IL164355A0 - New aryl imidazoles and related compounds as cra receptor modulators - Google Patents

New aryl imidazoles and related compounds as cra receptor modulators

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Publication number
IL164355A0
IL164355A0 IL16435503A IL16435503A IL164355A0 IL 164355 A0 IL164355 A0 IL 164355A0 IL 16435503 A IL16435503 A IL 16435503A IL 16435503 A IL16435503 A IL 16435503A IL 164355 A0 IL164355 A0 IL 164355A0
Authority
IL
Israel
Prior art keywords
cra
related compounds
receptor modulators
new aryl
aryl imidazoles
Prior art date
Application number
IL16435503A
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English (en)
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of IL164355A0 publication Critical patent/IL164355A0/xx

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    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
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    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
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IL16435503A 2002-03-29 2003-03-28 New aryl imidazoles and related compounds as cra receptor modulators IL164355A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36911202P 2002-03-29 2002-03-29
US39214502P 2002-06-26 2002-06-26
PCT/US2003/009938 WO2003082829A1 (en) 2002-03-29 2003-03-28 New aryl imidazoles and related compounds as c5a receptor modulators

Publications (1)

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IL164355A0 true IL164355A0 (en) 2005-12-18

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IL16435503A IL164355A0 (en) 2002-03-29 2003-03-28 New aryl imidazoles and related compounds as cra receptor modulators

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US (2) US7186734B2 (zh)
EP (1) EP1490343A1 (zh)
JP (1) JP2005528368A (zh)
KR (1) KR20040093487A (zh)
CN (1) CN1646497A (zh)
AU (1) AU2003228419A1 (zh)
BR (1) BR0308721A (zh)
CA (1) CA2480888A1 (zh)
IL (1) IL164355A0 (zh)
MX (1) MXPA04009419A (zh)
WO (1) WO2003082829A1 (zh)

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EP1745039A4 (en) * 2004-05-08 2009-07-22 Neurogen Corp 3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES
TW200635587A (en) 2004-12-01 2006-10-16 Kalypsys Inc Inducible nitric oxide synthase dimerization inhibitors
ES2644450T3 (es) * 2004-12-31 2017-11-29 Dr. Reddy's Laboratories Ltd. Nuevos derivados de bencilamina como inhibidores de CETP
EP1739078A1 (de) 2005-05-30 2007-01-03 Jerini AG C5a-Rezeptor-Antagonisten
JP5527923B2 (ja) * 2007-03-28 2014-06-25 公益財団法人相模中央化学研究所 パーフルオロアルキル基を有する複素環化合物およびその製造方法
US8722014B2 (en) * 2009-05-01 2014-05-13 Washington University 1 H-[1, 2, 3] triazole substituted amino acids and uses thereof
US9289467B2 (en) 2011-08-10 2016-03-22 Case Western Reserve University Compositions and methods for treating bone conditions
KR102447094B1 (ko) * 2014-08-13 2022-09-23 닛뽕소다 가부시키가이샤 디아릴이미다졸 화합물 및 유해 생물 방제제
JP2022504011A (ja) 2018-08-14 2022-01-13 オステオーク インコーポレイティド ピロロ-ジピリジン化合物
US12012385B1 (en) 2023-12-12 2024-06-18 King Faisal University 4,5-bis(4-methoxyphenyl)-1-hexyl-2-phenyl-1H-imidazole as an antimicrobial compound
US11970461B1 (en) 2023-12-14 2024-04-30 King Faisal University 1-hexyl-5-(4-methoxyphenyl)-2,4-diphenyl-1H-imidazole as an antimicrobial compound

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US5159083A (en) 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
US5646279A (en) 1990-12-28 1997-07-08 Neurogen Corporation Substituted 4-piperazinylmethyl 2-phenylimidazoles; dopamine receptor subtype specific ligands
US5633376A (en) 1990-12-28 1997-05-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; and 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype ligands
US5681956A (en) 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5478934A (en) 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
US6514686B2 (en) * 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US6723743B1 (en) * 1999-09-28 2004-04-20 Neurogen Corporation High affinity small molecule C5a receptor modulators
US6884815B1 (en) * 1999-09-28 2005-04-26 Neurogen Corporation High affinity small molecule C5a receptor modulators
DE60143297D1 (de) 2000-08-10 2010-12-02 Mitsubishi Tanabe Pharma Corp 3-substituierte harnstoffderivate und deren medizinische verwendung
DE60039921D1 (de) * 2000-09-29 2008-09-25 Neurogen Corp Hochaffine kleinmolekülige c5a-rezeptor-modulatoren

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US20070208048A1 (en) 2007-09-06
JP2005528368A (ja) 2005-09-22
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US8119665B2 (en) 2012-02-21
WO2003082829A1 (en) 2003-10-09
KR20040093487A (ko) 2004-11-05
US20040116424A1 (en) 2004-06-17
CN1646497A (zh) 2005-07-27
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