IL25425A - Process for the manufacture of 4,1-benzothiazepin-2-one derivatives and novel 4,1-benzothiazepin-2-one derivatives - Google Patents

Process for the manufacture of 4,1-benzothiazepin-2-one derivatives and novel 4,1-benzothiazepin-2-one derivatives

Info

Publication number
IL25425A
IL25425A IL25425A IL2542566A IL25425A IL 25425 A IL25425 A IL 25425A IL 25425 A IL25425 A IL 25425A IL 2542566 A IL2542566 A IL 2542566A IL 25425 A IL25425 A IL 25425A
Authority
IL
Israel
Prior art keywords
formula
process according
derivatives
compounds
benzothiazepin
Prior art date
Application number
IL25425A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US445248A external-priority patent/US3346638A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL25425A publication Critical patent/IL25425A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/18—Eight-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL25425A 1963-03-18 1966-03-21 Process for the manufacture of 4,1-benzothiazepin-2-one derivatives and novel 4,1-benzothiazepin-2-one derivatives IL25425A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26603063A 1963-03-18 1963-03-18
US44526465A 1965-04-02 1965-04-02
US445248A US3346638A (en) 1965-04-02 1965-04-02 Alpha-phenyl-2-amino-benzylmercaptanes
US535722A US3400119A (en) 1963-03-18 1966-03-21 Novel 4, 1-benzothiazepin-2(1h)-ones and 4, 1-benzothiazepines

Publications (1)

Publication Number Publication Date
IL25425A true IL25425A (en) 1970-07-19

Family

ID=27500875

Family Applications (4)

Application Number Title Priority Date Filing Date
IL25425A IL25425A (en) 1963-03-18 1966-03-21 Process for the manufacture of 4,1-benzothiazepin-2-one derivatives and novel 4,1-benzothiazepin-2-one derivatives
IL33557A IL33557A (en) 1963-03-18 1966-03-21 Benzothiazinones,benzoxazinethiones and benzothiazinethiones and their preparation
IL33556A IL33556A (en) 1963-03-18 1966-03-21 Alpha-phenyl-2-amino-benzyl-mercaptans
IL25447A IL25447A (en) 1963-03-18 1966-03-23 Benzothiazepines and benzothiazocines and their preparation

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL33557A IL33557A (en) 1963-03-18 1966-03-21 Benzothiazinones,benzoxazinethiones and benzothiazinethiones and their preparation
IL33556A IL33556A (en) 1963-03-18 1966-03-21 Alpha-phenyl-2-amino-benzyl-mercaptans
IL25447A IL25447A (en) 1963-03-18 1966-03-23 Benzothiazepines and benzothiazocines and their preparation

Country Status (13)

Country Link
US (1) US3400119A (xx)
BE (3) BE645242A (xx)
BR (3) BR6457097D0 (xx)
CH (7) CH442313A (xx)
DE (3) DE1445889A1 (xx)
DK (2) DK116362B (xx)
FR (3) FR3681M (xx)
GB (8) GB1043481A (xx)
IL (4) IL25425A (xx)
MY (2) MY6800087A (xx)
NL (3) NL139179B (xx)
NO (1) NO121211B (xx)
SE (2) SE345670B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485824A (en) * 1963-03-18 1969-12-23 Hoffmann La Roche 1-substituted 4,1-benzothiazepin-2(1h)-ones and 4,1-benzothiazepines
US3463774A (en) * 1963-03-18 1969-08-26 Hoffmann La Roche Novel 4,1-benzothiazepin-2-(1h)-ones and 4,1-benzothiazepines
DE1620642A1 (de) * 1965-09-15 1970-08-20 Ucb Sa Heterocyclische Derivate und Verfahren zu ihrer Herstellung
US3542767A (en) * 1968-02-29 1970-11-24 American Home Prod Substituted 1,3,4-benzotriazepin-5h-5-ones
US3539555A (en) * 1968-12-12 1970-11-10 Squibb & Sons Inc Dibenzo(b,f)(1,4)oxazocines,dibenzo(b,f)(1,4)oxazonines and thio analogs
US3682962A (en) * 1970-03-17 1972-08-08 Sterling Drug Inc 1-substituted-1,2,3,5-tetrahydro-4,1-benzothiozepines
US3697516A (en) * 1970-10-19 1972-10-10 Phillips Petroleum Co Certain thiazine-2-thione compounds and method of preparing same
DE3320746A1 (de) * 1982-06-17 1983-12-22 Sandoz-Patent-GmbH, 7850 Lörrach Benzolderivate, ihre herstellung und pharmazeutische praeparate welche sie enthalten
US5246791A (en) * 1988-07-06 1993-09-21 Johnson Matthey Public Limited Company Fuel cell containing a reforming catalyst
CA2016517C (en) * 1989-05-11 1999-01-12 Dale R. Shackle Solid state electrochemical cell having microroughened current collector
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
DE19924668A1 (de) 1999-05-28 2000-11-30 Bayer Ag Substituierte alpha-Phenyl-beta-Ketosulfone
WO2015120059A1 (en) * 2014-02-04 2015-08-13 Yates Charles Ryan Inhibitors of paxillin function and related compositions and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144439A (en) * 1964-08-11 Process for production of benzo-
US3155649A (en) * 1962-07-11 1964-11-03 Olin Mathieson Benzothiazocinones, related compounds and their preparation

Also Published As

Publication number Publication date
DE1695132A1 (de) 1970-12-10
SE345670B (xx) 1972-06-05
NL139179B (nl) 1973-06-15
BE645242A (xx) 1964-09-16
FR5746M (xx) 1968-01-29
US3400119A (en) 1968-09-03
BR6678325D0 (pt) 1973-09-18
GB1098803A (en) 1968-01-10
IL33557A (en) 1970-07-19
CH481131A (de) 1969-11-15
FR3681M (fr) 1965-11-15
BR6678152D0 (pt) 1973-09-06
CH448096A (de) 1967-12-15
DK116362B (da) 1970-01-05
DE1445889A1 (de) 1969-04-10
CH441327A (de) 1967-08-15
BE678771A (xx) 1966-09-30
CH441326A (de) 1967-08-15
GB1077276A (en) 1967-07-26
NL6604470A (xx) 1966-10-03
NL6604383A (xx) 1966-10-03
CH442313A (de) 1967-08-31
GB1098807A (en) 1968-01-10
IL33556A (en) 1970-07-19
NL6402756A (xx) 1964-09-21
CH441324A (de) 1967-08-15
BR6457097D0 (pt) 1973-08-09
MY6800086A (en) 1968-12-31
GB1098806A (en) 1968-01-10
BE678772A (xx) 1966-09-30
GB1098805A (en) 1968-01-10
FR5314M (xx) 1967-08-21
NO121211B (xx) 1971-02-01
SE356983B (xx) 1973-06-12
GB1077272A (en) 1967-07-26
GB1043481A (en) 1966-09-21
DE1695134A1 (de) 1970-12-10
MY6800087A (en) 1968-12-31
GB1098804A (en) 1968-01-10
IL25447A (en) 1970-06-17
DK126383B (da) 1973-07-09
CH471809A (de) 1969-04-30

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