IL144945A0 - Aromatic sulfone hydroxamic acid metalloprotease inhibitor - Google Patents
Aromatic sulfone hydroxamic acid metalloprotease inhibitorInfo
- Publication number
- IL144945A0 IL144945A0 IL14494500A IL14494500A IL144945A0 IL 144945 A0 IL144945 A0 IL 144945A0 IL 14494500 A IL14494500 A IL 14494500A IL 14494500 A IL14494500 A IL 14494500A IL 144945 A0 IL144945 A0 IL 144945A0
- Authority
- IL
- Israel
- Prior art keywords
- hydroxamic acid
- metalloprotease inhibitor
- aromatic sulfone
- sulfone hydroxamic
- acid metalloprotease
- Prior art date
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Classifications
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/256,948 US20010039287A1 (en) | 1997-11-14 | 1999-02-24 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
PCT/US2000/002518 WO2000050396A1 (en) | 1999-02-24 | 2000-02-22 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
IL144945A0 true IL144945A0 (en) | 2002-06-30 |
Family
ID=22974260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14494500A IL144945A0 (en) | 1999-02-24 | 2000-02-22 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
Country Status (19)
Country | Link |
---|---|
US (2) | US20010039287A1 (es) |
EP (1) | EP1230219A1 (es) |
JP (1) | JP2002537378A (es) |
KR (1) | KR20020092157A (es) |
CN (1) | CN1370144A (es) |
AR (1) | AR043676A1 (es) |
AU (1) | AU3478500A (es) |
BR (1) | BR0008491A (es) |
CA (1) | CA2371876A1 (es) |
CZ (1) | CZ20013038A3 (es) |
EA (1) | EA200100804A1 (es) |
HU (1) | HUP0200239A3 (es) |
IL (1) | IL144945A0 (es) |
MX (1) | MXPA01008568A (es) |
NO (1) | NO20013963L (es) |
NZ (1) | NZ513648A (es) |
PL (1) | PL351204A1 (es) |
WO (1) | WO2000050396A1 (es) |
ZA (1) | ZA200106780B (es) |
Families Citing this family (29)
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US6747027B1 (en) | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
US6638952B1 (en) | 1997-03-04 | 2003-10-28 | Pharmacia Corporation | Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds |
US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
PL341379A1 (en) * | 1997-11-14 | 2001-04-09 | Searle & Co | Aromatic sulphone substituted hydroxamic acid as inhibitor of metalloprotease |
US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
IL144783A0 (en) | 1999-02-08 | 2002-06-30 | Searle & Co | Sulfamato hydroxamic acid metalloprotease inhibitor |
US20010049449A1 (en) * | 1999-12-23 | 2001-12-06 | Becker Daniel P. | Aromatic sulfonyl alpha-cycloamino hydroxamates and their use as MMP inhibitors |
US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
US20040024024A1 (en) * | 2001-05-11 | 2004-02-05 | Freskos John N. | Aromatic sulfone hydroxamates and their use as protease inhibitors |
YU85403A (sh) * | 2001-05-11 | 2006-03-03 | Pharmacia Corporation | Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitora |
WO2003006006A1 (en) * | 2001-07-09 | 2003-01-23 | The Regents Of The University Of California | Use of matrix metalloproteinase inhibitors to mitigate nerve damage |
US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
WO2003042176A1 (fr) * | 2001-11-13 | 2003-05-22 | Shiseido Co., Ltd. | Compose azabicyclo, inhibiteur de metalloprotease matricielle et preparation cutanee |
CA2483314A1 (en) | 2002-04-25 | 2003-11-06 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
CA2490646A1 (en) * | 2002-06-25 | 2003-12-31 | Pharmacia Corporation | Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors |
CA2492035A1 (en) | 2002-07-11 | 2004-01-15 | Vicuron Pharmaceuticals, Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
US20050043533A1 (en) * | 2003-03-25 | 2005-02-24 | Babiak Kevin A. | Process for making alpha-substituted hydroxamic acids |
GB0319069D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Therapeutically useful compounds |
DE102004031620A1 (de) * | 2004-06-30 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | 4-Trifluormethoxyphenoxybenzol-4`-sulfonsäuren, Verfahren zu ihrer Herstellung und Verwendung in Arzneimitteln |
US20100226922A1 (en) * | 2006-06-08 | 2010-09-09 | Dorothea Maetzel | Specific protease inhibitors and their use in cancer therapy |
ITTO20060575A1 (it) | 2006-08-02 | 2008-02-03 | Univ Pisa | Inibitori di zinco proteinasi tioaril sostituiti e loro usi |
WO2013039851A1 (en) | 2011-09-12 | 2013-03-21 | Mallinckrodt Llc | Optical agents for imaging and visualization of matrix metalloproteinase enzymes |
CA3177929A1 (en) | 2012-12-21 | 2014-06-26 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
US11590226B2 (en) | 2018-06-29 | 2023-02-28 | Loyola University Of Chicago | Carborane hydroxamic acid matrix metalloproteinase inhibitors and agents for boron neutron capture therapy |
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US4595700A (en) | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
US4882434A (en) * | 1986-10-29 | 1989-11-21 | Takeda Chemical Industries, Ltd. | Gamma-lactonecarboxylic acid derivatives and their use as antibacterial agents or intermediates |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
JP3122161B2 (ja) | 1991-05-16 | 2001-01-09 | 武田薬品工業株式会社 | γ−ラクトン免疫抑制剤 |
ATE150452T1 (de) | 1992-04-07 | 1997-04-15 | British Biotech Pharm | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
US5376664A (en) | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
GB9307956D0 (en) | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
GB9320660D0 (en) | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
JPH09504793A (ja) | 1993-11-04 | 1997-05-13 | ザ リポソーム カンパニー、インコーポレーテッド | マルチラメラリポソーム性のアラキドン酸代謝物製剤 |
GB9323165D0 (en) | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
AU2394795A (en) | 1994-04-28 | 1995-11-29 | Du Pont Merck Pharmaceutical Company, The | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
GB9416897D0 (en) | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
PL183510B1 (pl) | 1994-10-05 | 2002-06-28 | Darwin Discovery Ltd | Związki peptydowe oraz środek farmaceutyczny |
TR199800990T2 (xx) | 1995-12-08 | 1998-07-21 | Agouron Pharmaceuticals, Inc. | Metaloproteinaz inhibit�rleri, bunlar� i�eren farmas�tik bile�imler, bunlar�n farmas�tik kullan�mlar� ve bunlar�n �retiminde kullan�labilecek y�ntemler ve ara �r�nler. |
ES2183905T3 (es) | 1995-12-20 | 2003-04-01 | Hoffmann La Roche | Inhibidores de metaloproteasa de matriz. |
WO1997024117A1 (en) * | 1996-01-02 | 1997-07-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds |
EP0994104A4 (en) | 1996-06-27 | 2001-09-12 | Ono Pharmaceutical Co | ARYL SULFIDE, SULFOXIDE AND SULPHONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM AS AN ACTIVE INGREDIENT |
CA2260859A1 (en) | 1996-07-22 | 1998-01-29 | Monsanto Company | Thiol sulfone metalloprotease inhibitors |
EE04150B1 (et) * | 1997-02-27 | 2003-10-15 | American Cyanamid Company | N-hüdroksü-2-(alküül-, arüül- või heteroarüülsulfanüül-, -sulfinüül- või -sulfonüül-)-3-asendatud -alküülamiidid, -arüülamiidid või -heteroarüülamiidid kui maatriksmetalloproteinaasi inhibiitorid |
US6300514B1 (en) | 1997-06-25 | 2001-10-09 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
HRP980443A2 (en) | 1997-08-18 | 1999-10-31 | Carl P. Decicco | Novel inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis |
US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
PL341379A1 (en) * | 1997-11-14 | 2001-04-09 | Searle & Co | Aromatic sulphone substituted hydroxamic acid as inhibitor of metalloprotease |
IL127496A0 (en) | 1997-12-19 | 1999-10-28 | Pfizer Prod Inc | The use of MMP inhibitors for the treatment of ocular angiogenesis |
SK12332000A3 (sk) * | 1998-02-19 | 2001-02-12 | American Cyanamid Company | N-hydroxy-2-(alkyl, aryl alebo heteroaryl sulfanyl, sulfinyl alebo sulfonyl)-3-substituované-alkyl, aryl alebo heteroarylamidy, farmaceutický prostriedok s ich obsahom a ich použitie |
IL144783A0 (en) | 1999-02-08 | 2002-06-30 | Searle & Co | Sulfamato hydroxamic acid metalloprotease inhibitor |
EP1165500A1 (en) | 1999-04-02 | 2002-01-02 | Du Pont Pharmaceuticals Company | Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase |
-
1999
- 1999-02-24 US US09/256,948 patent/US20010039287A1/en not_active Abandoned
-
2000
- 2000-02-22 CN CN00806608A patent/CN1370144A/zh active Pending
- 2000-02-22 KR KR1020017010886A patent/KR20020092157A/ko not_active Application Discontinuation
- 2000-02-22 EP EP00913317A patent/EP1230219A1/en not_active Withdrawn
- 2000-02-22 EA EA200100804A patent/EA200100804A1/ru unknown
- 2000-02-22 CA CA002371876A patent/CA2371876A1/en not_active Abandoned
- 2000-02-22 CZ CZ20013038A patent/CZ20013038A3/cs unknown
- 2000-02-22 NZ NZ513648A patent/NZ513648A/xx unknown
- 2000-02-22 IL IL14494500A patent/IL144945A0/xx unknown
- 2000-02-22 JP JP2000600979A patent/JP2002537378A/ja active Pending
- 2000-02-22 AU AU34785/00A patent/AU3478500A/en not_active Abandoned
- 2000-02-22 MX MXPA01008568A patent/MXPA01008568A/es unknown
- 2000-02-22 WO PCT/US2000/002518 patent/WO2000050396A1/en not_active Application Discontinuation
- 2000-02-22 BR BR0008491-3A patent/BR0008491A/pt not_active Application Discontinuation
- 2000-02-22 PL PL00351204A patent/PL351204A1/xx not_active Application Discontinuation
- 2000-02-22 HU HU0200239A patent/HUP0200239A3/hu unknown
- 2000-02-24 AR ARP000100800A patent/AR043676A1/es unknown
-
2001
- 2001-08-15 NO NO20013963A patent/NO20013963L/no not_active Application Discontinuation
- 2001-08-16 ZA ZA200106780A patent/ZA200106780B/en unknown
- 2001-09-17 US US09/954,451 patent/US6750233B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20010039287A1 (en) | 2001-11-08 |
CZ20013038A3 (cs) | 2002-07-17 |
CN1370144A (zh) | 2002-09-18 |
CA2371876A1 (en) | 2000-08-31 |
US6750233B2 (en) | 2004-06-15 |
NO20013963D0 (no) | 2001-08-15 |
HUP0200239A3 (en) | 2003-04-28 |
NZ513648A (en) | 2004-02-27 |
MXPA01008568A (es) | 2002-04-08 |
NO20013963L (no) | 2001-10-23 |
KR20020092157A (ko) | 2002-12-11 |
US20020177588A1 (en) | 2002-11-28 |
HUP0200239A2 (en) | 2002-06-29 |
PL351204A1 (en) | 2003-03-24 |
AU3478500A (en) | 2000-09-14 |
EA200100804A1 (ru) | 2002-04-25 |
JP2002537378A (ja) | 2002-11-05 |
AR043676A1 (es) | 2005-08-10 |
EP1230219A1 (en) | 2002-08-14 |
ZA200106780B (en) | 2002-08-16 |
WO2000050396A1 (en) | 2000-08-31 |
BR0008491A (pt) | 2002-09-17 |
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