IL157041A0 - Monoclonal antibodies to the clfa protein and method of use in treating and preventing infections - Google Patents

Monoclonal antibodies to the clfa protein and method of use in treating and preventing infections

Info

Publication number
IL157041A0
IL157041A0 IL15704102A IL15704102A IL157041A0 IL 157041 A0 IL157041 A0 IL 157041A0 IL 15704102 A IL15704102 A IL 15704102A IL 15704102 A IL15704102 A IL 15704102A IL 157041 A0 IL157041 A0 IL 157041A0
Authority
IL
Israel
Prior art keywords
clfa
protein
monoclonal antibodies
treating
bind
Prior art date
Application number
IL15704102A
Other languages
English (en)
Original Assignee
Inhibitex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibitex Inc filed Critical Inhibitex Inc
Publication of IL157041A0 publication Critical patent/IL157041A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
IL15704102A 2001-01-26 2002-01-28 Monoclonal antibodies to the clfa protein and method of use in treating and preventing infections IL157041A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26407201P 2001-01-26 2001-01-26
US27461101P 2001-03-12 2001-03-12
US29841301P 2001-06-18 2001-06-18
US30811601P 2001-07-30 2001-07-30
PCT/US2002/002296 WO2002072600A2 (en) 2001-01-26 2002-01-28 Monoclonal antibodies to the clfa protein and method of use in treating or preventing infections

Publications (1)

Publication Number Publication Date
IL157041A0 true IL157041A0 (en) 2004-02-08

Family

ID=27500806

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15704102A IL157041A0 (en) 2001-01-26 2002-01-28 Monoclonal antibodies to the clfa protein and method of use in treating and preventing infections
IL157041A IL157041A (en) 2001-01-26 2003-07-21 Monoclonal antibodies to CLFA protein and a method for their use in the treatment or prevention of infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL157041A IL157041A (en) 2001-01-26 2003-07-21 Monoclonal antibodies to CLFA protein and a method for their use in the treatment or prevention of infections

Country Status (15)

Country Link
US (2) US6979446B2 (da)
EP (1) EP1377314B1 (da)
JP (1) JP4171816B2 (da)
KR (2) KR20030071861A (da)
CN (2) CN1489474A (da)
AT (1) ATE524195T1 (da)
AU (1) AU2002256985B8 (da)
BR (1) BR0207068A (da)
CA (1) CA2434762A1 (da)
DK (1) DK1377314T3 (da)
ES (1) ES2372686T3 (da)
IL (2) IL157041A0 (da)
MX (1) MXPA03006651A (da)
PT (1) PT1377314E (da)
WO (1) WO2002072600A2 (da)

