 12, the control circuit 11 configured to control the power supply 12, and the puff circuit 16. The puff sensor is configured to sense when an adult smoker sucks the electronic smoking device 60 which causes operation of the power supply 12 through the control circuit 11 to activate the heater 19 and to cool the reservoir 14, The vaporization agent contained in the vaporization precursor is heated to form a vapor. The threaded portion 74 of the second portion 72 can be connected to the battery charger to charge the battery or power supply 12 when not connected to the first portion or the catheter 70.

As shown in Figure 3, in other exemplary embodiments, the valve 40 may be a bi-directional valve, and the reservoir 14 may be pressurized. For example, the reservoir 14 may be pressurized using a pressurization device 405 configured to apply a constant pressure to the reservoir 14. This facilitates the release of the vapor formed through the heating of the vaporization-prepellent agent contained in the reservoir 14. [

In the exemplary embodiments, the capillary 18 is formed of or comprises a conductive material, so that it acts as a heater 19 by itself passing the current through the tube. The capillary 18 may be any conductive material that can be heated by the resistor and not react with the vaporization-preformulation agent, while maintaining the structural integrity required at the operating temperature experienced by the capillary 18. Suitable materials for forming capillary 18 are one or more of stainless steel, copper, a copper alloy, a porous ceramic material coated with a membrane resistance material, a nickel-chromium alloy, and combinations thereof. For example, the capillary tube 18 is a stainless steel capillary tube 18 and functions as a heater 19 through electrical leads 26 attached for the passage of DC or alternating currents along the length of the capillary tube 18. Thus, the stainless steel capillary tube 18 is heated by resistance heating. Alternatively, the capillary 18 may be a non-metallic tube, such as, for example, a glass tube. In this embodiment, the heater 19 is formed of or comprises a conductive material that can be heated by a resistor, such as a stainless steel wire, a nichrome wire, or a platinum wire disposed along a glass tube. When the heater disposed along the glass tube is heated, the vaporization-pre-formulation in the capillary 18 is heated to a temperature sufficient to at least partially volatilize the vaporization-pre-formulation in the capillary 18.

In at least one embodiment, at least two electrical leads 26 are bonded to the metal capillary 18. One electrical lead 26 is coupled to the first upstream portion 101 of the capillary tube 18 and a second electrical lead 26 is connected to the downstream end portion 102 of the capillary tube 18. In one embodiment, .

In operation, when an adult smoker sucks the electronic smoking device, the puff sensor 16 senses the pressure gradient caused by the sucking of the adult smoker, and the control circuit 11 activates the heater 19, 14). ≪ / RTI > Once the capillary tube 18 is heated, the vaporized-before agent contained in the heated portion of the capillary tube 18 is volatilized and exited from the outlet 63, where the vaporized-before agent expands and mixes with the air to form the mixing chamber 240 ). ≪ / RTI >

The power supply 12 of the illustrative embodiment may include a battery disposed in the second portion 72 of the electronic smoking device 60. The power supply unit 12 is configured to apply a voltage to the heater 19, and the heater 19 volatilizes the vaporization-pretreating agent contained in the reservoir 14. [

In at least one embodiment, the electrical contacts or connections between the heater 19 and the electrical leads 26 are substantially conductive and temperature resistant, and the heater 19 is heated such that heat is generated primarily along the heater 19, And is substantially resistive.

The power supply or battery 12 may be rechargeable and may include circuitry to enable charging of the battery by an external charging device. In this case, the circuit supplies power for a predetermined number of suckings when it is charged, after which the circuit must be reconnected to the external charging device.

In at least one embodiment, the electronic smoking device 60 may comprise control circuitry, which may be present on the printed circuit board 11. The control circuit 11 may also include a heater working light 27 configured to illuminate when the heater 19 is activated. In at least one embodiment, the heater working light 27 includes at least one LED, and the heater working light 27 during the aspiration is directed to the electronic smoking device 60 so as to illuminate the cap shaped like the burning coal, As shown in FIG. In addition, the heater working light 27 may be configured to be visible to adult smokers. Light 27 may be configured to activate, deactivate, activate and deactivate light 27 when an adult smoker wishes, so that if desired, light 27 is not activated during smoking.

