IL194334A0 - Dialkylphenyl compounds having ??2 adrenergic receptor agonist and muscarinic receptor antagonist activity - Google Patents
Dialkylphenyl compounds having ??2 adrenergic receptor agonist and muscarinic receptor antagonist activityInfo
- Publication number
- IL194334A0 IL194334A0 IL194334A IL19433408A IL194334A0 IL 194334 A0 IL194334 A0 IL 194334A0 IL 194334 A IL194334 A IL 194334A IL 19433408 A IL19433408 A IL 19433408A IL 194334 A0 IL194334 A0 IL 194334A0
- Authority
- IL
- Israel
- Prior art keywords
- antagonist activity
- receptor antagonist
- receptor agonist
- dialkylphenyl
- compounds
- Prior art date
Links
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
- 239000000048 adrenergic agonist Substances 0.000 title 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000003149 muscarinic antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79470206P | 2006-04-25 | 2006-04-25 | |
| PCT/US2007/009925 WO2007127196A2 (en) | 2006-04-25 | 2007-04-24 | DIALKYLPHENYL COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL194334A0 true IL194334A0 (en) | 2009-08-03 |
Family
ID=38577470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL194334A IL194334A0 (en) | 2006-04-25 | 2008-09-25 | Dialkylphenyl compounds having ??2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7524965B2 (OSRAM) |
| EP (1) | EP2010489B1 (OSRAM) |
| JP (1) | JP2009541209A (OSRAM) |
| KR (1) | KR20090005389A (OSRAM) |
| CN (1) | CN101426764A (OSRAM) |
| AR (1) | AR060647A1 (OSRAM) |
| AU (1) | AU2007243481A1 (OSRAM) |
| BR (1) | BRPI0710767A2 (OSRAM) |
| CA (1) | CA2650530A1 (OSRAM) |
| CO (1) | CO6140054A2 (OSRAM) |
| ES (1) | ES2391584T3 (OSRAM) |
| IL (1) | IL194334A0 (OSRAM) |
| MA (1) | MA30556B1 (OSRAM) |
| MX (1) | MX2008013555A (OSRAM) |
| NO (1) | NO20084603L (OSRAM) |
| PE (1) | PE20080094A1 (OSRAM) |
| RU (1) | RU2008146383A (OSRAM) |
| TW (1) | TW200811105A (OSRAM) |
| WO (1) | WO2007127196A2 (OSRAM) |
| ZA (1) | ZA200808817B (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| TWI341836B (en) | 2004-03-11 | 2011-05-11 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| WO2006023457A1 (en) * | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| CA2713322C (en) * | 2008-02-06 | 2017-01-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and their use in the treatment of pulmonary disorders |
| CN102405218B (zh) | 2009-04-23 | 2014-06-04 | 施万制药 | 具蕈毒碱受体拮抗剂和β2 肾上腺素受体激动剂活性的二酰胺化合物 |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| DK3061821T3 (da) | 2009-07-22 | 2019-08-26 | PureTech Health LLC | Sammensætninger til behandling af forstyrrelser lindret af muskarinreceptoraktivering |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| GB201009801D0 (en) | 2010-06-11 | 2010-07-21 | Astrazeneca Ab | Compounds 950 |
| IL295341B2 (en) | 2018-09-28 | 2025-01-01 | Karuna Therapeutics Inc | Compositions and methods for treating diseases improved by activating muscarinic receptors |
| CN114409556B (zh) * | 2022-01-28 | 2024-10-18 | 兰州康鹏威耳化工有限公司 | 一种3,4-二取代-2-氨基苯甲醛的制备方法 |
| CN117924216A (zh) * | 2024-01-12 | 2024-04-26 | 王叔和生物医药(武汉)有限公司 | 一种1-哌啶丙酸的合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7545894A (en) | 1993-09-02 | 1995-03-22 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| CA2182568A1 (en) | 1994-02-10 | 1995-08-17 | Makoto Takeuchi | Novel carbamate derivative and medicinal composition containing the same |
| US6040344A (en) | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| US6541669B1 (en) * | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| EP1370521B1 (en) | 2001-03-22 | 2007-12-19 | Glaxo Group Limited | Formanilide derivatives as beta2-adrenoreceptor agonists |
| US20030018019A1 (en) | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| ES2329586T3 (es) * | 2003-11-21 | 2009-11-27 | Theravance, Inc. | Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino. |
| WO2005087735A1 (en) * | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| JP2008510015A (ja) | 2004-08-16 | 2008-04-03 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
| WO2006023457A1 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| TWI374883B (en) * | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
-
2007
- 2007-04-23 TW TW096114175A patent/TW200811105A/zh unknown
- 2007-04-24 WO PCT/US2007/009925 patent/WO2007127196A2/en not_active Ceased
- 2007-04-24 EP EP07776093A patent/EP2010489B1/en active Active
- 2007-04-24 AR ARP070101777A patent/AR060647A1/es unknown
- 2007-04-24 CN CNA2007800140984A patent/CN101426764A/zh active Pending
- 2007-04-24 KR KR1020087028589A patent/KR20090005389A/ko not_active Withdrawn
- 2007-04-24 US US11/789,300 patent/US7524965B2/en active Active
- 2007-04-24 PE PE2007000509A patent/PE20080094A1/es not_active Application Discontinuation
- 2007-04-24 RU RU2008146383/04A patent/RU2008146383A/ru not_active Application Discontinuation
- 2007-04-24 BR BRPI0710767-6A patent/BRPI0710767A2/pt not_active IP Right Cessation
- 2007-04-24 AU AU2007243481A patent/AU2007243481A1/en not_active Abandoned
- 2007-04-24 MX MX2008013555A patent/MX2008013555A/es active IP Right Grant
- 2007-04-24 CA CA002650530A patent/CA2650530A1/en not_active Abandoned
- 2007-04-24 ES ES07776093T patent/ES2391584T3/es active Active
- 2007-04-24 JP JP2009507757A patent/JP2009541209A/ja active Pending
-
2008
- 2008-09-25 IL IL194334A patent/IL194334A0/en unknown
- 2008-10-15 ZA ZA200808817A patent/ZA200808817B/xx unknown
- 2008-10-29 CO CO08115666A patent/CO6140054A2/es unknown
- 2008-10-30 NO NO20084603A patent/NO20084603L/no not_active Application Discontinuation
- 2008-11-14 MA MA31382A patent/MA30556B1/fr unknown
-
2009
- 2009-03-18 US US12/406,283 patent/US7687521B2/en active Active
-
2010
- 2010-02-05 US US12/701,108 patent/US8134006B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100137603A1 (en) | 2010-06-03 |
| ES2391584T3 (es) | 2012-11-28 |
| WO2007127196A2 (en) | 2007-11-08 |
| US20090176833A1 (en) | 2009-07-09 |
| WO2007127196A3 (en) | 2007-12-21 |
| CO6140054A2 (es) | 2010-03-19 |
| US8134006B2 (en) | 2012-03-13 |
| US7687521B2 (en) | 2010-03-30 |
| BRPI0710767A2 (pt) | 2011-06-07 |
| US20070249675A1 (en) | 2007-10-25 |
| JP2009541209A (ja) | 2009-11-26 |
| MA30556B1 (fr) | 2009-07-01 |
| AU2007243481A1 (en) | 2007-11-08 |
| CN101426764A (zh) | 2009-05-06 |
| EP2010489A2 (en) | 2009-01-07 |
| KR20090005389A (ko) | 2009-01-13 |
| NO20084603L (no) | 2008-11-19 |
| PE20080094A1 (es) | 2008-02-17 |
| AR060647A1 (es) | 2008-07-02 |
| EP2010489B1 (en) | 2012-08-22 |
| MX2008013555A (es) | 2008-11-04 |
| ZA200808817B (en) | 2010-03-31 |
| TW200811105A (en) | 2008-03-01 |
| CA2650530A1 (en) | 2007-11-08 |
| RU2008146383A (ru) | 2010-05-27 |
| US7524965B2 (en) | 2009-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL194334A0 (en) | Dialkylphenyl compounds having ??2 adrenergic receptor agonist and muscarinic receptor antagonist activity | |
| SI1615889T1 (sl) | Bifenilni derivati, ki imajo aktivnost kot agonisti beta 2 adrenergičnih receptorjev in antagonisti muskarinskih receptorjev | |
| EP2120575A4 (en) | AGONISTS AND ANTAGONISTS OF SPHINGOSINE-1-PHOSPHATE RECEPTORS | |
| HRP20190417T1 (hr) | Diamidni spojevi s aktivnošću antagonista muskarinskog receptora i agonista beta 2 adrenergičkog receptora | |
| IL178152A0 (en) | Muscarinic acetylcholine receptor antagonists | |
| IL177533A0 (en) | Benzimidazole derivative and use as a ii receptor antagonist | |
| AP2007004238A0 (en) | Muscarinic acetycholine receptor antagonists | |
| EP1725240A4 (en) | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR | |
| IL195807A0 (en) | Cgrp receptor antagonists | |
| IL176775A0 (en) | Muscarinic acetylcholine receptor antagonists | |
| EP1749012A4 (en) | ANTAGONISTS OF MUSCARIN ACETYLCHOLIN RECEPTOR | |
| EP1824483A4 (en) | ANTAGONISTS OF ACETYLCHOLINE MUSCARINIC RECEPTORS | |
| EP1765339A4 (en) | ANTAGONISTS OF MUSCARIN ACETYLCHOLIN RECEPTOR | |
| ZA200903873B (en) | Sphingosine-1-phosphate receptor agonist and antagonist compounds | |
| EP1781104A4 (en) | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR | |
| EP1781103A4 (en) | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR | |
| HK1128021A (en) | Dialkylphenyl compounds having 2 adrenergic receptor agonist and muscarinic receptor antagonist activity | |
| AP2008004537A0 (en) | Muscarinic receptor antagonists | |
| ZA200806223B (en) | Muscarinic receptor antagonists | |
| GB0525029D0 (en) | Receptor Antagonist | |
| HK1107979A (en) | Muscarinic receptor antagonists | |
| HK1124601A (en) | Muscarinic receptor antagonists | |
| HK1137942A (en) | Combination of a muscarinic receptor antagonist and a beta-2-adrenoceptor agonist |