IL254662B - Spirocyclyls having 8-12 carbons attached to bicyclyl containing nitrogen and heterocyclyl containing nitrogen having 6 carbon atoms including nitrogen and their uses as erk inhibitors - Google Patents
Spirocyclyls having 8-12 carbons attached to bicyclyl containing nitrogen and heterocyclyl containing nitrogen having 6 carbon atoms including nitrogen and their uses as erk inhibitorsInfo
- Publication number
- IL254662B IL254662B IL254662A IL25466217A IL254662B IL 254662 B IL254662 B IL 254662B IL 254662 A IL254662 A IL 254662A IL 25466217 A IL25466217 A IL 25466217A IL 254662 B IL254662 B IL 254662B
- Authority
- IL
- Israel
- Prior art keywords
- membered
- nitrogen
- spirocyclics
- bicyclyl
- erk inhibitors
- Prior art date
Links
- 239000012824 ERK inhibitor Substances 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562142946P | 2015-04-03 | 2015-04-03 | |
| PCT/US2016/025345 WO2016161160A1 (en) | 2015-04-03 | 2016-03-31 | Spirocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL254662A0 IL254662A0 (en) | 2017-11-30 |
| IL254662B true IL254662B (en) | 2021-02-28 |
Family
ID=57007413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL254662A IL254662B (en) | 2015-04-03 | 2017-09-25 | Spirocyclyls having 8-12 carbons attached to bicyclyl containing nitrogen and heterocyclyl containing nitrogen having 6 carbon atoms including nitrogen and their uses as erk inhibitors |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10525036B2 (OSRAM) |
| EP (1) | EP3277690B1 (OSRAM) |
| JP (1) | JP6737533B2 (OSRAM) |
| KR (1) | KR20170132307A (OSRAM) |
| CN (1) | CN107849053B (OSRAM) |
| AU (1) | AU2016242940B2 (OSRAM) |
| BR (1) | BR112017021194A2 (OSRAM) |
| CA (1) | CA2981055A1 (OSRAM) |
| CY (1) | CY1123019T1 (OSRAM) |
| DK (1) | DK3277690T3 (OSRAM) |
| ES (1) | ES2788160T3 (OSRAM) |
| HR (1) | HRP20200805T1 (OSRAM) |
| HU (1) | HUE049481T2 (OSRAM) |
| IL (1) | IL254662B (OSRAM) |
| LT (1) | LT3277690T (OSRAM) |
| MX (1) | MX379622B (OSRAM) |
| PL (1) | PL3277690T3 (OSRAM) |
| PT (1) | PT3277690T (OSRAM) |
| RS (1) | RS60340B1 (OSRAM) |
| RU (1) | RU2745069C2 (OSRAM) |
| SG (1) | SG11201707911VA (OSRAM) |
| SI (1) | SI3277690T1 (OSRAM) |
| SM (1) | SMT202000279T1 (OSRAM) |
| TW (1) | TWI705067B (OSRAM) |
| WO (1) | WO2016161160A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106999451B (zh) * | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
| SMT202000279T1 (it) | 2015-04-03 | 2020-07-08 | Recurium Ip Holdings Llc | Composti spirociclici |
| CN109890827A (zh) | 2016-10-05 | 2019-06-14 | 芝诺罗耶尔蒂里程碑有限责任公司 | 螺环化合物 |
| EA201991375A1 (ru) | 2016-12-08 | 2020-01-20 | Боард Оф Регентс, Зе Юниверсити Оф Тексас Систем | Бицикло[1.1.1]пентановые ингибиторы киназы, содержащей домен с двумя лейциновыми "застежками-молниями" (dlk), для лечения заболевания |
| PE20211455A1 (es) * | 2018-01-31 | 2021-08-05 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| AU2020257301B2 (en) | 2019-04-18 | 2025-10-23 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof |
| US11560366B2 (en) | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| CN115124542A (zh) * | 2022-07-08 | 2022-09-30 | 河南师范大学 | 羟基苯取代吡唑酮并吲唑[螺]吡唑酮类化合物的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
