IL220284A0 - Insulin analogues with chlorinated amino acids, compositions comprising the same and uses thereof - Google Patents

Insulin analogues with chlorinated amino acids, compositions comprising the same and uses thereof

Info

Publication number
IL220284A0
IL220284A0 IL220284A IL22028412A IL220284A0 IL 220284 A0 IL220284 A0 IL 220284A0 IL 220284 A IL220284 A IL 220284A IL 22028412 A IL22028412 A IL 22028412A IL 220284 A0 IL220284 A0 IL 220284A0
Authority
IL
Israel
Prior art keywords
compositions
amino acids
same
insulin analogues
chlorinated amino
Prior art date
Application number
IL220284A
Other languages
English (en)
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Publication of IL220284A0 publication Critical patent/IL220284A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL220284A 2009-12-11 2012-06-10 Insulin analogues with chlorinated amino acids, compositions comprising the same and uses thereof IL220284A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28595509P 2009-12-11 2009-12-11
PCT/US2010/060085 WO2011072288A2 (en) 2009-12-11 2010-12-13 Insulin analogues with chlorinated amino acids

Publications (1)

Publication Number Publication Date
IL220284A0 true IL220284A0 (en) 2012-07-31

Family

ID=44146220

Family Applications (1)

Application Number Title Priority Date Filing Date
IL220284A IL220284A0 (en) 2009-12-11 2012-06-10 Insulin analogues with chlorinated amino acids, compositions comprising the same and uses thereof

Country Status (16)

Country Link
US (2) US9079975B2 (de)
EP (1) EP2509995A4 (de)
JP (1) JP5866120B2 (de)
CN (1) CN102762589A (de)
AU (1) AU2010327949A1 (de)
BR (1) BR112012014025A2 (de)
CA (1) CA2783763A1 (de)
EA (1) EA201200717A1 (de)
IL (1) IL220284A0 (de)
MX (1) MX2012006568A (de)
MY (1) MY189079A (de)
NZ (1) NZ600477A (de)
RU (1) RU2012123642A (de)
SG (1) SG181527A1 (de)
WO (1) WO2011072288A2 (de)
ZA (1) ZA201204308B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8343914B2 (en) 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
CN102762589A (zh) 2009-12-11 2012-10-31 卡斯西部储备大学 带有氯化氨基酸的胰岛素类似物
WO2013010048A2 (en) * 2011-07-13 2013-01-17 Case Western Reserve University Non-standard insulin analogues
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
BR112016016290A2 (pt) * 2014-01-13 2017-10-03 Thermalin Diabetes Llc Composições farmacêuticas de insulina de ação rápida, conjunto de infusão, sistema de conjunto de infusão e usos de análogos monoméricos ou diméricos de insulina
JP6745468B2 (ja) * 2014-02-28 2020-08-26 国立研究開発法人理化学研究所 改変タンパク質及びその製造方法
JP6829928B2 (ja) 2014-10-06 2021-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 二相性単鎖インスリン類似体
US20240190937A1 (en) * 2021-04-22 2024-06-13 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Human insulin c-alpha-peptides and methods of use
EP4405384A1 (de) 2021-09-20 2024-07-31 Kyon Biotech AG Arginase-insulin-fusionsprotein

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
AU616205B2 (en) 1988-07-20 1991-10-24 Novo Nordisk A/S Human insulin analogs and preparations containing them
US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
DE3936876A1 (de) 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5422339A (en) * 1991-03-19 1995-06-06 Joslin Diabetes Center, Inc. Peptides having insulin autoantibody but not insulin receptor binding capacity
CZ342492A3 (en) 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
DE9115660U1 (de) * 1991-12-18 1992-07-30 Aventis Research & Technologies GmbH & Co KG, 65929 Frankfurt L-Phenylalanyl-tRNA-Synthetase mit erweiterter Substratselektivität aus Mikroorganismen
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US20030104981A1 (en) 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
DE19652713C2 (de) 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
HUP0004169A3 (en) 1997-10-24 2001-06-28 Lilly Co Eli Insoluble insulin compositions and process for production thereof
CO4970787A1 (es) 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
US6537806B1 (en) * 1998-06-02 2003-03-25 University Of Washington Compositions and methods for treating diabetes
US7449443B2 (en) 2000-03-23 2008-11-11 California Institute Of Technology Method for stabilization of proteins using non-natural amino acids
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
KR100449454B1 (ko) 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
US20070293426A1 (en) * 2001-04-02 2007-12-20 Hans-Ulrich Demuth Methods for improving islet signaling in diabetes mellitus and for its prevention
WO2003053460A1 (en) 2001-12-19 2003-07-03 Eli Lilly And Company Crystalline compositions for controlling blood glucose
SK2432004A3 (sk) 2001-12-20 2005-04-01 Eli Lilly And Company Inzulínová zlúčenina s protrahovaným účinkom
AU2003226619A1 (en) 2002-03-26 2003-10-08 Council Of Scientific And Industrial Research An adipocyte insulin and a method of treating diabetes
CA2485217C (en) 2002-05-06 2012-05-01 Thomas Jefferson University Insulin-associated peptides with effects on cerebral health
AU2004234345A1 (en) 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
MXPA05013723A (es) 2003-06-17 2006-03-13 Sembiosys Genetics Inc Metodos para loa produccion de insulina en plantas.
CA2543507C (en) * 2003-10-24 2012-05-01 Theratechnologies Inc. Use of ghrelin and unacylated ghrelin compositions in insulin-related disease conditions
JP5697831B2 (ja) 2003-12-03 2015-04-08 ノヴォ ノルディスク アー／エス 単鎖インシュリン
US8343914B2 (en) 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
JP2009527526A (ja) 2006-02-21 2009-07-30 ノボ・ノルデイスク・エー／エス 単鎖インスリンのアナログとその製薬的製剤
WO2007103307A2 (en) * 2006-03-03 2007-09-13 California Institute Of Technology Site-specific incorporation of amino acids into molecules
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
WO2008057609A2 (en) * 2006-11-10 2008-05-15 Genervon Biopharmaceuticals Llc Methods of treating neuronal disorders using mntf peptides and analogs thereof
US7790677B2 (en) 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
AU2009203809B2 (en) 2008-01-09 2013-07-25 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
NZ588857A (en) 2008-04-22 2012-07-27 Univ Case Western Reserve Isoform-specific insulin analogue for control blood sugar levels
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
EP2982687A1 (de) 2008-07-31 2016-02-10 Case Western Reserve University Halogenstabilisiertes insulin
US20110288011A1 (en) * 2008-12-05 2011-11-24 Jean-Paul Castaigne Peptide therapeutic conjugates and uses thereof
US20120184488A1 (en) 2009-09-01 2012-07-19 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
CN102762589A (zh) 2009-12-11 2012-10-31 卡斯西部储备大学 带有氯化氨基酸的胰岛素类似物
CN102770153B (zh) 2010-02-22 2014-05-07 卡斯西部储备大学 呈可溶和结晶形式的长效胰岛素类似物制剂

