IL152126A - Actinacidin analogues and pharmaceutical preparations containing them as anti-tumor substances - Google Patents
Actinacidin analogues and pharmaceutical preparations containing them as anti-tumor substancesInfo
- Publication number
- IL152126A IL152126A IL152126A IL15212601A IL152126A IL 152126 A IL152126 A IL 152126A IL 152126 A IL152126 A IL 152126A IL 15212601 A IL15212601 A IL 15212601A IL 152126 A IL152126 A IL 152126A
- Authority
- IL
- Israel
- Prior art keywords
- ecteinascidin
- analogs
- same
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229960000977 trabectedin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- -1 hydroxymethylene group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2000/001852 WO2000069862A2 (en) | 1999-05-14 | 2000-05-15 | Hemisynthetic method and intermediates thereof |
| PCT/GB2001/002110 WO2001087894A1 (en) | 1999-05-14 | 2001-05-15 | Antitumoral analogs of et-743 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL152126A0 IL152126A0 (en) | 2003-05-29 |
| IL152126A true IL152126A (en) | 2013-04-30 |
Family
ID=29415238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL152126A IL152126A (en) | 2000-05-15 | 2001-05-15 | Actinacidin analogues and pharmaceutical preparations containing them as anti-tumor substances |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7247629B2 (enExample) |
| JP (1) | JP5008812B2 (enExample) |
| AT (1) | ATE282624T1 (enExample) |
| BG (1) | BG65897B1 (enExample) |
| CA (1) | CA2405002C (enExample) |
| HU (1) | HU230699B1 (enExample) |
| IL (1) | IL152126A (enExample) |
| MX (1) | MXPA02011319A (enExample) |
| SK (1) | SK287833B6 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1077698B1 (en) * | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| AR035842A1 (es) * | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
| US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
| ATE299146T1 (de) * | 2000-04-12 | 2005-07-15 | Pharma Mar Sa | Ecteinaschidin derivate mit antikrebs wirkung |
| US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| KR100718946B1 (ko) * | 2000-11-06 | 2007-05-16 | 파르마 마르, 에스.에이. | 효과적인 항종양 치료 |
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| US20090117176A1 (en) * | 2004-10-26 | 2009-05-07 | Pharma Mar, S.A. Sociedad Unipersonal | Anticancer Treatments |
| NZ554761A (en) | 2004-10-29 | 2010-01-29 | Pharma Mar Sa | Formulations comprising ecteinascidin and a disaccharide |
| WO2006094012A2 (en) * | 2005-03-02 | 2006-09-08 | The Trustees Of Columbia University In The City Of New York | Pentacyclic alkaloid compounds and methods of use thereof |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| RU2519750C2 (ru) * | 2008-05-16 | 2014-06-20 | Фарма Мар, С.А. | Способы лечения множественной миеломы |
| WO2009140675A2 (en) * | 2008-05-16 | 2009-11-19 | Pharma Mar, S.A. | Combination therapy with an antitumor alkaloid |
| ES2534331T3 (es) | 2010-05-25 | 2015-04-21 | Pharma Mar S.A. | Proceso sintético para la producción de compuestos e intermedios de ecteinascidina |
| HUE042801T2 (hu) | 2010-11-12 | 2019-07-29 | Pharma Mar Sa | Kombinációs terápia mitózisgátlóval |
| GB2519773C (en) * | 2013-10-29 | 2018-01-03 | Solus Tech Limited | Mode-locking semiconductor disk laser (SDL) |
| CN107522698B (zh) * | 2016-06-20 | 2021-12-28 | 浙江海正药业股份有限公司 | 一种曲贝替定的制备方法及其中间体 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| PH12022551216A1 (en) | 2019-11-21 | 2023-07-17 | Pharma Mar Sa | Methods of treating small cell lung cancer with lurbinectedin formulations |
| WO2022186221A1 (ja) * | 2021-03-03 | 2022-09-09 | 国立大学法人東京大学 | マクロ環含有新規テトラヒドロイソキノリンアルカロイド化合物 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
| AU589282B2 (en) | 1986-06-09 | 1989-10-05 | University Of Illinois | Ecteinascidins 729, 743, 745, 759a, 759b and 770 |
| US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| DE3635711A1 (de) * | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
| EP0309744A3 (de) * | 1987-09-29 | 1989-06-28 | Siemens Aktiengesellschaft | Anordnung mit einem flächig sich erstreckenden Dünnfilmwellenleiter |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US20040059112A1 (en) * | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
| GB9508195D0 (en) * | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| JP4169368B2 (ja) * | 1996-01-15 | 2008-10-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 脈管形成阻害性ピリダジンアミン |
| US5721362A (en) | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) * | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| DE69936845T2 (de) * | 1998-04-06 | 2008-05-08 | The Board Of Trustees Of The University Of Illinois, Urbana | Halbsynthetische ectein-ascidine |
| DE69927014T2 (de) * | 1998-05-05 | 2006-06-14 | Pharma Mar Sa | Kultivierung von sessilen meerestieren |
| EP1077698B1 (en) * | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| AR035842A1 (es) * | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
| AU1750901A (en) * | 1999-07-23 | 2001-03-05 | American Superconductor Corporation | Dust cover/pellicle for a photomask |
| EP1254140A4 (en) * | 2000-01-19 | 2003-03-12 | Univ Columbia | SAFRAMYCIN-ECTEINASCIDIN SERIES COMPOUNDS, USES AND SYNTHESIS |
| US6815544B2 (en) * | 2000-02-11 | 2004-11-09 | President And Fellows Of Harvard College | Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds |
| US6569859B1 (en) * | 2000-02-22 | 2003-05-27 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| ATE299146T1 (de) | 2000-04-12 | 2005-07-15 | Pharma Mar Sa | Ecteinaschidin derivate mit antikrebs wirkung |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| WO2002014554A2 (en) * | 2000-08-11 | 2002-02-21 | City Of Hope | The anti-neoplastic agent et-743 inhibits trans activation by sxr |
| KR100718946B1 (ko) | 2000-11-06 | 2007-05-16 | 파르마 마르, 에스.에이. | 효과적인 항종양 치료 |
| EP1360337A1 (en) | 2001-02-09 | 2003-11-12 | The Regents Of The University Of California | Ecteinascidin family compounds: compositions and methods |
| GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| IL161430A0 (en) | 2001-10-19 | 2004-09-27 | Pharma Mar Sa | Pharmaceutical compositions containing ecteinascidin 743 |
| US20040019027A1 (en) * | 2002-04-12 | 2004-01-29 | Barry Forman | Method of treating cerebrotendinous xanthomatosis |
| GB0218813D0 (en) * | 2002-08-13 | 2002-09-18 | Pharma Mar Sa | DNA sequences from an endosymbiont and their uses |
| GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| SI1689404T1 (sl) * | 2003-11-13 | 2009-02-28 | Pharma Mar Sau | Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka |
| CN1897949A (zh) | 2003-11-14 | 2007-01-17 | 马尔药品公司 | 包含使用et－743和紫杉醇来治疗癌症的联合疗法 |
| GB0326486D0 (en) | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| CA2583464A1 (en) | 2004-09-29 | 2006-04-06 | Pharma Mar S.A., Sociedad Unipersonal | Ecteinascidin compounds as anti -inflammatory agents |
| US20090117176A1 (en) | 2004-10-26 | 2009-05-07 | Pharma Mar, S.A. Sociedad Unipersonal | Anticancer Treatments |
| NZ554761A (en) * | 2004-10-29 | 2010-01-29 | Pharma Mar Sa | Formulations comprising ecteinascidin and a disaccharide |
| JP2011500046A (ja) | 2007-10-19 | 2011-01-06 | ファルマ・マール・ソシエダード・アノニマ | Ｅｔ−７４３治療のための予後分子マーカー |
| WO2009140675A2 (en) | 2008-05-16 | 2009-11-19 | Pharma Mar, S.A. | Combination therapy with an antitumor alkaloid |
| RU2519750C2 (ru) | 2008-05-16 | 2014-06-20 | Фарма Мар, С.А. | Способы лечения множественной миеломы |
-
2000
- 2000-05-15 MX MXPA02011319A patent/MXPA02011319A/es active IP Right Grant
-
2001
- 2001-05-15 SK SK1601-2002A patent/SK287833B6/sk not_active IP Right Cessation
- 2001-05-15 CA CA2405002A patent/CA2405002C/en not_active Expired - Lifetime
- 2001-05-15 IL IL152126A patent/IL152126A/en active IP Right Grant
- 2001-05-15 US US10/257,857 patent/US7247629B2/en not_active Expired - Lifetime
- 2001-05-15 HU HUP0302327A patent/HU230699B1/hu unknown
- 2001-05-15 JP JP2001584288A patent/JP5008812B2/ja not_active Expired - Lifetime
- 2001-05-15 AT AT01929813T patent/ATE282624T1/de active
-
2002
- 2002-11-20 BG BG107302A patent/BG65897B1/bg unknown
-
2005
- 2005-01-26 US US11/045,595 patent/US7410969B2/en not_active Expired - Lifetime
-
2006
- 2006-12-22 US US11/645,356 patent/US8012975B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0302327A3 (en) | 2006-05-29 |
| US8012975B2 (en) | 2011-09-06 |
| MXPA02011319A (es) | 2003-06-06 |
| JP5008812B2 (ja) | 2012-08-22 |
| HK1053653A1 (en) | 2003-10-31 |
| US7410969B2 (en) | 2008-08-12 |
| HU230699B1 (hu) | 2017-09-28 |
| HUP0302327A2 (hu) | 2003-10-28 |
| CA2405002A1 (en) | 2001-11-22 |
| BG107302A (bg) | 2003-07-31 |
| US20040019056A1 (en) | 2004-01-29 |
| IL152126A0 (en) | 2003-05-29 |
| US7247629B2 (en) | 2007-07-24 |
| CA2405002C (en) | 2010-09-21 |
| US20080051407A1 (en) | 2008-02-28 |
| SK287833B6 (sk) | 2011-11-04 |
| BG65897B1 (bg) | 2010-04-30 |
| ATE282624T1 (de) | 2004-12-15 |
| JP2003533532A (ja) | 2003-11-11 |
| SK16012002A3 (sk) | 2003-05-02 |
| US20060019960A1 (en) | 2006-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |