IL239208B - תרכובות ושיטות לטיהור של פרוטאזות של סרין - Google Patents
תרכובות ושיטות לטיהור של פרוטאזות של סריןInfo
- Publication number
- IL239208B IL239208B IL239208A IL23920815A IL239208B IL 239208 B IL239208 B IL 239208B IL 239208 A IL239208 A IL 239208A IL 23920815 A IL23920815 A IL 23920815A IL 239208 B IL239208 B IL 239208B
- Authority
- IL
- Israel
- Prior art keywords
- purification
- compounds
- methods
- serine proteases
- proteases
- Prior art date
Links
- 102000012479 Serine Proteases Human genes 0.000 title 1
- 108010022999 Serine Proteases Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746544P | 2012-12-27 | 2012-12-27 | |
| US13/830,372 US9200268B2 (en) | 2012-12-27 | 2013-03-14 | Compounds and methods for purification of serine proteases |
| PCT/US2013/078130 WO2014106128A1 (en) | 2012-12-27 | 2013-12-27 | Compounds and methods for purification of serine proteases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL239208A0 IL239208A0 (he) | 2015-07-30 |
| IL239208B true IL239208B (he) | 2018-07-31 |
Family
ID=51017611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL239208A IL239208B (he) | 2012-12-27 | 2015-06-04 | תרכובות ושיטות לטיהור של פרוטאזות של סרין |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9200268B2 (he) |
| EP (2) | EP3293175B1 (he) |
| AU (1) | AU2013370215B9 (he) |
| CA (1) | CA2896512C (he) |
| ES (1) | ES2907133T3 (he) |
| IL (1) | IL239208B (he) |
| NZ (1) | NZ709541A (he) |
| SG (1) | SG11201504339TA (he) |
| WO (1) | WO2014106128A1 (he) |
| ZA (2) | ZA201505200B (he) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140346397A1 (en) | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| CN106831498B (zh) * | 2017-01-12 | 2018-10-30 | 广州润坤生物科技有限公司 | 呋喃西林代谢物sem衍生化半抗原、人工抗原的制备方法及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2002961A3 (cs) * | 1999-09-17 | 2002-08-14 | Millennium Pharmaceuticals, Inc. | Benzamidy a příbuzné sloučeniny pro inhibici faktoru Xa |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| EP1373194B1 (en) * | 2001-03-30 | 2007-08-01 | Millennium Pharmaceuticals, Inc. | BENZAMIDE INHIBITORS OF FACTOR Xa |
| US7022695B2 (en) * | 2003-10-09 | 2006-04-04 | Millennium Pharmaceuticals, Inc. | Thioether-substituted benzamides as inhibitors of Factor Xa |
| ATE457302T1 (de) * | 2004-11-24 | 2010-02-15 | Lilly Co Eli | Aromatische etherderivate als thrombin-hemmer |
| CN101304971B (zh) | 2005-11-08 | 2011-09-07 | 米伦纽姆医药公司 | Xa因子抑制剂n-(5-氯-2-吡啶基)-2-[[4-[(二甲氨基)亚氨基甲基]苯甲酰基]氨基]-5-甲氧基-苯甲酰胺的医药盐和多晶型 |
| EP2077995B1 (en) | 2006-11-02 | 2012-02-08 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
| PT2101760E (pt) * | 2006-12-08 | 2013-05-07 | Millennium Pharm Inc | Formulações de dose unitária e métodos de tratamento da trombose com um inibidor oral do fator xa |
| EP2155195B1 (en) | 2007-04-13 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor |
| KR101509829B1 (ko) | 2007-05-02 | 2015-04-06 | 포톨라 파마슈티컬스, 인코포레이티드 | 혈소판 ａｄｐ 수용체 억제제로 작용하는 화합물을 이용한 병용요법 |
| KR102069498B1 (ko) | 2007-09-28 | 2020-01-23 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법 |
| PL3604510T3 (pl) | 2009-03-30 | 2025-07-28 | Alexion Pharmaceuticals, Inc. | Antidota na inhibitory czynnika xa i sposoby ich stosowania |
| WO2010127980A1 (en) | 2009-05-05 | 2010-11-11 | F. Hoffmann-La Roche Ag | Fret-based binding assay |
| JP5766204B2 (ja) | 2009-12-17 | 2015-08-19 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 第Ｘａ因子阻害剤の合成方法 |
| TW201221128A (en) | 2010-09-01 | 2012-06-01 | Portola Pharm Inc | Crystalline forms of a factor Xa inhibitor |
| AR082803A1 (es) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Metodos y formulaciones para el tratamiento de la trombosis con betrixaban y un inhibidor de la glicoproteina p |
| JP2015507929A (ja) | 2012-02-14 | 2015-03-16 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 第Ｘａ因子阻害剤に対する組み換え拮抗剤を製作するためのプロセス |
| EP2861614B1 (en) | 2012-06-14 | 2016-11-30 | Portola Pharmaceuticals, Inc. | METHOD FOR PURIFICATION OF RECOMBINANT FACTOR Xa DERIVATIVES |
-
2013
- 2013-03-14 US US13/830,372 patent/US9200268B2/en active Active
- 2013-12-27 WO PCT/US2013/078130 patent/WO2014106128A1/en not_active Ceased
- 2013-12-27 EP EP17191911.1A patent/EP3293175B1/en active Active
- 2013-12-27 ES ES17191911T patent/ES2907133T3/es active Active
- 2013-12-27 AU AU2013370215A patent/AU2013370215B9/en active Active
- 2013-12-27 CA CA2896512A patent/CA2896512C/en active Active
- 2013-12-27 SG SG11201504339TA patent/SG11201504339TA/en unknown
- 2013-12-27 EP EP13822069.4A patent/EP2938596B1/en active Active
- 2013-12-27 NZ NZ709541A patent/NZ709541A/en not_active IP Right Cessation
-
2015
- 2015-06-04 IL IL239208A patent/IL239208B/he active IP Right Grant
- 2015-07-20 ZA ZA2015/05200A patent/ZA201505200B/en unknown
-
2018
- 2018-01-05 ZA ZA2018/00077A patent/ZA201800077B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014106128A1 (en) | 2014-07-03 |
| CA2896512C (en) | 2021-09-14 |
| US9200268B2 (en) | 2015-12-01 |
| ES2907133T3 (es) | 2022-04-22 |
| EP2938596A1 (en) | 2015-11-04 |
| US20140186923A1 (en) | 2014-07-03 |
| AU2013370215B9 (en) | 2018-04-19 |
| ZA201505200B (en) | 2022-09-28 |
| IL239208A0 (he) | 2015-07-30 |
| EP2938596B1 (en) | 2017-11-01 |
| EP3293175B1 (en) | 2021-12-01 |
| AU2013370215A1 (en) | 2015-07-16 |
| SG11201504339TA (en) | 2015-07-30 |
| CA2896512A1 (en) | 2014-07-03 |
| HK1216252A1 (en) | 2016-10-28 |
| EP3293175A1 (en) | 2018-03-14 |
| NZ709541A (en) | 2019-01-25 |
| HK1252173A1 (en) | 2019-05-17 |
| AU2013370215B2 (en) | 2018-04-05 |
| ZA201800077B (en) | 2019-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |