IL205000A0 - Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators - Google Patents
Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulatorsInfo
- Publication number
- IL205000A0 IL205000A0 IL205000A IL20500010A IL205000A0 IL 205000 A0 IL205000 A0 IL 205000A0 IL 205000 A IL205000 A IL 205000A IL 20500010 A IL20500010 A IL 20500010A IL 205000 A0 IL205000 A0 IL 205000A0
- Authority
- IL
- Israel
- Prior art keywords
- histamine
- phenyl
- substituted
- therapeutic use
- receptor modulators
- Prior art date
Links
- 102000004384 Histamine H3 receptors Human genes 0.000 title 1
- 108090000981 Histamine H3 receptors Proteins 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98060207P | 2007-10-17 | 2007-10-17 | |
| PCT/US2008/079758 WO2009052063A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL205000A0 true IL205000A0 (en) | 2010-11-30 |
Family
ID=40137955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL205000A IL205000A0 (en) | 2007-10-17 | 2010-04-11 | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8227504B2 (enExample) |
| EP (1) | EP2205558B1 (enExample) |
| JP (1) | JP5377504B2 (enExample) |
| KR (1) | KR20100092443A (enExample) |
| CN (1) | CN101903342B (enExample) |
| AU (1) | AU2008312636B2 (enExample) |
| BR (1) | BRPI0818766A2 (enExample) |
| CA (1) | CA2702834C (enExample) |
| DK (1) | DK2205558T3 (enExample) |
| ES (1) | ES2392122T3 (enExample) |
| IL (1) | IL205000A0 (enExample) |
| MA (1) | MA31857B1 (enExample) |
| MX (1) | MX2010004003A (enExample) |
| MY (1) | MY150210A (enExample) |
| NZ (1) | NZ584691A (enExample) |
| PT (1) | PT2205558E (enExample) |
| RU (1) | RU2477721C2 (enExample) |
| WO (1) | WO2009052063A1 (enExample) |
| ZA (1) | ZA201002113B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS52235B (sr) | 2007-10-17 | 2012-10-31 | Sanofi | Supstituisani n-fenil-bipirolidin karboksamidi i njihova terapeutska upotreba |
| HRP20110953T1 (hr) | 2007-10-17 | 2012-01-31 | Sanofi | Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji |
| ES2378011T3 (es) | 2007-10-17 | 2012-04-04 | Sanofi | N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas |
| AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| AR074466A1 (es) * | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
| TW201206444A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| AR081382A1 (es) * | 2010-05-11 | 2012-08-29 | Sanofi Aventis | Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central. |
| JP5833105B2 (ja) | 2010-05-11 | 2015-12-16 | サノフイ | 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用 |
| TW201206901A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| JP5766278B2 (ja) | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| RU2562461C1 (ru) * | 2014-04-30 | 2015-09-10 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | Спин-меченое производное кинуренина и способ его получения |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| EP1556046A1 (en) * | 2002-10-23 | 2005-07-27 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7951826B2 (en) * | 2005-03-17 | 2011-05-31 | Eli Lilly And Company | Pyrrolidine derivatives as histamine H3 receptor antagonists |
| AU2006232871B9 (en) * | 2005-04-01 | 2011-11-24 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| JP5193033B2 (ja) * | 2005-07-01 | 2013-05-08 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体薬剤、製剤及び治療的使用 |
| WO2007048595A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| BRPI0707872A2 (pt) * | 2006-02-15 | 2011-05-10 | Sanofi Aventis | arildiidroisoquinolinonas substituÍdas por azaciclila, processo para sua preparaÇço e seu uso como medicamentos |
| RS52235B (sr) | 2007-10-17 | 2012-10-31 | Sanofi | Supstituisani n-fenil-bipirolidin karboksamidi i njihova terapeutska upotreba |
| HRP20110953T1 (hr) | 2007-10-17 | 2012-01-31 | Sanofi | Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji |
| ES2378011T3 (es) * | 2007-10-17 | 2012-04-04 | Sanofi | N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas |
-
2008
- 2008-10-14 RU RU2010119530/04A patent/RU2477721C2/ru not_active IP Right Cessation
- 2008-10-14 AU AU2008312636A patent/AU2008312636B2/en not_active Ceased
- 2008-10-14 JP JP2010530050A patent/JP5377504B2/ja not_active Expired - Fee Related
- 2008-10-14 NZ NZ584691A patent/NZ584691A/en not_active IP Right Cessation
- 2008-10-14 CN CN2008801212575A patent/CN101903342B/zh not_active Expired - Fee Related
- 2008-10-14 BR BRPI0818766 patent/BRPI0818766A2/pt not_active IP Right Cessation
- 2008-10-14 KR KR1020107010710A patent/KR20100092443A/ko not_active Ceased
- 2008-10-14 DK DK08839706.2T patent/DK2205558T3/da active
- 2008-10-14 ES ES08839706T patent/ES2392122T3/es active Active
- 2008-10-14 MY MYPI2010001275A patent/MY150210A/en unknown
- 2008-10-14 MX MX2010004003A patent/MX2010004003A/es active IP Right Grant
- 2008-10-14 CA CA2702834A patent/CA2702834C/en not_active Expired - Fee Related
- 2008-10-14 PT PT08839706T patent/PT2205558E/pt unknown
- 2008-10-14 EP EP08839706A patent/EP2205558B1/en active Active
- 2008-10-14 WO PCT/US2008/079758 patent/WO2009052063A1/en not_active Ceased
-
2010
- 2010-03-15 US US12/724,044 patent/US8227504B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02113A patent/ZA201002113B/en unknown
- 2010-04-11 IL IL205000A patent/IL205000A0/en unknown
- 2010-05-17 MA MA32849A patent/MA31857B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ584691A (en) | 2011-09-30 |
| MX2010004003A (es) | 2010-04-30 |
| PT2205558E (pt) | 2012-11-02 |
| DK2205558T3 (da) | 2012-11-05 |
| US8227504B2 (en) | 2012-07-24 |
| MA31857B1 (fr) | 2010-11-01 |
| RU2010119530A (ru) | 2011-11-27 |
| ZA201002113B (en) | 2010-12-29 |
| HK1146055A1 (en) | 2011-05-13 |
| EP2205558B1 (en) | 2012-07-25 |
| WO2009052063A1 (en) | 2009-04-23 |
| BRPI0818766A2 (pt) | 2015-04-14 |
| JP2011500694A (ja) | 2011-01-06 |
| CA2702834C (en) | 2013-01-15 |
| AU2008312636A1 (en) | 2009-04-23 |
| MY150210A (en) | 2013-12-13 |
| ES2392122T3 (es) | 2012-12-04 |
| US20100173898A1 (en) | 2010-07-08 |
| CA2702834A1 (en) | 2009-04-23 |
| JP5377504B2 (ja) | 2013-12-25 |
| EP2205558A1 (en) | 2010-07-14 |
| KR20100092443A (ko) | 2010-08-20 |
| AU2008312636B2 (en) | 2013-03-14 |
| CN101903342A (zh) | 2010-12-01 |
| CN101903342B (zh) | 2012-11-21 |
| RU2477721C2 (ru) | 2013-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL205000A0 (en) | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators | |
| EP2150109A4 (en) | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | |
| GB0719803D0 (en) | Therapeutic compounds and their use | |
| GB0719644D0 (en) | Therapeutic compounds and their use | |
| GB0803018D0 (en) | Therapeutic compounds and their use | |
| AP2860A (en) | Carbazole compounds and therapeutic uses of the compounds | |
| GB0804685D0 (en) | Therapeutic compounds and their use | |
| SI2954932T1 (sl) | Terapevtska uporaba diaminofenotiazinov | |
| GB0724251D0 (en) | Therapeutic compounds and their use | |
| ZA200803337B (en) | Cyclopropyl amines as modulators of the histamine H3 receptor | |
| IL211694A0 (en) | Use of-anti-connexin agents for modulating the therapeutic effect of psychotropic drugs | |
| GB0817207D0 (en) | therapeutic apsac compounds and their use | |
| GB0722680D0 (en) | Therapeutic compounds and their use | |
| GB0807609D0 (en) | Therapeutic compounds and their use | |
| GB0817208D0 (en) | Therapeutic apsap compounds and their use | |
| IL195514A0 (en) | Substituted pyridiyl amide compounds as modulators of the histamine h3 receptor | |
| EP2200595A4 (en) | THIENO AND FURO PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | |
| GB0710981D0 (en) | New Therapeutic use | |
| GB0812913D0 (en) | Therapeutic compounds and their use | |
| EP2231163A4 (en) | COMPOUNDS AND THEIR THERAPEUTIC USE | |
| GB0802128D0 (en) | Therapeutic compounds and their use | |
| GB0808690D0 (en) | Therapeutic use | |
| GB0705517D0 (en) | Therapeutic compounds and their use | |
| GB0821539D0 (en) | Therapeutic compounds and their use | |
| GB0815134D0 (en) | Therapeutic compounds and their use |