ES2749951T3 - Intensity enhancers and method to improve intensity in an electronic vaping device - Google Patents

Abstract

A pre-vaporization formulation for an electronic vaping device, where the pre-vaporization formulation comprises: a vapor former including at least one of propylene glycol and glycerol; nicotine; one or more acids in a concentration of between 0.1 percent and 5 percent; and an additive that includes at least one of carvacrol, thymol, monomethyl succinate, N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropyl butanamide.

Description

DESCRIPTION

Intensity enhancers and method to improve intensity in an electronic vaping device

The present invention generally relates to a pre-vaporization formulation for electronic vaping devices. More particularly, the present invention relates to intensity enhancers in pre-vaporization formulations.

Electronic vaping devices are used to vaporize a pre-vaporization formulation such as, for example, a liquid material, into a vapor so that an adult vaper inhales the vapor. Electronic vaping devices typically include a heater that vaporizes the vaporization formulation to produce the vapor. An electronic vaping device may include various electronic vaping elements, including a power source, an electronic vaping cartridge or tank that includes the heater, and a reservoir containing the vaporization formulation.

A tobacco-based smoking article produces a vapor known to create a desired sensory experience for adult smokers, including a low to moderate harsh throat response and a feeling of warmth or intensity in the chest of an adult smoker.

Regarding electronic vaping devices, the roughness of the vapor, which is typically understood as the sensation experienced in the throat of an adult vaper, and the intensity of the vapor, which is typically understood as the sensation experienced in the chest. of the adult vaper may vary depending on the content and concentrations of the pre-vaporization formulation used to form the vapor inhaled by the adult vaper. Typically, for a similar amount of nicotine in the vaporization formulation, an electronic vaping device is rougher than a tobacco-based product, but has an intensity that is less than that of the tobacco-based product. Also, as an amount of nicotine increases in the gas phase of the vapor generated by the electronic vaping device, the roughness of the electronic vaping device also increases.

EP 2862 454 A1 describes a liquid composition for an electronic cigarette comprising glycerol as a TRP modulator and at least one TRP agonist / activator selected from 6 paradoxics and the like, in which the interaction of the TRP modulator and at least one TRP agonist / activator in the chemosensory imitation of inhaled cigarette smoke, and wherein the liquid composition does not contain nicotine. Preferably, 6-paradels and the like comprise 1'-acetoxicavicol acetate and the like, isothiocyanates and the like, camphor and the like, Grains of Paradise, thymol and the like and ethanol. One or more extracts comprising black pepper, horseradish, garlic, paprika, cinnamon, mint and acetic acid and citric acid can be used as another TRP agonist / activator in the liquid composition.

WO 2009/001085 A2 describes an inhalable composition comprising at least 22% by volume of oxygen and nicotine or a nicotine derivative or salt. The composition can comprise a solvent. Specific examples of suitable solvents include propylene glycol, polypropylene glycol, polyethylene glycol (PEG), glycerol, ethanol, and propanol. The composition can also include an antioxidant. Suitable antioxidants include phenolic compounds, flavonols, flavanones, flavones, flavon-3-ols, anthocyanins (flavonal), isoflavones, coumestanes, carotenes, xanthophylls, phytosterols, and tocopherols. Suitable phenolic compounds include monophenols, apiole, carnosol, carvacrol, dillapiole, rosemarinol, and flavonoids (polyphenols). Suitable cumestanes (phytoestrogens) include coumestrol, ellagic acid, gallic acid, salicylic acid, tannic acid, vanillin, capsaicin, curcumin (oxidizes to vanillin), hydroxycinnamic acids, caffeic acid, chlorogenic acid, cinnamic acid, ferulic acid, coumarin, lignans (phytoestrogens), silymarin and matairesinol, secoisolariciresinol, terpenes (isoprenoids) and carotenoids (tetraterpenoids). The composition can also include an essential oil. Suitable essential oils include geraniol, nerol, phenethyl alcohol, eugenol methyl ether, farnesol, linalool, citronellol, rose, cuminaldehyde, zingiberene, farnesol, verbenone, nootkatone, myrcene, menthol, citron, citronelal, pinene, thymol and menthol.

US 2015/038576 A1 describes compositions for delivery to the respiratory tract of a subject, comprising: a liquid that includes an agent, the agent is a TRPV3 channel activator and the agent that includes a terpenoid compound. The terpenoid compound can include one or more camphor, carvacrol, thymol, and incensole of plant or synthetic origin. US 2015/038576 A1 describes illustrative compositions comprising propylene glycol.

The present invention relates to an electronic vaping device configured to achieve a desirable balance of intensity and roughness, where the intensity increases without increasing the roughness.

The present invention relates to an electronic vaping device that is configured to provide a perceived sensory experience for adult vaporizer users that is similar to the sensory experience experienced when smoking a tobacco-based product.

The present invention relates to an electronic vaping device configured to provide a sensory experience that includes levels of harshness in the throat and perceived intensity or heat in the chest that are similar to those experienced when smoking a tobacco-based product. To achieve a desirable balance of intensity and roughness, the intensity of the electronic vaping product can be increased without increasing its roughness.

The present invention relates to a pre-vaporization formulation for an electronic vaping device includes a mixture of a vaporizer and one or more intensity enhancers or additives.

In accordance with the present invention, there is provided a pre-vaporization formulation for an electronic vaping device, the pre-vaporization formulation, comprising the pre-vaporization formulation: a vapor former including at least one of propylene glycol and glycerol; nicotine; one or more acids in a concentration of between 0.1 percent and 5 percent; and an additive that includes at least one of carvacrol, thymol, monomentyl succinate, N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropyl butanamide.

In accordance with the present invention, you are also provided with an electronic vaping device, comprising: a cartomizer including a reservoir containing a vaporization formulation, a nozzle and a heater configured to heat the vaporization formulation; and a power supply section connected to the cartomizer and including a puff sensor configured to detect a puff taking place at the nozzle, and a power source configured to supply power to the heater; wherein the pre-vaporization formulation includes: a vapor former including a combination of propylene glycol and glycerol; nicotine; one 0 more acids at a concentration of between 0.1 percent and 5 percent; and an additive that includes at least one of carvacrol, thymol, monomentyl succinate, N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropyl butanamide.

The pre-vaporization formulation may include water.

The pre-vaporization formulation can be a liquid formulation.

The pre-vaporization formulation comprises nicotine.

The intensity enhancer (s) or additives include at least one of carvacrol, thymol, monomethyl succinate, N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropyl butanamide.

In at least one embodiment, the intensity enhancer or additives may include at least one of cinnamaldehyde, menthone, eugenol, zingerone, and gingerol.

The one or more intensity enhancers or additives may further include at least one of bell pepper, allyl isothiocyanate, piperine, isoeugenol, and menthol.

In at least one embodiment, the aforementioned compounds, as well as different ones, can be found in extracts such as, for example, horseradish oil, garlic extract, onion oil, black pepper, cayenne pepper, ginger oil, thyme oil, cinnamon oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil, and andrographis extract. The intensity enhancer or additives may include at least one of these extracts.

The intensity enhancer (s) or additives may include one or more receptor-activating compounds in the respiratory system of an adult vaper, such as the transient potential receptor cation channel, subfamily A, member 1 (TRPA1). , transient potential receptor cation channel, subfamily V, member 1 (TRPV1), or nicotinic acetylcholine receptors in an adult vaping user, where the agonists become part of the vapor and are transferred into the respiratory tract of the adult vaper user during inhalation.

In at least one embodiment, the intensity enhancer or additives may include one or more of the aforementioned compounds, inter alia, in a composition range of between about 0.0001 percent and about 1 percent, or in concentrations of up to about 2 percent. Optionally, the concentration of the intensity enhancer or additives may be greater than about 2 percent when a plurality of combined intensity enhancers are used. For example, the total concentration of intensity enhancers can be up to about 5 percent.

One or more acids are included in the pre-vaporization formulation in order to achieve a desired balance of increased intensity and decreased roughness in an electronic vaping device.

In at least one embodiment, the intensity enhancer (s) or additives increase the intensity of the electronic vaping devices without increasing the nicotine supply and without increasing the roughness of the electronic vaping article.

The pre-vaporization formulation may comprise nicotine in an amount of between about 0.5 percent and about 2 percent by weight or more, or between about 0.5 percent and about 5 percent or more. In at least one embodiment, the steam generated by the steam former includes a gas phase and a particulate phase, and the nicotine concentration in the vapor phase is less than or equal to about 1 percent.

The pre-vaporization formulation in accordance with the present invention includes one or more acids in a concentration of between about 0.1 percent and about 5 percent.

The acid or acids can have a boiling point of at least around 100 ° C and are configured to volatilize when heated by the heater in the electronic vaping device. The pre-vaporization formulation can be configured to form a vapor having a particulate phase and a gas phase when heated by the heater in the electronic vaping device, the particulate phase contains protonated nicotine and the gas phase contains non-protonated nicotine. In embodiments, the vapor has a larger amount of the protonated nicotine and a smaller amount of the non-protonated nicotine.

In at least one embodiment, the pre-vaporization formulation is configured to form a vapor having a gas phase nicotine component after operation of the electronic vaping device. The acid may be included in an amount sufficient to reduce the gas phase nicotine component by about 70 percent or greater. In other embodiments, the addition of one or more acids can reduce the gas phase nicotine content by an amount in the range of about 40 percent to about 70 percent by weight, or in the range of about 40 percent and about 90 percent by weight.

In at least one embodiment, the acid can be selected to have a liquid-to-vapor transfer efficiency of about 50 percent or greater. The acid may be present in an amount sufficient to reduce the gas phase nicotine component.

In at least one embodiment, the one or more acids includes at least one of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, acid malic, tartaric acid, succinic acid, citric acid, benzoic acid, oleic acid, aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, 1-glutamic acid, heptanoic acid, hexaneic acid , 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid , hydrochloric acid, phosphoric acid and sulfuric acid.

In at least one embodiment, the acid includes pyruvic acid, lactic acid, benzoic acid, and acetic acid.

The vaporizer can include propylene glycol and glycerol or glycerin. The vaporizer can include essentially equal concentrations of propylene glycol and glycerol or glycerin.

The pre-vaporization formulation can include water in a concentration of between about 10 percent and about 20 percent.

An electronic vaping device can include a first section and a second section. The first section includes a vaporization formulation reservoir including a vaporization formulation in accordance with the present invention such as, for example, a liquid material, a heater, a wick in communication with the vaporization formulation reservoir and in communication with the heater, a nozzle, and a connector on a distal end of the first section. The second section includes a power supply, and a connector at a proximal end of the second section configured to fit the connector of the first section.

The first section can be a cartomizer. The first section includes a pre-spray formulation reservoir including a pre-spray formulation, in accordance with the present invention, a heater, and a mouthpiece end piece. The heater is configured to heat the flash formulation. The second section can be a power supply section. The second section includes a power source configured to supply power to the heater.

The first section may comprise a wick in communication with the pre-vaporization formulation reservoir and in communication with the heater. The first section may comprise a connector at a distal end of the first section.

The second section may include a shed sensor configured to sense suction occurring at the nozzle. The second section may comprise a connector at a proximal end of the second section configured to fit the connector of the first section.

The above and other features and advantages of the illustrative modalities will be more apparent when describing in detail the illustrative modalities with reference to the attached figures. The accompanying figures are intended to describe the illustrative modalities and should not be construed as limiting the intended scope in accordance with the claims. The attached drawings should not be considered as scaled unless this is explicitly stated.

Figure 1 is a side view of an electronic vaping device, in accordance with an illustrative embodiment; Figure 2 is a cross sectional view of an electronic vaping device, in accordance with an illustrative embodiment; Y

Figure 3 is a cross sectional view of another illustrative embodiment of an electronic vaping device.

Some detailed illustrative modalities are described in the present description. However, the specific functional and structural details disclosed herein are merely representative for the purpose of describing illustrative modalities. Illustrative modalities may, however, be represented in various alternative forms and should not be considered as limited to only the modalities set forth in the present disclosure.

Thus, while the illustrative embodiments are capable of various modifications and alternative forms, the embodiments thereof are shown by way of example in the figures and will be described in detail herein. It should be understood that, however, it is not intended to limit the illustrative modalities to the particular forms described, on the contrary, the illustrative modalities cover all modifications, equivalents, and alternatives that fall within the scope of illustrative modalities. Similar numbers refer to similar elements throughout the description of the figures.

It should be understood that when an element or layer is referred to as being "on", "connected to", "coupled to", or "covering" another element or layer may be present, it may be directly on, connected to, coupled to, or covering the other element or layer or intermediate elements or layers. Conversely, when an element is referred to as being "directly on," "directly connected to," or "directly coupled to" another element or layer, no intermediate elements or layers are present. Similar reference numbers refer to similar elements throughout the description.

It should be understood that although the terms first, second, third, and so on, may be used herein to describe various elements, components, regions, layers, or sections, these elements, components, regions, layers, or sections should not be limited. by these terms. These terms are used only to distinguish an element, component, region, layer, or section from another element, component, region, layer, or section. Therefore, a first element, component, region, layer, or section mentioned below may be qualified as a second element, component, region, layer, or section without departing from the teachings of the illustrative modalities.

The terms in relation to space (eg, "below," "below," "below," "above," "above," and the like) may be used herein to facilitate the description to describe the relationship. of an element or accessory with another element or accessory as illustrated in the figures. It should be understood that the terms in relation to space are intended to contemplate different orientations of the device during use or operation in addition to the orientation represented in the figures. For example, if the device in the figures is flipped, the elements described as "below" or "below" other elements or accessories would then be oriented "on top" of the other elements or accessories. Therefore, the term "below" can encompass both an above and below orientation. The device may be oriented in another way (rotated 90 degrees or in other orientations) and the space-related identifiers used in the present description are interpreted accordingly.

The terminology used in the present description is to describe various modalities only and is not intended to limit the illustrative modalities. As used herein, the singular forms "a," "one," and "the" include the plural forms as well, unless the context clearly indicates otherwise. It will further be understood that the terms "includes," "including," "comprises," and "comprising," when used in this description, specify the presence of accessories, integers, steps, operations, elements, or components, but does not exclude the presence or addition of one or more accessories, integers, stages, operations, elements, components, or their groups.

Illustrative embodiments are described in the present disclosure with reference to cross-section illustrations which are schematic illustrations of ideal (and intermediate structures) of illustrative embodiments. As such, variations in the shapes of the illustrations are expected as a result, for example, of tolerances or manufacturing techniques. Thus, illustrative embodiments should not be considered limited to the region shapes illustrated herein but should include deviations in shapes as a result, for example, of manufacturing. Thus, the regions illustrated in the figures are naturally schematic and their shapes are not intended to illustrate the actual shape of a region of a device and are not intended to limit the scope of the illustrative embodiments.

Unless otherwise defined, all terms (including technical and scientific terms) used in the present disclosure have the same meaning as that normally extended by one skilled in the art to which the illustrative embodiments pertain. It will further be understood that terms, including those defined in commonly used dictionaries, are to be construed as having a meaning that is consistent with their meanings. in the context of the relevant technique and will not be interpreted in an ideal or excessively formal sense unless expressly defined.

When the terms "approximately" or "essentially" are used in this description in relation to a numerical value, they are intended to have the associated numerical value include a tolerance of ± 10 percent around the declared numerical value. Furthermore, when referring to percentages in this description, the percentages are intended to be based on weight, ie percentages by weight. The term "up to" includes amounts from zero to the expressed upper limit and all intermediate values. When ranges are specified, the range includes all intermediate values such as 0.1 percent increments.

As used herein, the term "vapor former" describes any suitable and known compound or mixture of compounds which, in use, facilitate the formation of a vapor and which is essentially resistant to thermal degradation at the temperature of operation of the electronic vaping device. Suitable vapor formers consist of various components, such as, for example, polyhydric alcohols including at least one of propylene glycol, and glycerol or glycerin. In at least one embodiment, the vapor former is propylene glycol.

Figure 1 is a side view of an electronic vaping device 60, in accordance with an illustrative embodiment. In Figure 1, the electronic vaping device 60 includes a first section or cartomizer 70 and a second section 72, which are coupled together in a threaded joint 74 or by other connection structure such as one or more than one snug fit, fit snap, catch, loop, hook, or the like. In one embodiment, the first section or cartomizer 70 may be a replaceable cartridge and the second section 72 may be a reusable section. Alternatively, the first section or cartomizer 70 and the second section 72 may be integrally formed in one piece.

Figure 2 is a cross-sectional view of an illustrative embodiment of an electronic vaping device. As shown in Figure 2, the first section or cartomizer 70 can accommodate a nozzle insert 20, a capillary steam generator including a capillary tube 18, a heater 19 for heating at least a portion of the capillary tube 18, and a reservoir 14.

The second section 72 can house a power supply 12, a control circuit 11 configured to control the power supply 12 and a puff sensor 16. The puff sensor is configured to sense when an adult vaper puffs on the device electronic vaping 60, which results in the operation of the power supply 12 through the control circuit 11 to activate the heater 19 to heat the vaporization formulation housed in the tank 14 and form a vapor. A threaded portion 74 of the second section 72 can be connected to a battery charger, when not connected to the first section or cartomizer 70, to charge the battery or power supply 12.

As shown in Figure 3, in other illustrative embodiments, a valve 40 can be a two-way valve and reservoir 14 can be pressurized. For example, reservoir 14 can be pressurized using a pressurization arrangement 405 configured to apply constant pressure to reservoir 14. This facilitates the emission of steam formed by heating the pre-vaporization formulation housed in reservoir 14.

In illustrative embodiments, capillary tube 18 is formed from or includes a conductive material, and thus acts as its own heater 19 by passing current through the tube. Capillary tube 18 can be any electrically conductive material capable of being resistively heated, while retaining the necessary structural integrity at the operating temperature experienced by capillary tube 18, which is not reactive with the pre-vaporization formulation. Suitable materials for forming capillary tube 18 are one or more of stainless steel, copper, copper alloys, porous ceramic materials coated with a resistive film material, nickel-chromium alloys, and combinations thereof. For example, capillary tube 18 is a stainless steel capillary tube 18 and functions as a heater 19 via electrical wires 26 attached to the direct or alternating current conduit along a length of capillary tube 18. Therefore, the tube 18 stainless steel capillary is heated by resistance heating. Alternatively, the capillary tube 18 may be a non-metallic tube such as, for example, a glass tube. In such an embodiment, heater 19 is formed from or includes a conductive material capable of being resistively heated, such as, for example, stainless steel, nichrome, or platinum wire, arranged along the length of the glass tube. When the heater arranged along the glass tube is heated, the flash formulation in the capillary tube 18 is heated to a temperature sufficient to at least partially volatilize the flash formulation in the capillary tube 18.

