IL205780A - Synthetic peptides capable of suppressing intravenous production of anti-factor inhibitors viii - Google Patents

Synthetic peptides capable of suppressing intravenous production of anti-factor inhibitors viii

Info

Publication number
IL205780A
IL205780A IL205780A IL20578010A IL205780A IL 205780 A IL205780 A IL 205780A IL 205780 A IL205780 A IL 205780A IL 20578010 A IL20578010 A IL 20578010A IL 205780 A IL205780 A IL 205780A
Authority
IL
Israel
Prior art keywords
vivo
factor viii
synthetic peptides
peptides capable
inhibitor antibodies
Prior art date
Application number
IL205780A
Other languages
English (en)
Hebrew (he)
Other versions
IL205780A0 (en
Original Assignee
Apitope Int Nv
Apitope Technology Bristol Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apitope Int Nv, Apitope Technology Bristol Ltd filed Critical Apitope Int Nv
Publication of IL205780A0 publication Critical patent/IL205780A0/en
Publication of IL205780A publication Critical patent/IL205780A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL205780A 2007-12-04 2010-05-13 Synthetic peptides capable of suppressing intravenous production of anti-factor inhibitors viii IL205780A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0723712.6A GB0723712D0 (en) 2007-12-04 2007-12-04 Peptides
PCT/GB2008/003996 WO2009071886A1 (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Publications (2)

Publication Number Publication Date
IL205780A0 IL205780A0 (en) 2010-11-30
IL205780A true IL205780A (en) 2015-06-30

Family

ID=38982965

Family Applications (1)

Application Number Title Priority Date Filing Date
IL205780A IL205780A (en) 2007-12-04 2010-05-13 Synthetic peptides capable of suppressing intravenous production of anti-factor inhibitors viii

Country Status (25)

Country Link
US (1) US8445448B2 (cg-RX-API-DMAC7.html)
EP (1) EP2227488B3 (cg-RX-API-DMAC7.html)
JP (2) JP5501245B2 (cg-RX-API-DMAC7.html)
KR (1) KR101519840B1 (cg-RX-API-DMAC7.html)
CN (2) CN103709234B (cg-RX-API-DMAC7.html)
AU (1) AU2008332968B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0820143A2 (cg-RX-API-DMAC7.html)
CA (2) CA2707559C (cg-RX-API-DMAC7.html)
CY (1) CY1115168T1 (cg-RX-API-DMAC7.html)
DK (1) DK2227488T6 (cg-RX-API-DMAC7.html)
EA (1) EA019370B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP10010327A (cg-RX-API-DMAC7.html)
ES (1) ES2458315T7 (cg-RX-API-DMAC7.html)
GB (1) GB0723712D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20140344T4 (cg-RX-API-DMAC7.html)
IL (1) IL205780A (cg-RX-API-DMAC7.html)
MX (1) MX2010006084A (cg-RX-API-DMAC7.html)
MY (1) MY150995A (cg-RX-API-DMAC7.html)
NZ (1) NZ585217A (cg-RX-API-DMAC7.html)
PL (1) PL2227488T6 (cg-RX-API-DMAC7.html)
PT (1) PT2227488E (cg-RX-API-DMAC7.html)
SI (1) SI2227488T1 (cg-RX-API-DMAC7.html)
UA (1) UA101003C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009071886A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201002997B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2353347T3 (es) 2000-08-21 2011-03-01 Apitope Technology (Bristol) Limited Péptido.
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
SI2300497T1 (sl) * 2008-06-24 2013-02-28 Octapharma Ag Postopek za äťiĺˇäťenje koagulacijskega faktorja viii
GB0908515D0 (en) * 2009-05-18 2009-06-24 Apitope Technology Bristol Ltd Peptide
CA2765657A1 (en) * 2009-06-16 2010-12-23 Tokai University Anti-gram-negative bacteria agent
CN104926947A (zh) 2010-10-27 2015-09-23 巴克斯特国际公司 用于免疫耐受性诱导和免疫诊断的fviii肽
CA2863329C (en) 2012-01-12 2023-01-03 Biogen Idec Ma Inc. Methods of reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
EA036483B1 (ru) * 2012-11-12 2020-11-16 Эпитоп Интернэшнл Нв Пептиды, способные индуцировать толерантность к рекомбинантному fviii, содержащая их композиция, их применение и способ лечения гемофилии
GB201314052D0 (en) 2013-08-06 2013-09-18 Apitope Int Nv Peptides
CA3007262A1 (en) 2015-12-03 2017-06-08 Lucas James Thompson Modified chimeric receptors and related compositions and methods
KR20190091292A (ko) 2016-12-02 2019-08-05 바이오버라티브 테라퓨틱스 인크. 응고 인자에 대한 면역 내성 유도 방법
US12077607B2 (en) * 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5930890A (en) * 1989-06-20 1991-01-08 Scripps Clinic And Research Foundation The phospholipid binding domain of factor viii
BR9806793A (pt) * 1997-01-22 2000-05-16 Univ Texas Processos e composições de fator tissular para coagulação e tratamento de tumores.
ES2353347T3 (es) * 2000-08-21 2011-03-01 Apitope Technology (Bristol) Limited Péptido.
WO2002060917A2 (en) * 2000-12-01 2002-08-08 Regents Of The University Of Minnesota Method to treat hemophilia
HUP0303171A2 (hu) * 2001-02-19 2003-12-29 Merck Patent Gmbh Csökkentett immunogenitású mesterséges fehérjék
AU2002312660A1 (en) * 2001-05-31 2002-12-16 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
AU2003232482A1 (en) * 2002-04-18 2003-10-27 Merck Patent Gmbh Modified factor viii
AU2005211725B2 (en) * 2004-02-09 2010-07-15 Human Genome Sciences, Inc. Albumin fusion proteins
WO2006003183A1 (de) 2004-07-02 2006-01-12 Alois Jungbauer Peptide zur blockierung von fviii-inhibitoren
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin

