IL162319A0 - Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting - Google Patents
Amphiphilic compounds and vesicles/liposomes for organ-specific drug targetingInfo
- Publication number
- IL162319A0 IL162319A0 IL16231902A IL16231902A IL162319A0 IL 162319 A0 IL162319 A0 IL 162319A0 IL 16231902 A IL16231902 A IL 16231902A IL 16231902 A IL16231902 A IL 16231902A IL 162319 A0 IL162319 A0 IL 162319A0
- Authority
- IL
- Israel
- Prior art keywords
- vesicles
- liposomes
- organ
- specific drug
- drug targeting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33494001P | 2001-12-04 | 2001-12-04 | |
US39581302P | 2002-07-16 | 2002-07-16 | |
PCT/IL2002/000977 WO2003047499A2 (en) | 2001-12-04 | 2002-12-04 | Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting |
Publications (1)
Publication Number | Publication Date |
---|---|
IL162319A0 true IL162319A0 (en) | 2005-11-20 |
Family
ID=26989464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16231902A IL162319A0 (en) | 2001-12-04 | 2002-12-04 | Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting |
Country Status (7)
Country | Link |
---|---|
US (1) | US7887833B2 (de) |
EP (1) | EP1461014B1 (de) |
JP (1) | JP2005521645A (de) |
AU (1) | AU2002353485B2 (de) |
CA (1) | CA2478066C (de) |
IL (1) | IL162319A0 (de) |
WO (1) | WO2003047499A2 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
JP2006523683A (ja) * | 2003-04-15 | 2006-10-19 | オッパーバス・ホールディング・ビー・ブイ | タンパク質及び/またはポリペプチド及びコロイド粒子を含む医薬組成物 |
JP4747534B2 (ja) * | 2003-09-01 | 2011-08-17 | 大正製薬株式会社 | W/o/w型複合エマルション |
US7611863B2 (en) | 2004-01-08 | 2009-11-03 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Selective staining of biomembranes using voltage-sensitive dyes |
EP1553396A3 (de) * | 2004-01-08 | 2005-09-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Selektives Färben von Biomembranen mit Spannungs-sensitive Farbstoffen |
JP4787818B2 (ja) * | 2005-01-28 | 2011-10-05 | 独立行政法人科学技術振興機構 | 脱水縮合反応により相転移を生じ得る分子集合体およびその相転移方法 |
US8647613B2 (en) * | 2005-03-16 | 2014-02-11 | Jcr Pharmaceuticals Co., Ltd. | Drug carrier |
RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
SG2014013437A (en) | 2005-11-30 | 2014-07-30 | Abbott Lab | Monoclonal antibodies and uses thereof |
AU2006326404B2 (en) * | 2005-12-14 | 2011-11-03 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
GB0600134D0 (en) | 2006-01-05 | 2006-02-15 | Vernique Biotech Ltd | Use of epoxidised molecules |
US9259419B2 (en) | 2006-07-10 | 2016-02-16 | Synapsin Pharmaceuticals, Inc. | Compositions and methods relating to solenopsins and their uses in treating neurological disorders and enhancing physical performance |
EP2043642B1 (de) * | 2006-07-10 | 2015-03-25 | Synapsin Pharmaceuticals, Inc. | Zusammensetzungen und verfahren in zusammenhang mit solenopsinen und ihre verwendung zur behandlung neurologischer erkrankungen und erhöhung der körperlichen leistung |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
CA2672494A1 (en) | 2006-12-14 | 2008-06-19 | Nps Pharmaceuticals, Inc. | Use of d-serine derivatives for the treatment of anxiety disorders |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
WO2008130641A1 (en) * | 2007-04-20 | 2008-10-30 | Biocure, Inc. | Drug delivery vehicle containing vesicles in a hydrogel base |
CA2705031A1 (en) * | 2007-11-15 | 2009-05-22 | Lipodur Pharmaceutical Inc. | Gel-stabilized liposome compositions, methods for their preparation and uses thereof |
US8870847B2 (en) * | 2007-11-27 | 2014-10-28 | Abbott Cardiovascular Systems Inc. | Blood vessel permeability-enhancement for the treatment of vascular diseases |
WO2009129476A2 (en) * | 2008-04-17 | 2009-10-22 | Banyan Biomarkers, Inc. | An antibody bound synthetic vesicle containing active agent molecules |
US20100129430A1 (en) * | 2008-11-24 | 2010-05-27 | Stavroula Sofou | Liposome drug carriers with ph-sensitivity |
EP3539535A1 (de) | 2009-05-04 | 2019-09-18 | Ben-Gurion University of The Negev Research and Development Authority | Nanoskalige partikel mit mehrköpfigen amphiphilen zur gezielten arzneimittelabgabe |
CN102724877B (zh) | 2009-09-01 | 2015-05-13 | 凯特贝希制药公司 | 脂肪酸烟酸缀合物及其用途 |
USRE46608E1 (en) | 2009-09-01 | 2017-11-14 | Catabasis Pharmaceuticals, Inc. | Fatty acid niacin conjugates and their uses |
GB201004306D0 (en) * | 2010-03-15 | 2010-04-28 | Imp Innovations Ltd | Assay |
MX360403B (es) | 2010-04-15 | 2018-10-31 | Abbvie Inc | Proteinas de union a amiloide beta. |
