IL256441B - New p450–bm3 variants with enhanced activity - Google Patents
New p450–bm3 variants with enhanced activityInfo
- Publication number
- IL256441B IL256441B IL256441A IL25644117A IL256441B IL 256441 B IL256441 B IL 256441B IL 256441 A IL256441 A IL 256441A IL 25644117 A IL25644117 A IL 25644117A IL 256441 B IL256441 B IL 256441B
- Authority
- IL
- Israel
- Prior art keywords
- variants
- novel
- improved activity
- activity
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/14—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)
- C12Y114/14001—Unspecific monooxygenase (1.14.14.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562189281P | 2015-07-07 | 2015-07-07 | |
| PCT/US2016/035399 WO2017007547A1 (en) | 2015-07-07 | 2016-06-02 | Novel p450-bm3 variants with improved activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL256441A IL256441A (en) | 2018-02-28 |
| IL256441B true IL256441B (en) | 2020-02-27 |
Family
ID=57686072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL256441A IL256441B (en) | 2015-07-07 | 2017-12-20 | New p450–bm3 variants with enhanced activity |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US9683220B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3319987B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6691558B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108271374B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2991195C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3319987T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL256441B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017007547A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9708587B2 (en) | 2014-07-09 | 2017-07-18 | Codexis, Inc. | P450-BM3 variants with improved activity |
| JP6691558B2 (ja) | 2015-07-07 | 2020-04-28 | コデクシス， インコーポレイテッド | 改善された活性を持つ新規のｐ４５０−ｂｍ３バリアント |
| SI3370733T1 (sl) * | 2015-11-02 | 2021-11-30 | Board Of Regents The University Of Texas System | Postopek za aktivacijo CD40 in blokada imunske nadzorne točke |
| WO2019183358A2 (en) * | 2018-03-21 | 2019-09-26 | University Of Florida Research Foundation, Incorporated | Whole cell processes to produce nitroaromatics |
| WO2024112781A1 (en) * | 2022-11-22 | 2024-05-30 | Codexis, Inc. | P450-bm3 variants with improved activity |
| WO2024196434A1 (en) * | 2023-03-20 | 2024-09-26 | Codexis, Inc. | P450-bm3 variants with improved activity |
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| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| US20060257890A1 (en) | 1996-05-20 | 2006-11-16 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
| US6406855B1 (en) | 1994-02-17 | 2002-06-18 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US6395547B1 (en) | 1994-02-17 | 2002-05-28 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
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| CA2191718A1 (en) | 1994-06-03 | 1995-12-14 | Randy M. Berka | Phosphonyldipeptides useful in the treatment of cardiovascular diseases |
| ATE294871T1 (de) | 1994-06-30 | 2005-05-15 | Novozymes Biotech Inc | Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren |
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| EP2426198A1 (en) * | 2010-09-03 | 2012-03-07 | B.R.A.I.N. Biotechnology Research And Information Network AG | Cytochrome P450 monooxygenase variants |
| US9273342B2 (en) * | 2011-02-11 | 2016-03-01 | University Of Rochester | Methods and systems for evaluating and predicting the reactivity of monooxygenase enzymes |
| WO2013076258A2 (en) * | 2011-11-23 | 2013-05-30 | Dsm Ip Assets B.V. | P450 bm3 mutants and their use for regio- and stereoselective hydroxylation of alpha-and beta-ionone |
| CN102757944A (zh) * | 2012-07-24 | 2012-10-31 | 浙江大学宁波理工学院 | 细胞色素p450bm-3(d168l/e435t)变体酶及其编码基因和用途 |
| JP2015534464A (ja) * | 2012-10-09 | 2015-12-03 | カリフォルニア インスティチュート オブ テクノロジー | ヘム酵素によって触媒されるインビボおよびインビトロオレフィンシクロプロパン化 |
| US9708587B2 (en) | 2014-07-09 | 2017-07-18 | Codexis, Inc. | P450-BM3 variants with improved activity |
| JP6691558B2 (ja) * | 2015-07-07 | 2020-04-28 | コデクシス， インコーポレイテッド | 改善された活性を持つ新規のｐ４５０−ｂｍ３バリアント |
-
2016
- 2016-06-02 JP JP2017567368A patent/JP6691558B2/ja active Active
- 2016-06-02 DK DK16821779.2T patent/DK3319987T3/da active
- 2016-06-02 US US15/171,116 patent/US9683220B2/en active Active
- 2016-06-02 EP EP16821779.2A patent/EP3319987B1/en active Active
- 2016-06-02 CN CN201680040014.3A patent/CN108271374B/zh active Active
- 2016-06-02 CA CA2991195A patent/CA2991195C/en active Active
- 2016-06-02 WO PCT/US2016/035399 patent/WO2017007547A1/en not_active Ceased
-
2017
- 2017-05-10 US US15/591,816 patent/US10113153B2/en active Active
- 2017-12-20 IL IL256441A patent/IL256441B/en active IP Right Grant
-
2018
- 2018-10-05 US US16/152,709 patent/US10450550B2/en active Active
-
2019
- 2019-09-06 US US16/562,673 patent/US10704030B2/en active Active
-
2020
- 2020-06-02 US US16/890,408 patent/US10982197B2/en active Active
-
2021
- 2021-03-16 US US17/203,421 patent/US11591578B2/en active Active
-
2023
- 2023-01-12 US US18/153,620 patent/US20230250403A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017007547A1 (en) | 2017-01-12 |
| CA2991195A1 (en) | 2017-01-12 |
| JP6691558B2 (ja) | 2020-04-28 |
| DK3319987T3 (da) | 2021-06-21 |
| US9683220B2 (en) | 2017-06-20 |
| JP2018520674A (ja) | 2018-08-02 |
| CA2991195C (en) | 2021-06-29 |
| EP3319987B1 (en) | 2021-05-05 |
| CN108271374A (zh) | 2018-07-10 |
| US20200002685A1 (en) | 2020-01-02 |
| EP3319987A1 (en) | 2018-05-16 |
| CN108271374B (zh) | 2021-09-21 |
| US10704030B2 (en) | 2020-07-07 |
| EP3319987A4 (en) | 2018-12-19 |
| US10450550B2 (en) | 2019-10-22 |
| US20210214694A1 (en) | 2021-07-15 |
| US20230250403A1 (en) | 2023-08-10 |
| US10982197B2 (en) | 2021-04-20 |
| IL256441A (en) | 2018-02-28 |
| US20170009213A1 (en) | 2017-01-12 |
| US20190024059A1 (en) | 2019-01-24 |
| US11591578B2 (en) | 2023-02-28 |
| US20170247667A1 (en) | 2017-08-31 |
| US10113153B2 (en) | 2018-10-30 |
| US20200291365A1 (en) | 2020-09-17 |
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| FF | Patent granted | ||
| KB | Patent renewed |