Also Published As

Publication number Publication date
BRPI0820143A2 (pt) 2015-05-12
ES2458315T7 (es) 2015-02-18
NZ585217A (en) 2012-11-30
PT2227488E (pt) 2014-04-21
US20100323966A1 (en) 2010-12-23
SI2227488T1 (sl) 2014-06-30
MX2010006084A (es) 2010-06-23
AU2008332968A1 (en) 2009-06-11
EP2227488B3 (en) 2014-11-19
CY1115168T1 (el) 2016-12-14
ECSP10010327A (es) 2010-09-30
IL205780A0 (en) 2010-11-30
CN101889024A (zh) 2010-11-17
EA019370B1 (ru) 2014-03-31
CN103709234A (zh) 2014-04-09
PL2227488T3 (pl) 2014-07-31
DK2227488T6 (en) 2015-02-16
EP2227488B1 (en) 2014-01-22
CA3005013A1 (en) 2009-06-11
KR101519840B1 (ko) 2015-05-18
EA201070681A1 (ru) 2010-10-29
HK1144292A1 (en) 2011-02-11
HRP20140344T4 (hr) 2015-07-31
AU2008332968B2 (en) 2014-03-20
UA101003C2 (uk) 2013-02-25
ES2458315T3 (es) 2014-04-30
CA2707559C (en) 2018-07-03
DK2227488T3 (da) 2014-04-22
CN101889024B (zh) 2014-04-23
JP5501245B2 (ja) 2014-05-21
US8445448B2 (en) 2013-05-21
ZA201002997B (en) 2011-07-27
JP2011505414A (ja) 2011-02-24
HRP20140344T1 (en) 2014-05-09
MY150995A (en) 2014-03-31
PL2227488T6 (pl) 2015-04-30
CN103709234B (zh) 2017-01-18
GB0723712D0 (en) 2008-01-16
WO2009071886A1 (en) 2009-06-11
CA2707559A1 (en) 2009-06-11
KR20100087346A (ko) 2010-08-04
JP6063402B2 (ja) 2017-01-18
EP2227488A1 (en) 2010-09-15
JP2014088440A (ja) 2014-05-15
CA3005013C (en) 2021-11-16

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