In at least one embodiment, at least two electrical cables 26 are attached to the metallic capillary tube 18. In at least one embodiment, an electrical conductor 26 is coupled to a first upstream portion 101 of the capillary tube 18 and a second electrical conductor 26 is couples to a downstream end portion 102 of capillary tube 18.

During operation, when an adult vaper puffs on the electronic vaping device, the puff sensor 16 detects a pressure gradient caused by the puff of the adult vape, and control circuit 11 activates heater 19 to heat the formulation of pre-vaporization located in the tank 14. Once the tube capillary 18 is heated, the flash formulation contained within a heated portion of the capillary tube 18 is volatilized and exited via outlet 63 where the flash formulation expands and mixes with air and forms a vapor in a mixing chamber 240.

The power supply 12 of the illustrative embodiments may include a battery arranged in the second section 72 of the electronic vaping device 60. The power supply 12 is configured to apply voltage through the heater 19 and the heater 19 volatilizes the pre-vaporization formulation housed in tank 14.

In at least one embodiment, the electrical contacts or connections between heater 19 and electrical wires 26 are essentially conductive and temperature resistant while heater 19 is essentially resistive so that heat generation occurs primarily along the heater 19 and not in contacts.

The power supply or battery 12 can be rechargeable and include circuits that allow the battery to be charged by an external charging device. In this case, the circuits, when loaded, provide power for a predetermined number of puffs, after which the circuits may have to be reconnected to the external charging device.

In at least one embodiment, the electronic vaping device 60 may include a control circuit that may be located on a printed circuit board 11. Control circuit 11 may further include a heater activation light 27 that is configured to glow when heater 19 is activated. In at least one embodiment, the heater activation light 27 comprises at least one LED and is located at a distal end 28 of the electronic vaping device 60 such that the heater activation light 27 illuminates a lid that has the appearance of a coal burning during a puff. Furthermore, the heater activation light 27 can be configured to be visible to the adult vaper. Light 27 can be further configured so that the adult vaper can turn on, off, or turn light 27 on and off as desired, so light 27 would not turn on during vaping if desired.

In at least one embodiment, the electronic vaping device 60 further includes a mouth end end insert 20 having at least two diverging off-axis outputs 21. In at least one embodiment, the end end insert. Mouth 20 includes at least two diverging outlets 21 (eg, 3 to 8 outlets or more). In at least one embodiment, the outlets 21 of the mouth-side end insert 20 are located at ends of the off-axis passages 23 and tilt out relative to the longitudinal direction of the electronic vaping device 60 (i.e. , divergently). As used herein, the term "off-axis" denotes an angle with respect to the longitudinal direction of the electronic vaping device. In addition, the muzzle-side end insert (or flow guide) 20 may include outlets evenly distributed around the muzzle-side end insert 20 essentially to uniformly distribute steam into the mouth of an adult vape during the use.

In at least one embodiment, the electronic vaping device 60 is approximately the same size as a conventional cigarette. In some embodiments, the electronic vaping device 60 can be from about 80 millimeters to about 110 millimeters long, for example, from about 80 millimeters to about 100 millimeters long and from about 7 millimeters to about 10 millimeters from diameter.

The outer cylindrical housing 22 of the electronic vaping device 60 can be formed from or include any suitable material or combination of materials. In at least one embodiment, the outer cylindrical housing 22 is formed at least partially from metal and is part of the electrical circuit connecting the control circuit 11, the power supply 12, the shed sensor 16 and the heater 19.

Figure 3 is a cross sectional view of an electronic vaping device in accordance with an illustrative embodiment. As shown in FIG. 3, the electronic vaping device 60 may further include a middle section (third section) 73, which can accommodate the liquid vaporization formulation reservoir 14 and the heater 19. The middle section 73 can be configured to fitted with a threaded joint 74 'at an end upstream of the first section or cartomizer 70 and a threaded joint 74 at an end downstream of the second section 72. In this illustrative embodiment, the first section or cartomizer 70 houses the insert of the end of the mouth side 20, while the second section 72 houses the power supply 12 and the control circuit 11 that is configured to control the power supply 12.

In at least one embodiment, the first section or cartomizer 70, the second section 72, and the third section 73 include a common external cylindrical housing 22 that extends in a longitudinal direction along the length of the electronic vaping device 60. Furthermore , in at least one embodiment, the middle section 73 is disposable and one or both of the first section or cartomizer 70 and the second section 72 are reusable. The sections 70, 72, 73 can be coupled by threaded connections or connectors 74 and 74 'so that the middle section 73 can be replaced when the tank 14 runs out. In another embodiment, the first section or cartomizer 70 is replaceable to avoid the need to clean one or both of the capillary tube 18 and heater 19. In at least one embodiment, the first section or cartomizer 70, the second section 72 and the section media 73 can be integrally formed without threaded connections to form a disposable electronic vaping device.

