EP1414499A4 - Nicht invasives tumor-imaging mittels tumorgerichteter bakterien - Google Patents

Nicht invasives tumor-imaging mittels tumorgerichteter bakterien

Info

Publication number
EP1414499A4
EP1414499A4 EP00970577A EP00970577A EP1414499A4 EP 1414499 A4 EP1414499 A4 EP 1414499A4 EP 00970577 A EP00970577 A EP 00970577A EP 00970577 A EP00970577 A EP 00970577A EP 1414499 A4 EP1414499 A4 EP 1414499A4
Authority
EP
European Patent Office
Prior art keywords
tumor
targeted bacteria
invasive
imaging
tumor imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00970577A
Other languages
English (en)
French (fr)
Other versions
EP1414499A2 (de
Inventor
David G Bermudes
Ivan Cheung-Lam King
Ronald G Blasberg
Juri G Tjuvajev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Vion Pharmaceuticals Inc
Original Assignee
Sloan Kettering Institute for Cancer Research
Vion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research, Vion Pharmaceuticals Inc filed Critical Sloan Kettering Institute for Cancer Research
Publication of EP1414499A4 publication Critical patent/EP1414499A4/de
Publication of EP1414499A2 publication Critical patent/EP1414499A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
    • A61K49/0047—Green fluorescent protein [GFP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
EP00970577A 1999-10-04 2000-10-04 Nicht invasives tumor-imaging mittels tumorgerichteter bakterien Withdrawn EP1414499A2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15762099P 1999-10-04 1999-10-04
US157620P 1999-10-04
PCT/US2000/027397 WO2001025399A2 (en) 1999-10-04 2000-10-04 Non-invasive tumor imaging by tumor-targeted bacteria

Publications (2)

Publication Number Publication Date
EP1414499A4 true EP1414499A4 (de) 2004-05-06
EP1414499A2 EP1414499A2 (de) 2004-05-06

Family

ID=22564528

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00970577A Withdrawn EP1414499A2 (de) 1999-10-04 2000-10-04 Nicht invasives tumor-imaging mittels tumorgerichteter bakterien

Country Status (4)

Country Link
EP (1) EP1414499A2 (de)
AU (1) AU7993600A (de)
CA (1) CA2386806A1 (de)
WO (1) WO2001025399A2 (de)

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JP2005520781A (ja) * 2001-07-09 2005-07-14 アンチキャンサー インコーポレーテッド 蛍光タンパク質をマーカーとして用いた感染の画像化
EP1281767A3 (de) * 2001-07-31 2003-05-28 Aladar A. Szalay Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren
EP1281772A1 (de) * 2001-07-31 2003-02-05 Aladar A. Szalay Lichtemittierende Mikroorganismen und Zellen zum Nachweis und zur Therapie von Krebs
EP1914316B1 (de) * 2001-08-01 2009-12-16 Genelux Corporation LIVP Stamm von Vaccinia-Virus zur Diagnose und Behandlung von Tumoren
CN1304559C (zh) * 2001-10-09 2007-03-14 杭州康科生物技术有限公司 表达热休克蛋白的溶瘤微生物及其应用
CA2470411C (en) * 2001-12-31 2015-07-07 Anticancer, Inc. System for monitoring bacterial tumor treatment
EP1369491A1 (de) * 2002-06-05 2003-12-10 Aladar A. Szalay Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe
JP4634710B2 (ja) * 2002-07-31 2011-02-16 ゲネルクス コーポレーション 腫瘍の診断および治療のための微生物および細胞
EP1594560A4 (de) * 2003-01-09 2007-06-06 Univ Pennsylvania Zusammensetzungen, verfahren und kits zur verstärkung der immunogenität eines bakterienimpfstoffvektors
DE602004018927D1 (de) 2003-06-18 2009-02-26 Genelux Corp Modifizierte rekombinante vacciniaviren, verwendungen davon
CN101010002B (zh) * 2004-06-29 2012-10-10 抗癌公司 癌症选择性营养缺陷型
NZ569818A (en) 2005-12-16 2012-07-27 Catherine M Shachaf Diagnostic system for the detection and diagnosis of skin cancer
US8357486B2 (en) 2008-01-11 2013-01-22 Genelux Corporation Methods and compositions for detection of bacteria and treatment of diseases and disorders
WO2012112317A1 (en) * 2011-02-15 2012-08-23 Albert Einstein College Of Medicine Of Yeshiva University Radiobacteria for therapy of cancer
US11268958B2 (en) * 2012-09-14 2022-03-08 The Johns Hopkins University Bacteria-specific labeled substrtates as imaging biomarkers to diagnose, locate, and monitor infections
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
JP7097438B2 (ja) 2017-07-11 2022-07-07 アクティム・セラピューティクス・インコーポレイテッド 遺伝子操作された免疫刺激性細菌菌株およびその使用
BR112021000315A2 (pt) 2018-07-11 2021-08-03 Actym Therapeutics, Inc. cepas bacterianas imunoestimulantes modificadas geneticamente e seus usos
EP3844276A2 (de) 2018-08-28 2021-07-07 Actym Therapeutics, Inc. Manipulierte immunstimulierende bakterienstämme und verwendungen davon
KR102110993B1 (ko) * 2018-12-20 2020-05-14 한국생명공학연구원 클레브시엘라 아에로제네스(Klebsiella aerogenes) 균주를 유효성분으로 포함하는 암 진단, 예방 또는 치료용 조성물
CA3131017A1 (en) 2019-02-27 2020-09-03 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
CA3161450A1 (en) 2019-11-12 2021-05-20 Actym Therapeutics, Inc. Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products
AU2021324883A1 (en) 2020-08-12 2023-03-23 Actym Therapeutics, Inc. Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms
CA3235418A1 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005026A1 (en) * 1986-02-24 1987-08-27 The Trustees Of Columbia University In The City Of Dna encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof
US4863713A (en) * 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk

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GB8318575D0 (en) * 1983-07-08 1983-08-10 Cobbold S P Antibody preparations
US5703056A (en) * 1995-03-15 1997-12-30 Sloan-Kettering Institute For Cancer Research Non-invasive imaging of gene transfer
US5681745A (en) * 1995-05-01 1997-10-28 Trustees Of Boston University Biotin-binding containment systems
US6190657B1 (en) * 1995-06-07 2001-02-20 Yale University Vectors for the diagnosis and treatment of solid tumors including melanoma
US5824538A (en) * 1995-09-06 1998-10-20 The United States Of America As Represented By The Secretary Of The Army Shigella vector for delivering DNA to a mammalian cell
US5997881A (en) * 1995-11-22 1999-12-07 University Of Maryland, Baltimore Method of making non-pyrogenic lipopolysaccharide or A
WO1999013053A1 (en) * 1997-09-10 1999-03-18 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005026A1 (en) * 1986-02-24 1987-08-27 The Trustees Of Columbia University In The City Of Dna encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof
US4863713A (en) * 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CARMICHAEL E ET AL: "In vivo expression of functional cytosine deaminase utilizing a tumor-targeted bacterial vector", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 38, no. 0, 1997, Eighty-eighth Annual Meeting of the American Association for Cancer Research;San Diego, California, USA; April 12-16, 1997, 1997, pages 7, XP001156445, ISSN: 0197-016X *
CURTISS R ET AL: "RECOMBINANT AVIRULENT SALMONELLA VACCINE STRAINS WITH STABLE MAINTENANCE AND HIGH LEVEL EXPRESSION OF CLONED GENES IN VIVO", IMMUNOLOGICAL INVESTIGATIONS, MARCEL DEKKER, NEW YORK, NY, US, vol. 18, no. 1-4, 1989, pages 583 - 596, XP009014132, ISSN: 0882-0139 *
GALLIZIA A ET AL: "PRODUCTION OF A SOLUBLE AND FUNCTIONAL RECOMBINANT STREPTAVIDIN IN ESCHERICHIA COLI", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, US, vol. 14, no. 2, November 1998 (1998-11-01), pages 192 - 196, XP000952523, ISSN: 1046-5928 *
KOPS S K ET AL: "Salmonella typhimurium as an anti-cancer vector: Localization within solid tumors", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 38, no. 0, 1997, Eighty-eighth Annual Meeting of the American Association for Cancer Research;San Diego, California, USA; April 12-16, 1997, 1997, pages 7, XP001156444, ISSN: 0197-016X *
LAMBIN P ET AL: "Anaerobic bacteria as a potential tumour gene transfer system", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 33, September 1997 (1997-09-01), pages S220, XP004283842, ISSN: 0959-8049 *
LOW K B ET AL: "LIPID A MUTANT SALMONELLA WITH SUPPRESSED VIRULENCE AND TNFALPHA INDUCTION RETAIN TUMOR-TARGETING IN VIVO", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, January 1999 (1999-01-01), pages 37 - 41, XP002939098, ISSN: 1087-0156 *
PAWELEK J M ET AL: "TUMOR-TARGETED SALMONELLA AS A NOVEL ANTICANCER VECTOR", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, October 1997 (1997-10-01), pages 4537 - 4544, XP002939099, ISSN: 0008-5472 *
See also references of WO0125399A3 *
TJUVAJEV J G ET AL: "IMAGING HERPES VIRUS THYMIDINE KINASE GENE TRANSFER AND EXPRESSION BY POSITRON EMISSION TOMOGRAPHY", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 58, no. 19, 1 October 1998 (1998-10-01), pages 4333 - 4341, XP001073448, ISSN: 0008-5472 *
WATSON W S: "Targeted Salmonella--a new way to image tumours?", NUCLEAR MEDICINE COMMUNICATIONS. ENGLAND OCT 1998, vol. 19, no. 10, October 1998 (1998-10-01), pages 1019, XP009021973, ISSN: 0143-3636 *

Also Published As

Publication number Publication date
AU7993600A (en) 2001-05-10
WO2001025399A3 (en) 2001-08-23
CA2386806A1 (en) 2001-04-12
WO2001025399A2 (en) 2001-04-12
EP1414499A2 (de) 2004-05-06

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