Also Published As

Publication number Publication date
JP5866120B2 (ja) 2016-02-17
WO2011072288A3 (en) 2011-11-10
EP2509995A2 (de) 2012-10-17
MX2012006568A (es) 2012-12-17
JP2013513391A (ja) 2013-04-22
MY189079A (en) 2022-01-25
CN102762589A (zh) 2012-10-31
EP2509995A4 (de) 2013-08-21
AU2010327949A1 (en) 2012-06-28
WO2011072288A2 (en) 2011-06-16
US9758563B2 (en) 2017-09-12
EA201200717A1 (ru) 2013-03-29
SG181527A1 (en) 2012-07-30
RU2012123642A (ru) 2014-01-20
ZA201204308B (en) 2013-08-28
US20120277148A1 (en) 2012-11-01
NZ600477A (en) 2014-07-25
US9079975B2 (en) 2015-07-14
US20150361153A1 (en) 2015-12-17
BR112012014025A2 (pt) 2017-01-31
CA2783763A1 (en) 2011-06-16

Similar Documents

Publication Publication Date Title
IL220284A0 (en) Insulin analogues with chlorinated amino acids, compositions comprising the same and uses thereof
IL260158B (en) Pyrazine derivatives, preparations containing them and their uses
IL250938A0 (en) Enzymatic fusion proteins, preparations containing them and their uses
HRP20181353T1 (hr) Tuberkulozni protein rv2386c, njegovi pripravci i upotreba
IL220283A0 (en) 4-oxo-ih-quinoline-3- carboxamides, compositions comprising the same and uses thereof
IL215603A0 (en) Human protein scaffold with controlled serum pharmacokinetics, compositions comprising the same and uses thereof
IL211762A0 (en) Pegylated opiods, compositions comprising the same and uses thereof
IL216254A (en) Compounds, pharmaceutical compositions and their uses
EP2074140A4 (de) Fibrillationsresistentes insulin und insulinanaloga
ZA201106755B (en) Fast-acting insulin formulation
HK1182934A1 (zh) 種抗疲勞的組合物及其製劑和應用
IL223405B (en) Phosphoplatins, preparations containing them and their uses
IL214435A0 (en) Foxm1 peptides and vaccines containing the same
EP2309563A4 (de) Zusammensetzung und die zusammensetzung verwendendes lichtemittierendes element
IL229926A (en) 3neil peptides and vaccines containing them
EP2471553A4 (de) Immunogene zusammensetzung mit peptiden aus cytomegalovirus und ihre verwendung
IL213026A0 (en) TNA-a INHIBITING PEPTIDES, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF
EP2285827A4 (de) Peptide und ihre verwendung
IL225464B (en) 2nd peptides, preparations containing them and their uses
IL216828A0 (en) Styryl-triazine derivatives, compositions comprising the same and uses thereof
IL213318A0 (en) C1orf59 peptides and vaccines including the same
IL214453A0 (en) Vangli peptides and vaccines including the same
GB0818065D0 (en) Immunogenic peptides and uses thereof
EP2305770A4 (de) Zusammensetzung und selbiges enthaltendes lichtemittierendes element
EP2275437A4 (de) Polypeptid und das polypeptid enthaltende pharmazeutische zusammensetzung