DK2763981T3 - Fremgangsmåde til fremstilling af 1-(4-(4-(3,4-dichlor-2-fluorphenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-on-hydrochlorid og mellemprodukter anvendt deri - Google Patents
Fremgangsmåde til fremstilling af 1-(4-(4-(3,4-dichlor-2-fluorphenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-on-hydrochlorid og mellemprodukter anvendt deri Download PDFInfo
- Publication number
- DK2763981T3 DK2763981T3 DK12838558.0T DK12838558T DK2763981T3 DK 2763981 T3 DK2763981 T3 DK 2763981T3 DK 12838558 T DK12838558 T DK 12838558T DK 2763981 T3 DK2763981 T3 DK 2763981T3
- Authority
- DK
- Denmark
- Prior art keywords
- fluorphenylamino
- methoxyquinazolin
- dichlor
- yloxy
- piperidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020110101422A KR101272613B1 (ko) | 2011-10-05 | 2011-10-05 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온 염산염의 제조 방법 및 이에 사용되는 중간체 |
| PCT/KR2012/008077 WO2013051883A2 (en) | 2011-10-05 | 2012-10-05 | Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2763981T3 true DK2763981T3 (da) | 2020-03-16 |
Family
ID=48044309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12838558.0T DK2763981T3 (da) | 2011-10-05 | 2012-10-05 | Fremgangsmåde til fremstilling af 1-(4-(4-(3,4-dichlor-2-fluorphenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-on-hydrochlorid og mellemprodukter anvendt deri |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8859767B2 (da) |
| EP (2) | EP3611172A1 (da) |
| JP (1) | JP5805880B2 (da) |
| KR (1) | KR101272613B1 (da) |
| CN (2) | CN110003174A (da) |
| AU (1) | AU2012319291B2 (da) |
| BR (1) | BR112014007718B1 (da) |
| CA (1) | CA2850055C (da) |
| CY (1) | CY1122758T1 (da) |
| DK (1) | DK2763981T3 (da) |
| ES (1) | ES2775197T3 (da) |
| HR (1) | HRP20200426T1 (da) |
| HU (1) | HUE048798T2 (da) |
| IL (3) | IL231911B (da) |
| IN (1) | IN2014DN03447A (da) |
| LT (1) | LT2763981T (da) |
| MX (1) | MX348815B (da) |
| PL (1) | PL2763981T3 (da) |
| PT (1) | PT2763981T (da) |
| RS (1) | RS60118B1 (da) |
| RU (1) | RU2563630C1 (da) |
| SI (1) | SI2763981T1 (da) |
| WO (1) | WO2013051883A2 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101317809B1 (ko) | 2011-06-07 | 2013-10-16 | 한미약품 주식회사 | 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물 |
| KR20140096571A (ko) * | 2013-01-28 | 2014-08-06 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
| CN104513229A (zh) | 2013-09-28 | 2015-04-15 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物及其制备方法 |
| EP3272746B1 (en) | 2015-03-20 | 2019-12-25 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Salts of quinazoline derivative and method for preparing same |
| US20220040180A1 (en) * | 2018-09-14 | 2022-02-10 | Spectrum Pharmaceuticals, Inc. | Kits and methods for treating cancers |
| KR101950942B1 (ko) * | 2019-01-28 | 2019-02-22 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
| US20210221792A1 (en) * | 2020-01-16 | 2021-07-22 | Hanmi Pharm Co., Ltd. | Convergent synthesis of poziotinib derivative |
| WO2022043923A1 (en) * | 2020-08-28 | 2022-03-03 | Hanmi Science Co., Ltd. | Synthesis of poziotinib derivative |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
| EP1670782B1 (en) * | 2003-09-19 | 2007-02-14 | AstraZeneca AB | Quinazoline derivatives |
| GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
| JP2009518450A (ja) * | 2005-12-12 | 2009-05-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式複素環化合物、その化合物を含む薬剤、その使用及び製造方法 |
| TWI377944B (en) * | 2007-06-05 | 2012-12-01 | Hanmi Holdings Co Ltd | Novel amide derivative for inhibiting the growth of cancer cells |
| BRPI1013854A2 (pt) * | 2009-04-23 | 2017-05-16 | Astrazeneca Ab | processo para a preparação de composto, composto, e, sal de um composto |
-
2011
- 2011-10-05 KR KR1020110101422A patent/KR101272613B1/ko active IP Right Grant
-
2012
- 2012-10-05 BR BR112014007718-5A patent/BR112014007718B1/pt active IP Right Grant
- 2012-10-05 JP JP2014534478A patent/JP5805880B2/ja active Active
- 2012-10-05 SI SI201231742T patent/SI2763981T1/sl unknown
- 2012-10-05 CN CN201811593540.XA patent/CN110003174A/zh active Pending
- 2012-10-05 EP EP19201644.2A patent/EP3611172A1/en not_active Withdrawn
- 2012-10-05 AU AU2012319291A patent/AU2012319291B2/en not_active Ceased
- 2012-10-05 EP EP12838558.0A patent/EP2763981B1/en active Active
- 2012-10-05 CA CA2850055A patent/CA2850055C/en active Active
- 2012-10-05 LT LTEP12838558.0T patent/LT2763981T/lt unknown
- 2012-10-05 PT PT128385580T patent/PT2763981T/pt unknown
- 2012-10-05 PL PL12838558T patent/PL2763981T3/pl unknown
- 2012-10-05 RU RU2014117648/04A patent/RU2563630C1/ru active
- 2012-10-05 MX MX2014003959A patent/MX348815B/es active IP Right Grant
- 2012-10-05 ES ES12838558T patent/ES2775197T3/es active Active
- 2012-10-05 IN IN3447DEN2014 patent/IN2014DN03447A/en unknown
- 2012-10-05 HU HUE12838558A patent/HUE048798T2/hu unknown
- 2012-10-05 RS RS20200295A patent/RS60118B1/sr unknown
- 2012-10-05 US US14/349,887 patent/US8859767B2/en active Active
- 2012-10-05 WO PCT/KR2012/008077 patent/WO2013051883A2/en active Application Filing
- 2012-10-05 DK DK12838558.0T patent/DK2763981T3/da active
- 2012-10-05 CN CN201280049302.7A patent/CN103857672B/zh active Active
-
2014
- 2014-04-03 IL IL231911A patent/IL231911B/en active IP Right Grant
-
2018
- 2018-05-29 IL IL259694A patent/IL259694B/en unknown
-
2020
- 2020-03-11 CY CY20201100214T patent/CY1122758T1/el unknown
- 2020-03-16 HR HRP20200426TT patent/HRP20200426T1/hr unknown
-
2022
- 2022-03-27 IL IL291738A patent/IL291738A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2763981T3 (da) | Fremgangsmåde til fremstilling af 1-(4-(4-(3,4-dichlor-2-fluorphenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-on-hydrochlorid og mellemprodukter anvendt deri | |
| DK2501692T3 (da) | Fremgangsmåde til fremstilling af dabigatranetexilat | |
| SMT201600057B (it) | 3,5-diammino-6-cloro-n-(n-(4-(4-(2-(esil(2,3,4,5,6-pentaidrossiesil)ammino)etossi)fenil)butil)- carbammimidoil)pirazina-2-carbossammide | |
| DK3238709T3 (da) | Forbedrede parenterale formuleringer af lipofile farmaceutiske midler og fremgangsmåder til fremstilling og anvendelse af samme | |
| DK4082530T3 (da) | Proteasehæmmerholdige sammensætninger, sammensætninger omfattende samme og fremgangsmåder til fremstilling og anvendelse af samme | |
| DK3012329T3 (da) | Fremgangsmåder og materialer til at vurdere tab af heterozygositet | |
| DK2247582T3 (da) | Vandfri, krystallinsk form af dimethoxydocetaxel og fremgangsmåder til fremstilling heraf | |
| DK2794907T3 (da) | Fremgangsmåder og materialer til vurdering af tab af heterozygositet | |
| DK2739293T3 (da) | Fremgangsmåder og sammensætninger til frembringelse af vaccinavirus | |
| DK2882442T3 (da) | Fremgangsmåder til behandling af cancer under anvendelse af 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidin-2,6-dion | |
| DK2683708T3 (da) | Faste former af 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidin-2,6-dion og farmaceutiske sammensætninger og anvendelser deraf | |
| DK3456707T3 (da) | 4-(p-quinonyl)-2-hydroxybutanamidderivater til behandling af mitokondriesygdomme | |
| DK2632954T4 (da) | Midler og fremgangsmåder til behandling af dlbcl | |
| DK3795573T3 (da) | Bestemte triazolopyraziner, sammensætninger deraf og fremgangsmåder til anvendelse deraf | |
| DK2882737T3 (da) | Fast form af (s)-3-(4-((4-morpholinmethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidin-2,6-dion hydrochlorid | |
| DK2921491T3 (da) | Mellemforbindelser til fremstilling af heteroarylpiperidiner og ¿piperazinderivater som fungicider | |
| DK2297132T3 (da) | Fremgangsmåde til fremstilling af et mellemprodukt af dabigatran-etexilat | |
| DK2358691T3 (da) | Fremgangsmåde til fremstilling af piperazinforbindelser og hydrochloridsalte deraf | |
| DK2445912T3 (da) | Ny forbindelse anvendelig til behandlingen af degenerative og inflammatoriske sygdomme | |
| DK2533761T3 (da) | Fremgangsmåder og sammensætninger til fremstilling af aerosoler | |
| DK2315750T3 (da) | Forbedret fremgangsmåde til fremstilling af 2-trifluormethyl-5-(1-substituerede) alkylpyridiner | |
| DK2627656T3 (da) | Fremgangsmåde til fremstilling af dihydropteridinon og intermediater deraf | |
| DK3054927T3 (da) | Formuleringer af (s)-3-(4-((4-morpholinomethyl)benzyloxy)-1-oxoisoindolin-2-yl)piperidin-2,6-dion | |
| DK2462098T3 (da) | Fremgangsmåde til fremstillingen af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre | |
| DK2786757T3 (da) | 2-substitueret oleanolsyre-derivat, fremgangsmåde til fremstilling af samme, og anvendelse deraf |