In the exemplary embodiment illustrated in Figure 3, reservoir 14 is an elongated tubular body formed of or including an elastomeric material such that it is flexible and / or compressible when squeezed. In at least one embodiment, the elastomeric material can be one of silicone, plastic, rubber, latex, and combinations thereof.

In at least one embodiment, reservoir 14 has fluid communication with capillary tube 18 so that when squeezed, reservoir 14 can deliver a volume of a vaporization formulation such as a liquid material to capillary tube 18. At the same time that the supply of the pre-vaporization formulation to the capillary occurs, the energy supply 12 is activated after the application of manual pressure in the reservoir 14, and the capillary tube 18 is heated to form a heated section where the formulation of prevaporization volatilizes. After discharge from the heated capillary tube 18, the volatilized material expands, mixes with air, and forms a vapor.

As shown in Figure 3, reservoir 14 includes a valve 40 configured to hold the liquid vaporization formulation within reservoir 14 and to open when reservoir 14 is squeezed and pressure is applied to reservoir 14. In at least one embodiment, valve 40 opens when a critical minimum pressure is reached to prevent inadvertent dispensing of the flash formulation from reservoir 14 or heater 19 to activate. In at least one embodiment, the pressure required to press pressure switch 44 it is high enough so that accidental heating is avoided. Such an arrangement prevents activation of heater 19 in the absence of the vaporization formulation being pumped through the capillary.

Once pressure is released in reservoir 14, valve 40 closes and heated capillary tube 18 discharges any remaining pre-vaporization formulation downstream of valve 40.

In at least one embodiment, the intensity enhancers or additives can include cinnamaldehyde, menthone, eugenol, zingerone, and gingerol. Intensity enhancers can also include bell pepper, allyl isothiocyanate, piperine, isoeugenol, menthol. Intensity enhancers include one or more compounds that activate receptors in the respiratory system of an adult vaper, such as the transient potential receptor cation channel, subfamily A, member 1 (TRPA1), transient potential receptor cation channel, subfamily V, member 1 (TRPV1), or nicotinic acetylcholine receptors in an adult vaping user, where the receptors become part of the particulate phase and are carried in the respiratory tract of the adult vaping user with the particulate phase during inhalation.

In at least one embodiment, the aforementioned compounds, as well as different ones, can be found in extracts such as, for example, horseradish oil, garlic extract, onion oil, black pepper, cayenne pepper, ginger oil, thyme oil, cinnamon oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil, and andrographis extract.

In at least one embodiment, the pre-vaporization formulation may include one or more intensity enhancers in a composition range of between about 0.0001 percent and about 1 percent, in concentrations of up to about 2 percent, or at concentrations of more than about 2 percent or less than about 5 percent when the intensity enhancer is a combination of a plurality of intensity enhancers. These intensity enhancers can activate receptors in the respiratory system of an adult vaper.

The pre-vaporization formulation optionally includes water. Water can be included in an amount ranging from about 5 weight percent based on the weight of the pre-spray formulation to about 40 weight percent based on the weight of the pre-spray formulation. For example, water can be included in about 20 weight percent based on the weight of the pre-spray formulation.

The following examples describe multiple combinations and corresponding concentrations of intensity enhancers. The amount of nicotine in the various formulations can be between about 0.5 percent and about 1.5 percent, or between about 0.5 percent and about 2 percent. The various current enhancers are described above. The acid described below includes at least one of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid, malic acid, tartaric acid, acid succinic, citric acid, benzoic acid, oleic acid, aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, 1-glutamic acid, heptanoic acid, hexanoic acid, 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid and sulfuric acid. The following examples of pre-vaporization formulations are described:

EXAMPLE 1: A pre-vaporization formulation solution includes about a few ppm or about 0.001 percent to about 0.1 percent of an intensity enhancer or additive, about 60 percent to about 80 percent of a vaporizer (eg propylene glycol and glycerol in concentrations essentially the same), about 10 percent to about 20 percent water, about 0.5 to about 2 percent nicotine by weight (NBW), and up to about 5 percent acid.

EXAMPLE 2: A pre-vaporization formulation solution includes about 1 percent of an intensity enhancer or additive, about 60 percent to about 80 percent of a vaporizer (eg, propylene glycol and glycerol), about 15 percent to about 20 percent water, and about 1 percent and about 2 percent nicotine by weight (NBW), and up to about 3 percent of an acid.

EXAMPLE 3: A pre-vaporization formulation solution includes about 1.5 percent of an intensity enhancer or additive, about 60 percent to about 80 percent of a vaporizer (eg, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 1.5 percent nicotine by weight (NBW), and up to about 1 percent of an acid.

EXAMPLE 4: A pre-vaporization formulation solution includes about 2 percent of an intensity enhancer or additive, about 60 percent to about 80 percent of a vaporizer (eg, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and about 0.1 percent of the acid.

EXAMPLE 5: A pre-vaporization formulation solution includes about 2 percent to about 5 percent of a combination of a plurality of intensity enhancers or additives, about 60 percent to about 80 percent of a vaporizer (for example, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and about 0.1 percent of the acid.

EXAMPLE 6: A pre-vaporization formulation solution, which is not in accordance with the present invention includes about 0.1 percent of one of cinnamaldehyde, menthone, eugenol, zingerone and gingerol, about 60 percent to about 80 percent percent of a vaporizer (eg, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and up to about 5 percent of an acid.

EXAMPLE 7: A pre-vaporization formulation solution, which is not in accordance with the present invention, includes about 1 percent of one or more cinnamaldehyde, menthone, eugenol, zingerone, and gingerol, about 60 percent to about 80 percent percent of a vaporizer (eg, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and up to about 3 percent of an acid.

EXAMPLE 8: A pre-vaporization formulation solution, which is not in accordance with the present invention includes about 1.5 percent of one or more of cinnamaldehyde, menthone, eugenol, zingerone and gingerol, about 60 percent to about 80 percent of a vaporizer (eg propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW ), and up to about 1 percent of an acid. Alternatively, the pre-vaporization formulation includes about 1.5 percent of a combination of two or more of cinnamaldehyde, menthone, eugenol, zingerone, and gingerol.

EXAMPLE 9: A pre-vaporization formulation solution, which is not in accordance with the present invention includes about 2 percent of a combination of cinnamaldehyde, chin, eugenol, zingerone, and gingerol, about 60 percent to about 80 percent from a vaporizer (eg, propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and essentially no acid.

EXAMPLE 10: A pre-vaporization formulation solution, which is not in accordance with the present invention, includes more than about 2 percent of more than one of cinnamaldehyde, menthone, eugenol, zingerone and gingerol, about 60 percent to about 80 percent of a vaporizer (eg propylene glycol and glycerol), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW ), and essentially no acid. Alternatively, the prevaporization formulation includes more than about 2 percent of a combination of two or more of cinnamaldehyde, menthone, eugenol, zingerone, and gingerol.

EXAMPLE 11: A pre-vaporization formulation solution includes about 0.1 percent to about 2.5 percent of a combination of horseradish oil, garlic extract, onion oil, black pepper, cayenne pepper, oil ginger, thyme oil, cinnamon oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil, and andrographis extract, about 60 percent to about 80 percent vapor-forming (for example, propylene glycol and glycerin), about 15 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and an amount of acid up to about 5 percent .

EXAMPLE 12: A pre-vaporization formulation solution for a smoking cessation device includes about 0.1 percent to about 2 percent of an intensity enhancer or additive, about 60 percent to about 80 percent of a vaporizer (eg, propylene glycol and glycerol), about 10 percent to about 20 percent water, about 0.5 percent to about 2 percent nicotine by weight (NBW), and between about 0.1 percent to about 5 percent of an acid.

In at least one embodiment, the acid works on the steam generated from the vaporization formulation when the electronic vaping device is in operation, in order to reduce the amount of roughness perceived by the throat, while the intensity enhancer It works on the steam to increase the perceived intensity of the steam.

In accordance with at least one illustrative embodiment, the acid has the ability to transfer into a vaporized formulation. The efficiency of liquid to vapor transfer of an acid is the ratio of the mass fraction of the acid in the vaporized formulation to the mass fraction of the acid in the vaporization formulation. In at least one embodiment, the acid has a pre-vaporization formulation, such as a vapor to liquid transfer efficiency of about 50 percent or greater, eg, about 60 percent or greater. For example, pyruvic acid, lactic acid, oxalic acid, acetic acid, and glycolic acid have a liquid-to-vapor transfer efficiency of about 50 percent or greater. In at least one embodiment, the pre-vaporization formulation includes an acid that has a liquid-to-vapor transfer efficiency of about 50 percent or more. In another embodiment, the pre-vaporization formulation excludes any acid that has a liquid-to-vapor transfer efficiency of about 25 percent or less.

In accordance with at least one illustrative embodiment, the acid has a boiling point of at least about 100 degrees Celsius, and can be included in the pre-vaporization formulation in an amount sufficient to adjust the pH of the pre-vaporization formulation in the range of around 3 to around 8.

In accordance with at least one illustrative embodiment, the pre-vaporization formulation includes one or more of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, octanoic acid, lactic acid, sorbic acid. , malic acid, tartaric acid, succinic acid, citric acid, benzoic acid, oleic acid, aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, 1-glutamic acid, heptanoic acid, hexanoic acid, 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4-pentenoic acid, phenylacetic acid, 3-acid -phenylpropionic, hydrochloric acid, phosphoric acid, sulfuric acid, and combinations thereof. The acid is further incorporated in the form of a salt. The pre-vaporization formulation also includes a vaporizer, optionally water, nicotine, and flavorings.

