WO2009136884A3 - Metformin-pioglitazone formulation with antihyperglycemic effects - Google Patents
Metformin-pioglitazone formulation with antihyperglycemic effects Download PDFInfo
- Publication number
- WO2009136884A3 WO2009136884A3 PCT/TR2009/000057 TR2009000057W WO2009136884A3 WO 2009136884 A3 WO2009136884 A3 WO 2009136884A3 TR 2009000057 W TR2009000057 W TR 2009000057W WO 2009136884 A3 WO2009136884 A3 WO 2009136884A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pioglitazone
- metformin
- micronized
- acceptable salts
- diabetes treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
This invention relates to pharmaceutical products and manufacturing process which includes Metformin or pharmaceutical acceptable salts and especially hydrochloride salts with micronized Pioglitazone or it's pharmaceutical acceptable salts and especially hydrochloride salts. The oral solid dosage form compound which is developed by this invention includes one or more filling, binder, disintegrant and/or lubricant with meformin and micronized pioglitazone, which is manufactured by wet granulation in same carrier for diabetes treatment and especially Type-2 diabetes treatment.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2008/03177 | 2008-05-06 | ||
TR2008/03177A TR200803177A2 (en) | 2008-05-06 | 2008-05-06 | Metformin - pioglitazone formulation with antihyperglycemic action. |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009136884A2 WO2009136884A2 (en) | 2009-11-12 |
WO2009136884A3 true WO2009136884A3 (en) | 2009-12-23 |
Family
ID=41152147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/TR2009/000057 WO2009136884A2 (en) | 2008-05-06 | 2009-05-05 | Metformin-pioglitazone formulation with antihyperglycemic effects |
Country Status (2)
Country | Link |
---|---|
TR (1) | TR200803177A2 (en) |
WO (1) | WO2009136884A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2441442A1 (en) | 2010-10-08 | 2012-04-18 | LEK Pharmaceuticals d.d. | A pharmaceutical composition comprising a thiazolidinedione |
WO2014016371A1 (en) * | 2012-07-27 | 2014-01-30 | Ratiopharm Gmbh | Micronized aleglitazar |
TR201620309A2 (en) * | 2016-12-30 | 2018-07-23 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Pharmaceutical compositions of metformin hydrochloride and pioglitazone hydrochloride |
CN115804770B (en) * | 2022-11-16 | 2024-04-02 | 安徽杰玺医药有限公司 | Pharmaceutical preparation containing metformin hydrochloride and pioglitazone hydrochloride and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001035941A2 (en) * | 1999-11-16 | 2001-05-25 | Smithkline Beecham P.L.C. | Novel composition based on a thiazolidinedione and metformin and use |
US20050131027A1 (en) * | 2002-03-21 | 2005-06-16 | Guy Samburski | Fine particle size pioglitazone |
EP1552832A1 (en) * | 2002-07-11 | 2005-07-13 | Takeda Pharmaceutical Company Limited | Process for producing coated preparation |
EP1561472A1 (en) * | 2002-10-07 | 2005-08-10 | Takeda Pharmaceutical Company Limited | Solid preparation |
EP1738754A1 (en) * | 2004-04-14 | 2007-01-03 | Takeda Pharmaceutical Company Limited | Solid pharmaceutical preparation |
-
2008
- 2008-05-06 TR TR2008/03177A patent/TR200803177A2/en unknown
-
2009
- 2009-05-05 WO PCT/TR2009/000057 patent/WO2009136884A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001035941A2 (en) * | 1999-11-16 | 2001-05-25 | Smithkline Beecham P.L.C. | Novel composition based on a thiazolidinedione and metformin and use |
US20050131027A1 (en) * | 2002-03-21 | 2005-06-16 | Guy Samburski | Fine particle size pioglitazone |
EP1552832A1 (en) * | 2002-07-11 | 2005-07-13 | Takeda Pharmaceutical Company Limited | Process for producing coated preparation |
EP1561472A1 (en) * | 2002-10-07 | 2005-08-10 | Takeda Pharmaceutical Company Limited | Solid preparation |
EP1738754A1 (en) * | 2004-04-14 | 2007-01-03 | Takeda Pharmaceutical Company Limited | Solid pharmaceutical preparation |
Non-Patent Citations (1)
Title |
---|
KARIM AZIZ ET AL: "Oral antidiabetic drugs: Effect of food on absorption of pioglitazone and metformin from a fixed-dose combination tablet", JOURNAL OF CLINICAL PHARMACOLOGY, vol. 47, no. 1, January 2007 (2007-01-01), pages 48 - 55, XP009124359, ISSN: 0091-2700 * |
Also Published As
Publication number | Publication date |
---|---|
TR200803177A2 (en) | 2009-11-23 |
WO2009136884A2 (en) | 2009-11-12 |
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