IL164193A0 - Combined use of antitumor indolopyrrolocarbazole derivative and other antitumor agent - Google Patents
Combined use of antitumor indolopyrrolocarbazole derivative and other antitumor agentInfo
- Publication number
- IL164193A0 IL164193A0 IL16419304A IL16419304A IL164193A0 IL 164193 A0 IL164193 A0 IL 164193A0 IL 16419304 A IL16419304 A IL 16419304A IL 16419304 A IL16419304 A IL 16419304A IL 164193 A0 IL164193 A0 IL 164193A0
- Authority
- IL
- Israel
- Prior art keywords
- antitumor
- combined use
- indolopyrrolocarbazole derivative
- agent
- indolopyrrolocarbazole
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002084677 | 2002-03-26 | ||
| PCT/JP2002/010186 WO2003080077A1 (en) | 2002-03-26 | 2002-09-30 | Use of antitumor indolopyrrolocarbazole derivative and other anticancer agent in combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL164193A0 true IL164193A0 (en) | 2005-12-18 |
Family
ID=28449220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16419304A IL164193A0 (en) | 2002-03-26 | 2004-09-21 | Combined use of antitumor indolopyrrolocarbazole derivative and other antitumor agent |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20050171036A1 (pl) |
| EP (1) | EP1498127A4 (pl) |
| JP (1) | JPWO2003080077A1 (pl) |
| KR (1) | KR20040097237A (pl) |
| CN (1) | CN100490817C (pl) |
| AP (1) | AP2004003120A0 (pl) |
| AU (1) | AU2002335472B8 (pl) |
| BR (1) | BR0215650A (pl) |
| CA (1) | CA2480335A1 (pl) |
| CO (1) | CO5611155A2 (pl) |
| EA (1) | EA008302B1 (pl) |
| EC (1) | ECSP045301A (pl) |
| IL (1) | IL164193A0 (pl) |
| IS (1) | IS7379A (pl) |
| MA (1) | MA27247A1 (pl) |
| MX (1) | MXPA04009324A (pl) |
| NO (1) | NO20044030L (pl) |
| NZ (1) | NZ534914A (pl) |
| OA (1) | OA12794A (pl) |
| PL (1) | PL370866A1 (pl) |
| RS (1) | RS84904A (pl) |
| TN (1) | TNSN04185A1 (pl) |
| UA (1) | UA80552C2 (pl) |
| WO (1) | WO2003080077A1 (pl) |
| ZA (1) | ZA200406716B (pl) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO20014256D0 (no) | 2001-09-03 | 2001-09-03 | Bjoern Kristiansen | Fremstilling av immunstimulerende forbindelse |
| EP1604687B1 (en) * | 2003-03-20 | 2010-10-06 | Nippon Kayaku Kabushiki Kaisha | Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer |
| US7514085B2 (en) | 2004-07-16 | 2009-04-07 | Medimush A/S | Immune modulating compounds from fungi |
| JP4820758B2 (ja) | 2004-09-22 | 2011-11-24 | 日本化薬株式会社 | 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤 |
| KR100968818B1 (ko) * | 2004-12-03 | 2010-07-08 | 현대자동차주식회사 | 차량용 리어 쇽업쇼버의 보호 커버 구조 |
| US20110182909A1 (en) * | 2004-12-23 | 2011-07-28 | Threshold Pharmaceuticals, Inc. | Glufosfamide combination therapy |
| CN100358482C (zh) * | 2005-01-31 | 2008-01-02 | 武汉理工大学 | 多功能医用金属支架及制备方法 |
| CN100431607C (zh) * | 2005-02-03 | 2008-11-12 | 山东蓝金生物工程有限公司 | 一种抗实体肿瘤的药物组合物 |
| WO2006133707A2 (en) | 2005-06-15 | 2006-12-21 | Medimush A/S | Anti-cancer combination treatment and kit-of-part |
| CN101242822B (zh) * | 2005-07-18 | 2011-08-24 | 彼帕科学公司 | 治疗卵巢癌的药物 |
| RU2447095C2 (ru) * | 2006-05-18 | 2012-04-10 | Ниппон Каяку Кабусики Кайся | Высокомолекулярный конъюгат подофиллотоксинов |
| WO2008030883A2 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Treatment of cancer |
| US7994222B2 (en) | 2006-09-05 | 2011-08-09 | Bipar Sciences, Inc. | Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds |
| CA2664852A1 (en) * | 2006-10-03 | 2008-04-10 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of resorcinol derivatives |
| CN100571709C (zh) * | 2007-06-01 | 2009-12-23 | 中国医学科学院医药生物技术研究所 | 一种有抗肿瘤协同增效作用的药物组合物 |
| CN101808651B (zh) | 2007-09-28 | 2013-03-27 | 日本化药株式会社 | 类固醇类的高分子结合物 |
| EP2211854A4 (en) * | 2007-10-19 | 2011-01-12 | Bipar Sciences Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER USING BENZOPYRONE-TYPE PARP INHIBITORS |
| AU2008321128A1 (en) | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents |
| EP2082745B1 (en) * | 2007-12-28 | 2012-12-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Cancer therapy with a parvovirus combined with chemotherapy |
| CN101977631A (zh) * | 2008-03-18 | 2011-02-16 | 日本化药株式会社 | 生理活性物质的高分子量偶联物 |
| US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
| US8808749B2 (en) | 2009-05-15 | 2014-08-19 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of bioactive substance having hydroxy group |
| CN102198150B (zh) * | 2010-03-26 | 2013-11-06 | 中国医学科学院医药生物技术研究所 | 双活性成分抗肿瘤药物及其应用 |
| JP5856069B2 (ja) | 2010-11-17 | 2016-02-09 | 日本化薬株式会社 | 新規なシチジン系代謝拮抗剤の高分子誘導体 |
| CN102178676B (zh) * | 2011-04-29 | 2012-07-25 | 山东大学 | 一种治疗脑胶质瘤的药物组合物 |
| KR101849142B1 (ko) | 2011-09-11 | 2018-04-16 | 니폰 가야꾸 가부시끼가이샤 | 블록 공중합체의 제조방법 |
| CN117486782A (zh) * | 2023-12-29 | 2024-02-02 | 中国医学科学院药用植物研究所 | 一种n-取代咔唑衍生物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL172316B1 (en) * | 1991-11-29 | 1997-09-30 | Banyu Pharma Co Ltd | Method of obtaining novel derivatives of indolopyrrole carbazole |
| NZ245203A (en) * | 1991-11-29 | 1997-07-27 | Banyu Pharma Co Ltd | 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates |
| US5589365A (en) * | 1991-11-29 | 1996-12-31 | Banyu Pharmaceutical Co., Ltd. | Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms |
| CN1035878C (zh) * | 1992-02-18 | 1997-09-17 | 万有制药株式会社 | 吲哚并吡咯并咔唑衍生物 |
| US5922860A (en) * | 1994-05-09 | 1999-07-13 | Banyu Pharmaceutical Co., Ltd. | Antitumor indolopyrrolocarbazole derivatives |
| JP3536574B2 (ja) | 1997-02-28 | 2004-06-14 | 萬有製薬株式会社 | 抗腫瘍性インドロピロロカルバゾール誘導体 |
| FR2772763B1 (fr) * | 1997-12-24 | 2004-01-23 | Sod Conseils Rech Applic | Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| CA2408707C (en) * | 2000-05-15 | 2010-04-13 | Celgene Corp. | Compositions and methods for the treatment of cancer |
-
2002
- 2002-09-30 MX MXPA04009324A patent/MXPA04009324A/es not_active Application Discontinuation
- 2002-09-30 PL PL02370866A patent/PL370866A1/pl not_active Application Discontinuation
- 2002-09-30 AU AU2002335472A patent/AU2002335472B8/en not_active Ceased
- 2002-09-30 NZ NZ534914A patent/NZ534914A/en not_active IP Right Cessation
- 2002-09-30 RS YU84904A patent/RS84904A/sr unknown
- 2002-09-30 CA CA002480335A patent/CA2480335A1/en not_active Abandoned
- 2002-09-30 OA OA1200400252A patent/OA12794A/en unknown
- 2002-09-30 KR KR10-2004-7015417A patent/KR20040097237A/ko not_active Ceased
- 2002-09-30 US US10/509,061 patent/US20050171036A1/en not_active Abandoned
- 2002-09-30 JP JP2003577903A patent/JPWO2003080077A1/ja active Pending
- 2002-09-30 CN CNB028286251A patent/CN100490817C/zh not_active Expired - Fee Related
- 2002-09-30 EP EP02807108A patent/EP1498127A4/en not_active Withdrawn
- 2002-09-30 AP APAP/P/2004/003120A patent/AP2004003120A0/en unknown
- 2002-09-30 BR BR0215650-4A patent/BR0215650A/pt not_active IP Right Cessation
- 2002-09-30 EA EA200401254A patent/EA008302B1/ru not_active IP Right Cessation
- 2002-09-30 WO PCT/JP2002/010186 patent/WO2003080077A1/ja not_active Ceased
- 2002-09-30 UA UA20041008694A patent/UA80552C2/uk unknown
-
2004
- 2004-07-29 IS IS7379A patent/IS7379A/is unknown
- 2004-08-24 ZA ZA200406716A patent/ZA200406716B/en unknown
- 2004-09-10 MA MA27853A patent/MA27247A1/fr unknown
- 2004-09-17 EC EC2004005301A patent/ECSP045301A/es unknown
- 2004-09-21 IL IL16419304A patent/IL164193A0/xx unknown
- 2004-09-24 TN TNP2004000185A patent/TNSN04185A1/en unknown
- 2004-09-24 CO CO04095472A patent/CO5611155A2/es not_active Application Discontinuation
- 2004-09-24 NO NO20044030A patent/NO20044030L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| OA12794A (en) | 2006-07-10 |
| CA2480335A1 (en) | 2003-10-02 |
| EA008302B1 (ru) | 2007-04-27 |
| KR20040097237A (ko) | 2004-11-17 |
| NO20044030L (no) | 2004-12-16 |
| US20050171036A1 (en) | 2005-08-04 |
| MXPA04009324A (es) | 2005-01-25 |
| TNSN04185A1 (en) | 2007-03-12 |
| CO5611155A2 (es) | 2006-02-28 |
| CN1622814A (zh) | 2005-06-01 |
| CN100490817C (zh) | 2009-05-27 |
| AP2004003120A0 (en) | 2004-09-30 |
| EP1498127A1 (en) | 2005-01-19 |
| UA80552C2 (en) | 2007-10-10 |
| ZA200406716B (en) | 2006-07-26 |
| MA27247A1 (fr) | 2005-03-01 |
| AU2002335472B8 (en) | 2007-12-20 |
| PL370866A1 (pl) | 2005-05-30 |
| AU2002335472A1 (en) | 2003-10-08 |
| WO2003080077A1 (en) | 2003-10-02 |
| BR0215650A (pt) | 2005-01-04 |
| JPWO2003080077A1 (ja) | 2005-07-21 |
| EA200401254A1 (ru) | 2005-02-24 |
| RS84904A (sr) | 2006-12-15 |
| NZ534914A (en) | 2007-01-26 |
| ECSP045301A (es) | 2004-11-26 |
| IS7379A (is) | 2004-07-29 |
| EP1498127A4 (en) | 2008-02-06 |
| AU2002335472B2 (en) | 2007-12-13 |
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