Claims (17)

1. A pre-vaporization formulation for an electronic vaping device, where the pre-vaporization formulation comprises: a vapor former including at least one of propylene glycol and glycerol; nicotine; one or more acids in a concentration of between 0.1 percent and 5 percent; Y an additive including at least one of carvacrol, thymol, monomethyl succinate, N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropyl butanamide. 2. The pre-vaporization formulation according to claim 1, wherein the additive further comprises at least one of piperine, allyl isothiocyanate, capiscum, isoeugenol and menthol. 3. The pre-vaporization formulation according to claims 1 or 2, wherein the additive is an extract of at least one of zingerone, garlic extract, onion oil, thyme oil, cinnamon oil, turmeric, fenugreek, cardamom , rosemary extract, grapefruit oil and andrographis extract. 4. The pre-vaporization formulation according to any preceding claim, wherein the additive further comprises an extract of at least one of cinnamaldehyde, chin, eugenol, horseradish oil, black pepper, cayenne pepper, and ginger oil. 5. The pre-vaporization formulation according to any preceding claim, where a concentration of the additive is in a range of 0.0001 percent to 1 percent. 6. The pre-vaporization formulation according to any preceding claim, wherein a concentration of a combination of a plurality of additives in the pre-vaporization formulation is greater than 2 percent. 7. The pre-vaporization formulation according to claim 6, wherein the concentration of the combination of a plurality of additives in the pre-vaporization formulation is between 2 percent and 5 percent. 8. The pre-vaporization formulation according to claim 1, wherein a nicotine concentration in a vapor phase of the vaporizer is less than or equal to 1 percent. 9. The pre-vaporization formulation according to claims 1 or 8, wherein a nicotine concentration is in a range of from 0.5 percent to 2 percent by weight. 10. The pre-vaporization formulation according to any preceding claim, wherein the vaporizer comprises essentially equal concentrations of propylene glycol and glycerin. 11. The pre-vaporization formulation according to any preceding claim, further comprising water in a concentration of between 10 percent to 20 percent. 12. The pre-vaporization formulation according to claim 1, wherein the one or more acids comprise at least one of pyruvic acid, formic acid, oxalic acid, glycolic acid, acetic acid, isovaleric acid, valeric acid, propionic acid, acid octanoic, lactic acid, sorbic acid, malic acid, tartaric acid, succinic acid, citric acid, benzoic acid, oleic acid, aconitic acid, butyric acid, cinnamic acid, decanoic acid, 3,7-dimethyl-6-octenoic acid, acid 1-glutamic, heptanoic acid, hexanoic acid, 3-hexenoic acid, trans-2-hexenoic acid, isobutyric acid, lauric acid, 2-methylbutyric acid, 2-methylvaleric acid, myristic acid, nonanoic acid, palmitic acid, 4- pentenoic, phenylacetic acid, 3-phenylpropionic acid, hydrochloric acid, phosphoric acid and sulfuric acid. 13. The pre-vaporization formulation according to claim 1 or 12, wherein the one or more acids have a liquid-to-vapor transfer efficiency that is greater than 50 percent. 14. An electronic vaping device (60), comprising: a cartomizer (70, 73) including a reservoir (14) containing a pre-vaporization formulation, a nozzle (20) and a heater (19) which is configured to heat the pre-vaporization formulation; and a power supply section (72) connected to the cartomizer (70) and including a shed sensor (16) configured to sense suction occurring at the mouth end piece, and a power source (12) that it is configured to supply power to the heater; where the prevaporization formulation includes: a vaporizer including a combination of propylene glycol and glycerol; nicotine; one or more acids in a concentration of between 0.1 percent and 5 percent; Y an additive including at least one of carvacrol, thymol, monomethyl succinate, N- (2-hydroxyethyl) -2,3-dimethyl-2-isopropyl butanamide. 15. The electronic vaping device according to claim 14, wherein the additive is an extract of at least one of zingerone, garlic extract, onion oil, thyme oil, cinnamon oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil and andrographis extract. 16. The electronic vaping device according to claims 14 or 15, wherein at least one of: a concentration of the additive is in a range of 0.0001 percent to 1 percent; and a concentration of a combination of a plurality of additives in the pre-vaporization formulation is greater than 2 percent. 17. The electronic vaping device according to any claim 14 to 16, wherein at least one of: a nicotine concentration in a vapor phase of the vaporizer is less than or equal to 2 percent; the pre-vaporization formulation that also includes water in a concentration of between 10 percent and 20 percent; Y one or more acids have a liquid to vapor transfer efficiency that is greater than 50 percent.