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US6692739B1 (en) * 1998-08-31 2004-02-17 Inhibitex, Inc. Staphylococcal immunotherapeutics via donor selection and donor stimulation
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HUE026914T2 (en) 2002-11-07 2016-08-29 Immunogen Inc Anti-CD33 antibodies and a method of treating acute myeloid leukemia
US7425328B2 (en) * 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
WO2006138627A2 (en) * 2005-06-16 2006-12-28 Inhibitex, Inc. Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein
AU2007210170A1 (en) * 2006-01-27 2007-08-09 Merck Sharp & Dohme Corp. Antigen-binding proteins targeting S. aureus ORF0657n
WO2007100580A2 (en) * 2006-02-22 2007-09-07 The Texas A & M University System Antibodies recognizing a highly expressed putative antigen of ca-mrsa and methods of use
WO2008136861A2 (en) * 2006-11-22 2008-11-13 3M Innovative Properties Company Inactivated and dried biological preparations
US20100099115A1 (en) 2006-11-22 2010-04-22 Mach Patrick A Systems and methods for preparing and analyzing samples
US20100129837A1 (en) * 2006-11-22 2010-05-27 Mach Patrick A Methods of capturing bacterial whole cells and methods of analyzing samples for bacteria
WO2008131063A1 (en) * 2007-04-19 2008-10-30 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
CN101663581A (zh) * 2007-04-19 2010-03-03 3M创新有限公司 水分散性二氧化硅纳米颗粒在连接生物分子方面的用途
EP2164869A2 (en) * 2007-05-31 2010-03-24 Merck Sharp & Dohme Corp. Antigen-binding proteins targeting s. aureus orf0657n
EP2220500A4 (en) * 2007-11-20 2010-12-15 3M Innovative Properties Co METHOD FOR ANALYZING A BACTERIUM SAMPLE USING A POLYMER DETECTOR CONTAINING DIACETYLENE
JP2011516824A (ja) * 2008-02-20 2011-05-26 スリーエム イノベイティブ プロパティズ カンパニー 全細胞捕捉及びａｔｐ分析を用いた細菌試料の分析方法
CN102481352A (zh) 2009-06-22 2012-05-30 惠氏有限责任公司 金黄色葡萄球菌抗原的免疫原性组合物
TR201809128T4 (tr) 2009-07-15 2018-07-23 Aimm Therapeutics Bv Gram-pozitif bakterilere spesifik bağlanan bileşikler.
AU2010291835A1 (en) * 2009-09-03 2012-04-19 Vancouver Biotech Ltd. Monoclonal antibodies against gonadotropin-releasing hormone receptor
MX366890B (es) * 2009-10-23 2019-07-30 Millennium Pharm Inc Moléculas de anticuerpo anti - gcc y composiciones y métodos relacionados.
US8324352B2 (en) 2009-12-07 2012-12-04 Decimmune Therapeutics, Inc. Anti-inflammatory antibodies and uses therefor
CA2858350A1 (en) 2011-01-14 2013-07-19 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
KR101044438B1 (ko) * 2011-03-29 2011-06-27 최희선 저수탱크
US20140271649A1 (en) * 2011-07-15 2014-09-18 The University Of Chicago Methods and compositions for inhibiting staphylococcus agglutination in blood
JP2014534169A (ja) * 2011-09-23 2014-12-18 ユリウス・マクシミリアンス−ウニヴェルジテート・ヴュルツブルクＪｕｌｉｕｓ Ｍａｘｉｍｉｌｉａｎｓ−Ｕｎｉｖｅｒｓｉｔａｅｔ Ｗｕｅｒｚｂｕｒｇ Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓエピトープ結合部位を形成するペプチドまたはペプチドの配置
US8834898B2 (en) * 2011-12-16 2014-09-16 Boise State University Cholera toxin chimera and its use as a staph vaccine
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
EP2793944B1 (en) * 2011-12-23 2025-10-08 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
CA2871614C (en) 2012-04-27 2021-08-31 Millennium Pharmaceuticals, Inc. Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy
EP2705852A1 (en) * 2012-09-06 2014-03-12 Université de Lausanne An immunogenic composition against Staphylococcus aureus comprising an inactivated recombinant non-pathogenic bacterium
CN104968797B (zh) 2012-11-06 2018-11-30 米迪缪尼有限公司 金黄色葡萄球菌表面决定簇的抗体
US9409977B2 (en) 2013-03-12 2016-08-09 Decimmune Therapeutics, Inc. Humanized, anti-N2 antibodies
CA2920147C (en) 2013-08-07 2022-09-20 Yeda Research And Development Co. Ltd. Peptides capable of reactivating p53 mutants
KR20160097294A (ko) 2013-12-09 2016-08-17 뉴욕 유니버시티 항-포도상구균 제제의 식세포 전달을 위한 조성물 및 방법
US11446371B2 (en) * 2015-11-05 2022-09-20 The Texas A&M University System Targeting of ligand binding sites in ClfA
AU2017214733B2 (en) 2016-02-04 2022-09-29 Yeda Research And Development Co. Ltd. Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53
KR20190005998A (ko) 2016-05-18 2019-01-16 젠맵 비. 브이 항체 및 감염성 질환의 치료에서의 그의 사용 방법
EP3672635A4 (en) * 2017-08-23 2021-05-12 The Trustees of The University of Pennsylvania MONOCLONAL ANTIBODIES AGAINST PATHOLOGICAL ALPHA-SYNUCLEIN AND METHOD OF USING THEREOF
EP3784776A4 (en) * 2018-05-23 2022-01-26 National University of Singapore Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies
CN110632298B (zh) * 2018-06-25 2023-04-18 洛阳普泰生物技术有限公司 犬腺病毒1型单克隆抗体、可变区序列、杂交瘤细胞株及其应用
US11155606B2 (en) 2018-07-24 2021-10-26 Medimmune, Llc Antibody directed against S. aureus clumping factor a (ClfA)
BR112021006622A2 (pt) 2018-10-09 2021-07-20 Medimmune, Llc combinações de anticorpos anti-staphylococcus aureus
MA54945A (fr) 2019-02-12 2021-12-22 Regeneron Pharma Compositions et procédés d'utilisation d'anticorps bispécifiques pour lier un complément et un antigène cible
WO2020243616A1 (en) * 2019-05-31 2020-12-03 Seattle Children's Hospital D/B/A Seattle Children's Research Institute E-cadherin activating antibodies and uses thereof
KR20240167591A (ko) * 2023-05-18 2024-11-27 한국과학기술연구원 항-엔도글린 항체 및 이의 용도
WO2025010424A1 (en) 2023-07-06 2025-01-09 Vir Biotechnology, Inc. Antibodies against staphylococcus antigens and methods of using the same
CN118406141B (zh) * 2024-04-25 2024-11-22 中国人民解放军总医院第四医学中心 一种抗金黄葡萄球菌胞外黏着蛋白的纳米抗体及其衍生产品和应用

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Also Published As

Publication number Publication date
JP4171816B2 (ja) 2008-10-29
US20050287164A1 (en) 2005-12-29
ES2372686T3 (es) 2012-01-25
MXPA03006651A (es) 2004-11-12
KR20030071861A (ko) 2003-09-06
US6979446B2 (en) 2005-12-27
CA2434762A1 (en) 2002-09-19
IL157041A (en) 2010-05-31
US20030099656A1 (en) 2003-05-29
US7364738B2 (en) 2008-04-29
JP2004534000A (ja) 2004-11-11
KR20090039851A (ko) 2009-04-22
CN101928343A (zh) 2010-12-29
EP1377314A4 (en) 2005-05-11
CN101928343B (zh) 2014-09-17
BR0207068A (pt) 2004-12-21
CN1489474A (zh) 2004-04-14
EP1377314B1 (en) 2011-09-14
ATE524195T1 (de) 2011-09-15
AU2002256985B2 (en) 2007-10-11
AU2002256985B8 (en) 2008-03-20
DK1377314T3 (da) 2011-12-12
KR101015496B1 (ko) 2011-02-22
PT1377314E (pt) 2012-01-02
EP1377314A2 (en) 2004-01-07
WO2002072600A3 (en) 2003-11-06
WO2002072600A2 (en) 2002-09-19

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