In at least one embodiment, the electronic smoking device 60 further comprises a mouse end insertion portion 20 having at least two off-axis branch outlets 21. As shown in FIG. In at least one embodiment, the mouse end insert 20 may include at least two branch outlets 21 (e.g., three to eight outlets). In at least one embodiment, the outlet 21 of the mouth end insertion portion 20 is located at the distal end of the stock passage 23 and is inclined outwardly (i.e., branched) with respect to the longitudinal direction of the electronic smoking apparatus 60 Loses. As used herein, the term "off-axis" refers to the angle with respect to the longitudinal direction of the electronic smoking apparatus. In addition, the mouse end insert (or flow guide) 20 may include uniformly distributed outlets around the mouse end insert 20 to distribute the vapor substantially uniformly within the mouth of an adult smoker during use .

In at least one embodiment, the electronic smoking device 60 is approximately the same size as a conventional cigarette. In some embodiments, the electronic smoking device 60 may have a length of from about 80 mm to about 110 mm, for example from about 80 mm to about 100 mm, and may be from about 7 mm to about 10 mm in diameter.

The outer cylindrical housing 22 of the electronic smoking device 60 may be formed of or comprise any suitable material or combination of materials. In at least one embodiment, the outer cylindrical housing 22 is formed at least in part of metal and includes an electrical connection 11 for connecting the control circuit 11, the power supply 12, the puff sensor 16, It becomes part of the circuit.

3 is a cross-sectional view of an electronic smoking device according to an exemplary embodiment. 3, the electronic smoking apparatus 60 may further include an intermediate portion (third portion) 73 capable of accommodating the liquid vaporization-pretreatment reservoir 14 and the heater 19. As shown in Fig. The intermediate portion 73 can be configured to fit into the threaded joint 74 'at the upstream end of the first portion or catheter 70 and fit into the threaded joint 74 at the downstream end of the second portion 72 have. In this exemplary embodiment, the first portion or catheter 70 receives the mouse-end insertion portion 20 and the second portion 72 receives power to the power supply 12 and the power supply 12 And receives the configured control circuit 11.

In at least one embodiment, the first portion or catheter 70, the second portion 72, and the third portion 73 are formed in an outer cylindrical housing (not shown) extending longitudinally along the length of the electronic smoking device 60, (22). Also, in at least one embodiment, the intermediate portion 73 is disposable and one or both of the first portion or the catomizer 70 and the second portion 72 are reusable. The portions 70,72 and 73 may be attached by threaded connections or connections 74 and 74'and the middle portion 73 may be replaced when the reservoir 14 is exhausted. In other embodiments, the first portion or catheter 70 may be replaceable so that one or both of the capillary 18 and the heater 19 need not be cleaned. In at least one embodiment, the first portion or catheter 70, the second portion 72, and the third portion 73 may be integrally formed without a screw connection to form a disposable electronic smoking device.

In the exemplary embodiment shown in FIG. 3, the reservoir 14 is a tubular and elongate body formed of, or comprising, an elastomeric material such that it is flexible, compressible, or both when compressed. In at least one embodiment, the elastomeric material may be one of silicon, plastic, rubber, latex, and combinations thereof.

In at least one embodiment, the reservoir 14 is in fluid communication with the capillary 18 so that when the reservoir 14 is squeezed, the reservoir 14 can deliver a vapor-phase agent, such as a volume of liquid material, to the capillary 18 . The power supply 12 is activated when manual pressure is applied to the reservoir 14 so that the capillary 18 is heated to form a heated portion where the vaporization-prep agent is volatilized . When released from the heated capillary 18, the volatilized material expands and mixes with the air to form a vapor.

3, the reservoir 14 includes a valve 40 configured to hold the liquid vaporization-pretreatment agent in the reservoir 14 and to open when the reservoir 14 is squeezed and pressure is applied to the reservoir 14, . In at least one embodiment, the valve 40 is opened when it reaches the minimum critical pressure to inadvertently prevent the vaporization-prep agent from dispensing from the reservoir 14 or activating the heater 19. In at least one embodiment, the pressure required to depress the pressure switch 44 is high enough to prevent accidental heating. This arrangement prevents activation of the heater 19 in the absence of a vaporization-prep agent pumped through the capillary.

Once the pressure in the reservoir 14 has been released, the valve 40 is closed and the heated capillary 18 discharges any vaporization-prep agent remaining downstream of the valve 40.

