IL231911B - Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazoline-6-yloxy-piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this - Google Patents

Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazoline-6-yloxy-piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this

Info

Publication number
IL231911B
IL231911B IL231911A IL23191114A IL231911B IL 231911 B IL231911 B IL 231911B IL 231911 A IL231911 A IL 231911A IL 23191114 A IL23191114 A IL 23191114A IL 231911 B IL231911 B IL 231911B
Authority
IL
Israel
Prior art keywords
methoxyquinazolin
fluorophenylamino
yloxy
piperidin
prop
Prior art date
Application number
IL231911A
Other languages
English (en)
Hebrew (he)
Other versions
IL231911A0 (en
Original Assignee
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48044309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL231911(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd
Publication of IL231911A0 publication Critical patent/IL231911A0/en
Publication of IL231911B publication Critical patent/IL231911B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL231911A 2011-10-05 2014-04-03 Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazoline-6-yloxy-piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this IL231911B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110101422A KR101272613B1 (ko) 2011-10-05 2011-10-05 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온 염산염의 제조 방법 및 이에 사용되는 중간체
PCT/KR2012/008077 WO2013051883A2 (en) 2011-10-05 2012-10-05 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used therein

Publications (2)

Publication Number Publication Date
IL231911A0 IL231911A0 (en) 2014-05-28
IL231911B true IL231911B (en) 2018-06-28

Family

ID=48044309

Family Applications (3)

Application Number Title Priority Date Filing Date
IL231911A IL231911B (en) 2011-10-05 2014-04-03 Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazoline-6-yloxy-piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this
IL259694A IL259694B (en) 2011-10-05 2018-05-29 Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl-oxy)piperidine-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this
IL291738A IL291738A (en) 2011-10-05 2022-03-27 Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazoline-6-yloxy-piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL259694A IL259694B (en) 2011-10-05 2018-05-29 Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl-oxy)piperidine-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this
IL291738A IL291738A (en) 2011-10-05 2022-03-27 Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazoline-6-yloxy-piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this

Country Status (23)

Country Link
US (1) US8859767B2 (enExample)
EP (2) EP2763981B1 (enExample)
JP (1) JP5805880B2 (enExample)
KR (1) KR101272613B1 (enExample)
CN (2) CN110003174A (enExample)
AU (1) AU2012319291B2 (enExample)
BR (1) BR112014007718B1 (enExample)
CA (1) CA2850055C (enExample)
CY (1) CY1122758T1 (enExample)
DK (1) DK2763981T3 (enExample)
ES (1) ES2775197T3 (enExample)
HR (1) HRP20200426T1 (enExample)
HU (1) HUE048798T2 (enExample)
IL (3) IL231911B (enExample)
IN (1) IN2014DN03447A (enExample)
LT (1) LT2763981T (enExample)
MX (1) MX348815B (enExample)
PL (1) PL2763981T3 (enExample)
PT (1) PT2763981T (enExample)
RS (1) RS60118B1 (enExample)
RU (1) RU2563630C1 (enExample)
SI (1) SI2763981T1 (enExample)
WO (1) WO2013051883A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101317809B1 (ko) 2011-06-07 2013-10-16 한미약품 주식회사 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물
KR20140096571A (ko) * 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
CN104513229A (zh) * 2013-09-28 2015-04-15 正大天晴药业集团股份有限公司 喹唑啉衍生物及其制备方法
HK1244278B (zh) 2015-03-20 2020-04-17 正大天晴药业集团股份有限公司 喹唑啉衍生物的盐及其制备方法
KR102802129B1 (ko) * 2018-09-14 2025-05-02 한미약품 주식회사 퀴나졸린 화합물 및 이의 염산염의 결정 형태
KR101950942B1 (ko) * 2019-01-28 2019-02-22 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
US20210221792A1 (en) * 2020-01-16 2021-07-22 Hanmi Pharm Co., Ltd. Convergent synthesis of poziotinib derivative
WO2022043923A1 (en) * 2020-08-28 2022-03-03 Hanmi Science Co., Ltd. Synthesis of poziotinib derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200813014A (en) * 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
DE602004004811T2 (de) * 2003-09-19 2007-11-22 Astrazeneca Ab Chinazolinderivate
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
EP1966189A1 (de) * 2005-12-12 2008-09-10 Boehringer Ingelheim International Gmbh Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
TWI377944B (en) * 2007-06-05 2012-12-01 Hanmi Holdings Co Ltd Novel amide derivative for inhibiting the growth of cancer cells
CN102459174A (zh) * 2009-04-23 2012-05-16 阿斯利康(瑞典)有限公司 4-(3-氯-2-氟苯胺基)-7-甲氧基-6-[1-(n-甲基氨基甲酰基甲基)哌啶-4-基]喹唑啉的制备方法

Also Published As

Publication number Publication date
IL259694B (en) 2022-04-01
PT2763981T (pt) 2020-03-25
IL259694A (en) 2018-07-31
AU2012319291A1 (en) 2014-05-22
AU2012319291B2 (en) 2016-03-31
EP3611172A1 (en) 2020-02-19
WO2013051883A2 (en) 2013-04-11
MX348815B (es) 2017-06-30
JP2014528444A (ja) 2014-10-27
KR20130037079A (ko) 2013-04-15
EP2763981A4 (en) 2015-02-25
DK2763981T3 (da) 2020-03-16
WO2013051883A3 (en) 2013-06-06
CY1122758T1 (el) 2021-03-12
IN2014DN03447A (enExample) 2015-06-26
RS60118B1 (sr) 2020-05-29
CA2850055A1 (en) 2013-04-11
IL291738A (en) 2022-05-01
EP2763981B1 (en) 2020-01-08
CA2850055C (en) 2016-05-17
SI2763981T1 (sl) 2020-07-31
US8859767B2 (en) 2014-10-14
LT2763981T (lt) 2020-05-25
HUE048798T2 (hu) 2020-08-28
EP2763981A2 (en) 2014-08-13
HRP20200426T1 (hr) 2020-09-04
IL231911A0 (en) 2014-05-28
CN103857672B (zh) 2018-11-30
MX2014003959A (es) 2014-05-14
US20140275534A1 (en) 2014-09-18
PL2763981T3 (pl) 2020-08-10
CN110003174A (zh) 2019-07-12
BR112014007718B1 (pt) 2022-02-22
CA2850055E (en) 2013-04-11
JP5805880B2 (ja) 2015-11-10
BR112014007718A2 (pt) 2017-04-25
KR101272613B1 (ko) 2013-06-10
ES2775197T3 (es) 2020-07-24
RU2563630C1 (ru) 2015-09-20
CN103857672A (zh) 2014-06-11

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