IL218797A - Combination of n - {3 - [3 - cyclopropyl - 5 - (2 - fluoro - 4 - iodo - phenylamino) - 6, 8 - dimethyl - 2, 4, 7, trioxo - 3, 4, 6, 7 - tetrahydro - 2h - pyrido [4, 3 – d] pyrimidine – 1 – yl] phenyl} acetamide dimethyl sulfoxide, and n - {(1s) –2– amino-1 - [(3, 4-diplorophenyl) methyl] ethyl} - 5-Chloro-4 - (4-Chloro-Methyl-1 H - Google Patents
Combination of n - {3 - [3 - cyclopropyl - 5 - (2 - fluoro - 4 - iodo - phenylamino) - 6, 8 - dimethyl - 2, 4, 7, trioxo - 3, 4, 6, 7 - tetrahydro - 2h - pyrido [4, 3 – d] pyrimidine – 1 – yl] phenyl} acetamide dimethyl sulfoxide, and n - {(1s) –2– amino-1 - [(3, 4-diplorophenyl) methyl] ethyl} - 5-Chloro-4 - (4-Chloro-Methyl-1 HInfo
- Publication number
- IL218797A IL218797A IL218797A IL21879712A IL218797A IL 218797 A IL218797 A IL 218797A IL 218797 A IL218797 A IL 218797A IL 21879712 A IL21879712 A IL 21879712A IL 218797 A IL218797 A IL 218797A
- Authority
- IL
- Israel
- Prior art keywords
- chloro
- methyl
- furancarboxamide
- trioxo
- pyrido
- Prior art date
Links
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 title 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- AXTAPYRUEKNRBA-JTQLQIEISA-N n-[(2s)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide Chemical compound CN1N=CC(Cl)=C1C1=C(Cl)OC(C(=O)N[C@H](CN)CC=2C=C(F)C(F)=CC=2)=C1 AXTAPYRUEKNRBA-JTQLQIEISA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 description 8
- 229940126062 Compound A Drugs 0.000 description 6
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 6
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24501909P | 2009-09-23 | 2009-09-23 | |
| PCT/US2010/049946 WO2011038082A1 (en) | 2009-09-23 | 2010-09-23 | Combination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL218797A0 IL218797A0 (en) | 2012-06-28 |
| IL218797A true IL218797A (en) | 2014-11-30 |
Family
ID=43796197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL218797A IL218797A (en) | 2009-09-23 | 2012-03-22 | Combination of n - {3 - [3 - cyclopropyl - 5 - (2 - fluoro - 4 - iodo - phenylamino) - 6, 8 - dimethyl - 2, 4, 7, trioxo - 3, 4, 6, 7 - tetrahydro - 2h - pyrido [4, 3 – d] pyrimidine – 1 – yl] phenyl} acetamide dimethyl sulfoxide, and n - {(1s) –2– amino-1 - [(3, 4-diplorophenyl) methyl] ethyl} - 5-Chloro-4 - (4-Chloro-Methyl-1 H |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20120322817A1 (https=) |
| EP (1) | EP2480084B1 (https=) |
| JP (2) | JP2013505939A (https=) |
| KR (1) | KR20120099219A (https=) |
| CN (1) | CN102770026B (https=) |
| AU (1) | AU2010298277B2 (https=) |
| BR (1) | BR112012006693A2 (https=) |
| CA (1) | CA2775124A1 (https=) |
| EA (1) | EA021951B1 (https=) |
| ES (1) | ES2527625T3 (https=) |
| IL (1) | IL218797A (https=) |
| MX (1) | MX2012003546A (https=) |
| WO (1) | WO2011038082A1 (https=) |
| ZA (1) | ZA201202173B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012061683A2 (en) * | 2010-11-05 | 2012-05-10 | Glaxosmithkline Llc | Methods for treating cancer |
| TWI505828B (zh) | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產（第二）有限公司 | 新穎醫藥組成物 |
