IL234825A0 - Phenyl-urea and phenyl-carbamate derivatives as protein aggregation suppressors, preparations containing them and their uses - Google Patents
Phenyl-urea and phenyl-carbamate derivatives as protein aggregation suppressors, preparations containing them and their usesInfo
- Publication number
- IL234825A0 IL234825A0 IL234825A IL23482514A IL234825A0 IL 234825 A0 IL234825 A0 IL 234825A0 IL 234825 A IL234825 A IL 234825A IL 23482514 A IL23482514 A IL 23482514A IL 234825 A0 IL234825 A0 IL 234825A0
- Authority
- IL
- Israel
- Prior art keywords
- phenyl
- urea
- inhibitors
- compositions
- same
- Prior art date
Links
- LUBJCRLGQSPQNN-UHFFFAOYSA-N 1-Phenylurea Chemical compound NC(=O)NC1=CC=CC=C1 LUBJCRLGQSPQNN-UHFFFAOYSA-N 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- PWXJULSLLONQHY-UHFFFAOYSA-N phenylcarbamic acid Chemical class OC(=O)NC1=CC=CC=C1 PWXJULSLLONQHY-UHFFFAOYSA-N 0.000 title 1
- 230000004845 protein aggregation Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616771P | 2012-03-28 | 2012-03-28 | |
| PCT/US2013/032552 WO2013148365A1 (en) | 2012-03-28 | 2013-03-15 | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL234825A0 true IL234825A0 (en) | 2014-12-31 |
Family
ID=49261100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL234825A IL234825A0 (en) | 2012-03-28 | 2014-09-23 | Phenyl-urea and phenyl-carbamate derivatives as protein aggregation suppressors, preparations containing them and their uses |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9527852B2 (enExample) |
| EP (1) | EP2830608B8 (enExample) |
| JP (1) | JP6159388B2 (enExample) |
| KR (1) | KR20150002713A (enExample) |
| CN (1) | CN104363903A (enExample) |
| AU (1) | AU2013240219A1 (enExample) |
| CA (1) | CA2867175A1 (enExample) |
| ES (1) | ES2768602T3 (enExample) |
| HK (1) | HK1202452A1 (enExample) |
| IL (1) | IL234825A0 (enExample) |
| IN (1) | IN2014DN08633A (enExample) |
| MX (1) | MX2014011615A (enExample) |
| NZ (1) | NZ631388A (enExample) |
| RU (1) | RU2014143242A (enExample) |
| WO (1) | WO2013148365A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3348556T3 (pl) | 2014-01-29 | 2020-11-02 | UCB Biopharma SRL | Heteroaryloamidy jako inhibitory agregacji białka |
| WO2016040780A1 (en) * | 2014-09-11 | 2016-03-17 | Neuropore Therapies, Inc. | Aminomethyl- and methyloxy-linked tricyclic compounds as inhibitors of protein aggregation |
| EP3328379B1 (en) | 2015-07-29 | 2021-07-28 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| MX2019007053A (es) | 2017-01-26 | 2019-08-29 | Ucb Biopharma Sprl | Derivados de bis-heteroarilo como moduladores de la agregacion de proteinas. |
| EA201991753A1 (ru) | 2017-01-26 | 2020-01-14 | Юсб Байофарма Спрл | Алкоксибисгетероарильные производные в качестве модуляторов агрегации белков |
| US10889584B2 (en) | 2017-01-26 | 2021-01-12 | UCB Biopharma SRL | Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997027192A1 (de) * | 1996-01-26 | 1997-07-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 3-methylimidazopyridine |
| US6617351B1 (en) * | 1998-07-31 | 2003-09-09 | Eli Lilly And Company | Amide, carbamate, and urea derivatives |
| MXPA02004879A (es) * | 1999-11-16 | 2002-08-30 | Boehringer Ingelheim Pharma | Derivados de urea como agentes antiinflamatorios. |
| AU9578901A (en) * | 2000-10-30 | 2002-05-15 | Kudos Pharm Ltd | Phthalazinone derivatives |
| EP1402888A1 (en) | 2002-09-18 | 2004-03-31 | Jerini AG | The use of substituted carbocyclic compounds as rotamases inhibitors |
| BRPI0408205A (pt) | 2003-03-14 | 2006-02-14 | Lundbeck & Co As H | derivado de anilina substituìdo, composição farmacêutica, e, uso de uma composição farmacêutica |
| EP1613303A1 (en) | 2003-03-21 | 2006-01-11 | H. Lundbeck A/S | Substituted p-diaminobenzene derivatives |
| US20050267182A1 (en) * | 2003-11-13 | 2005-12-01 | Ambit Biosciences Corporation | Urea derivatives as FLT-3 modulators |
| DK2395004T3 (en) * | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| US8097626B2 (en) | 2006-04-21 | 2012-01-17 | Glaxosmithkline Llc | IL-8 receptor antagonists |
| WO2008044688A1 (en) * | 2006-10-11 | 2008-04-17 | Daiichi Sankyo Company, Limited | Urea derivative |
| WO2010036316A1 (en) | 2008-09-24 | 2010-04-01 | Yangbo Feng | Urea and carbamate compounds and analogs as kinase inhibitors |
| WO2011084642A1 (en) * | 2009-12-16 | 2011-07-14 | Neuropore Therapies, Inc. | Compound suitable for the treatment of synucleopathies |
-
2013
- 2013-03-15 JP JP2015503346A patent/JP6159388B2/ja active Active
- 2013-03-15 CN CN201380017441.6A patent/CN104363903A/zh active Pending
- 2013-03-15 MX MX2014011615A patent/MX2014011615A/es unknown
- 2013-03-15 HK HK15103189.8A patent/HK1202452A1/xx unknown
- 2013-03-15 ES ES13768915T patent/ES2768602T3/es active Active
- 2013-03-15 CA CA2867175A patent/CA2867175A1/en not_active Abandoned
- 2013-03-15 KR KR1020147030291A patent/KR20150002713A/ko not_active Withdrawn
- 2013-03-15 RU RU2014143242A patent/RU2014143242A/ru not_active Application Discontinuation
- 2013-03-15 EP EP13768915.4A patent/EP2830608B8/en active Active
- 2013-03-15 NZ NZ631388A patent/NZ631388A/en not_active IP Right Cessation
- 2013-03-15 US US14/388,783 patent/US9527852B2/en active Active
- 2013-03-15 WO PCT/US2013/032552 patent/WO2013148365A1/en not_active Ceased
- 2013-03-15 AU AU2013240219A patent/AU2013240219A1/en not_active Abandoned
-
2014
- 2014-09-23 IL IL234825A patent/IL234825A0/en unknown
- 2014-10-15 IN IN8633DEN2014 patent/IN2014DN08633A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150002713A (ko) | 2015-01-07 |
| US20150166543A1 (en) | 2015-06-18 |
| ES2768602T3 (es) | 2020-06-23 |
| CA2867175A1 (en) | 2013-10-03 |
| JP6159388B2 (ja) | 2017-07-05 |
| EP2830608B1 (en) | 2019-12-11 |
| CN104363903A (zh) | 2015-02-18 |
| NZ631388A (en) | 2016-01-29 |
| EP2830608B8 (en) | 2020-01-15 |
| WO2013148365A1 (en) | 2013-10-03 |
| EP2830608A4 (en) | 2015-08-19 |
| AU2013240219A1 (en) | 2014-10-09 |
| MX2014011615A (es) | 2015-01-19 |
| IN2014DN08633A (enExample) | 2015-05-22 |
| RU2014143242A (ru) | 2016-05-20 |
| US9527852B2 (en) | 2016-12-27 |
| HK1202452A1 (en) | 2015-10-02 |
| EP2830608A1 (en) | 2015-02-04 |
| JP2015515465A (ja) | 2015-05-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201401117B (en) | Kynurenine-3-monooxygenase inhibitors,pharmaceutical compositions,and methods of use thereof | |
| IL238959A0 (en) | Glutamase inhibitors, preparations containing them and their uses | |
| IL235944A0 (en) | β-lactamase inhibitor compounds, preparations containing them, methods for their preparation and their uses | |
| IL253911A0 (en) | Inhibitors of kynurenine-3-monooxygenase, pharmaceutical compositions, and methods of their use | |
| IL234884A0 (en) | Inhibitors of kynurenine-3-monooxygenase pharmaceutical compositions, and methods of their use | |
| IL232822B (en) | Furinone hydrochloride derivative, its crystals, preparations containing it and its uses | |
| IL231226A0 (en) | Compounds and preparations as kit inhibitors - c | |
| IL231227A0 (en) | Compounds and preparations as kit inhibitors - c | |
| IL238876A0 (en) | Indoleamine 2,3-dioxygenase inhibitors, preparations containing them and their uses | |
| ZA201206223B (en) | Certain kynurenine-3-monooxygenase inhibitors,pharmaceutical compositions, and methods of use thereof | |
| HUE044300T2 (hu) | 3-amino-cikloalkil-vegyületek, mint ROR-GAMMA-T inhibitorok és alkalmazásuk | |
| SG11201501292UA (en) | Anxiolytic composition, formulation and method of use | |
| IL235155B (en) | Arginase inhibitor compounds, compositions comprising same and uses thereof | |
| IL230705A0 (en) | Certain inhibitors of kynurenine-3-monooxygenase pharmaceutical compositions, and methods of their use | |
| IL232217A (en) | Derivatives of Azul, pharmaceutical preparations containing them and their use | |
| HUE050010T2 (hu) | Kazein készítmények alkalmazása | |
| IL233602A0 (en) | History of benzamide, their preparation and pharmaceutical preparations containing them | |
| EP3049389A4 (en) | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | |
| EP3049077A4 (en) | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | |
| EP2830608B8 (en) | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation | |
| ZA201306905B (en) | Novel octahydrothienoquinonline derivative,pharmaceutical composition comprising derivative, and use of these | |
| IL233682A0 (en) | Modified phenylazole derivatives, preparations containing them and their uses | |
| IL228439A0 (en) | Gallium compounds, medical preparations and methods of use |