IL160052A0 - Diagnostic and pharmaceutical compositions containing microorganisms or cells including a detectable protein - Google Patents
Diagnostic and pharmaceutical compositions containing microorganisms or cells including a detectable proteinInfo
- Publication number
- IL160052A0 IL160052A0 IL16005202A IL16005202A IL160052A0 IL 160052 A0 IL160052 A0 IL 160052A0 IL 16005202 A IL16005202 A IL 16005202A IL 16005202 A IL16005202 A IL 16005202A IL 160052 A0 IL160052 A0 IL 160052A0
- Authority
- IL
- Israel
- Prior art keywords
- protein
- diagnostic
- pharmaceutical compositions
- compositions containing
- cells including
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
- A61K49/0047—Green fluorescent protein [GFP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1896—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01118417A EP1281772A1 (de) | 2001-07-31 | 2001-07-31 | Lichtemittierende Mikroorganismen und Zellen zum Nachweis und zur Therapie von Krebs |
| EP01125911A EP1281767A3 (de) | 2001-07-31 | 2001-10-30 | Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren |
| PCT/IB2002/004767 WO2003014380A2 (en) | 2001-07-31 | 2002-07-31 | Microoroganisms and cells for diagnosis and therapy of tumors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL160052A0 true IL160052A0 (en) | 2004-06-20 |
Family
ID=26076668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16005202A IL160052A0 (en) | 2001-07-31 | 2002-07-31 | Diagnostic and pharmaceutical compositions containing microorganisms or cells including a detectable protein |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US20030059400A1 (de) |
| EP (2) | EP1281767A3 (de) |
| KR (3) | KR20040054668A (de) |
| CN (1) | CN100415897C (de) |
| AT (2) | ATE452205T1 (de) |
| BR (1) | BR0211546A (de) |
| CA (1) | CA2456055C (de) |
| DE (3) | DE60222910D1 (de) |
| IL (1) | IL160052A0 (de) |
| MX (1) | MXPA04000882A (de) |
| NO (1) | NO20040428L (de) |
| NZ (1) | NZ530818A (de) |
| PL (1) | PL374326A1 (de) |
| RU (1) | RU2357754C2 (de) |
| SG (1) | SG168404A1 (de) |
| TR (1) | TR200400149T2 (de) |
| WO (1) | WO2003014380A2 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080849A (en) * | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| AU749695B2 (en) * | 1997-09-10 | 2002-07-04 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| US6962696B1 (en) * | 1999-10-04 | 2005-11-08 | Vion Pharmaceuticals Inc. | Compositions and methods for tumor-targeted delivery of effector molecules |
| EP1281767A3 (de) | 2001-07-31 | 2003-05-28 | Aladar A. Szalay | Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren |
| CA2470411C (en) * | 2001-12-31 | 2015-07-07 | Anticancer, Inc. | System for monitoring bacterial tumor treatment |
| US20030228261A1 (en) * | 2002-06-05 | 2003-12-11 | Aladar Szalay | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue |
| EP1369491A1 (de) | 2002-06-05 | 2003-12-10 | Aladar A. Szalay | Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe |
| AU2003285930A1 (en) * | 2002-10-21 | 2004-05-13 | The Regents Of The University Of California | Optical imagiong of renilla luciferase reporter gene expression in living organisms |
| US20050008618A1 (en) * | 2003-02-27 | 2005-01-13 | Howard Kaufman | Composition for delivering an agent to a target cell and uses thereof |
| AU2004289953B2 (en) * | 2003-06-18 | 2008-09-25 | Genelux Corporation | Modified recombinant vaccina viruses and other microorganisms, uses thereof |
| US7155274B1 (en) | 2003-11-21 | 2006-12-26 | Imaging Diagnostic Systems, Inc. | Optical computed tomography scanner for small laboratory animals |
| US9107864B2 (en) | 2004-06-07 | 2015-08-18 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| US8501198B2 (en) * | 2004-06-07 | 2013-08-06 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| US7883535B2 (en) * | 2004-11-09 | 2011-02-08 | Institut National D'optique | Device and method for transmitting multiple optically-encoded stimulation signals to multiple cell locations |
| CN102423665B (zh) | 2005-04-25 | 2015-04-15 | 高级技术材料公司 | 具有空检测能力的基于衬里的液体储存和分配系统 |
| US20070231833A1 (en) * | 2005-05-23 | 2007-10-04 | Arcidiacono Steven M | Labeled antimicrobial peptides and method of using the same to detect microorganisms of interest |
| KR20080039373A (ko) | 2005-06-06 | 2008-05-07 | 어드밴스드 테크놀러지 머티리얼즈, 인코포레이티드 | 유체 저장 및 분배 시스템과 프로세스 |
| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| US20090098529A1 (en) | 2006-10-16 | 2009-04-16 | Nanhai Chen | Methods for attenuating virus strains for diagnostic and therapeutic uses |
| US20090081639A1 (en) * | 2007-05-31 | 2009-03-26 | Phil Hill | Assay for sensitivity to chemotherapeutic agents |
| EP2171071B1 (de) | 2007-06-15 | 2015-08-05 | Genelux Corporation | Für ein natriumabhängiges transporterprotein codierende vacciniavirus-vektoren zur bildlichen darstellung und/oder behandlung von tumoren |
| WO2009011924A1 (en) | 2007-07-18 | 2009-01-22 | Genelux Corporation | Use of a chemotherapeutic agent in the preparation of a medicament for treating or ameliorating an adverse side effect associated with oncolytic viral therapy |
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| US20110135575A1 (en) * | 2007-08-28 | 2011-06-09 | Massachusetts Institute Of Technology | Metalloprotein mri contrast agents and related methods |
| US20090074670A1 (en) * | 2007-09-07 | 2009-03-19 | Yousef Haik | Hyperthermia Therapeutic Agent Delivery System |
| US20090068112A1 (en) * | 2007-09-11 | 2009-03-12 | Yousef Haik | Magnetic Nanoparticles for Imaging |
| WO2009054996A2 (en) | 2007-10-25 | 2009-04-30 | Genelux Corporation | Systems and methods for viral therapy |
| US20090176260A1 (en) * | 2007-12-04 | 2009-07-09 | Joseph Ching-Ming Wu | Double-fusion human embryonic stem cells, methods of making double-fusion human embryonic stem cells, triple-fusion human embryonic stem cells, methods of making triple-fusion human embryonic stem cells, and methods of monitoring double-fusion human embryonic stem cells and triple-fusion human embryonic stem cells |
| US8357486B2 (en) | 2008-01-11 | 2013-01-22 | Genelux Corporation | Methods and compositions for detection of bacteria and treatment of diseases and disorders |
| EP2300023A2 (de) * | 2008-05-16 | 2011-03-30 | Genelux Corporation | Mikroorganismen zur prävention und behandlung von neoplasien neben einer zelltherapie |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
| GB2472790A (en) * | 2009-08-18 | 2011-02-23 | Laurence Christian Hayes | Dermatological preparations comprising microbes. |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| EP2593796A4 (de) | 2010-07-16 | 2016-07-27 | Auckland Uniservices Ltd | Bakterielle nitroreduktase-enzyme und verfahren dafür |
| PL2598165T3 (pl) | 2010-07-26 | 2018-02-28 | Qu Biologics Inc. | Immunogenne kompozycje przeciwzapalne |
| WO2012040105A2 (en) * | 2010-09-21 | 2012-03-29 | Kansas State University Research Foundation | Renilla/gaussia transfected cells as a light source for in-situ photodynamic therapy of cancer |
| ES2733211T3 (es) | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| US8859256B2 (en) | 2011-10-05 | 2014-10-14 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
| US8828681B2 (en) | 2012-01-13 | 2014-09-09 | Bell Biosystems, Inc. | Host cells with artificial endosymbionts |