JP6147665B2 (ja) | 2010-08-14 | 2017-06-14 | アッヴィ・インコーポレイテッド | アミロイドベータ結合タンパク質 |
EP2787977A4 (de) * | 2011-12-09 | 2015-05-06 | Univ California | Liposomale wirkstoffverkapselung |
AU2013312908A1 (en) * | 2012-09-04 | 2015-03-26 | Lauren Sciences Llc | Bolaamphiphilic compounds, compositions and uses thereof |
AU2013312910B2 (en) * | 2012-09-04 | 2017-09-14 | Lauren Sciences Llc | Bolaamphiphilic compounds, compositions and uses thereof |
WO2014039493A1 (en) * | 2012-09-04 | 2014-03-13 | Lauren Sciences Llc | Bolaamphiphilic compounds, compositions and uses thereof |
EP2892508A4 (de) * | 2012-09-04 | 2016-06-01 | Lauren Sciences Llc | Bolaamphiphile verbindungen, zusammensetzungen und verwendungen davon |
JP6659535B2 (ja) | 2013-06-28 | 2020-03-04 | オークランド ユニサービシーズ リミティド | アミノ酸及びペプチド接合体及び接合方法 |
WO2015070034A1 (en) | 2013-11-08 | 2015-05-14 | Promentis Pharmaceuticals, Inc. | Substituted n-acetyl-l-cysteine derivatives and related compounds |
JP2018505152A (ja) | 2014-12-23 | 2018-02-22 | アン ブリンブル マーガレット | アミノ酸複合体及びペプチド複合体ならびにそれらの使用 |
US20180291086A1 (en) * | 2015-10-05 | 2018-10-11 | The Regents Of The University Of Colorado, A Body Corporate | Lipoplexes formulated for catalytic delivery |
KR20180128915A (ko) | 2016-02-26 | 2018-12-04 | 오클랜드 유니서비시즈 리미티드 | 아미노산 및 펩티드 접합체 및 접합 방법 |
GB201614120D0 (en) * | 2016-08-18 | 2016-10-05 | Univ Of Kwazulu-Natal | pH-responsive lipids |
WO2020203998A1 (ja) * | 2019-03-29 | 2020-10-08 | 株式会社日本触媒 | 両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤 |
WO2022235514A1 (en) * | 2021-05-04 | 2022-11-10 | Mind Medicine, Inc. | Liposome delivery of psychedelics |
CN113350286B (zh) * | 2021-05-22 | 2022-07-26 | 南开大学 | “水桥”介导超响应的功能协同两性离子脂质及其制备方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU85971A1 (fr) * | 1985-06-25 | 1987-01-13 | Oreal | Nouveaux composes lipidiques amphiphiles, leur procede de preparation et leurs applications,notamnent en cosmetique et en dermopharmacie |
US5270053A (en) | 1990-04-03 | 1993-12-14 | Ciba-Geigy Corp. | Parenterally administerable liposome formulation comprising synthetic lipid |
WO1995021812A1 (en) * | 1994-02-14 | 1995-08-17 | Indiana University Foundation | Aminophospholipid compositions and uses thereof |
WO1996032930A1 (en) | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
GB9605915D0 (en) * | 1996-03-21 | 1996-05-22 | Univ Bruxelles | Liposome encapsulated amphiphilic drug compositions |
US6414139B1 (en) * | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
WO1998016199A1 (en) | 1996-10-15 | 1998-04-23 | The Liposome Company, Inc. | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
DK0964690T3 (da) | 1996-10-15 | 2003-10-20 | Liposome Co Inc | Peptid-lipidkonjugater, liposomer og liposomal lægemiddeladministration |
AU3659497A (en) | 1997-07-11 | 1999-02-08 | Canji, Inc. | Organ-specific targeting of cationic amphiphile/retinobl astoma encoding dna complexes for gene therapy |
US6217886B1 (en) * | 1997-07-14 | 2001-04-17 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved micelle compositions |
WO2001005375A1 (en) | 1999-07-16 | 2001-01-25 | Purdue Research Foundation | Vinyl ether lipids with cleavable hydrophilic headgroups |
US7939562B2 (en) | 2001-01-16 | 2011-05-10 | Ben-Gurion University Of The Negev Research And Development Authority | Amphiphilic derivatives for the production of vesicles, micelles and complexants, and precursors thereof |
-
2002
- 2002-12-04 EP EP02788510.2A patent/EP1461014B1/de not_active Expired - Lifetime
- 2002-12-04 US US10/497,705 patent/US7887833B2/en active Active
- 2002-12-04 CA CA002478066A patent/CA2478066C/en not_active Expired - Lifetime
- 2002-12-04 AU AU2002353485A patent/AU2002353485B2/en not_active Expired
- 2002-12-04 JP JP2003548760A patent/JP2005521645A/ja active Pending
- 2002-12-04 WO PCT/IL2002/000977 patent/WO2003047499A2/en active Application Filing
- 2002-12-04 IL IL16231902A patent/IL162319A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2478066A1 (en) | 2003-06-12 |
EP1461014B1 (de) | 2021-07-14 |
CA2478066C (en) | 2009-09-08 |
AU2002353485A1 (en) | 2003-06-17 |
US7887833B2 (en) | 2011-02-15 |
WO2003047499A3 (en) | 2004-03-18 |
EP1461014A2 (de) | 2004-09-29 |
JP2005521645A (ja) | 2005-07-21 |
AU2002353485B2 (en) | 2009-01-15 |
WO2003047499A2 (en) | 2003-06-12 |
US20060039962A1 (en) | 2006-02-23 |
EP1461014A4 (de) | 2010-11-10 |
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