| JP5380296B2 (ja) | 2006-11-17 | 2014-01-08 | ポリエラ コーポレイション | ジイミド系半導体材料ならびにジイミド系半導体材料を調製および使用する方法 |
| NZ587504A (en) | 2008-02-21 | 2012-09-28 | Merck Sharp & Dohme | Benzopyrazole derivatives as ERK inhibitors |
| US20110166124A1 (en) | 2008-07-23 | 2011-07-07 | Mccormick Kevin D | Tricyclic spirocycle derivatives and methods of use |
| JP2013506669A (ja) | 2009-09-30 | 2013-02-28 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｅｒｋ阻害剤である新規化合物 |
| EP3296398A1 (en) | 2009-12-07 | 2018-03-21 | Arbutus Biopharma Corporation | Compositions for nucleic acid delivery |
| ES2609579T3 (es) | 2011-08-29 | 2017-04-21 | VIIV Healthcare UK (No.5) Limited | Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH |
| CN103130775B (zh) * | 2011-11-22 | 2015-09-30 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
| US8987264B2 (en) * | 2012-11-09 | 2015-03-24 | Bristol-Myers Squibb Company | 1,3,5-triazine derivatives of spiro bicyclic oxalamide-compounds for treatment of hepatitis C |
| CA2903431C (en) * | 2013-03-14 | 2022-12-06 | Kalyra Pharmaceuticals, Inc. | Bicyclopentane analgesic compounds |
| CN105732636B (zh) | 2014-12-30 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| SMT202000279T1 (it) | 2015-04-03 | 2020-07-08 | Recurium Ip Holdings Llc | Composti spirociclici |
| CN109890827A (zh) | 2016-10-05 | 2019-06-14 | 芝诺罗耶尔蒂里程碑有限责任公司 | 螺环化合物 |
-
2016
- 2016-03-31 SM SM20200279T patent/SMT202000279T1/it unknown
- 2016-03-31 PT PT167742329T patent/PT3277690T/pt unknown
- 2016-03-31 WO PCT/US2016/025345 patent/WO2016161160A1/en not_active Ceased
- 2016-03-31 CA CA2981055A patent/CA2981055A1/en not_active Abandoned
- 2016-03-31 LT LTEP16774232.9T patent/LT3277690T/lt unknown
- 2016-03-31 HU HUE16774232A patent/HUE049481T2/hu unknown
- 2016-03-31 AU AU2016242940A patent/AU2016242940B2/en not_active Ceased
- 2016-03-31 KR KR1020177031578A patent/KR20170132307A/ko not_active Ceased
- 2016-03-31 EP EP16774232.9A patent/EP3277690B1/en active Active
- 2016-03-31 US US15/563,926 patent/US10525036B2/en not_active Expired - Fee Related
- 2016-03-31 SG SG11201707911VA patent/SG11201707911VA/en unknown
- 2016-03-31 HR HRP20200805TT patent/HRP20200805T1/hr unknown
- 2016-03-31 RU RU2017133973A patent/RU2745069C2/ru active
- 2016-03-31 MX MX2017012553A patent/MX379622B/es unknown
- 2016-03-31 RS RS20200577A patent/RS60340B1/sr unknown
- 2016-03-31 SI SI201630764T patent/SI3277690T1/sl unknown
- 2016-03-31 DK DK16774232.9T patent/DK3277690T3/da active
- 2016-03-31 ES ES16774232T patent/ES2788160T3/es active Active
- 2016-03-31 PL PL16774232T patent/PL3277690T3/pl unknown
- 2016-03-31 JP JP2017552060A patent/JP6737533B2/ja not_active Expired - Fee Related
- 2016-03-31 CN CN201680028591.0A patent/CN107849053B/zh not_active Expired - Fee Related
- 2016-03-31 BR BR112017021194A patent/BR112017021194A2/pt not_active IP Right Cessation
- 2016-04-01 TW TW105110691A patent/TWI705067B/zh not_active IP Right Cessation
-
2017
- 2017-09-25 IL IL254662A patent/IL254662B/en active IP Right Grant
-
2019
- 2019-03-15 US US16/354,949 patent/US10493060B2/en not_active Expired - Fee Related
-
2020
- 2020-01-06 US US16/734,857 patent/US20200268714A1/en not_active Abandoned
- 2020-04-10 CY CY20201100356T patent/CY1123019T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |