IL159068A0 - Method of treating hyperproliferative diseases using active vitamin d analogues - Google Patents
Method of treating hyperproliferative diseases using active vitamin d analoguesInfo
- Publication number
- IL159068A0 IL159068A0 IL15906802A IL15906802A IL159068A0 IL 159068 A0 IL159068 A0 IL 159068A0 IL 15906802 A IL15906802 A IL 15906802A IL 15906802 A IL15906802 A IL 15906802A IL 159068 A0 IL159068 A0 IL 159068A0
- Authority
- IL
- Israel
- Prior art keywords
- analogues
- hyperproliferative diseases
- active vitamin
- treating hyperproliferative
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/891,814 US6503893B2 (en) | 1996-12-30 | 2001-06-26 | Method of treating hyperproliferative diseases using active vitamin D analogues |
PCT/US2002/020475 WO2003000023A2 (en) | 2001-06-26 | 2002-06-26 | Method of treating hyperproliferative diseases using active vitamin d analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
IL159068A0 true IL159068A0 (en) | 2004-05-12 |
Family
ID=25398862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15906802A IL159068A0 (en) | 2001-06-26 | 2002-06-26 | Method of treating hyperproliferative diseases using active vitamin d analogues |
Country Status (10)
Country | Link |
---|---|
US (2) | US6503893B2 (xx) |
EP (1) | EP1408983A4 (xx) |
JP (1) | JP2004535429A (xx) |
KR (1) | KR20040015753A (xx) |
CN (1) | CN1234366C (xx) |
AU (1) | AU2002322346B2 (xx) |
CA (1) | CA2450942A1 (xx) |
IL (1) | IL159068A0 (xx) |
MX (1) | MXPA03011307A (xx) |
WO (1) | WO2003000023A2 (xx) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
WO1999049870A1 (en) * | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
GB9920548D0 (en) * | 1999-08-31 | 1999-11-03 | Rhone Poulenc Rorer Sa | Treatment of hepatocellular carcinoma |
CN100391464C (zh) * | 2001-12-03 | 2008-06-04 | 诺瓦西股份有限公司 | 含活性维生素d化合物的药物组合物 |
US20080249068A1 (en) * | 2002-09-05 | 2008-10-09 | Deluca Hector F | Method of Extending the Dose Range of Vitamin D Compounds |
US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
US20050222190A1 (en) * | 2004-03-30 | 2005-10-06 | Curd John G | 1,4-bis-N-oxide azaanthracenediones and the use thereof |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
US20060189543A1 (en) * | 2005-02-23 | 2006-08-24 | Rosenbloom Richard A | Compositions and methods for the treatment of leukemia |
US7914810B2 (en) * | 2005-05-06 | 2011-03-29 | Synthes Usa, Llc | Methods for the in situ treatment of bone cancer |
CA2882048C (en) | 2006-02-03 | 2020-03-24 | Proventiv Therapeutics, Llc | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
ES2497494T3 (es) | 2006-06-21 | 2014-09-23 | Opko Renal, Llc | Método de tratamiento y prevención del hiperparatiroidismo secundario |
TW200833345A (en) * | 2006-11-01 | 2008-08-16 | Novacea Inc | Use of vitamin D compounds and mimics thereof to enhance delivery of therapeutics and oxygen to tumors and other tissues |
US8501717B2 (en) * | 2007-02-09 | 2013-08-06 | Merck, Sharp & Dohme Corp. | Methods to treat and/or prevent mucositis |
KR20190028822A (ko) | 2007-04-25 | 2019-03-19 | 사이토크로마 인코포레이티드 | 비타민 d 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
WO2009047644A2 (en) | 2007-04-25 | 2009-04-16 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
WO2008134523A1 (en) * | 2007-04-25 | 2008-11-06 | Proventiv Therapeutics, Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
US8962239B2 (en) | 2008-04-02 | 2015-02-24 | Opko Renal, Llc | Methods useful for vitamin D deficiency and related disorders |
US20100009934A1 (en) * | 2008-06-09 | 2010-01-14 | Combinatorx, Incorporated | Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders |
EA026334B1 (ru) * | 2009-01-27 | 2017-03-31 | БЕРГ ЭлЭлСи | Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении |
CA2770683C (en) | 2009-08-14 | 2018-09-04 | Berg Biosystems, Llc | Vitamin d3 and analogs thereof for treating alopecia |
PT2552484T (pt) | 2010-03-29 | 2020-04-03 | Opko Ireland Global Holdings Ltd | Métodos e composições para redução dos níveis de parafróides |
KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
CN112156097A (zh) | 2013-05-29 | 2021-01-01 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
EP3193925A2 (en) | 2014-08-07 | 2017-07-26 | OPKO Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin d |
CN106674306A (zh) * | 2015-01-13 | 2017-05-17 | 南京理工大学 | 维生素d2糖苷类似物、合成及应用 |
IL290855B1 (en) | 2016-03-28 | 2024-02-01 | Eirgen Pharma Ltd | Treatment methods using vitamin D |
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US2383446A (en) | 1941-06-04 | 1945-08-28 | Du Pont | Antirachitic materials and processes for their production |
US3697559A (en) | 1971-02-25 | 1972-10-10 | Wisconsin Alumni Res Found | 1,25-dihydroxycholecalciferol |
US3741996A (en) | 1971-12-02 | 1973-06-26 | Wisconsin Alumni Res Found | 1{60 -hydroxycholecalciferol |
US4670190A (en) | 1973-01-10 | 1987-06-02 | Hesse Robert H | 1-α-hydroxy vitamin D compounds and process for preparing same |
US3907843A (en) | 1974-06-14 | 1975-09-23 | Wisconsin Alumni Res Found | 1{60 -Hydroxyergocalciferol and processes for preparing same |
US4202829A (en) | 1978-01-05 | 1980-05-13 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4260549A (en) | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4195027A (en) | 1978-01-16 | 1980-03-25 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
BE877356R (fr) | 1978-01-16 | 1979-10-15 | Wisconsin Alumni Res Found | Procede de preparation de composes 1alpha-hydroxyles |
US4225596A (en) | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
US4234495A (en) | 1979-09-10 | 1980-11-18 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxyvitamin D compounds from 1α-hydroxy-3,5-cyclovitamin D compounds |
US4362710A (en) | 1980-07-04 | 1982-12-07 | Nissan Gosei Kogyo Co., Ltd. | Feeds for baby pigs, process for preparing the same and method of breeding baby pigs |
JPS57149224A (en) | 1981-03-13 | 1982-09-14 | Chugai Pharmaceut Co Ltd | Tumor-suppressing agent |
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US4508651A (en) | 1983-03-21 | 1985-04-02 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxyergocalciferol |
NL193245C (nl) | 1983-05-09 | 1999-04-02 | Wisconsin Alumni Res Found | Aan 1Ó,25-dihydroxyvitamine D2 verwante verbinding en farmaceutisch preparaat met een het calciummetabolisme regulerende werking dat een dergelijke verbinding bevat. |
US4689180A (en) | 1984-01-30 | 1987-08-25 | Wisconsin Alumni Research Foundation | 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound |
US4588716A (en) | 1984-05-04 | 1986-05-13 | Wisconsin Alumni Research Foundation | Method for treating metabolic bone disease in mammals |
US4554106A (en) | 1984-11-01 | 1985-11-19 | Wisconsin Alumni Research Foundation | Method for preparing 1α-hydroxyvitamin D compounds |
US4555364A (en) | 1984-11-01 | 1985-11-26 | Wisconsin Alumni Research Foundation | Method for preparing 1-hydroxyvitamin D compounds |
US4661294A (en) | 1985-03-18 | 1987-04-28 | The General Hospital Corporation | Biologically active 1-thio derivatives of vitamin D |
IL78342A (en) | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
DE3666587D1 (en) | 1985-08-02 | 1989-11-30 | Leo Pharm Prod Ltd | Novel vitamin d analogues |
US4833125A (en) | 1986-12-05 | 1989-05-23 | The General Hospital Corporation | Method of increasing bone mass |
JP2550391B2 (ja) | 1988-06-30 | 1996-11-06 | 日清製粉株式会社 | 1β−ヒドロキシビタミンD▲下2▼およびD▲下3▼の製造方法 |
US5602116A (en) | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
US5104864A (en) | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
US5372996A (en) | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
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US5063221A (en) | 1989-04-05 | 1991-11-05 | Chugai Seiyaku Kabushiki Kaisha | Treatment for hyperparathyroidism with use of vitamin d derivatives |
US6025346A (en) | 1990-09-21 | 2000-02-15 | Bone Care International, Inc. | 1α-hydroxy vitamin D4 and novel intermediates and analogues |
US5801164A (en) | 1990-09-21 | 1998-09-01 | Bone Care International, Inc. | Methods of treating osteoporosis prophylactically or therapeutically |
DE69132862T2 (de) | 1990-09-21 | 2002-08-29 | Bone Care Internat Inc | Neues 1alpha-hydroxy vitamin-d4 und neue zwischenprodukte und analoge |
US5763428A (en) | 1990-09-21 | 1998-06-09 | Bone Care International, Inc. | Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof |
US5798345A (en) | 1990-09-21 | 1998-08-25 | Bone Care International, Inc. | Method of inhibiting the hyperproliferation of malignant cells |
US6538037B2 (en) * | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
US5786348A (en) | 1991-01-08 | 1998-07-28 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2 |
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AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
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DE69125836T2 (de) | 1991-11-14 | 1997-12-18 | Quantum Corp | Spindel- und Nabenausrüstung |
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EP0562497A1 (en) | 1992-03-27 | 1993-09-29 | Nisshin Flour Milling Co., Ltd. | 1 alpha-hydroxy vitamins D7 and D4' processes for the preparation thereof and pharmaceutical compositions |
DK0614456T3 (da) * | 1992-08-28 | 1999-12-06 | Bone Care Int Inc | 1alfa,24(S)-dihydroxy-vitamin D2, dets fremstilling og anvendelse |
US5350745A (en) | 1993-01-29 | 1994-09-27 | Lunar Corporation | Treatment of myocardial failure |
US5763429A (en) | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
ATE168367T1 (de) | 1994-01-20 | 1998-08-15 | Duphar Int Res | Vitamin-d-derivate und verfahren zu deren herstellung |
US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
DE19549243A1 (de) | 1995-12-21 | 1997-06-26 | Schering Ag | Pharmazeutische Präparate enthaltend Clathrate von Cyclodextrinen und nichtnatürliche Vitamin D-Analoga |
US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
WO1998020123A2 (en) * | 1996-11-04 | 1998-05-14 | Institut Curie | Stable cell lines expressing the cftr protein or a mutant of this protein, tool for selecting molecules having an effect on the intracellular transport of these proteins |
AUPO727097A0 (en) | 1997-06-10 | 1997-07-03 | Unisearch Limited | Method of treatment of hepatoma and pharmaceutical compositions for use therein |
US6087350A (en) | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
EP1066377A1 (en) | 1998-03-25 | 2001-01-10 | Cutanogen, Inc. | Methods for prevention and treatment of cancer |
WO1999049870A1 (en) | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
US20010002396A1 (en) | 1998-07-16 | 2001-05-31 | Charles Achkar | Compositions and methods of treating skin conditions |
ATE294585T1 (de) | 1999-09-29 | 2005-05-15 | Colotech As | Vorbeugung von kolorektalkrebs |
JP2003525254A (ja) * | 2000-03-02 | 2003-08-26 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 併用化学療法 |
-
2001
- 2001-06-26 US US09/891,814 patent/US6503893B2/en not_active Expired - Lifetime
-
2002
- 2002-06-26 MX MXPA03011307A patent/MXPA03011307A/es active IP Right Grant
- 2002-06-26 AU AU2002322346A patent/AU2002322346B2/en not_active Ceased
- 2002-06-26 CA CA002450942A patent/CA2450942A1/en not_active Abandoned
- 2002-06-26 IL IL15906802A patent/IL159068A0/xx unknown
- 2002-06-26 CN CNB028128818A patent/CN1234366C/zh not_active Expired - Fee Related
- 2002-06-26 KR KR10-2003-7016888A patent/KR20040015753A/ko not_active Application Discontinuation
- 2002-06-26 EP EP02756332A patent/EP1408983A4/en not_active Withdrawn
- 2002-06-26 WO PCT/US2002/020475 patent/WO2003000023A2/en active Application Filing
- 2002-06-26 JP JP2003506479A patent/JP2004535429A/ja active Pending
-
2003
- 2003-01-07 US US10/337,506 patent/US6680309B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1408983A2 (en) | 2004-04-21 |
WO2003000023A3 (en) | 2003-07-31 |
CN1520302A (zh) | 2004-08-11 |
JP2004535429A (ja) | 2004-11-25 |
AU2002322346B2 (en) | 2006-10-26 |
KR20040015753A (ko) | 2004-02-19 |
US6680309B2 (en) | 2004-01-20 |
WO2003000023A2 (en) | 2003-01-03 |
EP1408983A4 (en) | 2007-05-09 |
US20030130242A1 (en) | 2003-07-10 |
CA2450942A1 (en) | 2003-01-03 |
MXPA03011307A (es) | 2004-06-08 |
US6503893B2 (en) | 2003-01-07 |
US20020025950A1 (en) | 2002-02-28 |
CN1234366C (zh) | 2006-01-04 |
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