In at least one embodiment, the strength enhancer or additive may include cinnamaldehyde, menton, eugenol, gingerol or vanillylacetone and a firestorer. The strength enhancer may also be selected from the group consisting of capsicum, allyl isothiocyanate, piperine, iso eugenol, carbacol, thymol, menthol, monomenthyl succinate and N- (2-hydroxyethyl) Propyl butanamide. ≪ / RTI > Strength enhancers are receptors in respiratory tissues of adult smokers such as transient receptor potential cation channels, subfamily A, member 1 (TRPA1), transient receptor potential cation channel subfamily V member 1 (TPRV1), or nicotine- May contain one or more compounds that activate the cholinergic receptor agonist, receptors being part of the particulate matter, and being carried in particulate form in the respiratory tract of adult smokers during smoking.

In at least one embodiment, the compounds as well as others are selected from the group consisting of, for example, horseradish oil, garlic extract, onion oil, pepper, cayenne pepper, ginger oil, Oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil, and andrographis extract.

In at least one embodiment, the vaporization-prerequisite agent is present in a composition range of from about 0.0001% to about 1%, a concentration range of up to 2%, or greater than about 2% and less than about 2%, when the strength enhancer is a combination of multiple strength enhancers And may include one or more strength enhancers at a concentration of less than 5%. Strength enhancers can activate receptors in the respiratory tissues of adult smokers.

In at least one embodiment, the gas-phase agent, for example a liquid formulation, of an electronic smoking device comprises a vapor former, one or more strength enhancers, nicotine, one or more acids, and water.

The vaporization-pre-formulation optionally contains water. Water may be included in an amount ranging from about 5 wt% based on the weight of the vaporization precursor to about 40 wt% based on the weight of the vaporization precursor formulation. For example, water may be included at about 20% by weight, based on the weight of the vaporization precursor formulation.

The following examples describe various combinations and corresponding concentrations of strength-enhancing agents. The amount of nicotine in the various formulations may be from about 0.5% to about 1.5% or from about 0.5% to about 2%. A variety of strength enhancers are discussed above. The acids discussed below include those derived from pyruvic, formic, oxalic, glycolic, acetic, isovaleric, valeric, propionic, octanoic, lactic, sorbic, malic, tartaric, succinic, Heptanoic acid, hexanoic acid, 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methyl At least one of butyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid and sulfuric acid. The following examples of vaporization-ready agents will be discussed:

EXAMPLES Example 1: The vaporization-preform solution contains about a few ppm or from about 0.001% to about 0.1% of a strength enhancer or additive, from about 60% to about 80% of a vapor former (e.g., a substantially equal concentration of propylene glycol And glycerol), from about 10% to about 20% water, from about 0.5% to about 2% nicotine (NBW), and up to about 5% acid.

Example 2: The vaporization-preform solution comprises about 1% strength enhancer or additive, from about 60% to about 80% of a vapor forming agent (e.g., propylene glycol and glycerol), from about 15% to about 20% , And about 1 wt% to about 2 wt% nicotine (NBW) and up to about 3 wt% acid.

Example 3: The vaporization-preform solution comprises about 1.5% strength enhancer or additive, from about 60% to about 80% of a vapor forming agent (e.g., propylene glycol and glycerol), from about 15% to about 20% , From about 0.5 wt% to about 1.5 wt% nicotine (NBW), and up to about 1 wt% acid.

Example 4: The vaporization-preform solution comprises about 2% strength enhancer or additive, from about 60% to about 80% of a vapor forming agent (e.g., propylene glycol and glycerol), from about 15% to about 20% , About 0.5 wt% to about 2 wt% nicotine (NBW), and substantially no or about 0.1 wt% acid.

Example 5: The vaporization-preform solution comprises a combination of a plurality of strength enhancers or additives from about 2% to about 5%, from about 60% to about 80% of a vapor forming agent (e.g., propylene glycol and glycerol) From about 15% to about 20% water, from about 0.5% to about 2% nicotine (NBW) and substantially no or about 0.1% acid.

Example 6: The vaporization-prep formulations solution contains about 0.1% of cinnamaldehyde, menthone, eugenol, gingerone or vanillylacetone and a frit roll, from about 60% to about 80% of a vapor former (e.g., Propylene glycol and glycerol), from about 15% to about 20% water, from about 0.5% to about 2% nicotine (NBW), and up to about 5% acid.

