IL183392A0 - Inducible nitric oxide synthase dimerization inhibitors - Google Patents
Inducible nitric oxide synthase dimerization inhibitorsInfo
- Publication number
- IL183392A0 IL183392A0 IL183392A IL18339207A IL183392A0 IL 183392 A0 IL183392 A0 IL 183392A0 IL 183392 A IL183392 A IL 183392A IL 18339207 A IL18339207 A IL 18339207A IL 183392 A0 IL183392 A0 IL 183392A0
- Authority
- IL
- Israel
- Prior art keywords
- nitric oxide
- oxide synthase
- inducible nitric
- dimerization inhibitors
- synthase dimerization
- Prior art date
Links
- 102000011779 Nitric Oxide Synthase Type II Human genes 0.000 title 1
- 108010076864 Nitric Oxide Synthase Type II Proteins 0.000 title 1
- 238000006471 dimerization reaction Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63197104P | 2004-12-01 | 2004-12-01 | |
| US67200105P | 2005-04-14 | 2005-04-14 | |
| PCT/US2005/043190 WO2006060424A2 (en) | 2004-12-01 | 2005-11-28 | Inducible nitric oxide synthase dimerization inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL183392A0 true IL183392A0 (en) | 2007-09-20 |
Family
ID=36215758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL183392A IL183392A0 (en) | 2004-12-01 | 2007-05-24 | Inducible nitric oxide synthase dimerization inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7825256B2 (OSRAM) |
| EP (1) | EP1817030A2 (OSRAM) |
| JP (1) | JP2008521908A (OSRAM) |
| KR (1) | KR20070084574A (OSRAM) |
| AR (1) | AR055287A1 (OSRAM) |
| AU (1) | AU2005311985A1 (OSRAM) |
| BR (1) | BRPI0518096A (OSRAM) |
| CA (1) | CA2589433A1 (OSRAM) |
| IL (1) | IL183392A0 (OSRAM) |
| TW (1) | TW200635587A (OSRAM) |
| WO (1) | WO2006060424A2 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070123572A1 (en) * | 2005-11-28 | 2007-05-31 | Kalypsys, Inc. | Novel method of preparation of 5-chloro-3-imidazol-1-yl-[1,2,4]thiadiazole and (3-imidazol-1-yl-[1,2,4]thiadiazol-5yl)-dialkyl-amines |
| EP1954694A1 (en) * | 2005-11-28 | 2008-08-13 | Kalypsys, Inc. | Imidazole derivatives as nitric oxide synthase dimerisation inhibitor |
| WO2007062417A1 (en) * | 2005-11-28 | 2007-05-31 | Kalypsys, Inc. | Methods of preparing 2-imidazol-1-yl-4-methyl-6-pyrrolidin-2-yl-pyrimidine and 4-(1-alkylpyrrolidin-2-yl)-2-(1h-imidazol-1-yl)-6-methylpyrimidine derivatives |
| FR2903405B1 (fr) * | 2006-07-04 | 2011-09-09 | Pasteur Institut | Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications |
| EP2097405A2 (en) * | 2006-11-21 | 2009-09-09 | Smithkline Beecham Corporation | Anti-viral compounds |
| EP1939181A1 (en) * | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
| WO2008086176A2 (en) * | 2007-01-08 | 2008-07-17 | Kalypsys, Inc. | Topical pharmaceutical formulation comprising an inos inhibitor for the treatment of disease |
| JP2011510998A (ja) * | 2008-01-30 | 2011-04-07 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規ｓＥＨ阻害剤およびその使用 |
| WO2009097474A1 (en) * | 2008-01-30 | 2009-08-06 | Smithkline Beecham Corporation | Novel seh inhibitors and their use |
| US8478446B2 (en) | 2008-06-13 | 2013-07-02 | Air Products And Chemicals, Inc. | Oxygen control system for oxygen enhanced combustion |
| US8578892B2 (en) * | 2008-06-13 | 2013-11-12 | Air Products And Chemicals, Inc. | Oxygen control system for oxygen enhanced combustion of solid fuels |
| JP2015180606A (ja) * | 2012-08-01 | 2015-10-15 | アステラス製薬株式会社 | 抗癌剤の併用による癌治療方法 |
| CA2979530C (en) | 2014-04-08 | 2023-10-03 | The Methodist Hospital | Inos-inhibitory compositions and their use as breast cancer therapeutics |
| US9701661B2 (en) | 2014-07-11 | 2017-07-11 | Northwestern University | 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase |
| JP6460382B2 (ja) * | 2014-11-28 | 2019-01-30 | 株式会社豊田自動織機 | 飽和ヘテロ環含有化合物、並びにこれを用いた二次電池用電極及び二次電池、結着剤、蛍光物質 |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
| MX2019008078A (es) | 2017-02-14 | 2019-11-05 | Res Triangle Inst | Moduladores de receptores neuropeptido basados en prolina. |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1161237B (it) | 1983-04-26 | 1987-03-18 | Montedison Spa | 1,4-dichetoni-insaturi ad attivita' fungicida |
| DE3433953A1 (de) * | 1984-09-15 | 1986-03-27 | A. Nattermann & Cie GmbH, 5000 Köln | Neue, eine imidazol-gruppe enthaltende 3,4-dihydro-2(1h)-pyridone und2(1h)-pyridone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US5795905A (en) | 1995-06-06 | 1998-08-18 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| DE19541146A1 (de) * | 1995-10-25 | 1997-04-30 | Schering Ag | Imidazolderivate und deren Verwendung als Stickstoffmonoxid-Synthase-Inhibitoren |
| US5874452A (en) * | 1996-04-03 | 1999-02-23 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
| HUP0100815A3 (en) | 1996-05-31 | 2002-11-28 | Allelix Neuroscience Inc South | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
| DE19627310A1 (de) | 1996-06-27 | 1998-01-02 | Schering Ag | Imidazolderivate als Stickstoffmonoxid-Synthase-Inhibitoren |
| PL335235A1 (en) * | 1997-02-19 | 2000-04-10 | Berlex Lab | N-heterocyclic derivatives as nos inhibitors |
| US6432947B1 (en) * | 1997-02-19 | 2002-08-13 | Berlex Laboratories, Inc. | N-heterocyclic derivatives as NOS inhibitors |
| ID23510A (id) * | 1997-06-27 | 2000-04-27 | Bp Chem Int Ltd | Proses polimerisasi |
| US6861448B2 (en) * | 1998-01-14 | 2005-03-01 | Virtual Drug Development, Inc. | NAD synthetase inhibitors and uses thereof |
| US20030191279A1 (en) * | 1999-08-27 | 2003-10-09 | Goldstein Steven Wayne | Urea derivatives useful as anticancer agents |
| US6723743B1 (en) * | 1999-09-28 | 2004-04-20 | Neurogen Corporation | High affinity small molecule C5a receptor modulators |
| IL154993A0 (en) | 2000-09-29 | 2003-10-31 | Neurogen Corp | High affinity small molecule c5a receptor modulators |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| FR2827286A1 (fr) | 2001-07-11 | 2003-01-17 | Aventis Cropscience Sa | Nouveaux composes fongicides |
| AU2003226094A1 (en) | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Compounds and methods |
| JP2005528368A (ja) | 2002-03-29 | 2005-09-22 | ニューロジェン・コーポレーション | Ｃ５ａ受容体モジュレータである新規なアリールイミダゾール及び関連化合物。 |
| CA2480082A1 (en) | 2002-03-29 | 2003-10-16 | Neurogen Corporation | Combination therapy for the treatment of conditions with pathogenic inflammatory components |
| PL375256A1 (en) * | 2002-08-09 | 2005-11-28 | Astra Zeneca Ab | 1,2,4-oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| AU2003260033A1 (en) * | 2002-08-29 | 2004-03-19 | Schering Aktiengesellschaft | Methods of treating acute respiratory distress syndrome |
| US20060058326A1 (en) * | 2003-02-06 | 2006-03-16 | Basf Aktiengesllschaft | Pyrimidines, methods for the production thereof, and use thereof |
| EP1954694A1 (en) * | 2005-11-28 | 2008-08-13 | Kalypsys, Inc. | Imidazole derivatives as nitric oxide synthase dimerisation inhibitor |
-
2005
- 2005-11-28 EP EP05852447A patent/EP1817030A2/en not_active Withdrawn
- 2005-11-28 AR ARP050104970A patent/AR055287A1/es unknown
- 2005-11-28 BR BRPI0518096-1A patent/BRPI0518096A/pt not_active IP Right Cessation
- 2005-11-28 WO PCT/US2005/043190 patent/WO2006060424A2/en not_active Ceased
- 2005-11-28 TW TW094141754A patent/TW200635587A/zh unknown
- 2005-11-28 US US11/288,888 patent/US7825256B2/en not_active Expired - Fee Related
- 2005-11-28 KR KR1020077011898A patent/KR20070084574A/ko not_active Withdrawn
- 2005-11-28 JP JP2007544442A patent/JP2008521908A/ja active Pending
- 2005-11-28 CA CA002589433A patent/CA2589433A1/en not_active Abandoned
- 2005-11-28 AU AU2005311985A patent/AU2005311985A1/en not_active Abandoned
-
2007
- 2007-05-24 IL IL183392A patent/IL183392A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1817030A2 (en) | 2007-08-15 |
| KR20070084574A (ko) | 2007-08-24 |
| JP2008521908A (ja) | 2008-06-26 |
| BRPI0518096A (pt) | 2008-10-28 |
| US7825256B2 (en) | 2010-11-02 |
| AU2005311985A1 (en) | 2006-06-08 |
| WO2006060424A2 (en) | 2006-06-08 |
| US20060116515A1 (en) | 2006-06-01 |
| TW200635587A (en) | 2006-10-16 |
| WO2006060424A3 (en) | 2007-03-29 |
| AR055287A1 (es) | 2007-08-15 |
| CA2589433A1 (en) | 2006-06-08 |
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