| US10076579B2 (en) | 2012-01-13 | 2018-09-18 | Bell Biosystems, Inc. | Host cells with artificial endosymbionts |
| US9023612B2 (en) | 2012-01-13 | 2015-05-05 | Bell Biosystems, Inc. | Eukaryotic cells with artificial endosymbionts for multimodal detection |
| US8956873B2 (en) | 2012-01-13 | 2015-02-17 | Bell Biosystems, Inc. | Host cells with artificial endosymbionts |
| DK2823040T3 (en) * | 2012-03-06 | 2018-11-19 | Cellect Biotherapeutics Ltd | DEVICES AND METHODS FOR SELECTING APOPTOSE SIGNALING RESISTANT CELLS AND APPLICATIONS THEREOF |
| WO2013138522A2 (en) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
| WO2013158265A1 (en) | 2012-04-20 | 2013-10-24 | Genelux Corporation | Imaging methods for oncolytic virus therapy |
| US20140140959A1 (en) | 2012-10-05 | 2014-05-22 | Aladar A. Szalay | Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes |
| US9593339B1 (en) | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| WO2014145785A1 (en) | 2013-03-15 | 2014-09-18 | Bell Biosystems, Llc | Host cells with artificial endosymbionts |
| GB201310917D0 (en) * | 2013-06-19 | 2013-07-31 | Cancer Res Inst Royal | Vaccinia virus for gene-directed enzyme prodrug therapy |
| WO2015034962A1 (en) * | 2013-09-03 | 2015-03-12 | Bell Biosystems, Inc. | Host cell modification with artificial endosymbionts |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| SG11201606324TA (en) * | 2014-02-13 | 2016-08-30 | Bell Biosystems Inc | Systems for making host cells with artificial endosymbionts |
| US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
| RU2020120075A (ru) | 2014-05-02 | 2020-07-03 | Кью Байолоджикс Инк. | Противомикробная иммуномодуляция |
| CN104162175B (zh) * | 2014-06-18 | 2017-02-01 | 东华大学 | 功能化的基于树状大分子的spect‑ct双模态成像造影剂及其制备方法 |
| WO2016011336A1 (en) | 2014-07-17 | 2016-01-21 | Western Michigan University Research Foundation | Composition for treating cancerous cells and a method therefor |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN107365799A (zh) * | 2017-08-08 | 2017-11-21 | 四川省肿瘤医院 | Sod2慢病毒载体、构建方法及其在靶向性辐射防护和肿瘤增敏中的应用 |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| CA3177467A1 (en) | 2018-06-04 | 2019-12-12 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| EP3844276A2 (de) | 2018-08-28 | 2021-07-07 | Actym Therapeutics, Inc. | Manipulierte immunstimulierende bakterienstämme und verwendungen davon |
| JP7329593B2 (ja) | 2018-11-06 | 2023-08-18 | カリディ・バイオセラピューティクス・インコーポレイテッド | 細胞媒介性腫瘍溶解性ウイルス治療のための増強された系 |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| CA3176660A1 (en) | 2019-02-27 | 2020-09-03 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| GB201914096D0 (en) * | 2019-09-30 | 2019-11-13 | Rna Guardian Ltd | Cancer Biomarker |
| US12285437B2 (en) | 2019-10-30 | 2025-04-29 | The Research Foundation For The State University Of New York | Reversing the undesirable pH-profile of doxorubicin via activation of a disubstituted maleamic acid prodrug at tumor acidity |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US11297054B1 (en) * | 2020-10-06 | 2022-04-05 | International Business Machines Corporation | Authentication system(s) with multiple authentication modes using one-time passwords of increased security |
| RU2755010C1 (ru) * | 2021-01-26 | 2021-09-09 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр" Российской академии наук ("Томский НИМЦ") | Способ диагностики рака ободочной кишки |
| WO2025184411A1 (en) | 2024-02-27 | 2025-09-04 | Calidi Biotherapeutics (Nevada), Inc. | Serum-resistant eev viruses and uses thereof |
| CN118064333B (zh) * | 2024-04-18 | 2024-07-05 | 青岛诺和诺康生物科技有限公司 | 一株唾液联合乳杆菌及其在制备改善皮肤色泽产品中的应用 |
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