Example 7: The vaporization-prep formulations solution contains one or more of about 1% cinnamaldehyde, menton, eugenol, gingerol or vanillylacetone and fumigant, about 60% to about 80% Propylene glycol and glycerol), from about 15% to about 20% water, from about 0.5% to about 2% nicotine (NBW), and up to about 3% acid.

Example 8: The vaporization-preform solution contains about 1.5% of cinnamaldehyde, one or more of menthone, eugenol, gingerol or vanillylacetone and a fiance roll, about 60% to about 80% From about 15% to about 20% water, from about 0.5% to about 2% nicotine (NBW), and up to about 1% acid, for example, propylene glycol and glycerol. Alternatively, the vaporization-pre-formulation comprises about 1.5% of cinnamaldehyde, menton, eugenol, gingerol or vanilliacetone and a combination of two or more of the firestone rolls.

Example 9: The vaporization-preform solution comprises about 2% cinnamaldehyde, a combination of menthone, eugenol, gingerol or vanilliacetone and a firestorer, about 60% to about 80% of a vapor former (e.g., Propylene glycol and glycerol), from about 15% to about 20% water, from about 0.5% to about 2% nicotine (NBW) and substantially free of acids.

Example 10: The vaporization-preform solution contains about 60% to about 80% of a vapor former (e.g., about 2% of cinnamaldehyde, menton, eugenol, gingerol or vanillylacetone, Propylene glycol and glycerol), about 15% to about 20% water, about 0.5% to about 2% nicotine (NBW), and substantially free acid. Alternatively, the vapor-phase agent comprises more than about 2% cinnamaldehyde, menthone, eugenol, gingerol or vanilliacetone and a combination of two or more of the ginger rolls.

Example 11: The vaporization-preform solution comprises about 0.1% to about 2.5% of a mixture of a mixture of carrot, garlic extract, onion oil, pepper, cayenne pepper, ginger oil, time oil, cinnamon bark oil, turmeric, (E.g., propylene glycol and glycerol), from about 15% to about 20% water, from about 0.5% to about 0.5% of a combination of a cardamom, rosemary extract, grapefruit oil and andrographite extract, from about 60% to about 80% Wt% to about 2 wt% nicotine (NBW) and up to about 5 wt% acid.

Example 12: A vaporization-preform solution for a smoking cessation device comprises about 0.1% to about 2% strength enhancer or additive, about 60% to about 80% of a vapor forming agent (e.g., propylene glycol and glycerol) % To about 20% water, from about 0.5% to about 2% nicotine (NBW), and from about 0.1% to about 5% acid.

In at least one embodiment, the action of the acid on the vapor produced from the vaporization-pretreating agent during operation of the electronic smoking device reduces the amount of rough feel of the throat, while the strength enhancer acts on the steam to increase the sense of strength of the steam. .

According to at least one exemplary embodiment, the acid has the ability to convert to a vaporized formulation. The conversion efficiency of the acid from the liquid to the vapor is the ratio of the mass fraction of the acid in the vaporized formulation to the mass fraction of the acid in the vaporization precursor. In at least one embodiment, the acid has a vaporized formulation such as a conversion efficiency from liquid to vapor of at least about 50%, such as at least about 60%. For example, pyruvic acid, lactic acid, oxalic acid, acetic acid, and glycolic acid have conversion efficiencies of greater than about 50% liquid to vapor. In at least one embodiment, the vaporization-pre-formulation comprises an acid having a conversion efficiency from vapor to liquid of at least about 50%. In other embodiments, the vaporization-pre-formulation excludes any acid having a conversion efficiency from vapor to liquid of less than about 25%.

According to at least one exemplary embodiment, the acid has a boiling point of at least about 100 < 0 > C and may be included in the vaporization-prep agent in an amount sufficient to control the pH of the vaporization-preformulation agent in the range of from about 3 to about 8.

According to at least one exemplary embodiment, the vaporization-prerequisite is selected from the group consisting of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, malic acid, But are not limited to, citric acid, benzoic acid, oleic acid, aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, 1-glutamic acid, heptanoic acid, 2-methylbutyric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid, sulfuric acid, and And combinations of these. Such an acid may be included in the form of a salt. The vaporization-pre-formulation also contains a vapor former, optionally water, nicotine and flavoring.

Thus, while exemplary implementations have been described, it will be apparent that the same may be varied in many ways. Such variations are not to be regarded as a departure from the intended scope of the exemplary embodiments, and all such modifications as would be obvious to one skilled in the art are intended to be included within the scope of the following claims.

Claims (20)

A vapor-phase pretreatment agent for an electronic smoking device, wherein the vaporization-
A vapor-forming agent comprising at least one of propylene glycol and glycerol; And
Wherein the additive comprises at least one selected from the group consisting of carboclor, thymol, monomenthyl succinate, and N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropylbutanamide. The pre-vaporization formulation of claim 1, further comprising nicotine. 3. The pre-vaporization formulation of claim 1 or 2, wherein the additive further comprises at least one of piperine, allyl isothiocyanate, capsicum, iso eugenol, and menthol. The method of any one of claims 1 to 3, wherein the additive is selected from the group consisting of gingerol, garlic extract, onion oil, time oil, cinnamon bark oil, turmeric oil, fenugreek, cardamon, rosemary extract, grapefruit oil, Wherein the composition is an extract from at least one of Lapis extract. 5. The method of any one of claims 1 to 4, wherein the additive further comprises an extract from at least one of cinnamaldehyde, menton, eugenol, sweet red pepper, pepper, cayenne pepper and ginger oil. Formulation. 6. The vapor-phase agent according to any one of claims 1 to 5, wherein the concentration of the additive is in the range of 0.0001% to 1%. The pre-vaporization agent according to any one of claims 1 to 6, wherein the concentration of the combination of the plurality of additives in the vaporization-preform preparation is more than 2%. The pre-vaporization agent according to claim 7, wherein the concentration of the combination of the plurality of additives in the vaporization-preform preparation is 2% to 5%. The pre-vaporization formulation of claim 2, wherein the concentration of nicotine in the vapor phase of the vapor former is 1% or less. The pre-vaporization agent according to claim 2 or 9, wherein the concentration of nicotine ranges from 0.5 wt% to 2 wt%. 11. A vapor-phase preparation according to any one of claims 1 to 10, wherein the vapor former comprises substantially the same concentration of propylene glycol and glycerin. 12. The pre-vaporization formulation of any one of claims 1 to 11, further comprising water at a concentration of 10% to 20%. 13. The pre-vaporization preparation according to any one of claims 1 to 12, further comprising an acid at a concentration of 0.1% to 5%. 14. The method of claim 13, wherein the acid is selected from the group consisting of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, malic acid, tartaric acid, Butanedioic acid, lauric acid, lauric acid, isobutyric acid, lauric acid, isobutyric acid, lauric acid, lauric acid, Wherein the vaporization-preincubation step comprises at least one of 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid, Formulation. The pre-vaporization formulation of claim 13 or 14, wherein the acid has a conversion efficiency from liquid to vapor greater than 50%. An electronic smoking device comprising:
A catheter comprising a reservoir containing a vaporization precursor, a mouse-endpiece, and a heater configured to heat the vaporization precursor; And
A power supply portion coupled to the catheter and including a puff sensor configured to sense a puff occurring at the mouth-end piece, and a power supply configured to supply power to the heater;
Here, the vaporization-
A vapor forming agent comprising a combination of propylene glycol and glycerol; And
Wherein the additive comprises at least one of carbanic acid, carbacol, thymol, monomenthyl succinate, and N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropylbutanamide. 17. The electronic smoking device according to claim 16, wherein the vaporization-pre-agent further comprises nicotine. 18. The method of claim 16 or 17, wherein the additive is at least one of ginger, garlic extract, onion oil, time oil, cinnamon bark oil, turmeric, fenugreek, cardamon, rosemary extract, grapefruit oil, and andrographia extract An extract from one, an electronic smoking device. 19. The method according to any one of claims 16 to 18,
The concentration of the additive is in the range of 0.0001% to 1%; And
Wherein the concentration of the combination of the plurality of additives in the vaporization-requiring agent is more than 2%. 20. The method according to any one of claims 16 to 19,
The concentration of nicotine in the vapor phase of the vapor former is not more than 2%;
Wherein the vaporization-pre-agent further comprises water at a concentration of 10% to 20%; And
Wherein the vaporization-pre-agent further comprises an acid at a concentration of 0.1% to 5%, wherein the acid has a conversion efficiency from liquid to vapor of more than 50%.

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