IL165088A0 - Transgenic ungulates capable of human antibody production - Google Patents
Transgenic ungulates capable of human antibody productionInfo
- Publication number
- IL165088A0 IL165088A0 IL16508803A IL16508803A IL165088A0 IL 165088 A0 IL165088 A0 IL 165088A0 IL 16508803 A IL16508803 A IL 16508803A IL 16508803 A IL16508803 A IL 16508803A IL 165088 A0 IL165088 A0 IL 165088A0
- Authority
- IL
- Israel
- Prior art keywords
- antibodies
- human antibody
- antibody production
- transgenic ungulates
- inactivation
- Prior art date
Links
- 230000016784 immunoglobulin production Effects 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
- 230000002779 inactivation Effects 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 210000004507 artificial chromosome Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8773—Ovine embryos
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38153102P | 2002-05-17 | 2002-05-17 | |
| US42505602P | 2002-11-08 | 2002-11-08 | |
| PCT/US2003/015937 WO2003097812A2 (en) | 2002-05-17 | 2003-05-19 | Transgenic ungulates capable of human antibody production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL165088A0 true IL165088A0 (en) | 2005-12-18 |
Family
ID=29553536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16508803A IL165088A0 (en) | 2002-05-17 | 2003-05-19 | Transgenic ungulates capable of human antibody production |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1513397B1 (https=) |
| JP (1) | JP2005525817A (https=) |
| KR (1) | KR20050000558A (https=) |
| CN (1) | CN1668187A (https=) |
| AT (1) | ATE464389T1 (https=) |
| CA (1) | CA2484655A1 (https=) |
| DE (1) | DE60332111D1 (https=) |
| IL (1) | IL165088A0 (https=) |
| NZ (1) | NZ536341A (https=) |
| WO (1) | WO2003097812A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| NZ550106A (en) * | 2004-04-22 | 2009-06-26 | Kyowa Hakko Kirin Co Ltd | Transgenic animals and uses thereof |
| CA2569978C (en) * | 2004-06-09 | 2017-06-06 | The University Court Of The University Of Edinburgh | Neural stem cells |
| NZ554824A (en) | 2004-10-22 | 2010-10-29 | Revivicor Inc | Porcines that lack endogenous antibody chains and express exogenous immunoglobulins |
| CA2658204A1 (en) | 2006-07-07 | 2008-01-31 | Kyowa Hakko Kirin Co., Ltd. | Human artificial chromosome (hac) vector and human cell medicine comprising same |
| EP2348827B1 (en) | 2008-10-27 | 2015-07-01 | Revivicor, Inc. | Immunocompromised ungulates |
| US20100158878A1 (en) | 2008-12-23 | 2010-06-24 | Alexandra Capela | Target populations of oligodendrocyte precursor cells and methods of making and using same |
| NZ599847A (en) | 2009-11-13 | 2013-09-27 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist and methionine |
| US20120233715A1 (en) | 2009-11-17 | 2012-09-13 | Kyowa Hakko Kirin Co., Ltd | Human artificial chromosome vector |
| KR102159163B1 (ko) * | 2012-08-03 | 2020-09-23 | 에스에이비, 엘엘씨 | 유전자삽입 동물에서 인간 항체의 제조를 위한 복합 염색체 조작 |
| TW201444871A (zh) * | 2013-02-13 | 2014-12-01 | Lab Francais Du Fractionnement | 具有修飾的糖化作用之西妥昔單抗及其用途 |
| AU2014255285B2 (en) * | 2013-04-18 | 2019-07-11 | Institut National De La Sante Et De La Recherche Medicale | Composition with reduced immunogenicity |
| US11725044B2 (en) | 2014-10-15 | 2023-08-15 | Xenothera | Method for producing polyclonal antibodies with improved complement-dependent cytotoxicity |
| WO2021163035A1 (en) * | 2020-02-12 | 2021-08-19 | Sab, Llc. | Anti-thymocyte globulin |
| US20240279315A1 (en) * | 2023-02-17 | 2024-08-22 | Sab, Llc | Ungulate-derived polyclonal immunoglobulin specific for influenza virus and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5652373A (en) * | 1990-01-15 | 1997-07-29 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
| ATE300615T1 (de) * | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5789655A (en) * | 1994-05-13 | 1998-08-04 | The Regents Of The University Of California | Transgenic animals expressing artificial epitope-tagged proteins |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1997007671A1 (en) * | 1995-08-29 | 1997-03-06 | Kirin Beer Kabushiki Kaisha | Chimeric animal and method for constructing the same |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| WO2001035735A1 (en) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| DE60144305D1 (de) * | 2000-11-17 | 2011-05-05 | Kyowa Hakko Kirin Co Ltd | Expression von xenogenen (humanen) Immunglobulinen in klonierten, transgenen Huftieren |
| US20020108132A1 (en) * | 2001-02-02 | 2002-08-08 | Avigenics Inc. | Production of a monoclonal antibody by a transgenic chicken |
-
2003
- 2003-05-19 NZ NZ536341A patent/NZ536341A/en unknown
- 2003-05-19 CN CNA038167425A patent/CN1668187A/zh active Pending
- 2003-05-19 KR KR10-2004-7018599A patent/KR20050000558A/ko not_active Ceased
- 2003-05-19 IL IL16508803A patent/IL165088A0/xx unknown
- 2003-05-19 WO PCT/US2003/015937 patent/WO2003097812A2/en not_active Ceased
- 2003-05-19 AT AT03738939T patent/ATE464389T1/de not_active IP Right Cessation
- 2003-05-19 JP JP2004506471A patent/JP2005525817A/ja active Pending
- 2003-05-19 CA CA002484655A patent/CA2484655A1/en not_active Abandoned
- 2003-05-19 DE DE60332111T patent/DE60332111D1/de not_active Expired - Lifetime
- 2003-05-19 EP EP03738939A patent/EP1513397B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1513397A4 (en) | 2007-10-24 |
| CN1668187A (zh) | 2005-09-14 |
| WO2003097812A3 (en) | 2004-02-12 |
| KR20050000558A (ko) | 2005-01-05 |
| CA2484655A1 (en) | 2003-11-27 |
| ATE464389T1 (de) | 2010-04-15 |
| EP1513397A2 (en) | 2005-03-16 |
| JP2005525817A (ja) | 2005-09-02 |
| WO2003097812A2 (en) | 2003-11-27 |
| AU2003245300A1 (en) | 2003-12-02 |
| EP1513397B1 (en) | 2010-04-14 |
| DE60332111D1 (de) | 2010-05-27 |
| NZ536341A (en) | 2008-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60144305D1 (de) | Expression von xenogenen (humanen) Immunglobulinen in klonierten, transgenen Huftieren | |
| IL165088A0 (en) | Transgenic ungulates capable of human antibody production | |
| CY1123535T1 (el) | Υποκαταστατο θεραπευτικο τελικο σημειο για βασιζομενη σε anti-ctla-4 ανοσοθεραπεια ασθενειας | |
| NO2022001I1 (no) | Pazopanib | |
| EP1354034B8 (en) | Transgenic transchromosomal rodents for making human antibodies | |
| IL172854A0 (en) | Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations | |
| CY1110759T1 (el) | Παραλλαγες ανοσοσφαιρινων και χρησεις αυτων | |
| ATE423571T1 (de) | Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantworten | |
| NI200200128A (es) | "anticuerpos para cd40" | |
| ATE554107T1 (de) | Als therapeutika geeignete monovalente antikörperfragmente | |
| AU2003215188A1 (en) | Fusion proteins of humanized g250 specific antibodies and uses thereof | |
| CY1113243T1 (el) | Μεθοδοι θεραπειας με χρηση αντισωματων cτlα-4 | |
| IL244803B (en) | Human anti-beta antibodies and their use | |
| DE502005011119D1 (https=) | ||
| PH12014501872A1 (en) | P-cadherin antibodies | |
| WO2005042029A3 (en) | Psma formulations and uses thereof | |
| NO20045645L (no) | Noytraliserende humant anti-IGFR-antistoff | |
| DE602006021324D1 (de) | Verfahren zur herstellung stabiler b-lymphozyten | |
| WO2005049652A3 (en) | Methods of generating antibody diversity in vitro | |
| IL177825A0 (en) | Natural igm antibodies and inhibitors thereof | |
| WO2005047456A3 (en) | Anti-idiotype antibodies of the human monoclonal antibody sc-1, and their production and use | |
| ATE546157T1 (de) | Anti-pecam-therapie zur unterdrückung von metastasen |