| RU2013148817A (ru) * | 2011-04-01 | 2015-05-10 | Дженентек, Инк. | Комбинации соединений-ингибиторов акт и мек и способы их применения |
| EP2913048A1 (en) | 2014-02-27 | 2015-09-02 | ratiopharm GmbH | Pharmaceutical composition comprising trametinib |
| KR20200036022A (ko) * | 2017-08-11 | 2020-04-06 | 큐어매치, 아이엔씨. | 암에서 다중 돌연변이를 표적화하기 위한 약물 조합(drug combinations for targeting multiple mutations in cancer) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3811775B2 (ja) * | 2000-07-19 | 2006-08-23 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | ４−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル |
| US7378423B2 (en) * | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| SI1761528T1 (sl) * | 2004-06-11 | 2008-06-30 | Japan Tobacco Inc | 5-amino-2,4,7-triokso-3,4,7,8-tetrahidro-2H-pirido(2,3-D)pirimidinski derivati in sorodne spojine za zdravljenje raka |
| JP3821154B1 (ja) * | 2005-03-16 | 2006-09-13 | いすゞ自動車株式会社 | 排気ガス浄化方法及び排気ガス浄化システム |
| UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
-
2010
- 2010-09-23 KR KR1020127010303A patent/KR20120099219A/ko not_active Ceased
- 2010-09-23 WO PCT/US2010/049946 patent/WO2011038082A1/en not_active Ceased
- 2010-09-23 BR BR112012006693A patent/BR112012006693A2/pt not_active IP Right Cessation
- 2010-09-23 EP EP10819435.8A patent/EP2480084B1/en active Active
- 2010-09-23 ES ES10819435.8T patent/ES2527625T3/es active Active
- 2010-09-23 CN CN201080052971.0A patent/CN102770026B/zh not_active Expired - Fee Related
- 2010-09-23 AU AU2010298277A patent/AU2010298277B2/en not_active Ceased
- 2010-09-23 JP JP2012531018A patent/JP2013505939A/ja not_active Ceased
- 2010-09-23 MX MX2012003546A patent/MX2012003546A/es active IP Right Grant
- 2010-09-23 CA CA2775124A patent/CA2775124A1/en not_active Abandoned
- 2010-09-23 EA EA201270445A patent/EA021951B1/ru not_active IP Right Cessation
- 2010-09-23 US US13/497,576 patent/US20120322817A1/en not_active Abandoned
-
2012
- 2012-03-22 IL IL218797A patent/IL218797A/en not_active IP Right Cessation
- 2012-03-23 ZA ZA2012/02173A patent/ZA201202173B/en unknown
-
2014
- 2014-05-06 US US14/270,774 patent/US20150094321A1/en not_active Abandoned
-
2015
- 2015-12-18 JP JP2015246931A patent/JP2016106092A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EA201270445A1 (ru) | 2013-03-29 |
| EA021951B1 (ru) | 2015-10-30 |
| IL218797A0 (en) | 2012-06-28 |
| US20120322817A1 (en) | 2012-12-20 |
| WO2011038082A1 (en) | 2011-03-31 |
| EP2480084A4 (en) | 2013-02-20 |
| JP2013505939A (ja) | 2013-02-21 |
| KR20120099219A (ko) | 2012-09-07 |
| CN102770026A (zh) | 2012-11-07 |
| MX2012003546A (es) | 2012-09-07 |
| EP2480084B1 (en) | 2014-11-12 |
| BR112012006693A2 (pt) | 2015-09-08 |
| ES2527625T3 (es) | 2015-01-27 |
| CA2775124A1 (en) | 2011-03-31 |
| JP2016106092A (ja) | 2016-06-16 |
| EP2480084A1 (en) | 2012-08-01 |
| ZA201202173B (en) | 2012-11-28 |
| AU2010298277A1 (en) | 2012-04-19 |
| US20150094321A1 (en) | 2015-04-02 |
| AU2010298277B2 (en) | 2014-07-03 |
| CN102770026B (zh) | 2015-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |