IL196897A - Preparations based on 1- (3-Chloro-5 - {[4- (4-Chloro-Ophen-2-Il) -5- (4-Cyclohexylpiperazine-1-Il) Thiazole-2-Il] Carbamoyl} Pyridine-2-Il ) Carboxylic acid or salts, to increase levels of human platelet - Google Patents

Preparations based on 1- (3-Chloro-5 - {[4- (4-Chloro-Ophen-2-Il) -5- (4-Cyclohexylpiperazine-1-Il) Thiazole-2-Il] Carbamoyl} Pyridine-2-Il ) Carboxylic acid or salts, to increase levels of human platelet

Info

Publication number
IL196897A
IL196897A IL196897A IL19689709A IL196897A IL 196897 A IL196897 A IL 196897A IL 196897 A IL196897 A IL 196897A IL 19689709 A IL19689709 A IL 19689709A IL 196897 A IL196897 A IL 196897A
Authority
IL
Israel
Prior art keywords
cyclohexylpiperazin
piperadine
chlorothiophen
thiazol
carbamoyl
Prior art date
Application number
IL196897A
Other languages
English (en)
Hebrew (he)
Other versions
IL196897A0 (en
Inventor
Robert E Desjardins
Rudolph Lucek
Original Assignee
Akarx Inc
Robert E Desjardins
Rudolph Lucek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akarx Inc, Robert E Desjardins, Rudolph Lucek filed Critical Akarx Inc
Publication of IL196897A0 publication Critical patent/IL196897A0/en
Publication of IL196897A publication Critical patent/IL196897A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL196897A 2006-08-08 2009-02-04 Preparations based on 1- (3-Chloro-5 - {[4- (4-Chloro-Ophen-2-Il) -5- (4-Cyclohexylpiperazine-1-Il) Thiazole-2-Il] Carbamoyl} Pyridine-2-Il ) Carboxylic acid or salts, to increase levels of human platelet IL196897A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83633406P 2006-08-08 2006-08-08
PCT/US2007/017860 WO2008021283A2 (en) 2006-08-08 2007-08-08 Compositions and methods for increasing blood platelet levels in humans

Publications (2)

Publication Number Publication Date
IL196897A0 IL196897A0 (en) 2011-08-01
IL196897A true IL196897A (en) 2015-08-31

Family

ID=39082656

Family Applications (4)

Application Number Title Priority Date Filing Date
IL196897A IL196897A (en) 2006-08-08 2009-02-04 Preparations based on 1- (3-Chloro-5 - {[4- (4-Chloro-Ophen-2-Il) -5- (4-Cyclohexylpiperazine-1-Il) Thiazole-2-Il] Carbamoyl} Pyridine-2-Il ) Carboxylic acid or salts, to increase levels of human platelet
IL240323A IL240323A (en) 2006-08-08 2015-08-03 Preparations based on 1 - (3-chloro-5 - {[4- (4-chloro-phenyl-2-ram) -5- (4-cyclohexylpiperazine-1-ram) thiazole-2-ram] carbamoyl} pyridine-2-ram ) Carboxylic acid or salts, to increase levels of human platelet
IL240322A IL240322A0 (en) 2006-08-08 2015-08-03 Preparations based on 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazio-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl Piperadine-4-carboxylic acid or salts, to increase levels of platelets in human blood
IL245911A IL245911A0 (en) 2006-08-08 2016-05-29 Compositions and methods for increasing the level of blood platelets in humans

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL240323A IL240323A (en) 2006-08-08 2015-08-03 Preparations based on 1 - (3-chloro-5 - {[4- (4-chloro-phenyl-2-ram) -5- (4-cyclohexylpiperazine-1-ram) thiazole-2-ram] carbamoyl} pyridine-2-ram ) Carboxylic acid or salts, to increase levels of human platelet
IL240322A IL240322A0 (en) 2006-08-08 2015-08-03 Preparations based on 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazio-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl Piperadine-4-carboxylic acid or salts, to increase levels of platelets in human blood
IL245911A IL245911A0 (en) 2006-08-08 2016-05-29 Compositions and methods for increasing the level of blood platelets in humans

Country Status (8)

Country Link
US (2) US20080039475A1 (enExample)
EP (2) EP2452674B1 (enExample)
JP (3) JP2010500361A (enExample)
AU (2) AU2007284644B2 (enExample)
CA (1) CA2660283C (enExample)
ES (2) ES2452032T3 (enExample)
IL (4) IL196897A (enExample)
WO (1) WO2008021283A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2610611T3 (es) * 2002-01-18 2017-04-28 Astellas Pharma Inc. Derivado de 2-acilaminotiazol o sal del mismo
JP2013501811A (ja) * 2009-08-14 2013-01-17 エーザイ インコーポレーテッド 血小板産生を刺激するためのｅ５５０１の使用
CN112022825B (zh) * 2020-08-24 2024-03-22 瑞阳制药股份有限公司 马来酸阿伐曲泊帕片剂及其制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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US5330998A (en) * 1988-03-08 1994-07-19 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
US5256675A (en) * 1989-08-07 1993-10-26 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
FR2677356B1 (fr) * 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
US5250732A (en) * 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
GB9126677D0 (en) * 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
DE59401177D1 (de) * 1993-04-08 1997-01-16 Abb Management Ag Misch- und Flammenstabilisierungseinrichtung in einer Brennkammer mit Vormischverbrennung
ATE246686T1 (de) * 1995-03-09 2003-08-15 Kyowa Hakko Kogyo Kk Pyrrolocarbazolderivate
AU700837B2 (en) * 1995-04-28 1999-01-14 Banyu Pharmaceutical Co., Ltd. 1,4-di-substituted piperidine derivatives
ES2303338T3 (es) * 1995-06-07 2008-08-01 Glaxo Group Limited Peptidos y compuestos que se unen a un receptor de trombopoyetina.
US5963666A (en) * 1995-08-18 1999-10-05 International Business Machines Corporation Confusion matrix mediated word prediction
EP0798304B1 (en) * 1995-10-17 2003-03-12 Suntory Limited Remedies for thrombocytopenia
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
US6187797B1 (en) * 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
JP2002526482A (ja) * 1998-09-18 2002-08-20 バーテックス ファーマシューティカルズ インコーポレイテッド ｐ３８のインヒビター
AU1732900A (en) * 1998-11-17 2000-06-05 Ligand Pharmaceuticals Incorporated Methods of treating thrombocytopenia
TWI284639B (en) * 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
GB0028383D0 (en) * 2000-11-21 2001-01-03 Novartis Ag Organic compounds
WO2002062792A1 (en) * 2001-02-02 2002-08-15 Takeda Chemical Industries, Ltd. Jnk inhibitor
WO2002062775A1 (en) * 2001-02-02 2002-08-15 Yamanouchi Pharmaceutical Co., Ltd. 2-acylaminothiazole derivative or its salt
ES2610611T3 (es) * 2002-01-18 2017-04-28 Astellas Pharma Inc. Derivado de 2-acilaminotiazol o sal del mismo
AU2003243921B2 (en) * 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
WO2004029049A1 (ja) * 2002-09-30 2004-04-08 Yamanouchi Pharmaceutical Co., Ltd. 2-アシルアミノチアゾール誘導体の新規な塩
EP1610793A2 (en) * 2003-03-25 2006-01-04 Vertex Pharmaceuticals Incorporated Thiazoles useful as inhibitors of protein kinases
EP1647553A4 (en) * 2003-07-17 2008-12-31 Astellas Pharma Inc 2-ACYLAMINOTHIAZOL DERIVATIVE OR SALT THEREOF
CN103130739B (zh) * 2003-08-12 2015-09-16 盐野义制药株式会社 具有血小板生成素受体激动作用的化合物
EP1971368A4 (en) * 2005-11-08 2009-08-05 Astellas Pharma Inc COMPOSITIONS AND METHODS FOR TREATING THROMBOCYTOPENIA

Also Published As

Publication number Publication date
CA2660283A1 (en) 2008-02-21
ES2452032T3 (es) 2014-03-31
EP2452674A2 (en) 2012-05-16
AU2011253775A1 (en) 2011-12-22
ES2470333T3 (es) 2014-06-23
JP2010500361A (ja) 2010-01-07
CA2660283C (en) 2014-11-18
HK1170673A1 (en) 2013-03-08
WO2008021283A2 (en) 2008-02-21
JP6258264B2 (ja) 2018-01-10
IL196897A0 (en) 2011-08-01
AU2007284644B2 (en) 2011-09-01
EP2452674A3 (en) 2012-05-30
WO2008021283A3 (en) 2008-12-11
US20110224226A1 (en) 2011-09-15
EP2056826A2 (en) 2009-05-13
JP2013047257A (ja) 2013-03-07
AU2007284644A1 (en) 2008-02-21
EP2056826B1 (en) 2014-01-08
EP2452674B1 (en) 2014-03-26
IL245911A0 (en) 2016-07-31
IL240323A0 (en) 2015-09-24
IL240322A0 (en) 2015-09-24
EP2056826A4 (en) 2009-09-09
US20080039475A1 (en) 2008-02-14
JP2015221806A (ja) 2015-12-10
AU2011253775B2 (en) 2014-02-13
IL240323A (en) 2016-05-31

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