IL212170A - Mineral corticoid receptor antagonists, their atrophy isomers, their medicinal preparations and their use - Google Patents
Mineral corticoid receptor antagonists, their atrophy isomers, their medicinal preparations and their useInfo
- Publication number
- IL212170A IL212170A IL212170A IL21217011A IL212170A IL 212170 A IL212170 A IL 212170A IL 212170 A IL212170 A IL 212170A IL 21217011 A IL21217011 A IL 21217011A IL 212170 A IL212170 A IL 212170A
- Authority
- IL
- Israel
- Prior art keywords
- atropisomes
- pharmaceutical compositions
- receptor antagonists
- mineralocorticoid receptor
- mineralocorticoid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10371508P | 2008-10-08 | 2008-10-08 | |
| PCT/US2009/059847 WO2010042622A1 (en) | 2008-10-08 | 2009-10-07 | Atropisomers of (hydroxyalkyl) pyrrole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL212170A0 IL212170A0 (en) | 2011-06-30 |
| IL212170A true IL212170A (en) | 2016-03-31 |
Family
ID=41360127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL212170A IL212170A (en) | 2008-10-08 | 2011-04-06 | Mineral corticoid receptor antagonists, their atrophy isomers, their medicinal preparations and their use |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8487117B2 (OSRAM) |
| EP (1) | EP2349997B1 (OSRAM) |
| JP (2) | JP5767586B2 (OSRAM) |
| KR (1) | KR101643285B1 (OSRAM) |
| CN (1) | CN102186817B (OSRAM) |
| AU (1) | AU2009302371B2 (OSRAM) |
| BR (1) | BRPI0920459B1 (OSRAM) |
| CA (1) | CA2736923C (OSRAM) |
| ES (1) | ES2547697T3 (OSRAM) |
| IL (1) | IL212170A (OSRAM) |
| TW (2) | TWI593674B (OSRAM) |
| WO (1) | WO2010042622A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105473552B (zh) * | 2013-08-27 | 2017-11-10 | 第一三共株式会社 | 用于产生吡咯衍生物及其中间体的方法 |
| CN112707854B (zh) * | 2019-10-25 | 2022-03-15 | 年衍药业(珠海)有限公司 | 吡咯酰胺类化合物及其用途 |
| CA3213094A1 (en) * | 2021-03-30 | 2022-10-06 | Qiao ZONG | Crystalline form of pyrrole amide compound, preparation method therefor and use thereof |
| CN115784961B (zh) * | 2021-09-10 | 2026-03-31 | 上海鼎雅药物化学科技有限公司 | 埃沙西林酮及其中间体的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8026237B2 (en) * | 2004-07-30 | 2011-09-27 | Exelixis, Inc. | Pyrrole derivatives as pharmaceutical agents |
| ES2448498T3 (es) * | 2007-04-09 | 2014-03-14 | Daiichi Sankyo Company, Limited | Atropisómero de derivado de pirrol |
-
2009
- 2009-10-07 AU AU2009302371A patent/AU2009302371B2/en not_active Ceased
- 2009-10-07 ES ES09737501.8T patent/ES2547697T3/es active Active
- 2009-10-07 BR BRPI0920459-8A patent/BRPI0920459B1/pt active IP Right Grant
- 2009-10-07 CA CA2736923A patent/CA2736923C/en active Active
- 2009-10-07 JP JP2011531140A patent/JP5767586B2/ja active Active
- 2009-10-07 WO PCT/US2009/059847 patent/WO2010042622A1/en not_active Ceased
- 2009-10-07 EP EP09737501.8A patent/EP2349997B1/en active Active
- 2009-10-07 CN CN200980139822.5A patent/CN102186817B/zh active Active
- 2009-10-07 KR KR1020117010427A patent/KR101643285B1/ko active Active
- 2009-10-07 US US13/122,147 patent/US8487117B2/en active Active
- 2009-10-08 TW TW104142529A patent/TWI593674B/zh active
- 2009-10-08 TW TW098134174A patent/TWI547479B/zh active
-
2011
- 2011-04-06 IL IL212170A patent/IL212170A/en active IP Right Grant
-
2014
- 2014-07-22 JP JP2014148858A patent/JP6121952B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW201028377A (en) | 2010-08-01 |
| AU2009302371B2 (en) | 2015-02-12 |
| BRPI0920459A2 (pt) | 2020-08-11 |
| JP6121952B2 (ja) | 2017-04-26 |
| AU2009302371A1 (en) | 2010-04-15 |
| US8487117B2 (en) | 2013-07-16 |
| TWI547479B (zh) | 2016-09-01 |
| ES2547697T3 (es) | 2015-10-08 |
| EP2349997A1 (en) | 2011-08-03 |
| BRPI0920459B1 (pt) | 2021-12-14 |
| HK1155163A1 (zh) | 2012-05-11 |
| TW201627283A (zh) | 2016-08-01 |
| JP2012505225A (ja) | 2012-03-01 |
| KR101643285B1 (ko) | 2016-07-29 |
| EP2349997B1 (en) | 2015-08-12 |
| CA2736923C (en) | 2016-11-22 |
| IL212170A0 (en) | 2011-06-30 |
| CA2736923A1 (en) | 2010-04-15 |
| TWI593674B (zh) | 2017-08-01 |
| JP5767586B2 (ja) | 2015-08-19 |
| US20110263673A1 (en) | 2011-10-27 |
| WO2010042622A1 (en) | 2010-04-15 |
| KR20110091663A (ko) | 2011-08-12 |
| CN102186817A (zh) | 2011-09-14 |
| JP2014196365A (ja) | 2014-10-16 |
| CN102186817B (zh) | 2017-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |