IL245407B - Salts of 1-(3-methyl-2-oxo-3,2-dihydro-3,1-benzoxazol-6-yl)-4,2-dioxo-3-[(r1)-4-(trifluoromethyl)-3 2-dihydro-1h-indan-1-yl]-4,3,2,1-tetrahydropyrimidine-5-carboxylic acid - Google Patents
Salts of 1-(3-methyl-2-oxo-3,2-dihydro-3,1-benzoxazol-6-yl)-4,2-dioxo-3-[(r1)-4-(trifluoromethyl)-3 2-dihydro-1h-indan-1-yl]-4,3,2,1-tetrahydropyrimidine-5-carboxylic acidInfo
- Publication number
- IL245407B IL245407B IL24540716A IL24540716A IL245407B IL 245407 B IL245407 B IL 245407B IL 24540716 A IL24540716 A IL 24540716A IL 24540716 A IL24540716 A IL 24540716A IL 245407 B IL245407 B IL 245407B
- Authority
- IL
- Israel
- Prior art keywords
- dihydro
- trifluorethyl
- tetrahydropyrimidin
- benzoxazol
- inden
- Prior art date
Links
- JDHHMBZHLMLKEL-QGZVFWFLSA-N 1-(3-methyl-2-oxo-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)-4-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-inden-1-yl]pyrimidine-5-carboxylic acid Chemical class CN1C(OC2=C1C=CC(=C2)N1C(N(C(C(=C1)C(=O)O)=O)[C@@H]1CCC2=C(C=CC=C12)CC(F)(F)F)=O)=O JDHHMBZHLMLKEL-QGZVFWFLSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13192177 | 2013-11-08 | ||
| PCT/EP2014/073801 WO2015067652A1 (de) | 2013-11-08 | 2014-11-05 | Salze von 1 -(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1 r)-4-(trifluormethyl)-2,3-dihydro-1h-inden-1 -yl]-1,2,3,4-tetrahydropyrimidin-5-carbonsäure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL245407A0 IL245407A0 (en) | 2016-06-30 |
| IL245407B true IL245407B (en) | 2019-10-31 |
Family
ID=49552231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL24540716A IL245407B (en) | 2013-11-08 | 2016-05-01 | Salts of 1-(3-methyl-2-oxo-3,2-dihydro-3,1-benzoxazol-6-yl)-4,2-dioxo-3-[(r1)-4-(trifluoromethyl)-3 2-dihydro-1h-indan-1-yl]-4,3,2,1-tetrahydropyrimidine-5-carboxylic acid |
Country Status (32)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3338780A1 (de) | 2016-12-20 | 2018-06-27 | Bayer Pharma Aktiengesellschaft | Verwendung von chymaseinhibitoren zur behandlung von endometriose, post-operativer fibrose und erkrankungen die durch fibrosebildung gekennzeichnet sind |
| CA3061444A1 (en) * | 2017-04-27 | 2018-11-01 | Bayer Aktiengesellschaft | Selective adrenoreceptor .alpha.2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad) |
| WO2022135502A1 (zh) * | 2020-12-25 | 2022-06-30 | 广东东阳光药业有限公司 | 多取代的尿嘧啶衍生物及其用途 |
| KR20240170943A (ko) * | 2022-04-05 | 2024-12-05 | 스코프라 시앙스 쌍테 에 휴마이네스 에스.에.쎄. | 혈전성 또는 혈전색전성 장애에서 혈전의 선택적인 해소에 사용하기 위한 키마제의 억제제 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002032881A1 (en) * | 2000-10-19 | 2002-04-25 | Nippon Kayaku Kabushiki Kaisha | Novel remedies or preventives for angiostenosis |
| AT511788A1 (de) | 2011-07-29 | 2013-02-15 | Georg Dr Gaul | Vorrichtung zur vorgebbaren anordnung eines stents |
| EP2822405A4 (en) * | 2012-03-05 | 2015-04-29 | Gratuk Technologies Pty Ltd | FOOD SUPPLEMENTS |
| UA112897C2 (uk) * | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
| CA2929763A1 (en) * | 2013-11-08 | 2015-05-14 | Bayer Pharma Aktiengesellschaft | Substituted uracils as chymase inhibitors |
-
2014
- 2014-11-05 ES ES14793565.4T patent/ES2645480T3/es active Active
- 2014-11-05 AU AU2014345599A patent/AU2014345599B2/en active Active
- 2014-11-05 JP JP2016551038A patent/JP6446051B2/ja active Active
- 2014-11-05 LT LTEP14793565.4T patent/LT3066097T/lt unknown
- 2014-11-05 SI SI201430450T patent/SI3066097T1/sl unknown
- 2014-11-05 UA UAA201606202A patent/UA117686C2/uk unknown
- 2014-11-05 PL PL14793565T patent/PL3066097T3/pl unknown
- 2014-11-05 ME MEP-2017-249A patent/ME02907B/me unknown
- 2014-11-05 HR HRP20171603TT patent/HRP20171603T1/hr unknown
- 2014-11-05 BR BR112016010253A patent/BR112016010253A8/pt not_active Application Discontinuation
- 2014-11-05 CN CN201480057947.4A patent/CN105658647B/zh active Active
- 2014-11-05 PT PT147935654T patent/PT3066097T/pt unknown
- 2014-11-05 MA MA39020A patent/MA39020A1/fr unknown
- 2014-11-05 NO NO14793565A patent/NO3066097T3/no unknown
- 2014-11-05 MY MYPI2016701615A patent/MY190108A/en unknown
- 2014-11-05 TN TN2016000170A patent/TN2016000170A1/en unknown
- 2014-11-05 US US15/035,165 patent/US9926305B2/en active Active
- 2014-11-05 HU HUE14793565A patent/HUE035021T2/en unknown
- 2014-11-05 KR KR1020167011771A patent/KR102351418B1/ko active Active
- 2014-11-05 CA CA2929780A patent/CA2929780C/en active Active
- 2014-11-05 EA EA201600381A patent/EA033132B1/ru not_active IP Right Cessation
- 2014-11-05 EP EP14793565.4A patent/EP3066097B1/de active Active
- 2014-11-05 WO PCT/EP2014/073801 patent/WO2015067652A1/de not_active Ceased
- 2014-11-05 AP AP2016009181A patent/AP2016009181A0/en unknown
- 2014-11-05 MX MX2016005971A patent/MX366848B/es active IP Right Grant
- 2014-11-05 RS RS20171063A patent/RS56509B1/sr unknown
- 2014-11-05 DK DK14793565.4T patent/DK3066097T3/da active
-
2016
- 2016-05-01 IL IL24540716A patent/IL245407B/en active IP Right Grant
- 2016-05-06 CL CL2016001096A patent/CL2016001096A1/es unknown
- 2016-05-06 PH PH12016500853A patent/PH12016500853B1/en unknown
- 2016-05-08 SA SA516371082A patent/SA516371082B1/ar unknown
-
2017
- 2017-10-25 CY CY20171101110T patent/CY1119520T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ITMI20131102A1 (it) | Gestione harq-ack per subframe di dowlink non intenzionali | |
| EP3042261A4 (en) | Managing power feeds through waveform monitoring | |
| SMT201700003B (it) | Didropiridoni come inibitori del fattore xia | |
| EP3001864A4 (en) | Contextual heart rate monitoring | |
| EP2773398A4 (en) | SYRINGE WITH AN ANTISEPTIC CAP | |
| PT3010910T (pt) | Compostos de pirimidinadiona contra as condições cardíacas | |
| CO7061071A2 (es) | Procesos para la preparación de (s)-1-(3-etoxi-4-metoxifenil)-2-metansulfoniletilamina | |
| EP2773566A4 (en) | APPLICATORS FOR STORING, STERILIZING AND DISTRIBUTING A LIABILITY | |
| HRP20160250T1 (hr) | Postupak za pripravu 2-(2,3-dimetilfenil)-1-propanala s kloracetonom | |
| EP2863748A4 (en) | 1,2,4-triazine-6-CARBOXAMIDKINASEINHIBITOREN | |
| CL2017001467A1 (es) | Compuestos de dihidropirimidin - 2 - ona y sus usos médicos | |
| EP2889016A4 (en) | DENTAL SYRINGE | |
| IL245407B (en) | Salts of 1-(3-methyl-2-oxo-3,2-dihydro-3,1-benzoxazol-6-yl)-4,2-dioxo-3-[(r1)-4-(trifluoromethyl)-3 2-dihydro-1h-indan-1-yl]-4,3,2,1-tetrahydropyrimidine-5-carboxylic acid | |
| EP2973109A4 (en) | DYNAMIC WORKFLOW FOR SUPERBILLCODING | |
| UY34786A (es) | Procedimiento para la fabricación de una forma farmacéutica que comprende nifedipino y candesartan cilexetilo | |
| EP3212705A4 (en) | Oxalic acid diamides as modifiers for polyolefin catalysts | |
| ITMI20130722A1 (it) | Macchina di riempimento combinata, dotata di funzione di pesatura e di gestione del volume, per camere bianche | |
| ITMI20130708A1 (it) | Macchina di riempimento combinata, dotata di funzione di pesatura e di gestione del volume, per camere bianche | |
| SI2656843T1 (sl) | Estri bendamustina in povezane spojine ter njihova medicinska uporaba | |
| BR112017007509A2 (pt) | Processo para a preparação de 1-(3,5-dicloro-4- fluoro-fenil)-2,2,2-trifluoro-etanona | |
| MX373227B (es) | Sales farmacéuticamente aceptables de enantiómeros de pirlindol para utilizarse en medicina. | |
| GB2529601B (en) | Dynamic management of integration protocols | |
| GB201704861D0 (en) | Contextual workflow management | |
| BR112015028948A2 (pt) | gerenciamento de entrega de medicamento | |
| FR3003479B1 (fr) | Distributeur de produit fluide rechargeable. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |