IL146411A0 - Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins - Google Patents

Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins

Info

Publication number
IL146411A0
IL146411A0 IL14641100A IL14641100A IL146411A0 IL 146411 A0 IL146411 A0 IL 146411A0 IL 14641100 A IL14641100 A IL 14641100A IL 14641100 A IL14641100 A IL 14641100A IL 146411 A0 IL146411 A0 IL 146411A0
Authority
IL
Israel
Prior art keywords
buforin
therapeutic agent
botulinum toxin
specific inhibitor
tetanus neurotoxins
Prior art date
Application number
IL14641100A
Other languages
English (en)
Original Assignee
Us Army Med Res Mat Command
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Army Med Res Mat Command filed Critical Us Army Med Res Mat Command
Publication of IL146411A0 publication Critical patent/IL146411A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL14641100A 1999-05-14 2000-05-11 Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins IL146411A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13421699P 1999-05-14 1999-05-14
PCT/US2000/012909 WO2000069895A2 (en) 1999-05-14 2000-05-11 Bufornin 1 as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins

Publications (1)

Publication Number Publication Date
IL146411A0 true IL146411A0 (en) 2002-07-25

Family

ID=22462297

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14641100A IL146411A0 (en) 1999-05-14 2000-05-11 Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins

Country Status (6)

Country Link
EP (1) EP1179022A2 (xx)
JP (1) JP2003502023A (xx)
AU (1) AU781608B2 (xx)
CA (1) CA2369369A1 (xx)
IL (1) IL146411A0 (xx)
WO (1) WO2000069895A2 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7563874B2 (en) 1998-08-31 2009-07-21 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
KR20020051124A (ko) * 2000-12-22 2002-06-28 이한웅 부포린 유도체를 포함하는 함암제
JP2003009897A (ja) 2001-07-03 2003-01-14 Keiji Oguma ボツリヌス毒素の分離・精製法
US7700738B2 (en) 2005-01-27 2010-04-20 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
EP2134749B1 (en) 2007-03-22 2013-11-06 The Regents of the University of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
CA2732003A1 (en) 2008-07-31 2010-02-04 James D. Marks Antibodies that neutralize botulinum neurotoxins
US9243057B2 (en) 2010-08-31 2016-01-26 The Regents Of The University Of California Antibodies for botulinum neurotoxins
CN111100195B (zh) * 2018-10-25 2024-04-09 安尼根有限公司 buforin衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411138D0 (en) * 1994-06-03 1994-07-27 Microbiological Res Authority Toxin assay
WO1998007440A1 (en) * 1996-08-24 1998-02-26 Samyang Genex Co., Ltd. A novel antimicrobial peptide isolated from bufo bufo gargarizans
KR100263583B1 (ko) * 1997-05-28 2000-08-01 박종헌 항균 펩타이드의 대량 제조방법 및 그에 유용한 플라즈미드 벡타
KR100314721B1 (ko) * 1998-01-22 2001-11-23 김일웅 생물학적 활성이 있는 신규한 펩타이드

Also Published As

Publication number Publication date
AU781608B2 (en) 2005-06-02
WO2000069895A2 (en) 2000-11-23
WO2000069895A3 (en) 2001-08-09
CA2369369A1 (en) 2000-11-23
AU6197500A (en) 2000-12-05
EP1179022A2 (en) 2002-02-13
JP2003502023A (ja) 2003-01-21

Similar Documents

Publication Publication Date Title
IL146974A0 (en) Therapeutic composition comprising a botulinum neurotoxin
AU7085200A (en) Botulinum toxin for reducing catecholamine secretion
AU2001227930A1 (en) Clostridial toxin derivatives and methods for treating pain
AU3331501A (en) Botulinum toxin pharmaceutical compositions
AU2001265043A1 (en) Botulinum toxin implant
IL118657A0 (en) Inhibitors for picornavirus proteases
IL150964A0 (en) Protease inhibitors
AU2108601A (en) Salicylamides as serine protease inhibitors
IL146411A0 (en) Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins
AU6536200A (en) Proteases and protease inhibitors
EP1180999A4 (en) RECOMBINANT VACCINE AGAINST BOTULINUM NEUROTOXIN
EP1351990A4 (en) COMPOSITIONS AND METHODS FOR DETECTING PROTEOLYTIC ACTIVITY
EP1235577A4 (en) PROTEASE INHIBITORS
IL153421A0 (en) Protease inhibitors
EP1229912A4 (en) PROTEASE INHIBITORS
EP1229914A4 (en) PROTEASE INHIBITORS
EP1231921A4 (en) PROTEASE INHIBITORS
PL366040A1 (en) Protease inhibitors
EP1233771A4 (en) PROTEASE INHIBITORS
HK1044758A1 (zh) 蛋白酶抑制劑
EP1161237A4 (en) PROTEASE INHIBITORS
EP1229911A4 (en) PROTEASE INHIBITORS
AU1648901A (en) Neutralizing agent for toxin of microorganism belonging to the genus clostridium
GB9914861D0 (en) Tetanus toxin polypeptides
EP1232154A4 (en) PROTEASE INHIBITORS